Fahri Saatcioglu

Image of Fahri Saatcioglu
Norwegian version of this page
Phone +47 22854569
Room 3611
Username
Visiting address Blindernveien 31 0371 Oslo
Postal address Postboks 1066 Blindern 0316 Oslo

Research Interests

The goal of the studies in our laboratory is to understand how androgens, male sex hormones, exert their effects on the normal physiology, as well as their role in disease states. Androgens bind to an intracellular receptor, called the androgen receptor (AR), that belongs to a superfamily of ligand-activated transcription factors, called nuclear receptors, which bring about changes in the phenotype of the cell through modulation of gene expression. To understand this process, we are using molecular, biochemical, cell biological and genetic approaches. Since androgens and AR have a significant role in prostate cancer (PCa), this work is also relevant for identification and validation of biomarkers or therapeutic targets for prostate cancer. In this context, our recent work led us to discover the key role of the endoplasmic reticulum (ER) stress pathways in PCa. Termed the unfolded protein response (UPR), we have shown that two of the three canonical UPR pathways have key roles in PCa progression. A major focus in our laboratory has thus become stress signaling in cancer cells.


Teaching

BIOS1110      Cell and Molecular Biology
BIOS3601     Genetics and Developmental Biology
BIOS 3920    Research Literature in Cancer Biology
 

Academic appointments

1/2013-Present       Professor, Dept. of Biosciences, University of Oslo
1/2002-12/2012      Professor, Dept. of Molecular Biosciences, University of Oslo
10/2000-2015         Visiting Scientist, Harvard School of Public Health, Boston, USA
02/2011-Present     Researcher (20%), Institute for Cancer Genetics and Informatics, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway
7/1996-12/2001      Group Leader, Biotechnology Centre of Oslo, University of Oslo
10/1993-4/1996      Assistant Research Molecular Biologist, Department of Pharmacology, School of Medicine, University of California, San Diego, CA, USA
9/1990-9/1993        Post-doctoral fellow, Department of Pharmacology, School of Medicine, University of California, San Diego, CA, USA
3/1990-7/1990        Visiting scientist, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Mobility

01/2018-12/2018    Sabbatical, Harvard School of Public Health, Boston, USA
11/2009-08/2010    Sabbatical, Harvard School of Public Health, Boston, USA
10/2000-11/2001    Sabbatical, Harvard School of Public Health, Boston, USA


Honors and distinctions

2009-2012      Special Cancer Program Award, Norwegian Research Council
2004-2007      Top Researcher Award, Norwegian Research Council
2004-2007       Special Cancer Program Award, Norwegian Research Council
2001-2003      Top Researcher Award, Norwegian Research Council
2000-2003      Special Cancer Program Award, Norwegian Research Council
1995-1996      ACS Institutional Fellowship, University of California, San Diego
1994-1995      Research Committee Award, University of California, San Diego
1993-1995       New Investigator Award, AIDS Related Disease Research Program, University of California
1992-1993       Post-doctoral fellowship, American Heart Association
1990-1992       Post-doctoral fellowship, Tobacco Related Disease Research Program, University of California
1987, 89, 90    Visiting Scientist Fellowship, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (3-12 weeks at a time)
1987, 7-11       Visiting Researcher, Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD
1985                Salutatorian of the graduating class


Committees

Ad hoc grant review committees: Cancer Research UK; Prostate Cancer Charity UK; Australia Research Council; European Research Council. Member, Senior Editorial Board, American J. of Cancer Research, 2010-Present. Ad hoc reviewer for several international refereed journals, including Nature Communications, Nature Reviews Cancer, Nature Urology, Cancer Research, Clinical Cancer Research, ELife, Oncogene, etc. Director, PhD Program, IMBV, University of Oslo, 2006-present. Advisor to 11 PhD and 24 MSc students who have successfully completed their degrees, trained 11 postdoctoral fellows. Currently advisor for 3 PhD students, 4 MSc students, and 2 researchers.

