Arild Rustan

Norwegian version of this page
Phone +47-22856558
Mobile phone 97518761
Username
Visiting address Gydas vei 8 (STAMI-bygget)
Postal address Postboks 1068 Blindern 0316 OSLO

Academic Interests

I have extensive experience with functional studies on energy metabolism, mitochondrial function, metabolic switching and insulin resistance in different cell models, especially human skeletal muscle cells (myotubes) established from normal, obese or type 2 diabetic individuals.

Higher education and employment history

See CV

Collaboration

Participant, EU projects/networks:

Norwegian coordinator, Polish-Norwegian Research Fund (OPI-EAA)

MC member of MITOFOOD (COST-action FA0602), which is a research community for nutritional optimization of mitochondrial function for health promotion and disease resistance.

Publications

See Pubmed

 

Publications

  • Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar & Berge, Rolf Kristian (2019). A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats. PLOS ONE.  ISSN 1932-6203.  14:e0222558(9), s 1- 17 . doi: 10.1371/journal.pone.0222558
  • Pettersen, Ina Katrine Nitschke; Tusubira, Deusdedit; Ashrafi, Hanan; Dyrstad, Sissel Elisabeth; Hansen, Lena; Liu, Xiaozheng; Hodneland, Linn I.; Løvsletten, Nils Gunnar; Berge, Kjetil; Wergedahl, Hege; Bjørndal, Bodil; Fluge, Øystein; Bruland, Ove; Rustan, Arild; Halberg, Nils; Røsland, Gro Vatne; Berge, Rolf Kristian & Tronstad, Karl Johan (2019). Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion (Amsterdam. Print).  ISSN 1567-7249.  49, s 97- 110 . doi: 10.1016/j.mito.2019.07.009 Full text in Research Archive.
  • Lund, Jenny; Helle, Siw A; Li, Yuchuan; Løvsletten, Nils Gunnar; Stadheim, Hans Kristian; Jensen, Jørgen; Kase, Eili Tranheim; Thoresen, G. Hege & Rustan, Arild (2018). Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects. Scientific Reports.  ISSN 2045-2322.  8(1) . doi: 10.1038/s41598-018-35715-7 Full text in Research Archive. Show summary
  • Løvsletten, Nils Gunnar; Bakke, Siril Skaret; Kase, Eili Tranheim; Ouwens, D. Margriet; Thoresen, G. Hege & Rustan, Arild (2018). Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid. PLOS ONE.  ISSN 1932-6203.  13:e0208048(11), s 1- 15 . doi: 10.1371/journal.pone.0208048 Full text in Research Archive.
  • Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2017). Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research.  ISSN 0022-2275.  58(11), s 2147- 2161 . doi: 10.1194/jlr.M079764 Full text in Research Archive.
  • Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen & Thoresen, G. Hege (2017). Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism. PLOS ONE.  ISSN 1932-6203.  12:e0175441(4), s 1- 24 . doi: 10.1371/journal.pone.0175441 Full text in Research Archive.
  • Lund, Jenny; Tangen, Daniel S.; Wiig, Håvard; Stadheim, Hans Kristian; Siw, Anette Helle; Birk, Jesper B.; Ingemann-Hansen, Thorsten; Rustan, Arild; Thoresen, G. Hege; Wojtaszewski, Jørgen F.P.; Kase, Eili Tranheim & Jensen, Jørgen (2017). Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  124(2), s 119- 130 . doi: 10.1080/13813455.2017.1369547 Full text in Research Archive.
  • Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild & Falnes, Pål (2017). Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. Journal of Biological Chemistry.  ISSN 0021-9258.  292(43), s 17950- 17962 . doi: 10.1074/jbc.M117.808451 Full text in Research Archive.
