Arild Christian Rustan

Image of Arild Christian Rustan
Norwegian version of this page
Phone +47 22856558
Username
Visiting address Gydas vei 8 (STAMI-bygget)
Postal address Postboks 1068 Blindern 0316 Oslo

Academic Interests

I have extensive experience with functional studies on energy metabolism, mitochondrial function, metabolic switching and insulin resistance in different cell models, especially human skeletal muscle cells (myotubes) established from normal, obese or type 2 diabetic individuals.

Higher education and employment history

See CV

Collaboration

Participant, EU projects/networks:

Norwegian coordinator, Polish-Norwegian Research Fund (OPI-EAA)

MC member of MITOFOOD (COST-action FA0602), which is a research community for nutritional optimization of mitochondrial function for health promotion and disease resistance.

Publications

See Pubmed

 

Tags: Pharmacology, energy metabolism, mitochondria, fatty acids, exercise

Publications

  • Krajčová, Adéla; Skagen, Christine; Džupa, Valér; Urban, Tomáš; Rustan, Arild Christian & Jiroutková, Kateřina [Show all 9 contributors for this article] (2022). Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells. Intensive Care Medicine Experimental. ISSN 2197-425X. 10(1). doi: 10.1186/s40635-022-00474-3.
  • Schjølberg, Tiril; Asoawe, Lucia; Krapf, Solveig Astrid; Rustan, Arild Christian; Thoresen, G. Hege & Haugen, Fred (2022). Experimental Models for Cold Exposure of Muscle in vitro and in vivo. Bio-protocol. ISSN 2331-8325. 12(13). doi: 10.21769/BioProtoc.4461.
  • Mengeste, Abel Mulu; Nikolic, Natasa; Fernandez, Andrea Dalmao; Feng, Yuan Z.; Nyman, Tuula Anneli & Kersten, Sander [Show all 11 contributors for this article] (2022). Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome. Frontiers in Psychology. ISSN 1664-1078. 13. doi: 10.3389/fphys.2022.928195.
  • Mengeste, Abel Mulu; Katare, Parmeshwar Bajirao; Dalmao Fernandez, Andrea; Lund, Jenny; Bakke, Hege Gilbø & Baker, David [Show all 11 contributors for this article] (2022). Knockdown of sarcolipin (SLN) impairs substrate utilization in human skeletal muscle cells. Molecular Biology Reports. ISSN 0301-4851. doi: 10.1007/s11033-022-07387-0.
  • Fraser, David A.; Wang, Xiaoyu; Lund, Jenny; Nikolic, Natasa; Iruarrizaga-Lejarreta, Marta & Skjaeret, Tore [Show all 11 contributors for this article] (2022). A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH. Journal of Hepatology. ISSN 0168-8278. 76(4), p. 800–811. doi: 10.1016/j.jhep.2021.12.004.
  • Vid, Jan; Mis, Katarina; Nikolic, Natasa; Dolinar, Klemen; Petric, Metka & Bone, Andraz [Show all 11 contributors for this article] (2021). Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na+,K+-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0247377. Full text in Research Archive
  • Skagen, Christine; Nyman, Tuula Anneli; Xiao-Rong, Peng; O'Mahony, Sven; Kase, Eili Tranheim & Rustan, Arild Christian [Show all 7 contributors for this article] (2021). Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes. Current Research in Pharmacology and Drug Discovery (CRPHAR). ISSN 2590-2571. 2, p. 1–11. doi: 10.1016/j.crphar.2021.100039.
  • Mengeste, Abel Mulu; Lund, Jenny; Katare, Parmeshwar Bajirao; Ghobadi, Roya; Bakke, Hege Gilbø & Lunde, Per Kristian [Show all 13 contributors for this article] (2021). The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells. Current Research in Pharmacology and Drug Discovery (CRPHAR). ISSN 2590-2571. 2, p. 1–12. doi: 10.1016/j.crphar.2021.100060.