Current collaborations

University of Oslo
Oslo University Hospital
Cancer Registry of Norway
Umeå University, Sweden
Gothenborg University, Sweden
Lund University, Sweden
University of Porto, Portugal
Harvard University, USA
National Institutes of Health, USA
MD Anderson Cancer Center, USA
Georgetown University, USA
University of Washington, USA
Vancouver Prostate Cancer, Canada
 

Tags: Cell Signaling and Cancer

Publications

Representative Publications, Last 10 Years
1. ten Freyhaus, H., Calay, E.S., Yalcin, A., Vallerie, S.N., Yang, L., Calay, Z.Z., Saatcioglu, F., and Hotamisligil, G.S. (2012). Regulation of nicotinamide adenine dinucleotide phosphate-metabolism by STAMP2 is critical for macrophage inflammatory responses. Cell Metabolism16:81-89.
2. Jin, Y., Qu, S., Wang, L., Kristian, A., Maelandsmo, G.M., Jeronimo, C., Teixeira, M.R., Tekedereli, I., Sood, A., Lopez-Berestein, G., Ozpolat, B., Danielsen, H., and Saatcioglu, F. (2013). Kallikrein 4 integrates androgen and mTOR signalling in prostate cancer. Proc. Nat. Acad. Sci. USA, 110(28):E2572-81.
3. Jin, Y., Wang, L., Qu, S., Kristian, A., Mælandsmo, G.M., Yuca, E., Tekedereli, I., Gorgulu, K., Alpay, N., Sood, A., Lopez-Berestein, G., Fazli, L., Rennie, P., Risberg, B., Wæhre, H., Danielsen, H.D., Ozpolat, B., and Saatcioglu. F. (2015). STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO Mol Med, 7(3):315-31
4. Sheng, X., Arnoldussen, Y.W., Storm, M., Tesikova, M., Jin, Y., Nenseth, H.Z., Sen Zhao, S., Mills, I.G., Fazli, L., Rennie, P., Risberg, B., Wæhre, H., Danielsen, H.E. Hotamisligil, G.S., and Saatcioglu, F. (2015). Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med, e201404509. 
6. Tesikova, M., Dezitter, X., Nenseth, H.Z., Klokk, T.I., Mueller, F., Hager, G.L., Saatcioglu, F. (2016). Divergent Binding and Transactivation by Two Related Steroid Receptors at the Same Response Element. J Biol Chem. pii: jbc.M115.684480. 
7. Sheng, X., Nenseth, H.Z., Qu, S., Fazli, L., Frahnow, T., Simon, L., Rennie, P., Danielsen, H., Theis, F.J., Patterson, J.B., Mills, I.G., Jin, Y., Saatcioglu, F. (2019). IRE1α-XBP1s pathway promotes prostate cancer by activating oncogenic signaling pathways. Nature Comm., Jan 24;10(1):323. doi: 10.1038/s41467-018-08152-3. 
8. Sikkeland, J., Lindstad, T., Dezitter, X., Qu, S., Nenseth, H. Z., Muhumed, R. M., Erikci-Ertunc, M., Gregor, M.F., and Saatcioglu, F. (2019). ER stress down-regulates Stamp2 expression in adipocytes by disruption of C/EBP promoter recruitment. Metabolism, Jan 30. pii: S0026-0495(19)30029-0. 
9. Pallmann, N., Livgard, M., Nenseth, H. Z., Xi, Y., Koc, D., Kahraman, N., Mokhlis, H.M., Ozpolat, B., Fazli, L., Rennie, P., Danielsen, H., Jin, Y., Saatcioglu, F. (2019). Regulation of the Integrated Stress Response through ATF4 and FAM129A is Critical for Prostate Cancer. Oncogene, Jul 16. doi: 10.1038/s41388-019-0879-2. 
10. Pallmann N, Deng, K., Livgard M, Tesikova, M., Nenseth, H.Z., Kahraman, N., Mokhlis, H.M., Ozpolat, B., Fazli, L., Rennie, P., Danielsen, H., Jin, Y., Kuzu, O.F., Saatcioglu, F. (2021). Stress mediated reprogramming of prostate cancer one-carbon cycle drives disease progression. Cancer Res., 81(15):4066-4078.
 

  • Jin, Yixin; Lorvik, Kristina Berg; Jin, Yang; Beck, Carole; Sike, Adam & Persiconi, Irene [Show all 10 contributors for this article] (2022). Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer. Molecular Therapy - Oncolytics. ISSN 2372-7705. 26, p. 189–206. doi: 10.1016/j.omto.2022.06.007.
  • Pällmann, Nora; Ke, Deng; Livgård, Marte; Tesikova, Martina; Jin, Yixin & Frengen, Nicolai Sebastian [Show all 18 contributors for this article] (2021). Stress-mediated reprogramming of prostate cancer one-carbon cycle drives disease progression. Cancer Research. ISSN 0008-5472. 81(15), p. 4066–4078. doi: 10.1158/0008-5472.CAN-20-3956.
  • Nenseth, Hatice Zeynep; Sahu, Aparna; Saatcioglu, Fahri & Osguthorpe, Steven (2021). A Nutraceutical Formula Is Effective in Raising the Circulating Vitamin and Mineral Levels in Healthy Subjects: A Randomized Trial. Frontiers in Nutrition. ISSN 2296-861X. 8. doi: 10.3389/fnut.2021.703394. Full text in Research Archive
  • Pihlstrøm, Nicklas; Jin, Yang; Nenseth, Hatice Zeynep; Kuzu, Omer Faruk & Saatcioglu, Fahri (2021). Stamp2 expression mediated by cytokines attenuates their growth-limiting effects in prostate cancer cells. Cancers. ISSN 2072-6694. 13(7). doi: 10.3390/cancers13071579. Full text in Research Archive
  • Guldvik, Ingrid Jenny; Zuber, Verena; Braadland, Peder Rustøen; Grytli, Helene Hartvedt; Ramberg, Håkon Andre & Lilleby, Wolfgang [Show all 18 contributors for this article] (2020). Identification and Validation of Leucine-rich alpha-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification. European Urology Open Science. ISSN 2666-1691. 21, p. 51–61. doi: 10.1016/j.euros.2020.08.007. Full text in Research Archive
  • Jin, Yang & Saatcioglu, Fahri (2020). Targeting the unfolded protein response in hormone-regulated cancers. Trends in Cancer. ISSN 2405-8033. 6(2), p. 160–171. doi: 10.1016/j.trecan.2019.12.001.
  • Pällmann, Nora; Livgård, Marte; Tesikova, Martina; Nenseth, Hatice Zeynep; Akkus, Erman & Sikkeland, Jørgen [Show all 20 contributors for this article] (2019). Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene. ISSN 0950-9232. 38, p. 6301–6318. doi: 10.1038/s41388-019-0879-2. Full text in Research Archive
  • Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid & Simon, Lukas [Show all 16 contributors for this article] (2019). IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications. ISSN 2041-1723. 10:323, p. 1–12. doi: 10.1038/s41467-018-08152-3. Full text in Research Archive
  • Sikkeland, Jørgen; Lindstad, Torstein; Nenseth, Hatice Zeynep; Dezitter, Xavier Gabriel M; Qu, Su & Mohamed Muhumed, Ridhwan [Show all 9 contributors for this article] (2019). Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes. Metabolism: Clinical and Experimental. ISSN 0026-0495. 93, p. 75–85. doi: 10.1016/j.metabol.2019.01.014. Full text in Research Archive
  • Winje, Ivan; Sheng, Xia; Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Tennøe, Simen & Saatcioglu, Fahri [Show all 8 contributors for this article] (2018). Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice. Acta Physiologica. ISSN 1748-1708. p. 1–9. doi: 10.1111/apha.13204.
  • Jin, Yang; Nenseth, Hatice Zeynep & Saatcioglu, Fahri (2017). Role of PLZF as a tumor suppressor in prostate cancer. OncoTarget. ISSN 1949-2553. 8(41), p. 71317–71324. doi: 10.18632/oncotarget.19813.
  • Urbanucci, Alfonso; Barfeld, Stefan Jörg; Kytölä, Ville; Itkonen, Harri; Coleman, Ilsa M. & Vodák, Daniel [Show all 34 contributors for this article] (2017). Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer. Cell reports. ISSN 2211-1247. 19(10), p. 2045–2059. doi: 10.1016/j.celrep.2017.05.049. Full text in Research Archive
  • Lindstad, Torstein; Qu, Su; Sikkeland, Jørgen; Jin, Yang; Kristian, Alexandr & Mælandsmo, Gunhild [Show all 8 contributors for this article] (2016). STAMP2 is required for human adipose-derived stem cell differentiation and adiposite-facilitated prostrate cancer grown in vivo. OncoTarget. ISSN 1949-2553. 8(54), p. 91817–91827. doi: 10.18632/oncotarget.11131.