  • Åstrand, Ove Alexander Høgmoen; Viktorsson, Elvar Örn; Kristensen, Aleksander Lim; Ekeberg, Dag; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon; Gabrielsen, Mari; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål & Kase, Eili Tranheim (2017). Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  165, s 323- 330 . doi: 10.1016/j.jsbmb.2016.07.010 Full text in Research Archive.
  • Kong, Xiang Yi; Feng, Yuan Zeng; Eftestøl, Einar; Kase, Eili Tranheim; Haugum, Hanne; Eskild, Winnie; Rustan, Arild & Thoresen, G. Hege (2016). Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmpgt/gt mice. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  122(1), s 36- 45 . doi: 10.3109/13813455.2015.1120752
  • Lund, Jenny; Stensrud, Camilla; Rajender, Melanie Müller; Bohov, Pavol; Thoresen, G. Hege; Berge, Rolf Kristian; Wright, Michael; Kamal, Ahmed; Rustan, Arild; Miller, Andrew D. & Skorve, Jon (2016). The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  24(6), s 1191- 1203 . doi: 10.1016/j.bmc.2016.01.045
  • Aas, Vigdis; Lund, Jenny; Kase, Eili Tranheim; Feng, Yuan Zeng; Rustan, Arild & Thoresen, G. Hege (2015). Blodglukosesenkende legemidler ved type 2-diabetes. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  123(5), s 20- 24 Full text in Research Archive.
  • Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2015). Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects. PLOS ONE.  ISSN 1932-6203.  10(3) . doi: 10.1371/journal.pone.0119556 Full text in Research Archive.
  • Coué, Marine; Badin, Pierre-Marie; Vila, Isabelle K.; Laurens, Claire; Louche, Katie; Marquès, Marie-Adeline; Bourlier, Virginie; Mouisel, Etienne; Tavernier, Geneviève; Rustan, Arild; Galgani, Jose E.; Joanisse, Denis R.; Smith, Steven R.; Langin, Dominique & Moro, Cédric (2015). Defective natriuretic peptide receptor signaling in skeletal muscle links obesity to type 2 diabetes. Diabetes.  ISSN 0012-1797.  64(12), s 4033- 4045 . doi: 10.2337/db15-0305
  • Covington, Jeffrey D.; Myland, Cassandra K.; Rustan, Arild; Ravussin, Eric; Smith, Steven R. & Bajpeyi, Sudip (2015). Effect of serial cell passaging in the retention of fiber type and mitochondrial content in primary human myotubes. Obesity.  ISSN 1930-7381.  23(12), s 2414- 2420 . doi: 10.1002/oby.21192
  • Covington, Jeffrey D.; Noland, Robert C.; Hebert, R. Caitlin; Masinter, Blaine S.; Smith, Steven R.; Rustan, Arild; Ravussin, Eric & Bajpeyi, Sudip (2015). Perilipin 3 differentially regulates skeletal muscle lipid oxidation in active, sedentary, and type 2 diabetic males. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  100(10), s 3683- 3692 . doi: 10.1210/JC.2014-4125
  • Feng, Yuan Zeng; Nikolic, Natasa; Bakke, Siril Skaret; Kase, Eili Tranheim; Guderud, Kari; Hjelmesæth, Jøran; Aas, Vigdis; Rustan, Arild & Thoresen, G. Hege (2015). Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise. American Journal of Physiology - Cell Physiology.  ISSN 0363-6143.  308(7), s C548- C556 . doi: 10.1152/ajpcell.00314.2014
  • Kase, Eili Tranheim; Feng, Yuan Zeng; Badin, Pierre-Marie; Bakke, Siril Skaret; Laurens, C; Coue, M; Langin, Dominique; Gaster, Michael; Thoresen, G. Hege; Rustan, Arild & Moro, Cédric (2015). Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1851(9), s 1194- 1201 . doi: 10.1016/j.bbalip.2015.03.005