  • Lund, Jenny; Krapf, Solveig Astrid; Sistek, Medina; Bakke, Hege Gilbø; Bartesagi, Stefano & Xiao-Rong, Peng [Show all 9 contributors for this article] (2021). SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells. Current Research in Pharmacology and Drug Discovery (CRPHAR). ISSN 2590-2571. 2, p. 1–10. doi: 10.1016/j.crphar.2021.100061.
  • Tingstad, Ragna Husby; Norheim, Frode Amador; Haugen, Fred; Feng, Yuan Zeng; Tunsjø, Hege & Thoresen, G. Hege [Show all 9 contributors for this article] (2021). The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-03730-w. Full text in Research Archive
  • Mengeste, Abel Mulu; Rustan, Arild Christian & Lund, Jenny (2021). Skeletal muscle energy metabolism in obesity. Obesity. ISSN 1930-7381. 29(10), p. 1582–1595. doi: 10.1002/oby.23227.
  • Mars, Tomaz; Mis, Katarina; Meznaric, Marija; Mihevc, Sonja Prpar; Vid, Jan & Haugen, Fred [Show all 11 contributors for this article] (2020). Innervation and electrical pulse stimulation – in vitro effects on human skeletal muscle cells. Applied Physiology, Nutrition and Metabolism. ISSN 1715-5312. doi: 10.1139/apnm-2019-0575.
  • Lund, Jenny & Rustan, Arild (2020). Fatty Acids: Structures and Properties. Encyclopedia of Life Sciences. ISSN 1476-9506. doi: 10.1002/9780470015902.a0029198.
  • Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild & Lund, Jenny (2020). Substrate oxidation in primary human skeletal muscle cells is influenced by donor age. Cell and Tissue Research. ISSN 0302-766X. 382, p. 599–608. doi: 10.1007/s00441-020-03275-w. Full text in Research Archive
  • Løvsletten, Nils Gunnar; Vu, Helene Loang Ngo; Skagen, Christine; Lund, Jenny; Kase, Eili Tranheim & Thoresen, G. Hege [Show all 8 contributors for this article] (2020). Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism. Scientific Reports. ISSN 2045-2322. 10:238, p. 1–13. doi: 10.1038/s41598-019-57157-5. Full text in Research Archive
  • Løvsletten, Nils Gunnar; Rustan, Arild; Laurens, Claire; Thoresen, G. Hege; Moro, Cedric & Nikolic, Natasa (2019). Primary defects in lipid handling and resistance to exercise in myotubes from obese donors with and without type 2 diabetes. Applied Physiology, Nutrition and Metabolism. ISSN 1715-5312. doi: 10.1139/apnm-2019-0265.
  • Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Clason, Marie Karoliussen & Rustan, Arild [Show all 10 contributors for this article] (2019). A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats. PLOS ONE. ISSN 1932-6203. 14:e0222558(9), p. 1–17. doi: 10.1371/journal.pone.0222558. Full text in Research Archive
  • Pettersen, Ina Katrine Nitschke; Tusubira, Deusdedit; Ashrafi, Hanan; Dyrstad, Sissel Elisabeth; Hansen, Lena & Liu, Xiaozheng [Show all 18 contributors for this article] (2019). Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion (Amsterdam. Print). ISSN 1567-7249. 49, p. 97–110. doi: 10.1016/j.mito.2019.07.009. Full text in Research Archive
  • Løvsletten, Nils Gunnar; Bakke, Siril Skaret; Kase, Eili Tranheim; Ouwens, D. Margriet; Thoresen, G. Hege & Rustan, Arild (2018). Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid. PLOS ONE. ISSN 1932-6203. 13:e0208048(11), p. 1–15. doi: 10.1371/journal.pone.0208048. Full text in Research Archive
  • Lund, Jenny; Helle, Siw A; Li, Yuchuan; Løvsletten, Nils Gunnar; Stadheim, Hans Kristian & Jensen, Jørgen [Show all 9 contributors for this article] (2018). Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-35715-7. Full text in Research Archive
  • Lund, Jenny; Tangen, Daniel S.; Wiig, Håvard; Stadheim, Hans Kristian; Siw, Anette Helle & Birk, Jesper B. [Show all 12 contributors for this article] (2017). Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects. Archives of Physiology and Biochemistry. ISSN 1381-3455. 124(2), p. 119–130. doi: 10.1080/13813455.2017.1369547. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild & Falnes, Pål (2017). Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. Journal of Biological Chemistry. ISSN 0021-9258. 292(43), p. 17950–17962. doi: 10.1074/jbc.M117.808451. Full text in Research Archive
  • Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin; Bakke, Siril Skaret & Kase, Eili Tranheim [Show all 11 contributors for this article] (2017). Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research. ISSN 0022-2275. 58(11), p. 2147–2161. doi: 10.1194/jlr.M079764. Full text in Research Archive
  • Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal & Feng, Yuan Zeng [Show all 19 contributors for this article] (2017). Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism. PLOS ONE. ISSN 1932-6203. 12:e0175441(4), p. 1–24. doi: 10.1371/journal.pone.0175441. Full text in Research Archive
  • Åstrand, Ove Alexander Høgmoen; Viktorsson, Elvar Örn; Kristensen, Aleksander Lim; Ekeberg, Dag; Røberg-Larsen, Hanne & Wilson, Steven Ray Haakon [Show all 12 contributors for this article] (2017). Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 165, p. 323–330. doi: 10.1016/j.jsbmb.2016.07.010. Full text in Research Archive
  • Lund, Jenny; Stensrud, Camilla; Rajender, Melanie Müller; Bohov, Pavol; Thoresen, G. Hege & Berge, Rolf Kristian [Show all 11 contributors for this article] (2016). The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 24(6), p. 1191–1203. doi: 10.1016/j.bmc.2016.01.045.
  • Kong, Xiang Yi; Feng, Yuan Zeng; Eftestøl, Einar; Kase, Eili Tranheim; Haugum, Hanne & Eskild, Winnie [Show all 8 contributors for this article] (2016). Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmpgt/gt mice. Archives of Physiology and Biochemistry. ISSN 1381-3455. 122(1), p. 36–45. doi: 10.3109/13813455.2015.1120752.
  • Coué, Marine; Badin, Pierre-Marie; Vila, Isabelle K.; Laurens, Claire; Louche, Katie & Marquès, Marie-Adeline [Show all 15 contributors for this article] (2015). Defective natriuretic peptide receptor signaling in skeletal muscle links obesity to type 2 diabetes. Diabetes. ISSN 0012-1797. 64(12), p. 4033–4045. doi: 10.2337/db15-0305.
  • Covington, Jeffrey D.; Myland, Cassandra K.; Rustan, Arild; Ravussin, Eric; Smith, Steven R. & Bajpeyi, Sudip (2015). Effect of serial cell passaging in the retention of fiber type and mitochondrial content in primary human myotubes. Obesity. ISSN 1930-7381. 23(12), p. 2414–2420. doi: 10.1002/oby.21192.
  • Covington, Jeffrey D.; Noland, Robert C.; Hebert, R. Caitlin; Masinter, Blaine S.; Smith, Steven R. & Rustan, Arild [Show all 8 contributors for this article] (2015). Perilipin 3 differentially regulates skeletal muscle lipid oxidation in active, sedentary, and type 2 diabetic males. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 100(10), p. 3683–3692. doi: 10.1210/JC.2014-4125.
  • Kong, Xiang Yi; Kase, Eili Tranheim; Herskedal, Anette; Schjalm, Camilla; Damme, Markus & Nesset, Cecilie Kåsi [Show all 9 contributors for this article] (2015). Lack of the lysosomal membrane protein, GLMP, in mice results in metabolic dysregulation in liver. PLOS ONE. ISSN 1932-6203. 10(6). doi: 10.1371/journal.pone.0129402. Full text in Research Archive
  • Aas, Vigdis; Lund, Jenny; Kase, Eili Tranheim; Feng, Yuan Zeng; Rustan, Arild & Thoresen, G. Hege (2015). Blodglukosesenkende legemidler ved type 2-diabetes. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 123(5), p. 20–24. Full text in Research Archive
  • Kase, Eili Tranheim; Feng, Yuan Zeng; Badin, Pierre-Marie; Bakke, Siril Skaret; Laurens, C & Coue, M [Show all 11 contributors for this article] (2015). Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1851(9), p. 1194–1201. doi: 10.1016/j.bbalip.2015.03.005.
  • Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric & Stensrud, Camilla [Show all 14 contributors for this article] (2015). Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0119556. Full text in Research Archive
  • Feng, Yuan Zeng; Nikolic, Natasa; Bakke, Siril Skaret; Kase, Eili Tranheim; Guderud, Kari & Hjelmesæth, Jøran [Show all 9 contributors for this article] (2015). Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise. American Journal of Physiology - Cell Physiology. ISSN 0363-6143. 308(7), p. C548–C556. doi: 10.1152/ajpcell.00314.2014.
  • Covington, Jeffrey D.; Galgani, Jose E.; Moro, Cedric; LaGrange, Jamie M; Zhang, Zhengyu & Rustan, Arild [Show all 8 contributors for this article] (2014). Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. PLOS ONE. ISSN 1932-6203. 9(3). doi: 10.1371/journal.pone.0091675.
  • Bajpeyi, Sudip; Myrland, Cassandra Kim; Covington, Jeffrey D.; Obanda, Diana; Cefalu, W.T. & Smith, Steven R. [Show all 8 contributors for this article] (2014). Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes. Obesity. ISSN 1930-7381. 22(2), p. 426–434. doi: 10.1002/oby.20556.
  • Åstrand, Ove Alexander Høgmoen; Gikling, Ingveig; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege & Rongved, Pål [Show all 7 contributors for this article] (2014). Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. European Journal of Medicinal Chemistry. ISSN 0223-5234. 74, p. 258–263. doi: 10.1016/j.ejmech.2014.01.003.
  • Kong, Xiang Yi; Nesset, Cecilie Kåsi; Damme, Markus; Løberg, Else Marit; Lübke, Torben & Mæhlen, Jan [Show all 13 contributors for this article] (2014). Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Disease Models and Mechanisms. ISSN 1754-8403. 7(3), p. 351–362. doi: 10.1242/dmm.014050. Full text in Research Archive
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege [Show all 7 contributors for this article] (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLOS ONE. ISSN 1932-6203. 9(1:85721). doi: 10.1371/journal.pone.0085721.
  • Feng, Yuan Zeng; Nikolic, Natasa; Bakke, Siril Skaret; Boekschoten, Mark V.; Kersten, Sander & Kase, Eili Tranheim [Show all 8 contributors for this article] (2014). PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference. Archives of Physiology and Biochemistry. ISSN 1381-3455. 120(1), p. 12–21. doi: 10.3109/13813455.2013.829105.
  • Aas, Vigdis; Bakke, Siril Skaret; Feng, Yuan Zeng; Kase, Eili Tranheim; Jensen, Jørgen & Bajpeyi, Sudip [Show all 8 contributors for this article] (2013). Are cultured human myotubes far from home? Cell and Tissue Research. ISSN 0302-766X. 354(3), p. 671–682. doi: 10.1007/s00441-013-1655-1. Full text in Research Archive
  • Kase, Eili Tranheim; Nikolic, Natasa; Bakke, Siril Skaret; Bogen, Kaja Kamilla; Aas, Vigdis & Thoresen, G. Hege [Show all 7 contributors for this article] (2013). Remodelling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells. PLOS ONE. ISSN 1932-6203. 8(4). doi: 10.1371/journal.pone.0059972. Full text in Research Archive
  • Nikolic, Natasa; Rhedin, M; Rustan, Arild; Storlien, Len H.; Thoresen, G. Hege & Strømstedt, Maria (2012). Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells. Biochemistry Research International. ISSN 2090-2247. 2012. doi: 10.1155/2012/714074.
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal & Holen, Torgeir [Show all 12 contributors for this article] (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients. ISSN 2072-6643. 4(12), p. 1898–1944. doi: 10.3390/nu4121898.