  • Tesikova, Martina; Dezitter, Xavier Gabriel M; Nenseth, Hatice Zeynep; Klokk, Tove Irene; Mueller, Florian & Hager, Gordon L. [Show all 7 contributors for this article] (2016). Divergent binding and transactivation by two related steroid receptors at the same response element. Journal of Biological Chemistry. ISSN 0021-9258. 291(22), p. 11899–11910. doi: 10.1074/jbc.M115.684480.
  • Sikkeland, Jørgen; Sheng, Xia; Jin, Yang & Saatcioglu, Fahri (2016). STAMPing at the crossroads of normal physiology and disease states. Molecular and Cellular Endocrinology. ISSN 0303-7207. 425, p. 26–36. doi: 10.1016/j.mce.2016.02.013.
  • Storm, Margrethe Larsdatter; Sheng, Xia; Arnoldussen, Yke Jildouw & Saatcioglu, Fahri (2016). Prostate cancer and the unfolded protein response. OncoTarget. ISSN 1949-2553. 7(33), p. 54051–54066. doi: 10.18632/oncotarget.9912. Full text in Research Archive
  • Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep & Zhao, Sen [Show all 15 contributors for this article] (2015). Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(6), p. 788–801. doi: 10.15252/emmm.201404509. Full text in Research Archive
  • Jin, Yang; Ling, Wang; Qu, Su; Sheng, Xia; Kristian, Alexandr & Mælandsmo, Gunhild [Show all 20 contributors for this article] (2015). STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(3), p. 315–331. doi: 10.15252/emmm.201404181. Full text in Research Archive
  • Ertunc, Meric Erikci; Sikkeland, Jørgen; Fenaroli, Federico; Griffiths, Gareth Wyn; Daniels, Melissa C. & Cao, Haiming [Show all 8 contributors for this article] (2015). Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. Journal of Lipid Research. ISSN 0022-2275. 56(2), p. 423–434. doi: 10.1194/jlr.M055798.
  • Nenseth, Hatice Zeynep; Dezitter, Xavier; Tesikova, Martina; Mueller, Florian; Klokk, Tove Irene & Hager, Gordon L. [Show all 7 contributors for this article] (2014). Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells. PLOS ONE. ISSN 1932-6203. 9(8). doi: 10.1371/journal.pone.0105204. Full text in Research Archive
  • Sikkeland, Jørgen; Jin, Yang & Saatcioglu, Fahri (2014). Methods to assess lipid accumulation in cancer cells. Methods in Enzymology. ISSN 0076-6879. 542, p. 407–423. doi: 10.1016/B978-0-12-416618-9.00021-2.
  • Jin, Yang; Qu, Su; Tesikova, Martina; Ling, Wang; Kristian, Alexandr & Mælandsmo, Gunhild [Show all 19 contributors for this article] (2013). Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 110(28), p. E2572–E2581. doi: 10.1073/pnas.1304318110.
  • Kaarbø, Mari; Storm, Margrethe; Qu, Su; Wæhre, Haakon; Risberg, Bjørn Åke & Danielsen, Håvard Emil [Show all 7 contributors for this article] (2013). TCTP is an androgen-regulated gene implicated in prostate cancer. PLOS ONE. ISSN 1932-6203. 8(7:e69398). doi: 10.1371/journal.pone.0069398. Full text in Research Archive
  • Sikkeland, Jørgen & Saatcioglu, Fahri (2013). Differential Expression and Function of Stamp Family Proteins in Adipocyte Differentiation. PLOS ONE. ISSN 1932-6203. 8(7). doi: 10.1371/journal.pone.0068249. Full text in Research Archive
  • Qu, Su; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés & Saatcioglu, Fahri (2013). Rapid Gene Expression Changes in Peripheral Blood Lymphocytes upon Practice of a Comprehensive Yoga Program. PLOS ONE. ISSN 1932-6203. 8(4). doi: 10.1371/journal.pone.0061910.
  • ten Freyhaus, Henrik; Calay, Ediz S; Yalcin, Abdullah; Vallerie, Sara N; Yang, Ling & Calay, Zerrin Z [Show all 8 contributors for this article] (2012). Stamp2 Controls Macrophage Inflammation through Nicotinamide Adenine Dinucleotide Phosphate Homeostasis and Protects against Atherosclerosis. Cell Metabolism. ISSN 1550-4131. 16(1), p. 81–89. doi: 10.1016/j.cmet.2012.05.009.
  • Lazarevic, Bato; Hammarstrøm, Clara Louise; Yang, Jing; Ramberg, Håkon Andre; Diep, Lien My & Karlsen, Steinar [Show all 10 contributors for this article] (2012). The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy. British Journal of Nutrition. ISSN 0007-1145. 108(12), p. 2138–2147. doi: 10.1017/S0007114512000384.
  • Lazarevic, Bato; Boezelijn, Gro; Diep, Lien My; Kvernrød, Kristin; Øgren, Hans Olov & Ramberg, Håkon Andre [Show all 16 contributors for this article] (2011). Efficacy and Safety of Short-Term Genistein Intervention in Patients with Localized Prostate Cancer Prior to Radical Prostatectomy: A Randomized, Placebo-Controlled, Double-Blind Phase 2 Clinical Trial. Nutrition and Cancer. ISSN 0163-5581. 63(6), p. 889–898. doi: 10.1080/01635581.2011.582221.
