Patrick Riss

Image of Patrick Riss
Norwegian version of this page
Mobile phone +4795028669 +4795028669
Room VU 65B
Postal address Postboks 1033 0315 Oslo

Research Interests

  • Radiopharmaceutical Chemistry
  • Production and Application of Medical Radionuclides
  • Radiochemical Method Development
  • Chemical Neuroscience


KJM5950 - Radiopharmaceutical chemistry


  • 06/2009-03/2013, Wolfson Brain Imaging Centre, Cambridge, UK
  • 05/2011-09/2011, National Institute of Mental Health, Bethesda, MD, USA

  • 05/2008-07/2008, Brookhaven National Laboratory, Upton, NY, USA
  • 06/2006-07/2006, Institute of Organic Chemistry and Catalysis, TU Delft, The Netherlands

  • 10/2004-06/2009,Institute of Nuclear Chemistry, Mainz, Germany


  • 12/2012, Oral Presentation Prize of the UK PET Chemistry Group
  • 09/2009, Dissertation Prize of the Gesellschaft deutscher Chemiker (GdCh)

  • 07/2009, Dissertation Prize of the ‘Freunde der Universität Mainz. e.V.’
  • 07/2007, Attendant: 57th Lindau Nobel Laureates Meeting


Collaboration (alphabetical)


Ira Ronit Haraldsen, OUS-Rikshospitalet,

Jon Petter Omtvedt, SAFE

Rune Sundset,UNN/UiT

Thor Audun Saga, Norsk Medisinsk Syklotronsenter AS,



Dr Franklin I Aigbirhio, University of Cambridge, UK

Dr Tim D Fryer, University of Cambridge, UK

Prof Olaf Prante, Erlangen University Hospital, Germany

Prof Frank Roesch, University of Mainz, Germany

Prof Peter Scott, Radiology, Ann Arbor



Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth B, Henriksen G, Aigbirhio FI, Fryer TD, Dalley JW (2013) J Nucl Med. 54(2):299-305

Riss PJ, Lu S, Telu S, Aigbirhio FI, Pike VW (2012) Angew. Chem. Int. Ed. 51 (11): 2698–2702 Highlighted in SYNFACTS 2012

Riss PJ, Aigbirhio FI (2011) Chem Commun 47(43):11873-11875

Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011) J Cereb Blood Flow Metab 31(12): 2334-2342