  • Badin, Pierre-Marie; Loubière, Camille; Coonen, Maarten; Louche, Katie; Tavernier, Geneviève & Bourlier, Virginie [Show all 11 contributors for this article] (2012). Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. Journal of Lipid Research. ISSN 0022-2275. 53(5), p. 839–848. doi: 10.1194/jlr.M019182.
  • Bakke, Siril Skaret; Moro, Cedric; Nikolic, Natasa; Hessvik, Nina Pettersen; Badin, Pierre-Marie & Lauvhaug, Line [Show all 13 contributors for this article] (2012). Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1821(10), p. 1323–1333. doi: 10.1016/j.bbalip.2012.07.001.
  • Kase, Eili Tranheim; Nikolic, Natasa; Hessvik, Nina Pettersen; Fjeldheim, Åse-Karine; Jensen, Jørgen & Thoresen, G. Hege [Show all 7 contributors for this article] (2012). Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. ISSN 0024-4201. 47(5), p. 483–493. doi: 10.1007/s11745-012-3663-4.
  • Nikolic, Natasa; Bakke, Siril Skaret; Kase, Eili Tranheim; Rudberg, Ida; Halle, Ingeborg Flo & Rustan, Arild [Show all 8 contributors for this article] (2012). Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise. PLOS ONE. ISSN 1932-6203. 7(3). doi: 10.1371/journal.pone.0033203. Full text in Research Archive
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Smith, Robert; Ravna, aina westrheim; Sylte, Ingebrigt & Rustan, Arild [Show all 8 contributors for this article] (2012). The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 128, p. 154–164. doi: 10.1016/j.jsbmb.2011.10.006.
  • Fraser, David; Hessvik, Nina Pettersen; Nikolic, Natasa; Aas, Vigdis; Hanssen, Kristian Folkvord & Bøhn, Siv Kjølsrud [Show all 8 contributors for this article] (2012). Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes & Nutrition. ISSN 1555-8932. doi: 10.1007/s12263-011-0252-8. Full text in Research Archive
  • Norheim, Frode; Raastad, Truls; Thiede, Bernd; Rustan, Arild; Drevon, Christian A & Haugen, Fred (2011). Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 301(5), p. E1013–E1021. doi: 10.1152/ajpendo.00326.2011.
  • Ciocoiu, Calin C.; Ravna, aina westrheim; Sylte, Ingebrigt; Rustan, Arild & Hansen, Trond Vidar (2011). Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 19, p. 6982–6988. doi: 10.1016/j.bmc.2011.10.020.
  • Sparks, LM; Moro, C; Ukropcova, B; Bajpeyi, S; Civitarese, AE & Hulver, MW [Show all 9 contributors for this article] (2011). Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes. PLOS ONE. ISSN 1932-6203. 6(7). doi: 10.1371/journal.pone.0021068.
  • Nehlin, Jan O.; Just, Marlene; Rustan, Arild & Gaster, Michael (2011). Human myotubes from myoblast cultures undergoing senescence exhibit defects in glucose and lipid metabolism. Biogerontology (Dordrecht). ISSN 1389-5729. 12(4), p. 349–365. doi: 10.1007/s10522-011-9336-5.
  • Thoresen, G. Hege; Hessvik, Nina Pettersen; Bakke, Siril Skaret; Aas, Vigdis & Rustan, Arild (2011). Metabolic switching of human skeletal muscle cells in vitro. Prostaglandins, Leukotrienes and Essential Fatty Acids. ISSN 0952-3278. 85(5), p. 227–234. doi: 10.1016/j.plefa.2011.04.017. Full text in Research Archive
  • Badin, Pierre-Marie; Louche, Katie; Mairal, Aline; Liebisch, Gerhard; Schmitz, Gerd & Rustan, Arild [Show all 9 contributors for this article] (2011). Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans. Diabetes. ISSN 0012-1797. 60(6), p. 1734–1742. doi: 10.2337/db10-1364.
  • Aas, Vigdis; Hessvik, Nina Pettersen; Wettergreen, Marianne; Hvammen, Anders Wensaas; Hallen, Stefan & Thoresen, G. Hege [Show all 7 contributors for this article] (2011). Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1812(1), p. 94–105. doi: 10.1016/j.bbadis.2010.09.014. Full text in Research Archive
