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Solveig Kristensen

Dekan

E-post solveig.kristensen@mn.uio.no

Telefon +47 22 85 42 18

Mobiltelefon +47 40 28 65 74

Rom Fysikk Ø268 Dekanat

Brukernavn

Besøksadresse Sem Sælands vei 24 Fysikkbygningen 0371 OSLO

Postadresse Postboks 1032 Blindern 0315 OSLO

Pressebilde Last ned visittkort

Faglige ansvarsområder

Som dekan ved Norges eldste, største og fremste fakultet innen bredden av realfag og teknologi er en av mine viktigste oppgaver å hegne om universitetets og den enkelte forskers frie rolle i samfunnet. Dekanatets visjon er å videreutvikle og heve vårt fakultet ytterligere som et ledende europeisk forskningsfakultet med utdanning på høyt internasjonalt nivå. Basert på dette skal vi styrke og tydeliggjøre vår rolle som en sentral samfunnsaktør og være en attraktiv samarbeidspartner for næringsliv og offentlig sektor.

Realfag og teknologi er avgjørende for en bærekraftig utvikling innen grunnleggende områder som miljø og klima, produksjon av energi, drikkevann og mat, diagnostikk og behandling av sykdom, og ikke minst digitalisering av hele samfunnet. Ved fremragende forskning, utvikling av nye forskertalenter og utdanning av unge kandidater med høy etterspurt kompetanse bidrar fakultetet til kunnskapsgrunnlaget som samfunnet trenger. Dekanatets jobb er å legge forholdene godt til rette for å fylle disse oppgavene. Et godt arbeidsmiljø og læringsmiljø for ansatte og studenter er en forutsetning for å lykkes, og høyt prioritert i vårt dekanat. Vi har fokus på å utvikle fakultetet i en miljøvennlig retning, der bærekraft danner et viktig grunnlag for prioritering.

Forskning og undervisning

Som forsker har jeg vært opptatt av utvikling og karakterisering av legemiddelformuleringer til fotodynamisk terapi (PDT) og radioaktiv strålingsterapi, med fokus på kreftterapi og behandling av bakterieinfeksjoner. Studier av fotokjemisk stabilitet og kartlegging av fotokjemiske reaksjonsmekanismer har alltid vært en sentral del av min forskning.

Jeg har lang erfaring med utvikling og kvalitetssikring av det femårige integrerte Masterprogrammet i farmasi og videreutdanning innen Klinisk farmasi. Jeg har arbeidet med emneutvikling og undervisning innen:

Farmasi (master 5 år):

Klinisk farmasi (erfaringsbasert master):

FRM 5930V - Videregående farmakoterapi I

Bakgrunn

Dekan, MN-fakultetet, UiO, 2021-2028
Prodekan forskning, MN-fakultetet, UiO, 2019-2020
Prodekan studier, MN-fakultetet, UiO, 2013-2019
Professor Galenisk farmasi, UiO, 2009
1. amanuensis Galenisk farmasi, UiO, 1996-2009
Dr.scient Galenisk farmasi, UiO, 1997
Cand.pharm., UiO, 1990

Verv

Nasjonalt

Akershus universitetssykehus - styremedlem
Sigma2 - styremedlem
Oslotech - styremedlem
Norsk Regnesentral - valgstyret
Birkelandsenteret - styringsgruppen

Det matematisk-naturvitenskapelige fakultet og UiO

Fakultetsstyret - leder
Ansettelsesutvalget ved MN - leder
LIMU - Likestilling, inkludering og mangfoldsutvalget ved MN - leder
Dekanmøtet UiO - medlem
Dekanatmøtet MN - leder
Instituttledermøtet MN - leder
Livsvitenskap UiO - styringsgruppe
Livsvitenskap MN - leder
CCSE - Center for Computing in Science Education - styreleder
dScience - Centre for Computational and Data Science - styreleder

Prosjekter

Det matematisk-naturvitenskapelige fakultet

FRONT: Likestilt mangfold eller mangfoldig ulikestilling? NFR BALANSE-prosjekt 2024-2025

Diverse

Medlem av Norges tekniske vitenskapsakademi - NTVA
Kåret til en av Norges 50 fremste tech-kvinner 2021 v/ Abelia

Emneord: Life science, Farmasi, Legemidler, Legemiddelteknologi, Legemiddelformulering, Legemiddelstabilitet, Lysstabilitet, Fotodynamisk terapi, Radiofarmasi, Nanoteknologi

