Growing up as a farm boy in southern Sweden, most of my time was spent outside, surrounded by nature. I developed a deep fascination with the function of life. The unarticulated childhood questions on why we exist and why we die is something that still fascinates me today. The meaning of life must be something more or less than 42. I have a long term research-dream to find out more on the biology behind life span and the possibility of living a longer, and healthy life, without aging-related diseases. This would finally allow me, being very musically untalented, the time I need to learn how to play the piano.
I am a newly employed PhD-student at the Department of Biosciences at the University of Oslo where I am engaged in a project in the group of PI Ragnhild Eskeland, and part of the strategic research environment, PharmaTox. In my current PhD project I hope to contribute towards insights on the effects of pharmaceuticals on human neurotoxicity and neurodevelopment by doing epigenetic studies, using human embryonic stem cells exposed to paracetamol and other common drugs.
Brief project introduction
Throughout the world, thousands of pregnant women are regularly taking medications for ailments, often for pain relief and depression. Out of these women, roughly two-thirds will take at least one type of medication during their pregnancy, with over 60% being exposed to some type of prescription medication. Alarmingly, for many of these drugs, we have little to no knowledge regarding the long-term effects on the unborn child and during childhood. We simply need to know more about the medications we consider to be generally safe for use during pregnancy. Careful and accurate studies must be done fill this knowledge gap. The epigenetic effects on the unborn child caused by paracetamol, and many others of the common medications used by pregnant women, are largely unknown. Epigenetics have emerged as an important field of study on the changes in organisms caused by gene expression modifications, rather than the alteration of the genetic code itself, and have direct effects on the development of an organism.We hypothesize that the medications used by pregnant women play an unknown, but important, role in a child's neurodevelopment.
My master's thesis was in conjunction with the Lund Research School in Stem Cell Biology, the project was titled ’Engineering new molecular tools to study orphan small nucleolar RNAs in human cells’. Here I developed, together with my great supervisor Roberto Munita, novel molecular tools to study the biological role of orphan snoRNAs during stem cell differentiation.