Athanasios Saragliadis
Researcher
Norwegian version of this page
Phone
+47 22854792
Room
4212
Username
Visiting address
Blindernveien 31
0371 OSLO
Postal address
Postboks 1066 Blindern
0316 OSLO
Academic interests
My project aims at investigating the structure-function relationship in bacterial adhesins.
The main objective is to find lead compounds for inhibitors that target a specific class of adhesins widespread in Gram-negative bacterial pathogens (trimeric autotransporter adhesins).
Since adhesion of bacteria to host tissues is frequently among the first steps in host colonization by pathogens, it is of great importance to elucidate the mechanism of trimeric autotransporter biogenesis, and to obtain a molecular understanding of adhesin-host and adhesin-surface interactions.
I will be involved in the development of assays that will allow us to screen for small-molecule inhibitors of the above processes.
Background
PhD at University of Konstanz
- Conditional gene expression using ribozymes
Publications
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Hermansen, Simen; Ryoo, David; Orwick-Rydmark, Marcella; Saragliadis, Athanasios; Gumbart, James C & Linke, Dirk (2022). The Role of Extracellular Loops in the Folding of Outer Membrane Protein X (OmpX) of Escherichia coli. Frontiers in Molecular Biosciences. ISSN 2296-889X. 9. doi: 10.3389/fmolb.2022.918480. Full text in Research Archive
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Thibau, Arno; Hipp, K.; Vaca, Diana; Chowdhury, Sounak; Malmström, Johan & Saragliadis, Athanasios [Show all 9 contributors for this article] (2022). Long-read sequencing reveals genetic adaptation of Bartonella adhesin A among different Bartonella henselae isolates. Frontiers in Microbiology. ISSN 1664-302X. 13. doi: 10.3389/fmicb.2022.838267. Full text in Research Archive
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Beal, J.; Saragliadis, Athanasios & Linke, Dirk (2021). Comparative analysis of three studies measuring fluorescence from engineered bacterial genetic constructs. PLOS ONE. ISSN 1932-6203. 16(6). doi: 10.1371/journal.pone.0252263. Full text in Research Archive
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Joudeh, Nadeem; Saragliadis, Athanasios; Schulz, Christian; Voigt, Andre; Almaas, Eivind & Linke, Dirk (2021). Transcriptomic Response Analysis of Escherichia coli to Palladium Stress. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.741836. Full text in Research Archive
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Beal, J; Saragliadis, Athanasios & Linke, Dirk (2020). Robust estimation of bacterial cell count from optical density. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-01127-5. Full text in Research Archive
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Stephan, Mareike; Broeker, Nina; Saragliadis, Athanasios; Roos, Norbert; Linke, Dirk & Barbirz, Stefanie (2020). In vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles. Frontiers in Microbiology. ISSN 1664-302X. 11. doi: 10.3389/fmicb.2020.510638. Full text in Research Archive
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Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Pérez-Ortega, Jesús; Sittman, Carolin; Göttig, Stephan & Liskiewicz, Krystyna Anna [Show all 11 contributors for this article] (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology. ISSN 1462-2912. 22(7), p. 2939–2955. doi: 10.1111/1462-2920.15051. Full text in Research Archive
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Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen. The Cell Surface. ISSN 2468-2330. 5, p. 1–11. doi: 10.1016/j.tcsw.2019.100025. Full text in Research Archive
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Finke, Sarah; Fagerlund, Annette; Smith, Veronika; Krogstad, Veronica; Zhang, Mimmi Jingxi & Saragliadis, Athanasios [Show all 9 contributors for this article] (2019). Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control. The Cell Surface. ISSN 2468-2330. 5, p. 1–12. doi: 10.1016/j.tcsw.2019.100032. Full text in Research Archive
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Meuskens, Ina; Saragliadis, Athanasios; Leo, Jack Christopher & Linke, Dirk (2019). Type V secretion systems: An overview of passenger domain functions. Frontiers in Microbiology. ISSN 1664-302X. 10, p. 1–19. doi: 10.3389/fmicb.2019.01163. Full text in Research Archive
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Saragliadis, Athanasios; Trunk, Thomas & Leo, Jack Christopher (2018). Producing Gene Deletions in Escherichia coli by P1 Transduction with Excisable Antibiotic Resistance Cassettes. Journal of Visualized Experiments. ISSN 1940-087X. 2018(139). doi: 10.3791/58267. Full text in Research Archive
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Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Linke, Dirk; Colquhoun, Duncan J & Winther-Larsen, Hanne Cecilie (2021). Characterization of membrane vesicles from fish pathogens, their role in virulence and possible function as a vaccine in aquaculture.
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Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen.
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Saragliadis, Athanasios & Linke, Dirk (2019). Screening for small-molecule inhibitors of YadA adhesion to collagen.
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Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
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Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
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Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
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Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
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Saragliadis, Athanasios & Linke, Dirk (2017). STRUCTURE-FUNCTION RELATIONSHIP IN BACTERIAL ADHESINS.
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Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
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Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
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Hatlem, Daniel; Saragliadis, Athanasios; Leo, Jack Christopher; Shahid, Shakeel; van Rossum, Barth & Linke, Dirk (2015). TAAs: fibrous adhesins on the bacterial cell surface.
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Spence, Maria Helle; Linke, Dirk & Saragliadis, Athanasios (2022). Yersinia adhesins: Investigating the role of autotransporter adhesins in fish infection by Yersinia ruckeri. Universitetet i Oslo.
Published Nov. 5, 2015 9:12 PM
- Last modified Nov. 1, 2021 8:39 AM