Per Ottar Seglen

Phone +47-22845872
Username

I am a guest researcher at NCMM, where I work with Nikolai Engedal in the Autophagy Project Group. Link to www.ncmm.uio.no/ncmm.

Tags: autophagy

Publications

  • Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud Khaled; Abdoli, Asghar & Abudu, Yakubu Princely [Show all 50 contributors for this article] (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . Autophagy. ISSN 1554-8627. 17(1), p. 1–382. doi: 10.1080/15548627.2020.1797280.
  • Engedal, Nikolai; Luhr, Morten; Szalai, Paula & Seglen, Per O. (2019). Measurement of Bulk Autophagy by a Cargo Sequestration Assay. Methods in molecular biology. ISSN 1064-3745. 1880, p. 307–313. doi: 10.1007/978-1-4939-8873-0_20.
  • Luhr, Morten; Szalai, Paula; Sætre, Frank; Gerner, Lisa; Seglen, Per O. & Engedal, Nikolai (2017). A simple cargo sequestration assay for quantitative measurement of non-selective autophagy in cultured cells. Methods in Enzymology. ISSN 0076-6879. 587, p. 351–364. doi: 10.1016/bs.mie.2016.09.064.
  • Engedal, Kim Nikolai & Seglen, Per O. (2016). Autophagy of cytoplasmic bulk cargo does not require LC3. Autophagy. ISSN 1554-8627. 12(2), p. 439–441. doi: 10.1080/15548627.2015.1076606.
  • Sætre, Frank; Hagen, Linda K Korsberg; Engedal, Kim Nikolai & Seglen, Per O. (2015). Novel steps in the autophagic-lysosomal pathway. The FEBS Journal. ISSN 1742-464X. 282(11), p. 2202–2214. doi: 10.1111/febs.13268. Full text in Research Archive
  • Szalai, Paula; Hagen, Linda K Korsberg; Sætre, Frank; Luhr, Morten; Sponheim, Marianne & Øverbye, Anders [Show all 9 contributors for this article] (2015). Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs. Experimental Cell Research. ISSN 0014-4827. 333(1), p. 21–38. doi: 10.1016/j.yexcr.2015.02.003.
  • Seglen, Per O.; Luhr, Morten; Mills, Ian Geoffrey; Sætre, Frank; Szalai, Paula & Engedal, Kim Nikolai (2015). Macroautophagic cargo sequestration assays. Methods. ISSN 1046-2023. 75, p. 25–36. doi: 10.1016/j.ymeth.2014.12.021.
  • Patel, Khushbu K; Miyoshi, Hiroyuki; Beatty, Wandy L; Head, Richard D; Malvin, Nicole P & Cadwell, Ken [Show all 13 contributors for this article] (2013). Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO Journal. ISSN 0261-4189. 32(24), p. 3130–3144. doi: 10.1038/emboj.2013.233.
  • Engedal, Kim Nikolai; Torgersen, Maria Lyngaas; Guldvik, Ingrid Jenny; Barfeld, Stefan; Bakula, D & Sætre, Frank Ove [Show all 12 contributors for this article] (2013). Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. ISSN 1554-8627. 9(10), p. 1475–1490. doi: 10.4161/auto.25900.
  • Klionsky, Daniel J.; Abdalla, FC; Abeliovich, H; Abraham, RT; Acevedo-Arozena, A & Adeli, K [Show all 1,261 contributors for this article] (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. ISSN 1554-8627. 8(4), p. 445–544. doi: 10.4161/auto.19496.
  • Eskelinen, Eeva-Liisa; Reggiori, Fulvio; Baba, Misuzu; Kovács, Attila L. & Seglen, Per O. (2011). Seeing is believing The impact of electron microscopy on autophagy research. Autophagy. ISSN 1554-8627. 7(9), p. 935–956. doi: 10.4161/auto.7.9.15760.
  • Øverbye, Anders; Sætre, Frank Ove; Hagen, Linda K Korsberg; Johansen, Harald Thidemann & Seglen, Per O. (2011). Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain. Autophagy. ISSN 1554-8627. 7(9), p. 1011–1027. doi: 10.4161/auto.7.9.16436.
  • Seglen, Per Ottar & Brinchmann, Monica Fengsrud (2010). Purification of autophagosomes from rat hepatocytes. Autophagy. ISSN 1554-8627. 6(4), p. 542–547. doi: 10.4161/auto.6.4.11272.
  • Klionsky, Daniel J. & Seglen, Per O. (2010). The Norse god of autophagy. Autophagy. ISSN 1554-8627. 6(8), p. 1017–1031. doi: 10.4161/auto.6.8.13092.
  • Øverbye, Anders & Seglen, Per O. (2009). Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues. Biochemical Journal. ISSN 0264-6021. 417, p. 535–545. doi: 10.1042/BJ20081284.
  • Seglen, Per O.; Øverbye, Anders & Sætre, Frank (2009). Sequestration assays for mammalian autophagy. Methods in Enzymology. ISSN 0076-6879. 452, p. 63–83. doi: 10.1016/S0076-6879%2808%2903605-7.
