Athanasios Saragliadis

Researcher
Image of Athanasios Saragliadis
Norwegian version of this page
Phone +47 22854792
Room 4212
Username
Visiting address Blindernveien 31 0371 OSLO
Postal address Postboks 1066 Blindern 0316 OSLO

Academic interests

My project aims at investigating the structure-function relationship in bacterial adhesins.

The main objective is to find lead compounds for inhibitors that target a specific class of adhesins widespread in Gram-negative bacterial pathogens (trimeric autotransporter adhesins).

Since adhesion of bacteria to host tissues is frequently among the first steps in host colonization by pathogens, it is of great importance to elucidate the mechanism of trimeric autotransporter biogenesis, and to obtain a molecular understanding of adhesin-host and adhesin-surface interactions.

I will be involved in the development of assays that will allow us to screen for small-molecule inhibitors of the above processes.

Background

PhD at University of Konstanz

- Conditional gene expression using ribozymes

Tags: adhesion, Bacteria

Publications

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  • Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Linke, Dirk; Colquhoun, Duncan J & Winther-Larsen, Hanne Cecilie (2021). Characterization of membrane vesicles from fish pathogens, their role in virulence and possible function as a vaccine in aquaculture.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
  • Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
  • Saragliadis, Athanasios & Linke, Dirk (2017). STRUCTURE-FUNCTION RELATIONSHIP IN BACTERIAL ADHESINS.
  • Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
  • Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
  • Hatlem, Daniel; Saragliadis, Athanasios; Leo, Jack Christopher; Shahid, Shakeel; van Rossum, Barth & Linke, Dirk (2015). TAAs: fibrous adhesins on the bacterial cell surface.
  • Spence, Maria Helle; Linke, Dirk & Saragliadis, Athanasios (2022). Yersinia adhesins: Investigating the role of autotransporter adhesins in fish infection by Yersinia ruckeri. Universitetet i Oslo.

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Published Nov. 5, 2015 9:12 PM - Last modified Nov. 1, 2021 8:39 AM

Projects