Cuccato, Nicola; Nardo, Luca; Kristensen, Solveig; Tønnesen, Hanne Hjorth & Tovsen, Marianne Lilletvedt (2018). Solubilization of the chlorin TPCS2a in the presence of Pluronic® F127/Tween 80 mixtures. Pharmaceutical development and technology (Print). ISSN 1083-7450. doi: 10.1080/10837450.2018.1515955. Fulltekst i vitenarkiv
Frenvik, Janne Olsen; Dyrstad, Knut; Kristensen, Solveig & Ryan, Olav B. (2017). Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part I: purification of decayed thorium-227 on cation exchange columns. Drug Development and Industrial Pharmacy. ISSN 0363-9045. 43(2), s. 225–233. doi: 10.1080/03639045.2016.1234484. Fulltekst i vitenarkiv
Frenvik, Janne Olsen; Dyrstad, Knut; Kristensen, Solveig & Ryan, Olav B. (2017). Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part II: purification of targeted thorium conjugates on cation exchange columns. Drug Development and Industrial Pharmacy. ISSN 0363-9045. 43(9), s. 1440–1449. doi: 10.1080/03639045.2017.1318906. Fulltekst i vitenarkiv
Bjerknes, Kathrin; Bøyum, Silje; Kristensen, Solveig; Brustugun, Jørgen & Wang, Siri (2017). Manipulating tablets and capsules given to hospitalised children in Norway is common practice. Acta Paediatrica. ISSN 0803-5253. 106(3), s. 503–508. doi: 10.1111/apa.13700. Fulltekst i vitenarkiv
Baertschi, Steven W.; Clapham, David; Foti, Chris; Kleinman, Mark H.; Kristensen, Solveig & Reed, Robert A. [Vis alle 8 forfattere av denne artikkelen] (2015). Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 2: Topical Drug Product. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 104(9), s. 2688–2701. doi: 10.1002/jps.24396. Fulltekst i vitenarkiv
Generalov, Roman; Kuan, Woo Boon; Chen, Wei; Kristensen, Solveig & Juzenas, Petras (2015). Radiosensitizing effect of zinc oxide and silica nanocomposites on cancer cells. Colloids and Surfaces B: Biointerfaces. ISSN 0927-7765. 129, s. 79–86. doi: 10.1016/j.colsurfb.2015.03.026. Fulltekst i vitenarkiv
Tovsen, Marianne Lilletvedt; Smistad, Gro; Bjerke, Trude Marie; Tønnesen, Hanne Hjorth & Kristensen, Solveig (2015). Physicochemical Stability of Emulsions and Admixtures for Parenteral Nutrition during Irradiation by Glass-Filtered Daylight at Standardized Conditions. PDA journal of pharmaceutical science and technology. ISSN 1079-7440. 69, s. 346–354. doi: 10.5731/pdajpst.2015.01036. Fulltekst i vitenarkiv
Sobczynski, Jan; Smistad, Gro; Hegge, Anne Bee & Kristensen, Solveig (2015). Molecular interactions and solubilization of structurally related meso-porphyrin photosensitizers by amphiphilic block copolymers (Pluronics). Drug Development and Industrial Pharmacy. ISSN 0363-9045. 41(8), s. 1237–1246. doi: 10.3109/03639045.2014.938657. Fulltekst i vitenarkiv
Frenvik, Janne Olsen; Kristensen, Solveig & Ryan, Olav Benjamin (2015). Development of separation technology for the removal of radium-223 from decayed thorium-227 in drug formulations. Material screening and method development. Drug Development and Industrial Pharmacy. ISSN 0363-9045. 42(8), s. 1215–1224. doi: 10.3109/03639045.2015.1118494. Fulltekst i vitenarkiv
Tovsen, Marianne Lilletvedt; Bruzell, Ellen; Ferrari, Erika; Saladini, Monica; Gaware, Vivek S. & Másson, Már [Vis alle 8 forfattere av denne artikkelen] (2014). Antibacterial phototoxic effects of synthetic asymmetric and glycosylated curcuminoids in aqueous formulations: Studies on curcumin and curcuminoids. LIV. Journal of Photochemistry and Photobiology. B: Biology. ISSN 1011-1344. 140, s. 150–156. doi: 10.1016/j.jphotobiol.2014.07.013. Fulltekst i vitenarkiv
Sobczynski, Jan; Kristensen, Solveig & Berg, Alf Kristian (2014). The influence of Pluronics nanovehicles on dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers in cancer cells. Photochemical and Photobiological Sciences. ISSN 1474-905X. 13(1), s. 8–22. doi: 10.1039/c3pp50181g. Fulltekst i vitenarkiv Vis sammendrag
Many photosensitizers (PSs) for use in photodynamic therapy (PDT) are characterized by poor solubility and a tendency to aggregate in aqueous environments. Nanovehicles of Pluronics block copolymers may be used for drug delivery of antineoplastic agents and may also exert a separate effect in enhancing drug efficiency. The objective of this study was to determine the effects of selected Pluronics (F127, P123, L44 and F68) on the dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers, tetraphenyl porphyrins 4-substituted on the phenyl groups with trimethylamine (TAPP), hydroxyl (THPP), sulfonate (TSPP) and carboxyl (TCPP) in cancer cells. The selected PSs showed a 3 log range in sensitivity to cellular photoinactivation. Pluronics were found to efficiently deaggregate the PSs and improve PS solubility as analyzed by fluorescence spectroscopy and dynamic light scattering. The Pluronics had moderate to profound effects on intracellular localization of the PSs and cellular sensitivity to photoinactivation. Confocal microscopy was used to determine the localization of PSs in colon adenocarcinoma cell line (WiDr), guided by co-staining with nuclear (Hoechst 33342) and endolysosomal (LysoTracker Green DND® 26 and Dextran