The Transplantation group at OUS-Rikshospitalet
The focus of this research collaboration has been on pharmacokinetics topics, but also physiological investigations have been performed. The collaboration has resulted in many international publications.
Center for Psychopharmacology, Diakonhjemmet Hospital
The metabolism of psychotropic drugs is mainly mediated via different CYP enzymes of which different genotypes have been described. The use of patient genotyping to better understand the efficacy/adverse event of these drugs has been a main focus of our cooperation.
Morbid Obesity Centre, Vestfold Hospital Trust, Tønsberg
In order to limit the nutritional uptake in morbidly obese patients they may be subjected to bariatric surgery. The stomach size is reduced and the length of the intestine is shortened in this type of surgery. The bioavailability of drugs will also be affected by this type of surgery and this is a unique human model for investigation of the mechanisms that determine drug bioavailability. The PK-group has in collaboration with the Morbid Obesity Centre performed clinical trials where the effect o bariatric surgery on bioavailability of different drugs have been investigated.
Clinical Research Unit, OUS-Rikshospitalet
Our research group also collaborate with the Clinical Research Unit, Department of Pharmacology, Oslo University Hospital. We have in close collaboration with the Clinical Research Unit performed patient studies where we investigate CYP3A-activity in different patient populations.
International collaboration
Our main international collaborating partners:
- AstraZeneca AB, Mölndal, Sweden
- University of Uppsala, Sweden
- University of Sheffield, UK
- University of Manchester, UK
- Laboratory of Applied Pharmacokinetics and Bioinformatics, US