Roesch F, Riss PJ (2010) Curr Top Med Chem 10(16):1633-68 

  • Lehnert, Wencke; Riss, Patrick Johannes; Hurtado de Mendoza, Ana; Lopez, Sandra; Fernandez, Gonzalo & Ilheu, Marcelo [Show all 8 contributors for this article] (2022). Whole-body biodistribution and radiation dosimetry of [<sup>18</sup>F]PR04.MZ: a new PET radiotracer for clinical management of patients with movement disorders. EJNMMI Research. ISSN 2191-219X. 12(1). doi: 10.1186/s13550-021-00873-9.
  • Perez Garcia, Raul Manuel; Grønnevik, Gaute & Riss, Patrick (2021). A General Protocol for Cu-Mediated Fluoro-deamination: Sandmeyer Fluorination of Diverse Aromatic Substrates. Organic Letters. ISSN 1523-7060. 23(3), p. 1011–1015. doi: 10.1021/acs.orglett.0c04209. Full text in Research Archive
  • Juri, Carlos; Kramer, Vasko; Riss, Patrick; Soza-Ried, Cristian; Haeger, Arlette & Pruzzo, Rossana [Show all 9 contributors for this article] (2021). 18F]PR04.MZ PET/CT Imaging for Evaluation of Nigrostriatal Neuron Integrity in Patients With Parkinson Disease. Clinical Nuclear Medicine. ISSN 0363-9762. 46(2), p. 119–124. doi: 10.1097/RLU.0000000000003430. Full text in Research Archive
  • Gurin, Andrey; Chakrova, Yelena; Matveyeva, Ilona & Riss, Patrick Johannes (2020). Optimization of reaction parameters for the synthesis of 177Lu-DOTAELA. Revista de chimie (Bucuresti). ISSN 0034-7752. 71(8), p. 55–62. doi: 10.37358/RC.20.8.8278.
  • Kramer, Vasko; Brooks, Allen; Haeger, Arlette; Kuljs, Rodrigo; Muhammad Rafique, Waqas & Koeppe, Robert [Show all 11 contributors for this article] (2020). Evaluation of [18F]N-methyl-lansoprazole as a tau PET imaging agent in first-in-human studies. . ACS Chemical Neuroscience. ISSN 1948-7193. 11(3), p. 427–435. doi: 10.1021/acschemneuro.9b00639.
  • Gurin, A.N.; Riss, Patrick; Chakrova, E.T.; Matveyeva, I.V. & Kadyrbaev, E.A. (2020). Study of the Purification of <sup>177</sup>Lu-DOTAELA Complex. Pharmaceutical Chemistry Journal. ISSN 0091-150X. 54(1), p. 64–68. doi: 10.1007/s11094-020-02157-3.
  • Wærsted, Frøydis Meen; Riss, Patrick & Skipperud, Lindis (2020). The effect of water exchange on the leaching of alum shale. Applied Geochemistry. ISSN 0883-2927. 119. doi: 10.1016/j.apgeochem.2020.104610. Full text in Research Archive
  • Ott, Julian; Spilhaug, Mona M.; Maschauer, Simone; Rafique, Waqas; Jakobsson, Jimmy Erik & Hartvig, Karoline [Show all 10 contributors for this article] (2020). Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with 18F-Labeled Derivatives in Rats. Journal of Medicinal Chemistry. ISSN 0022-2623. 63(17), p. 9484–9499. doi: 10.1021/acs.jmedchem.0c00683. Full text in Research Archive
  • Stefan, Katja; Leck, Lionel Yi Wen; Namasivayam, Vigneshwaran; Bascuñana, Pablo; Huang, Michael Li-Hsuan & Riss, Patrick [Show all 9 contributors for this article] (2020). Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development. Future Drug Discovery. ISSN 2631-3316. 4:FDD51(2), p. 1–8. doi: 10.4155/fdd-2020-0025. Full text in Research Archive
  • Bekker, Roberto Bartholomeus Wilhelmus; Fjellaksel, Richard; Hjornevik, Trine; Nuruddin, Syed; Rafique, Waqas & Hansen, Jørn H [Show all 9 contributors for this article] (2020). Discovery of a lead brain-penetrating gonadotropin-releasing hormone receptor antagonist with saturable binding in brain. ChemMedChem. ISSN 1860-7179. 15(17), p. 1624–1628. doi: 10.1002/cmdc.202000256. Full text in Research Archive
  • Kramer, Vasko; Juri, Carlos; Riss, Patrick; Pruzzo, Rossana; Soza-Ried, Cristian & Flores, Jonathan [Show all 10 contributors for this article] (2019). Pharmacokinetic evaluation of [18F]PR04.MZ for PET/CT imaging and quantification of dopamine transporters in the human brain. European Journal of Nuclear Medicine and Molecular Imaging. ISSN 1619-7070. p. 1–11. doi: 10.1007/s00259-019-04594-z.
  • Alluri, Santosh Reddy; Pitman, Kathinka; Malinen, Eirik & Riss, Patrick (2019). Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 63(1), p. 6–14. doi: 10.1002/jlcr.3814. Full text in Research Archive