  • Kong, Xiang Yi; Kase, Eili Tranheim; Herskedal, Anette; Schjalm, Camilla; Damme, Markus; Nesset, Cecilie Kåsi; Thoresen, G. Hege; Rustan, Arild & Eskild, Winnie (2015). Lack of the lysosomal membrane protein, GLMP, in mice results in metabolic dysregulation in liver. PLOS ONE.  ISSN 1932-6203.  10(6) . doi: 10.1371/journal.pone.0129402 Full text in Research Archive.
  • Bajpeyi, Sudip; Myrland, Cassandra Kim; Covington, Jeffrey D.; Obanda, Diana; Cefalu, W.T.; Smith, Steven R.; Rustan, Arild & Ravussin, Eric (2014). Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes. Obesity.  ISSN 1930-7381.  22(2), s 426- 434 . doi: 10.1002/oby.20556
  • Covington, Jeffrey D.; Galgani, Jose E.; Moro, Cedric; LaGrange, Jamie M; Zhang, Zhengyu; Rustan, Arild; Ravussin, Eric & Bajpeyi, Sudip (2014). Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. PLOS ONE.  ISSN 1932-6203.  9(3) . doi: 10.1371/journal.pone.0091675
  • Feng, Yuan Zeng; Nikolic, Natasa; Bakke, Siril Skaret; Boekschoten, Mark V.; Kersten, Sander; Kase, Eili Tranheim; Rustan, Arild & Thoresen, G. Hege (2014). PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  120(1), s 12- 21 . doi: 10.3109/13813455.2013.829105
  • Kong, Xiang Yi; Nesset, Cecilie Kåsi; Damme, Markus; Løberg, Else Marit; Lübke, Torben; Mæhlen, Jan; Andersson, Kristin Brevik; Lorenzo, Petra Isabel O.; Roos, Norbert; Thoresen, G. Hege; Rustan, Arild; Kase, Eili Tranheim & Eskild, Winnie (2014). Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Disease Models and Mechanisms.  ISSN 1754-8403.  7(3), s 351- 362 . doi: 10.1242/dmm.014050 Full text in Research Archive.
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Johansen, Harald Thidemann (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLOS ONE.  ISSN 1932-6203.  9(1:85721) . doi: 10.1371/journal.pone.0085721
  • Åstrand, Ove Alexander Høgmoen; Gikling, Ingveig; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål & Kase, Eili Tranheim (2014). Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  74, s 258- 263 . doi: 10.1016/j.ejmech.2014.01.003
  • Aas, Vigdis; Bakke, Siril Skaret; Feng, Yuan Zeng; Kase, Eili Tranheim; Jensen, Jørgen; Bajpeyi, Sudip; Thoresen, G. Hege & Rustan, Arild (2013). Are cultured human myotubes far from home?. Cell and Tissue Research.  ISSN 0302-766X.  354(3), s 671- 682 . doi: 10.1007/s00441-013-1655-1 Full text in Research Archive.
  • Kase, Eili Tranheim; Nikolic, Natasa; Bakke, Siril Skaret; Bogen, Kaja Kamilla; Aas, Vigdis; Thoresen, G. Hege & Rustan, Arild (2013). Remodelling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells. PLOS ONE.  ISSN 1932-6203.  8(4) . doi: 10.1371/journal.pone.0059972 Full text in Research Archive.
  • Badin, Pierre-Marie; Loubière, Camille; Coonen, Maarten; Louche, Katie; Tavernier, Geneviève; Bourlier, Virginie; Mairal, Aline; Rustan, Arild; Smith, Steven R.; Langin, Dominique & Moro, Cedric (2012). Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. Journal of Lipid Research.  ISSN 0022-2275.  53(5), s 839- 848 . doi: 10.1194/jlr.M019182