  • Klionsky, DJ; Abeliovich, H; Agostinis, P; Agrawal, DK; Aliev, G & Askew, DS [Show all 235 contributors for this article] (2008). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. ISSN 1554-8627. 4(2), p. 151–175.
  • Øverbye, Anders; Fengsrud, Monica & Seglen, Per Ottar (2007). Proteomic analysis of membrane-associated proteins from rat liver autophagosomes. Autophagy. ISSN 1554-8627. 3(4), p. 300–322.
  • Samari, Hamid R.; Møller, Michael T.N.; Holden, Lise; Asmyhr, Tonje & Seglen, Per O. (2005). Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. Biochemical Journal. ISSN 0264-6021. 386, p. 237–244.
  • Asmyhr, Tonje; Samari, Hamid R.; Hildonen, Siri; Helgerud, Marit; Dahl, Mai B. & Seglen, Per O. (2005). Multiphosphorylation of hepatocellular AMPK: implications for ageing. Giornale di Gerontologia. ISSN 0017-0305. 53, p. 40–41.
  • Lindstad, Rune I.; Sylte, Ingebrigt; Mikalsen, Svein O.; Seglen, Per O.; Berg, Eli & Winberg, Jan O. (2005). Pancreatic trypsin activates human promatrix metalloproteinase-2. Journal of Molecular Biology (JMB). ISSN 0022-2836. 350, p. 682–698.
  • Lunde Sneve, Marianne; Øverbye, Anders; Fengsrud, Monica & Seglen, Per O. (2005). Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels. Autophagy. ISSN 1554-8627. 1, p. 157–162.
  • Samari, Hamid Reza; Møller, Michael T. N; Holden, Lise; Asmyhr, Tonje & Seglen, Per O. (2005). Biochem. J. (2005) 386, 237–244 (Printed in Great Britain) 237 Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. Biochemical Journal. ISSN 0264-6021. 386, p. 237–244. doi: 10.1042/BJ20040609.
  • Fengsrud, Monica ; Lunde Sneve, Marianne; Øverbye, Anders & Seglen, Per O. (2004). Structural aspects of mammalian autophagy, Autophagy (Klionsky, D.J., ed.). Landes Bioscience. ISSN 1-58706-203-8. p. 11–25.
  • Møller, Michael T.N.; Samari, Hamid R.; Holden, Lise & Seglen, Per O. (2004). Regulation of mammalian autophagy by protein phosphorylation, Autophagy (Klionsky, D.J., ed.). Landes Bioscience. ISSN 1-58706-203-8. p. 48–59.
  • Rusten, Tor E.; Lindmo, Karine; Juhász, Gábor; Sass, Miklós; Seglen, Per O. & Brech, Andreas [Show all 7 contributors for this article] (2004). Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Developmental Cell. ISSN 1534-5807. 7, p. 179–192.
  • Møller, Michael T. N; Samari, Hamid R. & Seglen, Per O. (2004). Toxin-induced tail phosphorylation of hepatocellular S6 kinase: Evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. Toxicological Sciences. ISSN 1096-6080. p. 628–637. doi: 10.1093/toxsci/kfh273.
  • Seglen, Per O. (2003). Bibliometric analysis - what can it tell us? Proceedings / Max Planck Forum. 6, p. 139–151.
  • Møller, Michael T. N; Samari, Hamid R.; Fengsrud, Monica ; Strømhaug, Per E.; Østvold, Anne C. & Seglen, Per O. (2003). Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. Biochemical Journal. ISSN 0264-6021. 373, p. 505–513. doi: 10.1042/BJ20030502.
  • Ruud Larsen, Ann K.; Møller, Michael T. N; Blankson, Henrietta; Samari, Hamid R.; Holden, Lise & Seglen, Per O. (2002). Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes. Journal of Biological Chemistry. ISSN 0021-9258. 277, p. 34826–34835. doi: 10.1074/jbc.M205028200. Full text in Research Archive
  • Berven, Grethe; Sætre, Frank; Halvorsen, Kathrine & Seglen, Per O. (2001). Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. Toxicon. ISSN 0041-0101. 39, p. 349–362.
  • Mousavi, Seyed A.; Kjeken, Rune; Berg, Trond O.; Seglen, Per O.; Berg, Trond & Brech, Andreas (2001). Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. Biochimica et Biophysica Acta. ISSN 0006-3002. 1510, p. 243–257.
  • Seglen, Per O. (2001). Evaluating biology: A scientometric study of a university biology department. NIFU skriftserie. ISSN 0808-4572. p. 1–70.
  • Aksnes, Dag W.; Olsen, Terje B. & Seglen, Per O. (2000). Validation of bibliometric indicators in the field of microbiology: A Norwegian case study. Scientometrics. ISSN 0138-9130. 49, p. 7–22.
  • Seglen, Per O. & Aksnes, Dag W. (2000). Scientific productivity and group size: A bibliometric analysis of Norwegian microbiological research. Scientometrics. ISSN 0138-9130. 49, p. 125–143.