Alexa Fluor® 488) markers. Of the most significant effects P123 and F127 strongly attenuated the uptake and photocytotoxicity of THPP and redirected the cellular uptake to endocytosis. P123 stimulated translocation of TAPP from endocytic vesicles to a cytosolic and nuclear localization followed by an enhanced phototoxicity. In the absence of Pluronics TCPP was found to localize partly in endocytic vesicles and partly in the cytosol and nucleus, while P123 and F127 lowered the fraction in endocytic vesicles followed by a reduced sensitivity to photoinactivation. F68 had only moderate effects on intracellular localization of the evaluated PSs with the exception of a higher endocytic accumulation of TCPP and lowered photocytotoxicity of TCPP and THPP. In conclusion, Pluronics are attractive solubilizers of porphyrin-based PSs which have in many cases substantial effects on intracellular localization and efficacy of the PSs.
Singh, Ravinder; Tønnesen, Hanne Hjorth; Kristensen, Solveig & Berg, Kristian (2013). The influence of Pluronics (R) on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX. Photochemical and Photobiological Sciences. ISSN 1474-905X. 12(3), s. 559–575. doi: 10.1039/c2pp25249j. Fulltekst i vitenarkiv
Singh, Ravinder; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2013). Influence of vehicle properties and excipients on hydrolytic and photochemical stability of curcumin in preparations containing Pluronics. Pharmazie. ISSN 0031-7144. 68, s. 160–169. Fulltekst i vitenarkiv
Baertschi, Steven W; Clapham, David; Foti, Chris; Jansen, Patrick; Kristensen, Solveig & Reed, Robert A. [Vis alle 8 forfattere av denne artikkelen] (2013). Implications of in -use photostability: proposed guidance for photostability testing and labeling to support the administration of photosensitive pharmaceutical products, part 1: drug products administered by injection. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 102(11), s. 3888–3899. doi: 10.1002/jps.23717. Fulltekst i vitenarkiv
Sobczynski, Jan; Tønnesen, Hanne Hjorth & Kristensen, Solveig (2013). Influence of aqueous media properties on aggregation and solubility of four structurally related meso-porphyrin photosensitizers evaluated by spectrophotometric measurements. Pharmazie. ISSN 0031-7144. 68, s. 100–109. doi: 10.1691/ph.2013.2130. Fulltekst i vitenarkiv
Hegge, Anne Bee; Vukicevic, Milica; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2013). Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT) Studies on curcumin and curcuminoides L. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 83(1), s. 95–105. doi: 10.1016/j.ejpb.2012.09.011. Fulltekst i vitenarkiv Vis sammendrag
Curcumin is under investigation as a potential photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT). The therapeutic potential of curcumin as a PS is limited by its low aqueous solubility, susceptibility to hydrolytic and photolytic degradation, and limited phototoxicity toward Gram negative (G−) bacteria. Supersaturated solutions of curcumin have demonstrated high phototoxicity toward several species of Gram positive (G+) bacteria as well as the G− Escherichia (E) coli. Thus, solid dispersions that can form supersaturated solutions of curcumin upon hydration may be beneficial in aPDT. In the present study, solid dispersions of curcumin have been prepared through lyophilization of concentrated solutions obtained from dissolution of hydroxypropyl-β-cyclodextrin (HPβCD)-curcumin co-precipitates. Hydroxypropyl methylcellulose (HPMC) was added to curcumin solutions prior to lyophilization. The resulting lyophilizates were porous, amorphous and hydrated and dissolved rapidly in contact with a model physiological salt solution. The detected drug load of the lyophilizates was in the range 0.5–1.0% (w/w) and was dependent on the selected ratio between HPβCD and curcumin in the co-precipitate. The lyophilizate with the highest drug load could easily be dissolved in aqueous medium to form curcumin solutions of relevant concentrations for aPDT (i.e., 10 μM). Selected solutions of the curcumin solid dispersions showed a pronounced decrease in curcumin concentration up to 90% after storage for 168 h, which indicated that supersaturated curcumin solutions were initially formed upon dissolution of the lyophilizates. Both freshly prepared and 2 days old solutions of one selected curcumin lyophilizate induced significant inactivation of E. coli (∼1% bacterial survival) after exposure to a light dose of only 5 J/cm2.
Nardo, Luca; Kristensen, Solveig; Tønnesen, Hanne Hjorth; Høgset, Anders & Lilletvedt, Marianne (2012). Solubilization of the photosensitizers TPCS2a and TPPS2a in aqueous media evaluated by time-resolved fluorescence analysis. Pharmazie. ISSN 0031-7144. 67(7), s. 598–600. doi: 10.1691/ph.2012.1791. Fulltekst i vitenarkiv
Singh, Ravinder; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2012). Influence of cosolvents, ionic strength and the method of sample preparation on the solubilization of curcumin by Pluronics and HP-γ-cyclodextrin Studies of curcumin and curcuminoids, XLIV. Pharmazie. ISSN 0031-7144. 67(2), s. 131–142. doi: 10.1691/ph.2012.1097. Fulltekst i vitenarkiv