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Fredriksson, K; Boekschoten, MV; Fjørkenstad, Anne & Koster, Gerbrand [Show all 11 contributors for this article] (2010). Metabolic switching of human myotubes is improved by n-3 fatty acids. Journal of Lipid Research. ISSN 0022-2275. 51(8), p. 2090–2104. doi: 10.1194/jlr.M003319.
  • Hessvik, Nina Pettersen; Boekschoten, MV; Baltzersen, Rose Mari-Ann; Kersten, S; Xu, X & Andersen, H [Show all 8 contributors for this article] (2010). LXR beta is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 298(3), p. E602–E613. doi: 10.1152/ajpendo.00553.2009.
  • Corpeleijn, Eva; Hessvik, Nina Pettersen; Bakke, Siril Skaret; Levin, K; Blaak, Ellen E. & Thoresen, G. Hege [Show all 8 contributors for this article] (2010). Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 299(1), p. E14–E22. doi: 10.1152/ajpendo.00187.2010.
  • Rokling-Andersen, Merethe H.; Rustan, Arild; Kaalhus, Olav; Wergedahl, Hege & Drevon, Christian A. (2009). Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. British Journal of Nutrition. ISSN 0007-1145. 102(7), p. 995–1006.
  • Wensaas, Andreas J.; Rustan, Arild C.; Just, Marlene; Marlene, Just; Berge, Rolf Kristian & Rolf K, Berge [Show all 8 contributors for this article] (2009). Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation. Diabetes. ISSN 0012-1797. 58(3), p. 527–535. doi: 10.2337/db08-1043.
  • Løvås, K; Wensaas, AJ; Røst, TH; Rustan, AC; Rokling-Andersen, MH & Skorve, Jon [Show all 16 contributors for this article] (2009). Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets. Diabetes, obesity and metabolism. ISSN 1462-8902. 11(11), p. 1034–1049. doi: 10.1111/j.1463-1326.2009.01092.x.
  • Rokling-Andersen, Merethe; Rokling-Andersen, MH; Rustan, AC; Wensaas, AJ; Kaalhus, O & Wergedahl, Hege [Show all 12 contributors for this article] (2009). Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. British Journal of Nutrition. ISSN 0007-1145. 102(7), p. 995–1006. doi: 10.1017/S0007114509353210.
  • Løvås, Kristian; Lovas, K; Røst, Therese Halvorsen; Rost, TH; Skorve, Jon & Ulvik, Rune Johan [Show all 12 contributors for this article] (2009). Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation. Diabetes, obesity and metabolism. ISSN 1462-8902. 11(4), p. 304–314. doi: 10.1111/j.1463-1326.2008.00958.x.
  • Wensaas, Andreas Johansen; Rustan, Arild; Rokling-Andersen, Merethe; Caesar, Robert; Jensen, Jørgen & Kaalhus, O [Show all 10 contributors for this article] (2009). Dietary supplementation of tetradecylhioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed high fat diets. Diabetes, obesity and metabolism. ISSN 1462-8902. 11(11), p. 1034–1049.
  • Kjær, Marte Avranden; Vegusdal, Anne; Gjøen, Tor; Rustan, Arild; Todorcevic, Marijana & Ruyter, Bente (2008). Effect of rapeseed oil and dietary n-3 fatty acids on triacylglycerol synthesis and secretion in Atlantic salmon hepatocytes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1781(3), p. 112–122. doi: 10.1016/j.bbalip.2007.12.004.
  • Kjær, Marte Avranden; Vegusdal, Anne; Gjøen, Tor; Rustan, Arild; Todorevic, M & Ruyter, B (2008). Effect of rapeseed oil and dietary n-3 fatty acids on triacylglycerol synthesis and secretion in Atlantic salmon hepatocytes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1781. doi: 10.1016/j.bbalip.2007.12.004.
  • Meyer, BJ; Hammervold, T; Rustan, Arild & Howe, PRC (2007). Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. Lipids. ISSN 0024-4201. 42. doi: 10.1007/s11745-006-3014-4.
  • Kase, Eili Tranheim; Thoresen, G. Hege; Westerlund, S; Højlund, K; Rustan, Arild & Gaster, M (2007). Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals. Diabetologia. ISSN 0012-186X. 50, p. 2171–2180. doi: 10.1007/s00125-007-0760-7.

