Research
I work on the cytoarchitecture of skeletal muscle cells in normal as well as hyper- and atrophic conditions. Muscle cells are huge on a cellular scale, more than 10 000 times the volume of a large mononucleated cell. Because of their size, muscle cells meet several challenges regarding the production and delivery of proteins and nucleic acids to the different parts of the cytosol. Presumably for this reason, muscle cells are multinucleated, and contain thousands of nuclei orderly distributed along the fiber length.
By using an in vivo approach to labeling nuclei, we are investigating the number and distribution of myonuclei under varying conditions and at different stages of an animal's life. A dye is injected into the muscle cell (See figure) and the injected cells can be identified after several weeks (inset). Specially engineered software is used to analyze the distribution and cytosolic domain sizes for each nucleus, and how these parameters are changed under various conditions, like denervation, training and ageing.
Career
Cand. scient - 1999, Research at UiO, Kristian Gundersens group.
PhD - 2005 Funded by The Norwegian Research Council, Research at UiO, Kristian Gundersens group.
Post Doc. - 2005 - Funded By UiO (EMBIO), Researh in Antoine Triller's group, Paris, Biologie de la synapse et régulation de la survie neuronale, Ecole Normale Supérierure
Post doc. - 2006-2008 - Funded by The Norwegian Research Council, Research at UiO, Kristian Gundersens group.
Resercher - 2006-2008 - Funded by UiO (EMBIO), Research at UiO, Kristian Gundersens group.
Jobs/ Experience
2010
Teacher in Cell biology at Atlantis Medisinske Høgskole
2009-2011
Leader of the Norwegian Physiological Society
2010
Member of the hiring committee for 4 Post doc positions at the department for molecular biosciences
2010
Elected representative for temporary employees in the Board of directors at the Institute for Molecular Biosciences, Univeristy of Oslo
2009-2011
Member of the Board for Scentific Communication, at the Institute for Molecular Biosciences, University of Oslo
2009
Examinator in Cell biology/Physiology at Atlantis Medisinske Høgskole
2009
Elected substitute representative for temporary employees in the Board of directors at the Institute for Molecular Biosciences, University of Oslo
2007-2008
Elected representative for temporary employees in the Board of directors at the Institute for Molecular Biosciences, Univeristy of Oslo.
2004-2009
Secretary in the Norwegian Physiological Society
2001-2003
Leading the lab course w/ lectures for lower grade students at Institute for Biology, University of Oslo
1999-2000
Civil service at The Norwegian Board of Education.