Patrick Riss

Associate Professor - Environmental Sciences
Image of Patrick Riss
Norwegian version of this page
Mobile phone 95028669 +4795028669
Room VU 65B
Visiting address Sem Sælands vei 26 None 0371 OSLO
Postal address Postboks 1033 0315 OSLO

Research Interests

  • Radiopharmaceutical Chemistry
  • Production and Application of Medical Radionuclides
  • Radiochemical Method Development
  • Chemical Neuroscience


KJM5950 - Radiopharmaceutical chemistry


  • 06/2009-03/2013, Wolfson Brain Imaging Centre, Cambridge, UK
  • 05/2011-09/2011, National Institute of Mental Health, Bethesda, MD, USA

  • 05/2008-07/2008, Brookhaven National Laboratory, Upton, NY, USA
  • 06/2006-07/2006, Institute of Organic Chemistry and Catalysis, TU Delft, The Netherlands

  • 10/2004-06/2009,Institute of Nuclear Chemistry, Mainz, Germany


  • 12/2012, Oral Presentation Prize of the UK PET Chemistry Group
  • 09/2009, Dissertation Prize of the Gesellschaft deutscher Chemiker (GdCh)

  • 07/2009, Dissertation Prize of the ‘Freunde der Universität Mainz. e.V.’
  • 07/2007, Attendant: 57th Lindau Nobel Laureates Meeting


Collaboration (alphabetical)


Ira Ronit Haraldsen, OUS-Rikshospitalet,

Jon Petter Omtvedt, SAFE

Rune Sundset,UNN/UiT

Thor Audun Saga, Norsk Medisinsk Syklotronsenter AS,



Dr Franklin I Aigbirhio, University of Cambridge, UK

Dr Tim D Fryer, University of Cambridge, UK

Prof Olaf Prante, Erlangen University Hospital, Germany

Prof Frank Roesch, University of Mainz, Germany

Prof Peter Scott, Radiology, Ann Arbor



Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth B, Henriksen G, Aigbirhio FI, Fryer TD, Dalley JW (2013) J Nucl Med. 54(2):299-305

Riss PJ, Lu S, Telu S, Aigbirhio FI, Pike VW (2012) Angew. Chem. Int. Ed. 51 (11): 2698–2702 Highlighted in SYNFACTS 2012

Riss PJ, Aigbirhio FI (2011) Chem Commun 47(43):11873-11875

Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011) J Cereb Blood Flow Metab 31(12): 2334-2342