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  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Rustan, Arild; Thoresen, G. Hege; Kase, Eili Tranheim & Rongved, Pål (2015). Analogs of 22-S-hydroxycholesterol as potential Liver X Receptor-modulators: Synthesis and biological evaluation.
  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Bakke, Siril S.; Lund, Jenny; Lee, Y.K. & kimmel, Alan [Show all 9 contributors for this article] (2015). Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2.
  • Kong, Xiang Yi; Nesset, Cecilie Kåsi; Schjalm, Camilla; Løberg, Else Marit; Rustan, Arild & Thoresen, G. Hege [Show all 8 contributors for this article] (2014). NCU-G1GT/GT MICE: A LONG-LIVED MODEL FOR LIVER FIBROSIS.
  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Lund, Jenny; Lee, Y.K.; kimmel, Alan & Thoresen, G. Hege [Show all 8 contributors for this article] (2014). Increased lipid oxidation and decreased lipid storage in myotubes lacking perilipin2.
  • Kase, Eili Tranheim; Lund, Jenny; Feng, Yuan Zeng; Langleite, Torgrim Mikal; Aas, Vigdis & Jensen, Jan S. [Show all 11 contributors for this article] (2013). Effect of exercise on fatty acid and glucose metabolism in cultured human myotubes. Diabetologia. ISSN 0012-186X. 56, p. S250–S250.
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege [Show all 7 contributors for this article] (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Covington, Jeffrey D.; Galgani, Jose E.; Rustan, Arild; Zhang, Zhengyu; Moro, Cedric & Smith, Steven R. [Show all 8 contributors for this article] (2013). Muscle perilipin 3 is reduced using in vitro and in vivo exercise models and negatively associated with exercise lipid oxidation. The FASEB Journal. ISSN 0892-6638. 27.
  • Bakke, Siril Skaret; Feng, Yuan Zeng; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2012). Lower lipolysis to counteract the development of type 2 diabetes mellitus - evidence from myotubes established from extremely obese subjects.
  • Aas, Vigdis; Bakke, Siril Skaret; Nikolic, Natasa; Hjelmesæth, Jøran; Thoresen, G. Hege & Rustan, Arild (2012). Altered energy metabolism in skeletal muscle cells derived from morbidly obese subjects.
  • Bakke, Siril Skaret; Nikolic, Natasa; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2012). ALTERED ENERGY METABOLISM IN SKELETAL MUSCLE CELLS DERIVED FROM MORBIDLY OBESE INDIVIDUALS.
  • Bakke, Siril Skaret; Nikolic, Natasa; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2012). Altered energy metabolism in skeletal muscle cells derived from morbidly obese donors.
  • Bakke, Siril Skaret; Nikolic, Natasa; Moro, Cedric; Lauvhaug, Line; Hessvik, Nina Pettersen & Thoresen, G. Hege [Show all 7 contributors for this article] (2011). DIFFERENT HANDLING OF PALMITIC ACID AND OLEIC ACID IN HUMAN SKELETAL MUSCLE CELLS.
  • Bakke, Siril Skaret; Nikolic, Natasa; Moro, Cedric; Lauvhaug, Line; Hessvik, Nina Pettersen & Thoresen, G. Hege [Show all 7 contributors for this article] (2011). Different handling of palmitic acid and oleic acid in human skeletal muscle cells.