Hegge, Anne Bee; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2012). Photoinactivation of Stahpylococcus epidermidis biofilms and suspensions by the hydrophobic photosensitizer curcumin- effect of selected nanocarrierStudies of curcumin and curcuminoides XLVII. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 47(1), s. 65–74. doi: 10.1016/j.ejps.2012.05.002. Fulltekst i vitenarkiv
Singh, Ravinder; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2012). Influence of vehicle properties and excipients on hydrolytic and photochemical stability of curcumin in preparations containing Pluronics. Studies on curcumin and curcuminoids XLVIII. Pharmazie. ISSN 0031-7144. 67(11), s. 1–10. doi: 10.1039/c2pp25249j. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Smistad, Gro; Tønnesen, Hanne Hjorth; Høgset, Anders & Kristensen, Solveig (2011). Solubilization of the novel anionic amphiphilic photosensitizer TPCS2a by nonionic Pluronic block copolymers. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 43(3), s. 180–187. doi: 10.1016/j.ejps.2011.04.004. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, Therese; Melvik, J.E.; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2011). Formulation and Bacterial Phototoxicity of Curcumin Loaded Alginate Foams for Wound Treatment Applications: Studies on Curcumin and Curcuminoides XLII. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 100(1), s. 174–185. doi: 10.1002/jps.22263. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Høgset, Anders; Sande, Sverre Arne & Kristensen, Solveig (2011). Evaluation of physicochemical properties and aggregation of the photosensitizers TPCS2a and TPPS2a in aqueous media. Pharmazie. ISSN 0031-7144. 66(5), s. 325–333. doi: 10.1691/ph.2011.0337. Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, E; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2011). A screening of curcumin derivatives for antibacterial phototoxic effects Studies on curcumin and curcuminoids. XLIII. Pharmazie. ISSN 0031-7144. 66(1), s. 69–74. doi: 10.1691/ph.2011.0154. Fulltekst i vitenarkiv
Generalov, Roman; Kavaliauskiene, Simona; Westrøm, Sara; Chen, Wei; Kristensen, Solveig & Juzenas, Petras (2011). Entrapment in phospholipid vesicles quenches photoactivity of quantum dots. International Journal of Nanomedicine. ISSN 1176-9114. 6, s. 1875–1888. doi: 10.2147/IJN.S22953. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2010). Lumichrome complexation by cyclodextrins: Influence of pharmaceutical excipients. Pharmazie. ISSN 0031-7144. 65(12), s. 871–876. doi: 10.1691/ph.2010.0680. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Kristensen, Solveig; Tønnesen, Hanne Hjorth; Høgset, Anders & Nardo, Luca (2010). Time-domain evaluation of drug-solvent interactions of the photosensitizers TPCS2a and TPPS2a as part of physicochemical characterization. Journal of Photochemistry and Photobiology A: Chemistry (JPPA). ISSN 1010-6030. 214(1), s. 40–47. doi: 10.1016/j.jphotochem.2010.06.004. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, T; Melvik, Jan Egil; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2010). Phototoxicity of curcumin loaded alginate foams to Enterococcus faecalis and Escherichia coil in vitro. Journal of Pharmacy and Pharmacology (JPP). ISSN 0022-3573. 62(10), s. 1458–1459. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Høgset, Anders; Nardo, Luca & Kristensen, Solveig (2010). Physicochemical characterization of the photosensitizers TPCS2a and TPPS2a 1. Spectroscopic evaluation of drug - solvent interactions. Pharmazie. ISSN 0031-7144. 65(8), s. 588–595. doi: 10.1691/ph.2010.0025. Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2010). Photokilling of bacteria by curcumin in selected polyethylene glycol 400 (PEG 400) preparations Studies on curcumin and curcuminoids, XLI. Pharmazie. ISSN 0031-7144. 65(8), s. 600–606. doi: 10.1691/ph.2010.0048. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, T; Melvik, Jan Egil; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2010). Evaluation of Novel Alginate Foams as Drug Delivery Systems in Antimicrobial Photodynamic Therapy (aPDT) of Infected Wounds An In Vitro Study: Studies on Curcumin and Curcuminoides XL. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 99(8), s. 3499–3513. doi: 10.1002/jps.22119. Fulltekst i vitenarkiv
Generalov, Roman; Christensen, Ingeborg Lie; Chen, Wei; Sun, Ya-Ping; Kristensen, Solveig & Juzenas, Petras (2009). Generation of singlet oxygen and other radical species by quantum dot and carbon dot nanosensitizers. Proceedings of SPIE, the International Society for Optical Engineering. ISSN 0277-786X. 7380. doi: 10.1117/12.830353. Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Photokilling of bacteria by curcumin in different aqueous preparations. Studies on curcumin and curcuminoids XXXVII. Pharmazie. ISSN 0031-7144. 64(10), s. 666–673. doi: 10.1691/ph.2009.9130. Fulltekst i vitenarkiv