  • Varisli, Lokman; Gonen-Korkmaz, Ceren; Debelec-Butuner, Bilge; Erbaykent-Tepedelen, Burcu; Muhammed, Hamed Sayed & Bogurcu, Nuray [Show all 8 contributors for this article] (2011). Ubiquitously Expressed Hematological and Neurological Expressed 1 Downregulates Akt-Mediated GSK3 beta Signaling, and Its Knockdown Results in Deregulated G2/M Transition in Prostate Cells. DNA and Cell Biology. ISSN 1044-5498. 30(6), p. 419–429. doi: 10.1089/dna.2010.1128.
  • Lindstad, Torstein; Jin, Yang; Ling, Wang; Qu, Su & Saatcioglu, Fahri (2010). STAMPs at the Crossroads of Cancer and Nutrition. Nutrition and Cancer. ISSN 0163-5581. 62(7), p. 891–895. doi: 10.1080/01635581.2010.509836.
  • Ling, Wang; Jin, Yang; Arnoldussen, Yke Jildouw; Jonson, Ida; Qu, Su & Mælandsmo, Gunhild [Show all 11 contributors for this article] (2010). STAMP1 Is Both a Proliferative and an Antiapoptotic Factor in Prostate Cancer. Cancer Research. ISSN 0008-5472. 70(14), p. 5818–5828. doi: 10.1158/0008-5472.CAN-09-4697.
  • Kaarbø, Mari; Mikkelsen, Øyvind Løveseter; Malerød, Lene; Qu, Su; Lobert, Viola & Akgul, Gulcan [Show all 9 contributors for this article] (2010). PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells. Cellular Oncology. ISSN 1570-5870. 32(1-2), p. 11–27. doi: 10.3233/CLO-2009-0487.
  • Arnoldussen, Yke Jildouw & Saatcioglu, Fahri (2009). Dual specificity phosphatases in prostate cancer. Molecular and Cellular Endocrinology. ISSN 0303-7207. 309(1-2), p. 1–7. doi: 10.1016/j.mce.2009.05.019.
  • Fladeby, Cathrine; Nigam, Shailly; Gupta, Shailly N.; Barois, Nicolas; Lorenzo, Petri & Simpson, Jeremy C. [Show all 8 contributors for this article] (2008). Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells. International Journal of Cancer. ISSN 0020-7136. 122(6), p. 1229–1235. doi: 10.1002/ijc.23185.
  • Lazarevic, Bato; Karlsen, Steinar & Saatcioglu, Fahri (2008). Genistein differentially modulates androgen-responsive gene expression and activates JNK in LNCaP cells. Oncology Reports. ISSN 1021-335X. 19, p. 1231–1235.
  • Arnoldussen, Yke Jildouw; Lorenzo, Petra Isabel O.; Einarsen, Maria; Wæhre, Haakon; Risberg, Bjørn & Mælandsmo, Gunhild M [Show all 8 contributors for this article] (2008). The Mitogen-Activated Protein Kinase Phosphatase Vaccinia H1-Related Protein Inhibits Apoptosis in Prostate Cancer Cells and Is Overexpressed in Prostate Cancer. Cancer Research. ISSN 0008-5472. 68(22), p. 9255–9264. doi: 10.1158/0008-5472.CAN-08-1224.
  • Lorenzo, Petra Isabel O. & Saatcioglu, Fahri (2008). Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation. Neoplasia. ISSN 1522-8002. 10, p. 418–428. doi: 10.1593/neo.07985.
  • Kaarbø, Mari; Klokk, Tove Irene & Saatcioglu, Fahri (2007). Androgen signaling and its interaction with other signaling pathways in prostate cancer. Bioessays. ISSN 0265-9247. 29, p. 1227–1238. doi: 10.1002/bies.20676.
  • Klokk, Tove Irene; Kurys, Piotr Jerzy; Elbi, C; Nagaich, AK; Hendarwanto, A & Slagsvold, Thomas [Show all 9 contributors for this article] (2007). Ligand-specific dynamics of the androgen receptor at its response element in living cells. Molecular and Cellular Biology. ISSN 0270-7306. 27. doi: 10.1128/MCB.01297-06.
  • Klokk, Tove Irene; Kilander, Anette; Xi, Zhijun; Wæhre, Haakon; Risberg, Bjørn & Danielsen, Håvard Emil [Show all 7 contributors for this article] (2007). Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Cancer Research. ISSN 0008-5472. 67, p. 5221–5230. doi: 10.1158/0008-5472.CAN-06-4728.
  • Wellen, KE; Fucho, R; Gregor, MF; Furuhashi, M; Morgan, C & Lindstad, Torstein [Show all 10 contributors for this article] (2007). Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell. ISSN 0092-8674. 129. doi: 10.1016/j.cell.2007.02.049.
  • Davidson, B; Xi, Zhijun & Saatcioglu, Fahri (2007). Kallikrein 4 is expressed in malignant mesotheliorna-further evidence for the histogenetic link between mesothelial and epithelial cells. Diagnostic Cytopathology. ISSN 8755-1039. 35. doi: 10.1002/dc.20588.
  • Irer, SV; Alper, GE; Sezer, ED; Duman, E; Saatcioglu, Fahri & Yilmaz, C (2007). The effect of l-deprenyl on tissue mRNA expressions of NOS isoforms and NO levels in an experimental diabetes mellitus model. Journal of Neural Transmission. ISSN 0300-9564. 114. doi: 10.1007/s00702-007-0693-9.
  • kjellgren, a; bood, sa; Axelsson, K; Norlander, T & Saatcioglu, Fahri (2007). Wellness through a comprehensive Yogic breathing program - A controlled pilot trial. BMC Complementary and Alternative Medicine. ISSN 1472-6882. 7(1).
  • Aslan, G; Irer, B; Tuna, B; Yorukoglu, K; Saatcioglu, Fahri & Celebi, I (2006). analysis of NKX3.1 expression in prostate cancer tissues and correlation with clinicopathologic features. Pathology, Research and Practice. ISSN 0344-0338. 202(2), p. 93–98.
  • Frønsdal, Katrine & Saatcioglu, Fahri (2005). Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. The Prostate. ISSN 0270-4137. 62(3), p. 299–306.
  • Frønsdal, K. & Saatcioglu, Fahri (2005). Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. The Prostate. ISSN 0270-4137. 62(3), p. 299–306.
  • Lind, Gruo Elisabeth; Skotheim, Rolf Inge; Fraga, Mario F; Abeler, Vera Maria; Henrique, Rui & Saatcioglu, Fahri [Show all 9 contributors for this article] (2005). The loss of NKX3.1 expression in testicular - and prostate - cancers is not caused by promoter hypermethylation. Molecular Cancer. ISSN 1476-4598. 4(1). doi: 10.1186/1476-4598-4-8.
  • Davidson, Ben; Xi, Zhijun; Klokk, Tove Irene; Tropé, Claes Gøran; Dorum, Anne & Scheistroen, M [Show all 7 contributors for this article] (2005). Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions. American Journal of Clinical Pathology. ISSN 0002-9173. 123(3), p. 360–368.
  • Fronsdal, K & Saatcioglu, Fahri (2005). Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. The Prostate. ISSN 0270-4137. 62.
  • Korkmaz, Ceren; Korkmaz, Kemal; Kurys, Piotr Jerzy; Elbi, Cem; Ling, Wang & Klokk, Tove Irene [Show all 10 contributors for this article] (2005). Molecular cloning and characterization of STAMP2, an andogen-regulated six transmembrane protein that is overexpressed in prostate cancer. Oncogene. ISSN 0950-9232. 24(31), p. 4934–45.
  • Xi, Zhijun; Kærn, Janne; Davidson, Ben; Klokk, Tove Irene; Risberg, Bjørn & Tropé, Claes Gøran [Show all 7 contributors for this article] (2004). Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer. Gynecologic Oncology. ISSN 0090-8258. 94, p. 80–85. doi: 10.1016/j.ygyno.2004.03.044.
  • Xi, Zhijun; Klokk, Tove Irene; Korkmaz, Kemal; Kurys, Piotr Jerzy; Elbi, C & Risberg, Bjørn [Show all 9 contributors for this article] (2004). Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer. Cancer Research. ISSN 0008-5472. 64(7), p. 2365–2370.
  • Lorenzo, Petra Isabel O. & Saatcioglu, Fahri (2004). Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. Journal of Endocrinology. ISSN 0022-0795. 182.
  • Korkmaz, Ceren; Korkmaz, Kemal; Manola, Judith; Xi, Zhijun; Risberg, Bjørn & Danielsen, Håvard Emil [Show all 9 contributors for this article] (2004). Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis. Journal of Urology. ISSN 0022-5347. 172, p. 1134–1139.
  • Skotheim, Rolf Inge; Korkmaz, Kemal; Klokk, Tove Irene; Abeler, Vera M; Korlmaz, CG & Nesland, Jahn M [Show all 9 contributors for this article] (2003). NKX3.1 expression is lost in testicular germ cell tumors. American Journal of Pathology. ISSN 0002-9440. 163(6), p. 2149–2154.
  • Bratland, Åse; Ragnhildstveit, Erlend; Bjørnland, Kristin; Andersen, Kristin; Mælandsmo, Gunhild Mari & Fodstad, Øystein [Show all 8 contributors for this article] (2003). The metalloproteinase inhibitor TIMP-2 is down-regulated by androgens in LNCaP prostate carcinoma cells. Clinical and Experimental Metastasis. ISSN 0262-0898. 20(6), p. 541–547.
  • Thuestad, Gunnar; Berghagen, Hege; Ragnhildstveit, Erlend; Krogsrud, Kristin; Apriletti, James & Saatcioglu, Fahri (2002). Corepressor SMRT Functions as a Coactivator for Thyroid Hormone Receptor T3Ralpha from a Negative Hormone Response Element. Journal of Biological Chemistry. ISSN 0021-9258. 277(51), p. 49517–49522.