  • Fjellaksel, Richard; Moldes-Anaya, Angel; Vasskog, Terje; Oteiza, Ana; Martin-Armas, Maria Montserrat & Hjelstuen, Ole Kristian [Show all 9 contributors for this article] (2019). Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. p. 1–13. doi: 10.1002/jlcr.3820. Full text in Research Archive
  • Jakobsson, Jimmy Erik; Gourni, Eleni; Shivashankar, Shivashankar; Brito, Beatriz & Riss, Patrick (2019). Synthesis and Characterization in Rodent Brain of the Subtype-Selective NR2B NMDA Receptor Ligand [11C]Ro04-5595 as a Potential Radiotracer for Positron Emission Tomography. ACS Omega. ISSN 2470-1343. 4(6), p. 9925–9931. doi: 10.1021/acsomega.9b00357.
  • Pitman, Kathinka; Alluri, Santosh Reddy; Kristian, Alexandr; Aarnes, Eva-Katrine; Lyng, Heidi & Riss, Patrick [Show all 7 contributors for this article] (2019). Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts. European Journal of Nuclear Medicine and Molecular Imaging. ISSN 1619-7070. 46(10), p. 2190–2198. doi: 10.1007/s00259-019-04375-8.
  • Fjellaksel, Richard; Oteiza, Ana; Martin-Armas, Montserrat; Riss, Patrick; Hjelstuen, Ole Kristian & Kuttner, Samuel [Show all 8 contributors for this article] (2018). First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor. BMC Research Notes. ISSN 1756-0500. 11(1), p. 1–6. doi: 10.1186/s13104-018-3924-2. Full text in Research Archive
  • Rafique, Waqas; Kramer, Vasko; Pardo, Tania; Smits, René; Spilhaug, Mona M. & Hoepping, Alexander [Show all 11 contributors for this article] (2018). Image-guided development of heterocyclic sulfoxides as ligands for tau neurofibrillary tangles: From first-in-man to second-generation ligands. ACS Omega. ISSN 2470-1343. 3(7), p. 7567–7579. doi: 10.1021/acsomega.8b00975.
  • Jakobsson, Jimmy Erik; Grønnevik, Gaute; Rafique, Waqas; Hartvig, Karoline & Riss, Patrick (2018). Formamide as an Unconventional Amine Protecting Group for PET Radiochemistry. European Journal of Organic Chemistry. ISSN 1434-193X. 2018(27), p. 3701–3704. doi: 10.1002/ejoc.201800554.
  • Munthe, Else; Riss, Patrick; Saga, T.; Haraldsen, Ira Hebold; Grad, Iwona & Bogsrud, Trond [Show all 7 contributors for this article] (2018). FDG-based quantitative comparison of glucose metabolism in vitro, exemplified by a head-to-head comparison between a triple-negative breast cancer cell line and a non-malignant foetal cell line. Clinical Physiology and Functional Imaging. ISSN 1475-0961. 38(1), p. 34–37. doi: 10.1111/cpf.12378.
  • Jakobsson, Jimmy Erik & Riss, Patrick (2018). Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex. RSC Advances. ISSN 2046-2069. 8(38), p. 21288–21291. doi: 10.1039/c8ra03757d.
  • Alluri, Santosh Reddy & Riss, Patrick (2018). Poly(ADP-ribose) polymerase in neurodegeneration: Radiosynthesis and radioligand binding in ARC-SWE tg mice. ACS Chemical Neuroscience. ISSN 1948-7193. 9(6), p. 1259–1263. doi: 10.1021/acschemneuro.8b00053.
  • Alluri, Santosh Reddy & Riss, Patrick (2018). Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography. Organic and biomolecular chemistry. ISSN 1477-0520. 16(13), p. 2219–2224. doi: 10.1039/c8ob00184g.
  • Fjellaksel, Richard; Sundset, Rune; Riss, Patrick & Hansen, Jørn H (2018). Copper-mediated late-stage iodination and 123I-labelling of triazole-benzimidazole bioactives. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. ISSN 0936-5214. 29(11), p. 1491–1495. doi: 10.1055/s-0036-1591985.
  • Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian & Sundset, Rune [Show all 7 contributors for this article] (2018). An acylation-Finkelstein approach to radioiodination of bioactives: The role of amide group anchimeric assistance. Journal of Physical Organic Chemistry. ISSN 0894-3230. 31(7), p. 1–12. doi: 10.1002/poc.3835. Full text in Research Archive