Sue-Chu, Monica; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Photoinduced color changes in two different qualities of riboflavin in the solid state and in various tablet formulations Photoreactivity of biologically active compounds. XX. Pharmazie. ISSN 0031-7144. 64(7), s. 428–435. Fulltekst i vitenarkiv
Brustugun, Jørgen; Lao, Yvonne E.; Fagernæs, Charlotte; Brænden, Jorunn U. & Kristensen, Solveig (2009). Long-term stability of extemporaneously prepared captopril oral liquids in glass bottles. American Journal of Health-System Pharmacy. ISSN 1079-2082. 66(19), s. 1722–1725. doi: 10.2146/ajhp080542. Fulltekst i vitenarkiv
Kristensen, Solveig & Brustugun, Jørgen (2009). Reformulering av orale kaptopriloppløsninger til barn basert på stabilitetsstudier. Norsk Farmaceutisk Tidsskrift (NFT). ISSN 0029-1935. 117(9), s. 20–23. Fulltekst i vitenarkiv
Kristensen, Solveig; Edge, Ruth; Tønnesen, Hanne Hjorth; Bisby, Roger H. & Navaratnam, Suppiah (2009). Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine. Journal of Photochemistry and Photobiology. B: Biology. ISSN 1011-1344. 94(3), s. 147–157. doi: 10.1016/j.jphotobiol.2008.11.006. Fulltekst i vitenarkiv
Hegge, Anne Bee; Másson, Már; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Investigation of curcumin-cyclodextrin inclusion complexation in aqueous solutions containing various alcoholic co-solvents and alginates using an UV-VIS titration method. Pharmazie. ISSN 0031-7144. 64(6), s. 382–389. doi: 10.1691/ph.2009.8380. Fulltekst i vitenarkiv
Sue-Chu, Monica; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). Influence on lag-time between light exposure and color evaluation of riboflavin in the solid state. Pharmazie. ISSN 0031-7144. 63, s. 545–546. Fulltekst i vitenarkiv
Tønnesen, Hanne Hjorth; Kristensen, Solveig & Karlsen, Jan (2008). Formulering av legemidler et satsningsområde. Norsk Farmaceutisk Tidsskrift (NFT). ISSN 0029-1935. 116(1), s. 28–32. Fulltekst i vitenarkiv
Kristensen, Solveig; Lao, Yvonne E.; Brustugun, Jørgen & Brænden, Jorunn U. (2008). Influence of formulation properties on chemical stability of captopril in aqueous preparations. Pharmazie. ISSN 0031-7144. 63(12), s. 872–877. Fulltekst i vitenarkiv
Kristensen, Solveig; Edge, Ruth; Tønnesen, Hanne Hjorth; Bisby, Roger H. & Navaratnam, Suppiah (2008). Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine. Journal of Photochemistry and Photobiology. B: Biology. ISSN 1011-1344. 94, s. 147–157. Fulltekst i vitenarkiv
Malinovic, Jelena & Kristensen, Solveig (2008). Håndtering av lysfølsomme parenterale preparater ved sykehusapotek og sykehusposter. Norsk Farmaceutisk Tidsskrift (NFT). ISSN 0029-1935. 116(3), s. 25–28. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schuller, RB; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII. Pharmazie. ISSN 0031-7144. 63, s. 585–592. doi: 10.1691/ph.2008.8059. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schüller, Reidar Barfod; Kristensen, Solveig & Tønnesen, Hanne Hjort (2008). In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII. Pharmazie. ISSN 0031-7144. 63(8), s. 585–592. Fulltekst i vitenarkiv Vis sammendrag
Combinations of cyclodextrins and alginates were used to solubilize the hydrophobic compound curcumin in aqueous vehicles intended for topical delivery. A careful selection of the excipients is necessary to achieve a sufficient release of curcumin towards a membrane of hydrophilic character, e.g. mucosa. The aim of the study was to investigate the effect of different combinations of cyclodextrins and alginates on curcumin release towards hydrophilic membranes in vitro. The curcumin flux through semi-permeable membranes of different molecular weight cut-off was measured to differentiate between the flux of curcumin in its uncomplexed form (restricted flux), its uncomplexed form together with its inclusion complexes (partly restricted flux) and the overall flux of curcumin-cyclodextrin complexes and uncomplexed curcumin (unrestricted flux). A high viscosity of the vehicle was expected to inhibit curcumin flux. Vehicles containing 3% alginate were found to have lower unrestricted flux than the vehicles containing 0.5% alginate independent of the type of cyclodextrin used. The results indicate that the unrestricted curcumin flux (e.g. in the case of wounded skin) is rather independent of the composition of the hydrophilic vehicle and mostly limited by the viscosity. However, partly restricted and restricted curcumin flux were found to depend on both the viscosity and the composition of the vehicles. The cyclodextrin with the demonstrated lowest solubilisation capacity (i.e. hydroxypropyl-beta-cyclodextrin) resulted in the highest values of both the restricted and unrestricted curcumin flux. In conclusion, a combination of hydroxypropyl-beta-cyclodextrin and propylene glycol alginate seemed to be the best choice with respect to curcumin solubility and release from the vehicle.
Sue-Chu, Monica; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). Influence of lag-time between light exposure and color evaluation of riboflavin in the solid state. Pharmazie. ISSN 0031-7144. 63, s. 545–546. doi: 10.1691/ph.2008.8070. Fulltekst i vitenarkiv