  • Berghagen, H.; Krogsrud, K.; Ragnhildstveit, Erlend; Thuestad, Gunnar; Aprilletti, J. & Saatcioglu, Fahri (2002). Corepressor SMRT Functions as a Coactivator for Thyroid Hormone Receptor T3Ralpha from a Negative Hormone Response Element. Journal of Biological Chemistry. ISSN 0021-9258. 277(51), p. 49517–49522.
  • Korkmaz, Kemal; Elbi, C.; Korkmaz, Ceren; Loda, M.; Hager, G. & Saatcioglu, Fahri (2002). Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. Journal of Biological Chemistry. ISSN 0021-9258. 277(39), p. 36689–36696.
  • Yamamoto, Takeshi; Saatcioglu, Fahri & Matsuda, T. (2002). Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Endocrinology. ISSN 0013-7227. 143(7), p. 2635–2642.
  • Engedal, Nikolai; Korkmaz, Ceren & Saatcioglu, Fahri (2002). C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. Oncogene. ISSN 0950-9232. 21(7), p. 1017–1027.
  • Saatcioglu, Fahri & Engedal, Nikolai (2001). Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features. The Prostate. ISSN 0270-4137. 46, p. 289–297.
  • Thompson, J.H.; Saatcioglu, Fahri; Jänne, O. A. & Palvimo, J. J. (2001). Discrupted Amino-and Carboxyl-terminal Interactions of the Androgen Receptor Are Linked to Androgen Insensitivity. Molecular Endocrinology. ISSN 0888-8809. 15, p. 923–935.
  • Matsuda, T.; Junicho, A.; Yamamoto, Takeshi; Kishi, H.; Korkmaz, Kemal & Saatcioglu, Fahri [Show all 8 contributors for this article] (2001). Coss-talk between IL-6 and androgen receptor signaling in prostate carcinoma cells. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 283, p. 179–187.
  • Korkmaz, Kemal; Korkmaz, Ceren; Ragnhildstveit, Erlend; Pretlow, T. G. & Saatcioglu, Fahri (2001). KLK4/KLK1/Prostase has a distinctly different gene structure compared with other members of the kallikrein family Alternative cDNA forms and regulation by multiple hormones. DNA and Cell Biology. ISSN 1044-5498. 20, p. 435–445.
  • Slagsvold, Tore; Kraus, I.; Frønsdal, K. & Saatcioglu, Fahri (2001). A novel transcriptional function of the androgen receptor through triggering of coactivators. Journal of Biological Chemistry. ISSN 0021-9258. 276, p. 31030–31036.
  • Matsuda, T.; Yamamoto, Takeshi; Muraguchi, A. & Saatcioglu, Fahri (2001). Cross-talk between transforming growth factor-b and estrogen receptor signaling through Smad3. Journal of Biological Chemistry. ISSN 0021-9258. 276, p. 42908–42914.
  • Engedal, Nikolai; Korkmaz, Ceren & Saatcioglu, Fahri (2001). c-Jun N-terminal kinase is required for the induction of apoptosis in prostate cancer cells. Oncogene. ISSN 0950-9232. In Press.
  • Saatcioglu, Fahri; Engedal, Nikolai & Frønsdal, K. (2000). Efficient methods for DNA-mediated gene transfer into prostate cancer cell line LNCaP. The Prostate. ISSN 0270-4137. p. 111–117.
  • Saatcioglu, Fahri; Apriletti, J.; Thuestad, Gunnar & Kraus, I. (2000). The N-terminal domain of thyroid hormone receptor alpha is required for all of its biological activities. DNA and Cell Biology. ISSN 1044-5498. p. 389–399.
  • Saatcioglu, Fahri; Korkmaz, Kemal; Korkmaz, Ceren; Ragnhildstveit, Erlend & Pretlow, T. G. (2000). An Efficient procedure to clone hormone responsive genes from a specific tissue. DNA and Cell Biology. ISSN 1044-5498. p. 499–506.
  • Saatcioglu, Fahri; Slagsvold, Tore; Bentzen, Tore; Kraus, I. & Palvimo, J. J. (2000). Mutational analysis of the androgen receptor AF-2 core domain reveals functional and mechanistic differences of conserved residues compared with other nuclear receptors. Molecular Endocrinology. ISSN 0888-8809. p. 1603–1617.
  • Saatcioglu, Fahri; Korkmaz, Kemal; Korkmaz, Ceren; Ragnhildstveit, Erlend & Pretlow, T. G. (2000). Full-length cDNA sequence and genomic organization of human NKX3.1-Alternative forms and regulation by both androgens and estrogens. Gene. ISSN 0378-1119. p. 25–36.
  • Saatcioglu, Fahri; Junicho, A.; Matsuda, T.; Yamamoto, Takeshi; Kishi, H. & Korkmaz, Kemal [Show all 8 contributors for this article] (2000). Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. p. 9–13.
  • Yamamoto, Takeshi; Matsuda, T.; Junicho, A.; Kishi, H.; Saatcioglu, Fahri & Muraguchi, A. (2000). Cross-talk between signal transducer and activator of transcription 3 and estrogen receptor signaling. FEBS Letters. ISSN 0014-5793. p. 143–148.

