Athanasios Saragliadis
Academic interests
My project aims at investigating the structure-function relationship in bacterial adhesins.
The main objective is to find lead compounds for inhibitors that target a specific class of adhesins widespread in Gram-negative bacterial pathogens (trimeric autotransporter adhesins).
Since adhesion of bacteria to host tissues is frequently among the first steps in host colonization by pathogens, it is of great importance to elucidate the mechanism of trimeric autotransporter biogenesis, and to obtain a molecular understanding of adhesin-host and adhesin-surface interactions.
I will be involved in the development of assays that will allow us to screen for small-molecule inhibitors of the above processes.
Background
PhD at University of Konstanz
- Conditional gene expression using ribozymes
Publications
- Finke, Sarah; Fagerlund, Annette; Smith, Veronika; Krogstad, Veronica; Zhang, Mimmi; Saragliadis, Athanasios; Linke, Dirk; Nielsen-Leroux, Christina & Økstad, Ole Andreas (2019). Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control. The Cell Surface. ISSN 2468-2330. 5 . doi: 10.1016/j.tcsw.2019.100032
- Meuskens, Ina; Saragliadis, Athanasios; Leo, Jack Christopher & Linke, Dirk (2019). Type V secretion systems: An overview of passenger domain functions. Frontiers in Microbiology. ISSN 1664-302X. 10:11(19), s 63- 1 . doi: 10.3389/fmicb.2019.01163
- Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of bacterial adhesion to collagen. The Cell Surface. ISSN 2468-2330. 5 . doi: https://doi.org/10.1016/j.tcsw.2019.100025
- Saragliadis, Athanasios; Trunk, Thomas & Leo, Jack Christopher (2018). Producing Gene Deletions in Escherichia coli by P1 Transduction with Excisable Antibiotic Resistance Cassettes. Journal of Visualized Experiments. ISSN 1940-087X. 2018(139) . doi: 10.3791/58267 Full text in Research Archive.
- Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
- Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen.
- Saragliadis, Athanasios & Linke, Dirk (2019). Screening for small-molecule inhibitors of YadA adhesion to collagen.
- Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
- Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
- Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
- Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
- Saragliadis, Athanasios & Linke, Dirk (2017). STRUCTURE-FUNCTION RELATIONSHIP IN BACTERIAL ADHESINS.
- Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
- Hatlem, Daniel; Saragliadis, Athanasios; Leo, Jack Christopher; Shahid, Shakeel; van Rossum, Barth & Linke, Dirk (2015). TAAs: fibrous adhesins on the bacterial cell surface.