Se alle arbeider i NVA

Sandset, Tony Joakim Ananiassen; Kristensen, Solveig; Amundsen, Marthe & Harbo, Hanne-Cathrin Flinstad (2026). Likestilling og mangfold som kvalitetspolitikk i akademia. Fulltekst i vitenarkiv
Persson, Aksel Faanes; Borsch, Rebekka; Kristensen, Solveig; Hagen, Trond Runar; Jaber, Munir & Bjørlo, Alfred (2025). Kan deep tech bli en gullgruve for Norge? (live-opptak fra Arendalsuka 2025). doi: https:/shows.acast.com/smart-forklart/episodes/kan-deep-tech-bli-en-gullgruve-for-norge. Fulltekst i vitenarkiv
Kristensen, Solveig (2022). Foreword. I Holter, Øystein Gullvåg & Snickare, Lotta Karin (Red.), Gender Equality in Academia – from Knowledge to Change. Cappelen Damm Akademisk. ISSN 9788202778026. s. 9–12. Fulltekst i vitenarkiv
Fyhn, Marianne; Kristensen, Solveig; Mørken, Knut Martin; Sølna, Hanne; Tellefsen, Cathrine Wahlstrøm & Villanger, Ilan Dehli (2017). Helhetlig fokus på utdanningsutvikling. Fulltekst i vitenarkiv
Turlotte, Chloè; Gadmar, Tone Charlotte; Haraldsen, Kirsten Borse; Kristensen, Solveig; Rustad, Brit Heidi & Snickare, Lotta Karin [Vis alle 18 forfattere av denne artikkelen] (2017). DAMER! 100 år med kvinner i realfagene ved UiO. Fulltekst i vitenarkiv Vis sammendrag
Kvinnenes plass i realfagene er nå som før et aktuelt diskusjonstema i akademia. Kvinnelige forskere er viktige rollemodeller for unge jenter som skal velge utdannelse og yrkesvei. Utstillingen trekker fram kvinnelige forskere ved Universitetet i Oslo; fra pionerene som virket tidlig på 1900-tallet til dagens og morgendagens forskere. Utstillingen presenteres i tre deler: Første del presenterer ‘Pionerene’, de første kvinner som fikk fast vitenskapelig stilling ved Universitetet i Oslo. Andre del gir kontekstuell informasjon om sosiale og kulturelle forhold for kvinner gjennom det 20. århundret. Temaer som kvinnefrigjøring og utdanningsmuligheter blir presentert. Tredje del presenterer sitater plukket fra «den gode samtale» med noen av MN-fakultetets (fantastiske) kvinnelige forskere i dag, hvor de gir et lite innblikk i hvordan Damene selv opplever sin hverdag og hvordan unge kvinnelige stipendiater ser for seg en eventuell fremtid som forsker.
Holter, Øystein Gullvåg; Liestøl, Knut; Tallaksen, Lena M. & Kristensen, Solveig (2016). Universitetene er sterkt konkurransedrevet. I dette løpet taper kvinnene. Kronikk Aftenposten 7.3.2016 http://www.aftenposten.no/meninger/kronikker/Kronikk-Universitetene-er-sterk t-konkurransedrevet-I-dette-lopet-taper-kvinnene-8380246.html. Fulltekst i vitenarkiv
Frenvik, Janne Olsen; Kristensen, Solveig & Ryan, Olav Benjamin (2013). Towards the development of a technology platform for the formulation of Targeted Thorium Conjugates. Fulltekst i vitenarkiv
Sobczynski, Jan; Kristensen, Solveig; Smistad, Gro; Hegge, Anne Bee; Tønnesen, Hanne Hjorth & Berg, Alf Kristian (2013). The influence of Pluronic block copolymers on solubilization and photocytotoxicity of porphyrin photosensitizers. Fulltekst i vitenarkiv
Frenvik, Janne Olsen; Kristensen, Solveig & Ryan, Olav Benjamin (2013). Towards the development of a technology platform for the formulation of Targeted Thorium Conjugates. Fulltekst i vitenarkiv
Kristensen, Solveig; Lilletvedt, Marianne; Sobczyński, Jan; Tønnesen, Hanne Hjorth; Smistad, Gro & Nardo, Luca [Vis alle 7 forfattere av denne artikkelen] (2012). INCORPORATION OF PORPHYRIN PHOTOSENSITIZERS INTO NONIONIC PLURONIC BLOCK COPOLYMERIC NANOCARRIERS. Fulltekst i vitenarkiv
Kristensen, Solveig (2012). Parenterale preparater. Fulltekst i vitenarkiv
Kristensen, Solveig (2012). Kvalitetssikring av aseptisk produksjon. Fulltekst i vitenarkiv
Kristensen, Solveig (2012). Fortynning og holdbarhet av bruksferdige parenterale preparater - del II. Fulltekst i vitenarkiv
Kristensen, Solveig (2012). Forskning ved sykehusapotek - utfordringer og muligheter. Fulltekst i vitenarkiv
Kristensen, Solveig (2012). Fortynning og holdbarhet av bruksferdige parenterale preparater - del I. Fulltekst i vitenarkiv