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  • Storm, Margrethe; Kaarbo, Mari; Qu, Su; Wæhre, Haakon; Risberg, Bjørn Åke & Danielsen, Håkon [Show all 7 contributors for this article] (2013). TCTP is Androgen-Regulated and Over-Expressed in Prostate Cancer. The FASEB Journal. ISSN 0892-6638. 27.
  • Tesikova, Martina; Dezitter, Xavier; Klokk, Tove Irene; Kirli, Zeynep; Hager, Gordon L. & Saatcioglu, Fahri (2011). Differential effects of histone deacetylase inhibitors on transcription factor dynamics and activity at the same response element. The FASEB Journal. ISSN 0892-6638. 25.
  • Lorenzo, Petra Isabel O.; Arnoldussen, Yke Jildouw & Saatcioglu, Fahri (2007). Molecular mechanisms of apoptosis in prostate cancer. Critical reviews in oncogenesis. ISSN 0893-9675. 13(1), p. 1–38.
  • Lindstad, Torstein & Saatcioglu, Fahri (2007). Feit og frisk? [Internet]. Forskning.no.
  • Lindstad, Torstein & Saatcioglu, Fahri (2007). Mus mot fedme. [Newspaper]. Dagbladet.
  • Davidson, Ben; Xi, Zhijun; Klokk, Tove Irene; Trope, Claes Gøran; Dørum, Anne & Scheistrøen, Marit [Show all 7 contributors for this article] (2004). Expression of kallikrein 4 in epithelial ovarian carcinoma at different sites - evidence of divergent clinical role for tumor and stromal cells. Abstr. nr 128, s 451. Gynecologic Oncology. ISSN 0090-8258. 92(1), p. 393–511.
  • Lazarevic, B; Karlsen, Steinar; Kucuk, O & Saatcioglu, Fahri (2004). Genistein differentially regulates prostate-enriched protein expression in prostate cancer. Journal of Nutrition. ISSN 0022-3166. 134, p. 1258S–1258S.
  • Saatcioglu, Fahri (2004). Kallikrein 4 is a secreted protein - Response. Cancer Research. ISSN 0008-5472. 64, p. 8482–8483.
  • Xi, Zhijun; Klokk, Tove Irene & Saatcioglu, Fahri (2004). Expression of kallikrein 4 in epithelial ovarian carcinoma at different sites - evidence of divergent clinical role for tumor and stromal cells. Abstr 128.
  • Lazarevic, B; Karlsen, Steinar; Kucuk, O & Saatcioglu, Fahri (2003). Genistein differentially regulates prostate enriched protein expression in prostate cancer cells.
  • Thuestad, Gunnar; Kraus, Irene; Apriletti, James & Saatcioglu, Fahri (2000). DNA and Cell Biology The N-Terminal Domain of Thyroid Hormone Receptor-α Is Required for Its Biological Activities. ?. 19(7), p. 389–399.

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Published Nov. 4, 2010 2:47 PM - Last modified Jan. 11, 2022 3:19 PM

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