Athanasios Saragliadis
Postdoctoral Research Fellow
Norwegian version of this page
Phone
+47 22854792
Room
3515
Username
Visiting address
Blindernveien 31
0371 OSLO
Postal address
Postboks 1066 Blindern
0316 OSLO
Academic interests
My project aims at investigating the structure-function relationship in bacterial adhesins.
The main objective is to find lead compounds for inhibitors that target a specific class of adhesins widespread in Gram-negative bacterial pathogens (trimeric autotransporter adhesins).
Since adhesion of bacteria to host tissues is frequently among the first steps in host colonization by pathogens, it is of great importance to elucidate the mechanism of trimeric autotransporter biogenesis, and to obtain a molecular understanding of adhesin-host and adhesin-surface interactions.
I will be involved in the development of assays that will allow us to screen for small-molecule inhibitors of the above processes.
Background
PhD at University of Konstanz
- Conditional gene expression using ribozymes
Publications
- Stephan, Mareike; Broeker, Nina; Saragliadis, Athanasios; Roos, Norbert; Linke, Dirk & Barbirz, Stefanie (2020). In vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles. Frontiers in Microbiology. ISSN 1664-302X. 11 . doi: doi.org/10.3389/fmicb.2020.510638 Full text in Research Archive.
- Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Perez-Ortega, J; Sittman, C; Gottig, Stephan; Liskiewicz, Krystyna Anna; Spence, Maria Helle; Schneider, Kenneth; Leo, Jack Christopher; Arenas, J & Linke, Dirk (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology. ISSN 1462-2912. 22(7), s 2939- 2955 . doi: 10.1111/1462-2920.15051 Full text in Research Archive.
- Finke, Sarah; Fagerlund, Annette; Smith, Veronika; Krogstad, Veronica; Zhang, Mimmi Jingxi; Saragliadis, Athanasios; Linke, Dirk; Nielsen-Leroux, Christina & Økstad, Ole Andreas (2019). Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control. The Cell Surface. ISSN 2468-2330. 5, s 1- 12 . doi: 10.1016/j.tcsw.2019.100032 Full text in Research Archive.
- Meuskens, Ina; Saragliadis, Athanasios; Leo, Jack Christopher & Linke, Dirk (2019). Type V secretion systems: An overview of passenger domain functions. Frontiers in Microbiology. ISSN 1664-302X. 10, s 1- 19 . doi: 10.3389/fmicb.2019.01163 Full text in Research Archive.
- Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen. The Cell Surface. ISSN 2468-2330. 5, s 1- 11 . doi: 10.1016/j.tcsw.2019.100025 Full text in Research Archive.
- Saragliadis, Athanasios; Trunk, Thomas & Leo, Jack Christopher (2018). Producing Gene Deletions in Escherichia coli by P1 Transduction with Excisable Antibiotic Resistance Cassettes. Journal of Visualized Experiments. ISSN 1940-087X. 2018(139) . doi: 10.3791/58267 Full text in Research Archive.
- Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
- Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen.
- Saragliadis, Athanasios & Linke, Dirk (2019). Screening for small-molecule inhibitors of YadA adhesion to collagen.
- Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
- Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
- Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
- Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
- Saragliadis, Athanasios & Linke, Dirk (2017). STRUCTURE-FUNCTION RELATIONSHIP IN BACTERIAL ADHESINS.
- Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
- Hatlem, Daniel; Saragliadis, Athanasios; Leo, Jack Christopher; Shahid, Shakeel; van Rossum, Barth & Linke, Dirk (2015). TAAs: fibrous adhesins on the bacterial cell surface.
Published Nov. 5, 2015 9:12 PM
- Last modified Mar. 3, 2016 12:38 PM