The Disputation will be live streamed for everyone else.
The livestream will be activated 15 minutes before the Defense starts.
Trial lecture
May 3rd, 10:15 AM, Auditorium 3, Chemistry building
Trial lecture title:
"The use of bioactive compounds in marketed foods"
The trial lecture will be live streamed for everyone else.
The livestream will be activated 15 minutes before the trial lecture starts.
Kreeringssammendrag/Conferral summary
I avhandlingen ble en bioteknologisk prosess brukt for å lage et verdiskapende produkt fra en underutnyttet råvare. Bioaktive peptider ble produsert gjennom enzymatisk hydrolyse av sidestrømmer fra fjærfeforedling. Studien viste at disse bioaktive peptidene har potensial for å virke på terapeutiske mål relevante for behandling av type II diabetes mellitus og kardiovaskulære sykdommer.
Main research findings
The biotechnological transformation of underutilized resources, through processes like enzymatic hydrolysis, can contribute to the production of value-added products by using biomolecules (enzymes) to modify raw materials. Such value-added products can be, for example, nutraceuticals produced from food processing by-products. This dissertation demonstrated that enzymatic protein hydrolysis of chicken processing by-products can produce bioactive peptides with promising health-promoting effects. Bioanalytical methods were employed to screen, identify, and characterize bioactive peptides in a complex mixture of a crude protein hydrolysate. The bioactivities explored were blood pressure- and blood glucose regulation as well as antioxidant activity. Three bioactive peptides were identified from a mechanically deboned chicken residue (MDCR) hydrolysate. Our findings indicate that MDCR is a promising raw material to produce bioactive peptides. A low molecular weight peptide fraction isolated from the crude hydrolysate demonstrated a dual pharmacological effect (blood pressure- and blood glucose regulation). Dual activity is particularly valuable for management of complex diseases (e.g., diabetes) often requiring multi-drug regimen. Bioavailability of the identified bioactive peptides was evaluated. While the bioactive peptides demonstrated good gastrointestinal stability, their intestinal permeability could not be demonstrated. The dissertation demonstrated a promising potential of chicken by-product hydrolysates as a source of health-promoting bioactive peptides.
Candidate contact information
LinkedIn: https://www.linkedin.com/in/liudmila-sorokina/