  • Jakobsson, Jimmy Erik; Grønnevik, Gaute & Riss, Patrick (2017). Organocatalyst-assisted Ar-18F bond formation: A universal procedure for direct aromatic radiofluorination. Chemical Communications. ISSN 1359-7345. 53(96), p. 12906–12909. doi: 10.1039/c7cc07211b.
  • Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri & Klaveness, Jo (2017). Recent development of non-peptide GnRH antagonists. Molecules. ISSN 1420-3049. 22:2188(12), p. 1–25. doi: 10.3390/molecules22122188. Full text in Research Archive
  • Rafique, Waqas; Shivashankar, Shivashankar; Milde, Mona & Riss, Patrick (2017). Reaching out for sensitive evaluation of the Mu opioid receptor in vivo: positron emission tomography imaging of the Agonist [11C]AH7921. ACS Chemical Neuroscience. ISSN 1948-7193. 8(9), p. 1847–1852. doi: 10.1021/acschemneuro.7b00075.
  • Fjellaksel, Richard; Boomgaren, Marc; Sundset, Rune; Haraldsen, Ira Hebold; Hansen, Jørn H & Riss, Patrick (2017). Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor. MedChemComm. ISSN 2040-2503. 8(10), p. 1965–1969. doi: 10.1039/c7md00320j. Full text in Research Archive
  • Maschauer, Simone; Haller, Adelina; Riss, Patrick; Kuwert, Torsten; Prante, Olaf & Cumming, Paul (2015). Specific binding of [18F]fluoroethyl-harmol to monoamine oxidase A in rat brain cryostat sections, and compartmental analysis of binding in living brain. Journal of Neurochemistry. ISSN 0022-3042. 135(5), p. 908–917. doi: 10.1111/jnc.13370.
  • Sommer, Theis; Bjerregaard-Andersen, Kaare; Simensen, Stine Marie; Jensen, Jan K.; Jochimsen, Bjarne & Riss, Patrick [Show all 8 contributors for this article] (2015). Enzymatic detection and quantification assay of isatin, a putative stress biomarker in blood. ACS Chemical Neuroscience. ISSN 1948-7193. 6(8), p. 1353–1360. doi: 10.1021/cn500346x.
  • Cumming, Paul; Maschauer, Simone; Riss, Patrick; Grill, Eva; Pischetsrieder, Monika & Kuwert, Torsten [Show all 7 contributors for this article] (2015). Perturbed Development of Striatal Dopamine Transporters in Fatty Versus Lean Zucker Rats: a Follow-up Small Animal PET Study. Molecular Imaging and Biology. ISSN 1536-1632. 17(4), p. 521–528. doi: 10.1007/s11307-014-0811-7.
  • Lien, Vegard Torp & Riss, Patrick (2014). Radiosynthesis of [18F]trifluoroalkyl groups: Scope and limitations. BioMed Research International. ISSN 2314-6133. 2014:380124. doi: 10.1155/2014/380124.
  • Cumming, Paul; Maschauer, Simone; Riss, Patrick; Tschammer, Nuska; Fehler, Stefanie K. & Heinrich, Markus R. [Show all 8 contributors for this article] (2014). Radiosynthesis and validation of 18 F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 34(7), p. 1148–1156. doi: 10.1038/jcbfm.2014.63.
  • Rühl, Thomas; Rafique, Waqas; Lien, Vegard Torp & Riss, Patrick (2014). Cu(I)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes†. Chemical Communications. ISSN 1359-7345. 50(45), p. 6056–6059. doi: 10.1039/c4cc01641f.
  • Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm & Engebråten, Olav [Show all 8 contributors for this article] (2014). Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts. Acta Oncologica. ISSN 0284-186X. 53(8), p. 1086–1092. doi: 10.3109/0284186X.2014.934398.
  • Riss, Patrick; Hoehnemann, Sabine; Piel, Markus & Roesch, F. (2013). Two-step radiosynthesis of [18F]FE--CIT and [18F]PR04.MZ. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 56(7), p. 356–359. doi: 10.1002/jlcr.3032.
  • Riss, Patrick; Brichard, Laurent; Ferrari, Valentina; Williamson, David J.; Fryer, Tim D. & Hong, Young T. [Show all 8 contributors for this article] (2013). Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of tau-pathology. MedChemComm. ISSN 2040-2503. 4(5), p. 852–855. doi: 10.1039/c3md00017f.
  • Riss, Patrick; Hong, Young T.; Marton, Janos; Caprioli, Daniele; Williamson, Derek & Ferrari, Valentina [Show all 12 contributors for this article] (2013). Synthesis and Evaluation of F-18-FE-PEO in Rodents: An F-18-Labeled Full Agonist for Opioid Receptor Imaging. Journal of Nuclear Medicine. ISSN 0161-5505. 54(2), p. 299–305. doi: 10.2967/jnumed.112.108688.

