Fredagskollokvium: The (R)evolution of DNA sequencing - from 3 billion to 1 thousand dollar genome

DNA sequencing technology has undergone a revolution in terms of performance, output and price during the last 15 years. Whereas the first human genome was sequenced in a multinational effort during the period of 1990-2003 with a cost of 3 billion US dollars, the newest sequencing technology released last year can sequence nearly 50 human genomes per day at the cost of 1000 USD per genome. Biomedical research is going through a revolution thanks to the high throughput and the low cost of DNA sequencing. In this talk I will explain the principles of DNA sequencing from the earliest Sanger sequencing to today's single-molecule sequencing technology.