  • Bakke, Siril Skaret; Moro, Cedric; Nikolic, Natasa; Hessvik, Nina Pettersen; Badin, Pierre-Marie; Lauvhaug, Line; Fredriksson, Katarina; Hesselink, Matthijs K. C.; Boekschoten, Mark V.; Kersten, Sander; Gaster, Michael; Thoresen, G. Hege & Rustan, Arild (2012). Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1821(10), s 1323- 1333 . doi: 10.1016/j.bbalip.2012.07.001
  • Fraser, David; Hessvik, Nina Pettersen; Nikolic, Natasa; Aas, Vigdis; Hanssen, Kristian Folkvord; Bøhn, Siv Kjølsrud; Thoresen, G. Hege & Rustan, Arild (2012). Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes & Nutrition.  ISSN 1555-8932. . doi: 10.1007/s12263-011-0252-8 Full text in Research Archive.
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Smith, Robert; Ravna, aina westrheim; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege & Kase, Eili Tranheim (2012). The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  128, s 154- 164 . doi: 10.1016/j.jsbmb.2011.10.006
  • Kase, Eili Tranheim; Nikolic, Natasa; Hessvik, Nina Pettersen; Fjeldheim, Åse-Karine; Jensen, Jørgen; Thoresen, G. Hege & Rustan, Arild (2012). Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids.  ISSN 0024-4201.  47(5), s 483- 493 . doi: 10.1007/s11745-012-3663-4 Show summary
  • Nikolic, Natasa; Bakke, Siril Skaret; Kase, Eili Tranheim; Rudberg, Ida; Halle, Ingeborg Flo; Rustan, Arild; Thoresen, G. Hege & Aas, Vigdis (2012). Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise. PLOS ONE.  ISSN 1932-6203.  7(3) . doi: 10.1371/journal.pone.0033203 Full text in Research Archive.
  • Nikolic, Natasa; Rhedin, M; Rustan, Arild; Storlien, Len H.; Thoresen, G. Hege & Strømstedt, Maria (2012). Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells. Biochemistry Research International.  ISSN 2090-2247.  2012 . doi: 10.1155/2012/714074
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild & Drevon, Christian A (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients.  ISSN 2072-6643.  4(12), s 1898- 1944 . doi: 10.3390/nu4121898 Show summary
  • Aas, Vigdis; Hessvik, Nina Pettersen; Wettergreen, Marianne; Hvammen, Anders Wensaas; Hallen, Stefan; Thoresen, G. Hege & Rustan, Arild (2011). Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes. Biochimica et Biophysica Acta - Molecular Basis of Disease.  ISSN 0925-4439.  1812(1), s 94- 105 . doi: 10.1016/j.bbadis.2010.09.014 Full text in Research Archive.
  • Badin, Pierre-Marie; Louche, Katie; Mairal, Aline; Liebisch, Gerhard; Schmitz, Gerd; Rustan, Arild; Smith, Steven R.; Langin, Dominique & Moro, Cedric (2011). Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans. Diabetes.  ISSN 0012-1797.  60(6), s 1734- 1742 . doi: 10.2337/db10-1364
  • Ciocoiu, Calin C.; Ravna, aina westrheim; Sylte, Ingebrigt; Rustan, Arild & Hansen, Trond Vidar (2011). Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  19, s 6982- 6988 . doi: 10.1016/j.bmc.2011.10.020
  • Nehlin, Jan O.; Just, Marlene; Rustan, Arild & Gaster, Michael (2011). Human myotubes from myoblast cultures undergoing senescence exhibit defects in glucose and lipid metabolism. Biogerontology (Dordrecht).  ISSN 1389-5729.  12(4), s 349- 365 . doi: 10.1007/s10522-011-9336-5
  • Norheim, Frode; Raastad, Truls; Thiede, Bernd; Rustan, Arild; Drevon, Christian A & Haugen, Fred (2011). Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  301(5), s E1013- E1021 . doi: 10.1152/ajpendo.00326.2011