Roesch F, Riss PJ (2010) Curr Top Med Chem 10(16):1633-68 

  • Alluri, Santosh Reddy & Riss, Patrick (2018). Poly(ADP-ribose) polymerase in neurodegeneration: Radiosynthesis and radioligand binding in ARC-SWE tg mice. ACS Chemical Neuroscience.  ISSN 1948-7193.  9(6), s 1259- 1263 . doi: 10.1021/acschemneuro.8b00053
  • Alluri, Santosh Reddy & Riss, Patrick (2018). Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography. Organic and biomolecular chemistry.  ISSN 1477-0520.  16(13), s 2219- 2224 . doi: 10.1039/c8ob00184g
  • Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian; Sundset, Rune & Hansen, Jørn H (2018). An acylation-Finkelstein approach to radioiodination of bioactives: The role of amide group anchimeric assistance. Journal of Physical Organic Chemistry.  ISSN 0894-3230.  31:e3835(7), s 1- 12 . doi: 10.1002/poc.3835
  • Fjellaksel, Richard; Sundset, Rune; Riss, Patrick & Hansen, Jørn H (2018). Copper-mediated late-stage iodination and 123I-labelling of triazole-benzimidazole bioactives. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.  ISSN 0936-5214.  29(11), s 1491- 1495 . doi: 10.1055/s-0036-1591985
  • Jakobsson, Jimmy Erik & Riss, Patrick (2018). Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex. RSC Advances.  ISSN 2046-2069.  8(38), s 21288- 21291 . doi: 10.1039/c8ra03757d
  • Munthe, Else; Riss, Patrick; Saga, T.; Haraldsen, Ira Hebold; Grad, Iwona; Bogsrud, Trond & Bach-Gansmo, Tore (2018). FDG-based quantitative comparison of glucose metabolism in vitro, exemplified by a head-to-head comparison between a triple-negative breast cancer cell line and a non-malignant foetal cell line. Clinical Physiology and Functional Imaging.  ISSN 1475-0961.  38(1), s 34- 37 . doi: 10.1111/cpf.12378
  • Fjellaksel, Richard; Boomgaren, Marc; Sundset, Rune; Haraldsen, Ira Hebold; Hansen, Jørn H & Riss, Patrick (2017). Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor. MedChemComm.  ISSN 2040-2503.  8(10), s 1965- 1969 . doi: 10.1039/c7md00320j
  • Jakobsson, Jimmy Erik; Grønnevik, Gaute & Riss, Patrick (2017). Organocatalyst-assisted Ar-18F bond formation: A universal procedure for direct aromatic radiofluorination. Chemical Communications.  ISSN 1359-7345.  53(96), s 12906- 12909 . doi: 10.1039/c7cc07211b
  • Rafique, Waqas; Shivashankar, Shivashankar; Milde, Mona & Riss, Patrick (2017). Reaching out for sensitive evaluation of the Mu opioid receptor in vivo: positron emission tomography imaging of the Agonist [11C]AH7921. ACS Chemical Neuroscience.  ISSN 1948-7193.  8(9), s 1847- 1852 . doi: 10.1021/acschemneuro.7b00075
  • Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri & Klaveness, Jo (2017). Recent development of non-peptide GnRH antagonists. Molecules.  ISSN 1420-3049.  22:2188(12), s 1- 25 . doi: 10.3390/molecules22122188
  • Cumming, Paul; Maschauer, Simone; Riss, Patrick; Grill, Eva; Pischetsrieder, Monika; Kuwert, Torsten & Prante, Olaf (2015). Perturbed Development of Striatal Dopamine Transporters in Fatty Versus Lean Zucker Rats: a Follow-up Small Animal PET Study. Molecular Imaging and Biology.  ISSN 1536-1632.  17(4), s 521- 528 . doi: 10.1007/s11307-014-0811-7
  • Maschauer, Simone; Haller, Adelina; Riss, Patrick; Kuwert, Torsten; Prante, Olaf & Cumming, Paul (2015). Specific binding of [18F]fluoroethyl-harmol to monoamine oxidase A in rat brain cryostat sections, and compartmental analysis of binding in living brain. Journal of Neurochemistry.  ISSN 0022-3042.  135(5), s 908- 917 . doi: 10.1111/jnc.13370
  • Sommer, Theis; Bjerregaard-Andersen, Kaare; Simensen, Stine Marie; Jensen, Jan K.; Jochimsen, Bjarne; Riss, Patrick; Etzerodt, Michael & Morth, Jens Preben (2015). Enzymatic detection and quantification assay of isatin, a putative stress biomarker in blood. ACS Chemical Neuroscience.  ISSN 1948-7193.  6(8), s 1353- 1360 . doi: 10.1021/cn500346x
  • Cumming, Paul; Maschauer, Simone; Riss, Patrick; Tschammer, Nuska; Fehler, Stefanie K.; Heinrich, Markus R.; Kuwert, Torsten & Prante, Olaf (2014). Radiosynthesis and validation of 18 F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  34(7), s 1148- 1156 . doi: 10.1038/jcbfm.2014.63
  • Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm; Engebråten, Olav; Mælandsmo, Gunhild & Malinen, Eirik (2014). Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts. Acta Oncologica.  ISSN 0284-186X.  53(8), s 1086- 1092 . doi: 10.3109/0284186X.2014.934398
  • Lien, Vegard Torp & Riss, Patrick (2014). Radiosynthesis of [18F]trifluoroalkyl groups: Scope and limitations. BioMed Research International.  ISSN 2314-6133.  2014:380124 . doi: 10.1155/2014/380124
  • Rühl, Thomas; Rafique, Waqas; Lien, Vegard Torp & Riss, Patrick (2014). Cu(I)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes†. Chemical Communications.  ISSN 1359-7345.  50(45), s 6056- 6059 . doi: 10.1039/c4cc01641f
  • Riss, Patrick; Brichard, Laurent; Ferrari, Valentina; Williamson, David J.; Fryer, Tim D.; Hong, Young T.; Baron, Jean-Claude & Aigbirhio, Franklin I. (2013). Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of tau-pathology. MedChemComm.  ISSN 2040-2503.  4(5), s 852- 855 . doi: 10.1039/c3md00017f
  • Riss, Patrick; Hoehnemann, Sabine; Piel, Markus & Roesch, F. (2013). Two-step radiosynthesis of [18F]FE--CIT and [18F]PR04.MZ. Journal of labelled compounds & radiopharmaceuticals.  ISSN 0362-4803.  56(7), s 356- 359 . doi: 10.1002/jlcr.3032
  • Riss, Patrick; Hong, Young T.; Marton, Janos; Caprioli, Daniele; Williamson, Derek; Ferrari, Valentina; Saigal, Neil; Roth, Bryan L.; Henriksen, Gjermund; Fryer, Tim D.; Dalley, Jeffrey W. & Aigbirhio, Franklin I. (2013). Synthesis and Evaluation of F-18-FE-PEO in Rodents: An F-18-Labeled Full Agonist for Opioid Receptor Imaging. Journal of Nuclear Medicine.  ISSN 0161-5505.  54(2), s 299- 305 . doi: 10.2967/jnumed.112.108688

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Published Apr. 8, 2013 2:28 PM - Last modified Oct. 25, 2017 10:52 AM