  • Fengsrud, Monica ; Raiborg, Camilla; Berg, Trond O.; Strømhaug, Per E.; Ueno, Takashi & Erichsen, Egil S. [Show all 7 contributors for this article] (2000). Autophagosome-associated variant isoforms of cytosolic enzymes. Biochemical Journal. ISSN 0264-6021. 352, p. 773–781.
  • Fengsrud, Monica ; Erichsen, Egil S.; Berg, Trond O.; Raiborg, Camilla & Seglen, Per O. (2000). Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy. European Journal of Cell Biology. ISSN 0171-9335. 79, p. 871–882.
  • Blankson, Henrietta; Grotterød, Else M. & Seglen, Per O. (2000). Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. Cell Death and Differentiation. ISSN 1350-9047. 7, p. 739–746.
  • Aksnes, Dag W.; Olsen, Terje B. & Seglen, Per O. (1999). Inadequacy of a journal-based research field delineation. Incomplete recovery of Norwegian microbiology articles in ISI's Microbiology field. In Macías-Chapula, César A. (Eds.), Proceedings of the Seventh Conference of the International Society for Scientometrics and Informetrics. Universidad de Colima. ISSN 968-6190-91-0. p. 1–10.
  • Rundén, Elise; Seglen, Per O.; Haug, Finn M.; Ottersen, Ole P.; Wieloch, Tadeusz & Shamloo, Mehrdad [Show all 7 contributors for this article] (1998). Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism. Journal of Neuroscience. ISSN 0270-6474. 18, p. 7296–7305.
  • Samari, Hamid R. & Seglen, Per O. (1998). Inhibition of hepatocytic autophagy by adenosine, AICAR and N6-mercaptopurine riboside: Evidence for involvement of AMP-activated protein kinase. Journal of Biological Chemistry. ISSN 0021-9258. 273, p. 23758–23763.
  • Strømhaug, Per E.; Berg, Trond O.; Fengsrud, Monica & Seglen, Per O. (1998). Purification and characterization of autophagosomes from rat hepatocytes. Biochemical Journal. ISSN 0264-6021. 335, p. 217–224.
  • Kovács, Attila L.; Gordon, Paul B.; Grotterød, Else M. & Seglen, Per O. (1998). Inhibition of hepatocytic autophagy by adenosine, adenosine analogues and AMP. Biological chemistry. ISSN 1431-6730. 379, p. 1341–1347.
  • Berg, Trond O.; Fengsrud, Monica ; Strømhaug, Per E.; Berg, Trond & Seglen, Per O. (1998). Isolation and characterization of rat liver amphisomes: Evidence for fusion of autophagosomes with both early and late endosomes. Journal of Biological Chemistry. ISSN 0021-9258. 273, p. 21883–21892.
  • Seglen, Per O. (1998). Citation rates and journal impact factors are not suitable for evaluation of research. Acta Orthopaedica Scandinavica. ISSN 0001-6470. 69, p. 224–229.
  • Strømhaug, Per E.; Fengsrud, Monica ; Berg, Trond Olav; Møller, Michael T. N; Grotterød, Else M. & Samari, Hamid Reza [Show all 12 contributors for this article] (1997). Regulation of autophagy by protein phosphorylation, Proteolysis in cell function. IOS Press. p. 357–366.
  • Strømhaug, Per E.; Berg, Trond O.; Gjøen, Tor & Seglen, Per O. (1997). Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes. European Journal of Cell Biology. ISSN 0171-9335. 73, p. 28–39.
  • Seglen, Per O.; Berg, Trond Olav; Blankson, Henrietta; Fengsrud, Monica ; Holen, Ingunn & Strømhaug, Per E. (1996). Structural aspects of autophagy. In Suzuki, Koichi & Bond, Judith S. (Ed.), Intracellular Protein Catabolism. Springer. ISSN 978-1-4613-8003-0. p. 103–11.
  • Holen, Ingunn; Strømhaug, Per E.; Gordon, Paul B.; Fengsrud, Monica ; Berg, Trond Olav & Seglen, Per O. (1995). Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins). Journal of Biological Chemistry. ISSN 0021-9258. 270(21), p. 12823–31.
  • Fengsrud, Monica ; Roos, Norbert; Berg, Trond; Liou, Willisa; Slot, Jan W & Seglen, Per O. (1995). Ultrastructural and immunocytochemical characterization of autophagic vacoules in isolated hepatocytes: Effects of vinblastine and asparagine on vacoule distributions. Experimental Cell Research. ISSN 0014-4827. 221, p. 504–519.
  • Holen, Ingunn; Gordon, Paul B.; Strømhaug, Per E.; Berg, Trond Olav; Fengsrud, Monica & Brech, Andreas [Show all 9 contributors for this article] (1995). Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors. Biochemical Journal. ISSN 0264-6021. 311, p. 317–326.

