Research Aims
To integrate data from population-based surveys, cancer screening, national registries, and clinical studies with omics analyses of related biological samples to understand cancer development and develop cancer biomarkers.
We will take advantage of our expertise in molecular biology, next-generation sequencing protocols, and other omics technologies, bioinformatics, high-performance computing, and machine learning methods. These will be combined with the use of unique biobank materials and data sources to discover how early molecular changes in non-invasive fluids/materials can predict cancer. Our current focus is genomics, transcriptomics, epigenomics, and microbiome analyses of faecal and blood samples. We are always looking for new, innovative partners and projects supporting our vision.
Projects
- CRCbiome - The microbiome as a colorectal cancer screening biomarker
- VegMeatCRC
- Sequencing HPV for biomarker discovery
- Small non-coding RNA as early detection cancer biomarkers
- Epigenetics and Cancer
- EradicateGBC
- Fin-HIT - The Finnish Health in Teens study
Research Topics
Identification of early biomarkers that can predict cancer
People
- Trine Rounge - group leader
- Einar Birkeland - Researcher
- Cecilie Bucher-Johannesen - PhD student
- Maja Jacobsen - Project coordinator
- Ekaterina Avershina - Researcher
- Paula Istvan - Postdoctoral research fellow
Software
Onboarding material
- refer to cancer registry webpages
- contact Trine
Publications
Publications 2024
Differential levels of circulating RNAs prior to endometrial cancer diagnosis
Int J Cancer (in press)
DOI 10.1002/ijc.34951, PubMed 38733362
Changes in intrahost genetic diversity according to lesion severity in longitudinal HPV16 samples
J Med Virol, 96 (5), e29641
DOI 10.1002/jmv.29641, PubMed 38708811
Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
Nat Commun, 15 (1), 1791
DOI 10.1038/s41467-024-46033-0, PubMed 38424056
Publications 2023
Profiling small RNAs in fecal immunochemical tests: is it possible?
Mol Cancer, 22 (1), 161
DOI 10.1186/s12943-023-01869-w, PubMed 37789383
HoCoRT: host contamination removal tool
BMC Bioinformatics, 24 (1), 371
DOI 10.1186/s12859-023-05492-w, PubMed 37784008
Correction: Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping
PLoS One, 18 (7), e0288418
DOI 10.1371/journal.pone.0288418, PubMed 37418482
Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine
Cell Genom, 3 (8), 100348
DOI 10.1016/j.xgen.2023.100348, PubMed 37601971
Associations of the 2018 World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) cancer prevention recommendations with stages of colorectal carcinogenesis
Cancer Med, 12 (13), 14806-14819
DOI 10.1002/cam4.6119, PubMed 37212529
Long-term follow-up of colorectal cancer screening attendees identifies differences in Phascolarctobacterium spp. using 16S rRNA and metagenome sequencing
Front Oncol, 13, 1183039
DOI 10.3389/fonc.2023.1183039, PubMed 37182146
TaME-seq2: tagmentation-assisted multiplex PCR enrichment sequencing for viral genomic profiling
Virol J, 20 (1), 44
DOI 10.1186/s12985-023-02002-5, PubMed 36890572
Microbial dynamics with CRC progression: a study of the mucosal microbiota at multiple sites in cancers, adenomatous polyps, and healthy controls
Eur J Clin Microbiol Infect Dis, 42 (3), 305-322
DOI 10.1007/s10096-023-04551-7, PubMed 36703031
Dynamic and static circulating cancer microRNA biomarkers - a validation study
RNA Biol, 20 (1), 1-9
DOI 10.1080/15476286.2022.2154470, PubMed 36511578
Publications 2022
Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny
Tumour Virus Res, 14, 200247
DOI 10.1016/j.tvr.2022.200247, PubMed 36100161
Associations of red and processed meat intake with screen-detected colorectal lesions
