The LIPCHEM group combines synthetic organic chemistry, medicinal chemistry and total organic synthesis to study the chemistry and biology of lipids. We have prepared polyunsaturated fatty acids, oxygenated fatty acids and specialized pro-resolving lipid mediators that have been subjected to biological investigations. In addition, we have contributed to the development of new methodology within synthetic organic chemistry, and the identification of new lead compounds in medicinal chemistry projects targeting diseases such as cancer and type-2 diabetes. These life science oriented projects are conducts in collaboration with groups both abroad and in Norway (see below).
We are currently involved in the synthesis of specialized pro-resolving mediators, i.e. protectins, resolvins and maresins and their analogs. In addition, we are also making analogs of the anti-cancer agent 2-methoxyestradiol (2-ME) and modulators of the PPARs. We are also involved in developing new methodology (halocyclizations, stereoselective reductions) and the total synthesis of other natural products.
Professor Charles N. Serhan, Harvard Medical School, USA.
Dr. Jesmond Dalli, The Barts and The London School of Medicine and Dentistry and Queen Mary College, William Harvey Research Institute, UK.
Professor Toshinori Hoshi, Perelman School of Medicine, University of Pennsylvania
Associate Research Fellow Jing-Jy Cheng, National Research Institute of Chinese Medicine, Taipei, Taiwan.
Dr. Arne Yndestad, Oslo University Hospital, Norway.
Professor Pål Aukrust, Oslo University Hospital, Norway.
Professor James Lorens, University of Bergen, Norway.
Professor Yngve Stenstrøm, Norwegian University of Life Sciences, Norway.
Professor Ingebrigt Sylte, University of Tromsø, Norway.
Dr. Jeanette Hammer Andersen, University of Tromsø, Norway.
In addition we have internal cooporation with other research groups at the School of Pharmacy, University of Oslo
Members of LIPCHEM are currently involved in the following courses at the School of Pharmacy: