The Disputation will be live streamed for everyone else.
The livestream will be activated 15 minutes before the Defence starts.
Trial lecture
April 12th, 10:15 AM, Auditorium 3, Chemistry building
Trial lecture title:
“Applying the principles of lipid self-assembly for encapsulating drugs, proteins, and nucleic acids.”
The trial lecture will be live streamed for everyone else.
The livestream will be activated 15 minutes before the trial lecture starts.
Kreeringssammendrag/Conferral summary
Surfaktanter er en gruppe molekyler som inkluderer alt fra lipider, som bygger opp cellemembranen til alt, til detergenter som finnes i rengjøringsprodukter og kosmetikk. Disse molekylene kan spontant danne mange forskjellige typer nanostrukturerer som kan gi egenskaper. I denne avhandlingen har vi sett på hvordan slike nano-strukturer kan forandre seg i påvirkning av ytre stimuli og hvordan lipidmembranen løses opp av detergenter.
Main research findings
The pathways involved in the self-assembly of surfactant molecules are important in a wide range of applications such as drug delivery systems, industrial and household cleaning, and biochemical protocols. This thesis has explored both the kinetic pathways in photocontrollable surfactant systems, where the self-assembly can be modulated using light irradiation, and the structural intermediates that are involved in the solubilization of the phospholipid membrane.
For the photocontrollable surfactant AzoTMA, we found that while the growth mechanism is dominated by exchange of single molecules, the dissolution of micelles upon photoisomerization can occur both through fission and unimer expulsion depending on the conditions. In a mixed lipid:AzoTMA system, the presence of lipids slow down the reorganization of the assemblies that occurs upon light irradiation.
In the investigation of the interactions of popular detergent surfactants with lipid membranes and the solubilizations pathways, the structures formed at different detergent concentrations and temperatures were mapped for two lipid types mixed with three different detergents, and in addition the polysoap of styrene-maleic acid units was investigated. Additionally, it was found that the detergent Triton X-100 can induce a collapse and rippling of the bilayer structure, despite very little detergent being incorporated, resulting a novel nanostructure.
Candidate contact information
LinkedIn: www.linkedin.com/in/victoria-ariel-bjoernestad-3439967b
E-mail: v.a.bjornestad@kjemi.uio.no
Phone: +47 94195496