  • Lauvhaug, Line; Bakke, Siril Skaret; Thoresen, G. Hege & Rustan, Arild (2011). Different handling of oleic, palmitic, linoleic and eicosapentaenoic acids in cultured human skeletal muscle cells.
  • Halle, Ingeborg F.; Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2011). Electrical pulse stimulation of cultured human skeletal muscle cells as a model of exercise in vitro.
  • Dembinska-Kiec, A.; Knapp, A.; Kiec-Wilk, B.; Sliwa, A.; Czech, U. & Korczynska, M. [Show all 7 contributors for this article] (2010). Metabolism of endothelial and adipose stromal vascular (SVF) fraction in the presence of fatty acids. European Journal of Clinical Investigation. ISSN 0014-2972. 40, p. 78–79.
  • Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2010). Chronic electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise.
  • Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2010). Energimetabolismen i humane skjelettmuskelceller - Utvikling av in vitro treningsmodell.
  • Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2010). Chronic electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise.
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Kase, Eili Tranheim (2010). Effects of 22-S-hydroxycholesterol (a liver X receptor modulator) on Lipid Metabolism.
  • Bakke, Siril Skaret; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2010). The impact of the n-3 fatty acid eicosapentaenoic acid (EPA) on metabolic switching in human skeletal muscle cells.
  • Bakke, Siril Skaret; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2010). HANDLING OF PALMITIC ACID AND OLEIC ACID IN HUMAN SKELETAL MUSCLE CELLS.
  • Aas, Vigdis; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2010). Chronic hyperglycemia impairs mitochondrial function in human myotubes.
  • Rustan, Arild (2010). The impact of eicosapentaenoic acid (EPA) on regulation of fatty acid metabolism, metabolic flexibility and gene expression in human skeletal muscle cells.
  • Rustan, Arild Chr.; Wettergreen, Marianne; Hessvik, Nina; Thoresen, G. Hege & Aas, Vigdis (2010). Chronic hyperglycaemia impairs metabolic switching of human myotubes.
  • Aas, Vigdis; Hessvik, Nina; Thoresen, Hege & Rustan, Arild Chr. (2010). Chronic hyperglycaemia impairs mitochondrial function in human myotubes.
  • Bakke, Siril Skaret; Hessvik, Nina Pettersen; Fjørkenstad, Anne; Koster, Gerbrand; Rustan, Arild & Thoresen, G. Hege (2009). Eicosapentaenoic acid improves metabolic switching of human myotubes.
  • Aas, Vigdis; Wettergreen, Marianne; Hessvik, Nina P.; Thoresen, G. Hege & Rustan, Arild Chr. (2009). Chronic hyperglycemia reduces myotube mitochondrial function without changing mitochondrial gene expression or mitochondrial content.
  • Corpeleijn, E; Hessvik, Nina Pettersen; Blaak, EE; Thoresen, G. Hege; Gaster, M & Rustan, Arild (2008). Utilization of intramyocellular lipids for oxidation in human skeletal muscle cells from lean and type 2 diabetic subjects. Diabetologia. ISSN 0012-186X. 51, p. S303–S303.

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Published Nov. 3, 2010 3:43 PM - Last modified Sep. 7, 2022 10:52 PM

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