Kristensen, Solveig; Lilletvedt, Marianne; Sobczyński, Jan; Smistad, Gro; Nardo, Luca & Høgset, Anders [Vis alle 7 forfattere av denne artikkelen] (2012). Solubilization of porphyrin photosensitizers by nonionic Pluronic block copolymers. Fulltekst i vitenarkiv
Kristensen, Solveig (2012). Legemidler med krav til sterilitet. Fulltekst i vitenarkiv
Vukicevic, Milica; Hegge, Anne Bee; Tuveng, Tina Rise; Tønnesen, Hanne Hjorth & Kristensen, Solveig (2012). Solid state characterization of dispersions of the poorly soluble photosensitizer curcumin. Fulltekst i vitenarkiv
Hegge, Anne Bee; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2012). Photoinactivation of bacterial biofilms and supensions by cyclodextrin complexes of curcumin. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Smistad, Gro; Nardo, Luca; Høgset, Anders & Kristensen, Solveig (2012). Pharmaceutical preformulation of a novel photosensitizer for use in the technology of photochemical internalization (PCI). Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Høgset, Anders; Smistad, Gro & Kristensen, Solveig (2011). Pharmaceutical preformulation of the novel photosensitizer TPCS2a for use in photochemical internalization (PCI). Fulltekst i vitenarkiv
Kristensen, Solveig & Stickler, Ellen-Anette (2011). Utvikling av vaksiner. Fulltekst i vitenarkiv
Kristensen, Solveig & Tønnesen, Hanne Hjorth (2011). Drug formulation – a key issue in drug development. What can the University offer? Fulltekst i vitenarkiv
Sobczynski, Jan; Tønnesen, Hanne Hjorth & Kristensen, Solveig (2011). Physicochemical evaluation of four structurally related meso-porphyrin photosensitizers as part of drug formulation. Fulltekst i vitenarkiv
Vukicevic, Milica; Randeberg, Lise Lyngsnes; Boschker, Jos Emiel; Tybell, Thomas; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2011). PHOTOINDUCED COLOR CHANGES IN TWO POLYMORFIC FORMS OF RIBOFLAVIN;. Fulltekst i vitenarkiv
Sobczynski, Jan; Tønnesen, Hanne Hjorth & Kristensen, Solveig (2011). Physicochemical evaluation of four structurally related meso-porphyrin photosensitizers as part of drug formulation. Fulltekst i vitenarkiv
Vukicevic, Milica; Randeberg, Lise Lyngsnes; Boschker, Jos Emiel; Tybell, Thomas; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2011). PHOTOINDUCED COLOR CHANGES IN TWO POLYMORFIC FORMS OF RIBOFLAVIN. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, Therese; Melvik, Jan Egil; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2010). Phototoxicity of curcumin loaded alginate foams to Enterococcus faecalis and Escherichia coli in vitro. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Nardo, Luca; Høgset, Anders & Kristensen, Solveig (2010). Characterization of the spectroscopic properties of the photosensitizers TPCS2a and TPPS2a as part of pharmaceutical preformulation. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, Therese; Melvik, Jan Egil; Bruzell, Ellen; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2010). In vitro photokilling of Enterococcus faecalis using the natural compound curcumin in vehicles of alginate and cyclodextrin. Fulltekst i vitenarkiv
Kristensen, Solveig & Stickler, Ellen-Anette (2010). Utvikling av vaksiner. Fulltekst i vitenarkiv
Generalov, Roman; Christensen, Ingeborg Lie; Chen, Wei; Sun, Ya-Ping; Kristensen, Solveig & Juzenas, Petras (2009). Generation of singlet oxygen and other radical species by quantum dot and carbon dot nanosensitizers. Fulltekst i vitenarkiv
Generalov, Roman; Chen, Wei; Kristensen, Solveig & Juzenas, Petras (2009). Non-toxic scintillating nanoparticle-based radiosensitizers for increasing efficacy of radiotherapy. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, Therese; Melvik, Jan Egil; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Evaluation of novel alginate foams containing cyclodextrins as drug delivery systems in topical photodynamic therapy of infected wounds. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, Therese; Melvik, Jan Egil; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Effects of excipients on the photostability and drug release in formulations of a novel wound-dressing for Photodynamic Antimicrobial therapy (PACT). Fulltekst i vitenarkiv