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  • Gurin, A.N.; Riss, Patrick Johannes; Chakrova, E.T.; Matveyeva, I.V. & Kadyrbaev, E.A. (2020). Correction to: Study of the Purification of <sup>177</sup>Lu-DOTAELA Complex (Pharmaceutical Chemistry Journal, (2020), 54, 1, (64-68), 10.1007/s11094-020-02157-3). Pharmaceutical Chemistry Journal. ISSN 0091-150X. 54(7). doi: 10.1007/s11094-020-02270-3.
  • Gee, Antony D.; Andersson, Jan; Bhalla, Rajiv; Choe, Yearn Seong; Dick, David W. & Herth, Matthias M. [Show all 28 contributors for this article] (2020). Training the next generation of radiopharmaceutical scientists. Nuclear Medicine and Biology. ISSN 0969-8051. 88-89, p. 10–13. doi: 10.1016/j.nucmedbio.2020.06.004.
  • Fjellaksel, Richard; Oteiza, Ana; Martin, armas maria montserrat; Hansen, Jørn H; Moldes-Anaya, Angel & Vasskog, Terje [Show all 9 contributors for this article] (2018). Development and evaluation of gonadotropin releasing hormone SPECT radioligands.
  • Fjellaksel, Richard; Hansen, Jørn H; Moldes-Anaya, Angel; Martin, armas maria montserrat; Oteiza, Ana & Riss, Patrick [Show all 7 contributors for this article] (2017). Development and evaluation of gonadotropin releasing hormone (GnRH) SPECT radioligands.
  • Prante, Olaf; Haubner, Roland; Riss, Patrick & Neumaier, Bernd (2014). Recent trends in pharmaceutical radiochemistry for molecular PET imaging. BioMed Research International. ISSN 2314-6133. 2014. doi: 10.1155/2014/890540.
  • Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm & Engebråten, Olav [Show all 8 contributors for this article] (2014). Pharmacokinetic modeling of dynamic 18F‐Choline PET reflects choline metabolism in breast carcinoma xenografts.
  • Hartvig, Karoline; Riss, Patrick; Hjelstuen, Olaug & Brevik, Ellen Mengshoel (2020). Synthesis and evaluation of radiopharmaceuticals for targeted radionuclide therapy. Kjemisk Institutt, Universitetet i Oslo.
  • Alluri, Santosh Reddy; Riss, Patrick & Henriksen, Gjermund (2018). Target oriented synthesis methods for imaging of proteins linked to cell-damage. University of Oslo. 2018(2049).
  • Rafique, Waqas; Riss, Patrick & Omtvedt, Jon Petter (2018). Synthesis of Fluorine-18 Labelled Radiotraces and Their Pre-Clinical and Clinical Characterization. Kjemisk institutt, Universitetet i Oslo. ISSN 1501-7710. 2018(2013).
  • Grønnevik, Gaute; Riss, Patrick & Jakobsson, Jimmy Erik (2017). Radiofluorination of amines via hypervalent iodonium (III) ylides, reduction and activating group approach. Universitetet i Oslo.

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Published Apr. 8, 2013 2:28 PM - Last modified Oct. 20, 2020 10:31 AM

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