Br J Nutr, 129 (12), 1-11 (in press)
DOI 10.1017/S0007114522002860, PubMed 36069337
A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor
Front Oncol, 12, 892043
DOI 10.3389/fonc.2022.892043, PubMed 35774118
Serum RNAs can predict lung cancer up to 10 years prior to diagnosis
Elife, 11
DOI 10.7554/eLife.71035, PubMed 35147498
Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression
Cancers (Basel), 14 (3)
DOI 10.3390/cancers14030634, PubMed 35158906
Publications 2021
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
BMC Cancer, 21 (1), 930
DOI 10.1186/s12885-021-08640-8, PubMed 34407780
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples
Tumour Virus Res, 12, 200221
DOI 10.1016/j.tvr.2021.200221, PubMed 34175494
Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer
Hepatology, 73 (6), 2293-2310
DOI 10.1002/hep.31585, PubMed 33020926
Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes
Clin Epigenetics, 13 (1), 107
DOI 10.1186/s13148-021-01097-3, PubMed 33980276
Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping
PLoS One, 16 (4), e0250426
DOI 10.1371/journal.pone.0250426, PubMed 33901223
Publications 2020
Serum RNA Profiling in the 10-Years Period Prior to Diagnosis of Testicular Germ Cell Tumor
Front Oncol, 10, 574977
DOI 10.3389/fonc.2020.574977, PubMed 33251139
Lifetime antimicrobial use is associated with weight status in early adolescence-A register-based cohort study
Pediatr Obes, 16 (3), e12727
DOI 10.1111/ijpo.12727, PubMed 32959492
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling
Cancers (Basel), 12 (9)
DOI 10.3390/cancers12092510, PubMed 32899426
Antimicrobial drug use in the first decade of life influences saliva microbiota diversity and composition
Microbiome, 8 (1), 121
DOI 10.1186/s40168-020-00893-y, PubMed 32825849
Competitive learning suggests circulating miRNA profiles for cancers decades prior to diagnosis
RNA Biol, 17 (10), 1416-1426
DOI 10.1080/15476286.2020.1771945, PubMed 32456538
Meal Regularity Plays a Role in Shaping the Saliva Microbiota
Front Microbiol, 11, 757
DOI 10.3389/fmicb.2020.00757, PubMed 32390990
A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis
Mol Oncol, 14 (2), 235-247
DOI 10.1002/1878-0261.12620, PubMed 31851411
Publications 2019
Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome
Clin Epigenetics, 11 (1), 179
DOI 10.1186/s13148-019-0764-4, PubMed 31796056
Publications 2018
Mitochondrial genome variation of Atlantic cod
BMC Res Notes, 11 (1), 397
DOI 10.1186/s13104-018-3506-3, PubMed 29921324
Publications 2013
From green to red: horizontal gene transfer of the phycoerythrin gene cluster between Planktothrix strains
Appl Environ Microbiol, 79 (21), 6803-12
DOI 10.1128/AEM.01455-13, PubMed 23995927
Publications 2012
Gene flow, recombination, and selection in cyanobacteria: population structure of geographically related Planktothrix freshwater strains
Appl Environ Microbiol, 79 (2), 508-15
DOI 10.1128/AEM.02417-12, PubMed 23124237
Publications 2011
The genome sequence of Atlantic cod reveals a unique immune system
Nature, 477 (7363), 207-10
DOI 10.1038/nature10342, PubMed 21832995
Publications 2010
SUBPOPULATION DIFFERENTIATION ASSOCIATED WITH NONRIBOSOMAL PEPTIDE SYNTHETASE GENE CLUSTER DYNAMICS IN THE CYANOBACTERIUM PLANKTOTHRIX SPP.1
J. Phycol., 46 (4), 645-652
DOI 10.1111/j.1529-8817.2010.00856.x
Publications 2009
A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain
BMC Genomics, 10, 396
DOI 10.1186/1471-2164-10-396, PubMed 19706155
Publications 2008
Recombination and selectional forces in cyanopeptolin NRPS operons from highly similar, but geographically remote Planktothrix strains
BMC Microbiol, 8, 141
DOI 10.1186/1471-2180-8-141, PubMed 18727817