Tønnesen, Hanne Hjorth; Hegge, Anne Bee; Haukvik, Tone & Kristensen, Solveig (2009). Antimicrobial photodynamic therapy: Minimization of compound-related failure by optimization of the drug formulation. Fulltekst i vitenarkiv
Kristensen, Solveig (2009). Lysstabilitet og lysbeskyttelse av farmasøytiske preparater. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Høgset, Anders & Kristensen, Solveig (2009). Spectroscopic evaluation of drug-solvent interactions of the photosensitizers TPCS2a and TPPS2a. Fulltekst i vitenarkiv
Hegge, Anne Bee; Andersen, Therese; Melvik, Jan Egil; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Preparation and evaluation of novel alginate-wound dressings loaded with a model photosensitizer. Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, Ellen; Dragland, Inger Sofie; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Photokilling of Bacteria by Curcumin in Selected Polyethyleneglycol (PEG) Preparations. Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, Ellen; Dragland, Inger Sofie; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2009). Photokilling of Bacteria by Curcumin in Selected Polyethyleneglycol (PEG) Preparations. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schüller, Reidar; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). In vitro release of a hydrophobic compound from topical formulations containing alginate and cyclodextrin. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schüller, Reidar; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). In vitro release of Curcumin, a hydrophobic photosensitizer from topical formulations containing alginate and cyclodextrin. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schüller, Reidar; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). Formulering av Curcumin med alginat og cyclodextrin. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Høgset, Anders & Kristensen, Solveig (2008). Ph.D project presentation “Developement of parenteral preparations of a patented photosensitizer for applications in photochemical internalization” (PCI). Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, Ellen; Dragland, Inger Sofie; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). Photokilling of bacteria by curcumin in selected aqueous preparations. Fulltekst i vitenarkiv
Haukvik, Tone; Bruzell, Ellen; Dragland, Inger Sofie; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). Photokilling of bacteria by curcumin in selected aqueous preparations. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schüller, Reidar; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). In vitro release of Curcumin, a hydrophobic photosensitizer from topical formulations containing alginate and cyclodextrin. Fulltekst i vitenarkiv
Hegge, Anne Bee; Schüller, Reidar; Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). In vitro release of Curcumin, a hydrophobic photosensitizer from topical formulations containing alginate and cyclodextrin. Fulltekst i vitenarkiv
Lilletvedt, Marianne; Tønnesen, Hanne Hjorth; Høgset, Anders & Kristensen, Solveig (2008). Development of parenteral preparations of a patented photosensitizer for applications in photochemical internalization. Fulltekst i vitenarkiv
Kristensen, Solveig (2008). Formulation of photolabile and photoactivated pharmaceutical preparations. Fulltekst i vitenarkiv
Brustugun, Jørgen; Lao, Yvonne E.; Brænden, Jorunn U. & Kristensen, Solveig (2008). Captopril oral liquids – the long way towards increased shelf-life. Fulltekst i vitenarkiv
Kristensen, Solveig & Tønnesen, Hanne Hjorth (2008). In-use photostability of pharmaceutical preparations. Fulltekst i vitenarkiv
Haukvik, Tone; Tønnesen, Hanne Hjorth; Kristensen, Solveig; Dahl, Jon Einar & Bruzell, Ellen (2012). Curcumin as a photosensitizer in antibacterial photodynamic therapy. Influence of formulation and molecular structure modifications. Universitetet i Oslo. Fulltekst i vitenarkiv

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Publisert 7. jan. 2013 12:40 - Sist endret 7. aug. 2025 13:44