View all works in Cristin

  • Klionsky, DJ; Elazar, Z; Seglen, Per O. & Rubinsztein, DC (2008). Does bafilomycin A(1) block the fusion of autophagosomes with lysosomes? Autophagy. ISSN 1554-8627. 4(7), p. 849–850.
  • Klionsky, DJ; Cuervo, AM; Dunn, WA; Levine, B; van der Klei, I & Seglen, Per O. (2007). How shall I eat thee? Autophagy. ISSN 1554-8627. 3.
  • Seglen, Per O. (1998). Isolation of hepatocytes. In Celis, Julio E. (Eds.), Cell Biology: A Laboratory Handbook. Academic Press. ISSN 0-12-164726-9. p. 119–124.
  • Laake, Jon H.; Rundén, Elise; Seglen, Per O. & Ottersen, Ole P. (1996). In vitro ischemia and phosphatase 1/2a inhibition cause selective neuronal damage in hippocampal slice cultures. Neuropharmacology. ISSN 0028-3908. 35.
  • Seglen, Per O. (2004). Økologisk samspill i Bærum: Vegetasjon og insektliv på Isi. Naturvernforbundet i Bærum.
  • Seglen, Per O. (2003). Biologisk mangfold i Bærum: Sommerfuglfaunaen på Isi. Naturvernforbundet i Bærum.

View all works in Cristin

Published Nov. 4, 2010 2:48 PM - Last modified Feb. 1, 2019 2:10 PM