  • Sparks, LM; Moro, C; Ukropcova, B; Bajpeyi, S; Civitarese, AE; Hulver, MW; Thoresen, G. Hege; Rustan, Arild & Smith, SR (2011). Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes. PLOS ONE.  ISSN 1932-6203.  6(7) . doi: 10.1371/journal.pone.0021068
  • Thoresen, G. Hege; Hessvik, Nina Pettersen; Bakke, Siril Skaret; Aas, Vigdis & Rustan, Arild (2011). Metabolic switching of human skeletal muscle cells in vitro. Prostaglandins, Leukotrienes and Essential Fatty Acids.  ISSN 0952-3278.  85(5), s 227- 234 . doi: 10.1016/j.plefa.2011.04.017 Full text in Research Archive.
  • Corpeleijn, Eva; Hessvik, Nina Pettersen; Bakke, Siril Skaret; Levin, K; Blaak, Ellen E.; Thoresen, G. Hege; Gaster, Michael & Rustan, Arild (2010). Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  299(1), s E14- E22 . doi: 10.1152/ajpendo.00187.2010
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Fredriksson, K; Boekschoten, MV; Fjørkenstad, Anne; Koster, Gerbrand; Hesselink, Martinj; Kersten, S; Kase, Eili Tranheim; Rustan, Arild & Thoresen, G. Hege (2010). Metabolic switching of human myotubes is improved by n-3 fatty acids. Journal of Lipid Research.  ISSN 0022-2275.  51(8), s 2090- 2104 . doi: 10.1194/jlr.M003319
  • Hessvik, Nina Pettersen; Boekschoten, MV; Baltzersen, Rose Mari-Ann; Kersten, S; Xu, X; Andersen, H; Rustan, Arild & Thoresen, G. Hege (2010). LXR beta is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  298(3), s E602- E613 . doi: 10.1152/ajpendo.00553.2009
  • Wensaas, Andreas Johansen; Rustan, Arild; Rokling-Andersen, Merethe; Caesar, Robert; Jensen, Jørgen; Kaalhus, O; Graff, BA; Gulbrandsen, OA; Berge, RK & Drevon, Christian A (2009). Dietary supplementation of tetradecylhioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed high fat diets. Diabetes, obesity and metabolism.  ISSN 1462-8902.  11(11), s 1034- 1049
  • Løvås, K; Wensaas, AJ; Røst, TH; Rustan, AC; Rokling-Andersen, MH; Skorve, Jon; Caesar, R; Ulvik, RJ; Jensen, J; Kaalhus, O; Bohov, P; Graff, Bjørn Anton; Gudbrandsen, OA; Berge, RK; Husebye, ES & Drevon, CA (2009). Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets. Diabetes, obesity and metabolism.  ISSN 1462-8902.  11(11), s 1034- 1049 . doi: 10.1111/j.1463-1326.2009.01092.x Show summary
  • Løvås, Kristian; Lovas, K; Røst, Therese Halvorsen; Rost, TH; Skorve, Jon; Ulvik, Rune Johan; Gudbrandsen, Oddrun Anita; Bohov, Pavol; Wensaas, Andreas J.; Rustan, Arild C.; Berge, Rolf Kristian & Husebye, Eystein Sverre (2009). Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation. Diabetes, obesity and metabolism.  ISSN 1462-8902.  11(4), s 304- 314 . doi: 10.1111/j.1463-1326.2008.00958.x
  • Rokling-Andersen, Merethe H.; Rustan, Arild; Kaalhus, Olav; Wergedahl, Hege & Drevon, Christian A. (2009). Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. British Journal of Nutrition.  ISSN 0007-1145.  102(7), s 995- 1006 Show summary
  • Rokling-Andersen, Merethe; Rokling-Andersen, MH; Rustan, AC; Wensaas, AJ; Kaalhus, O; Wergedahl, Hege; Røst, Therese H.; Rost, TH; Jensen, J; Graff, Bjørn Anton; Caesar, R & Drevon, CA (2009). Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. British Journal of Nutrition.  ISSN 0007-1145.  102(7), s 995- 1006 . doi: 10.1017/S0007114509353210 Show summary
  • Wensaas, Andreas J.; Rustan, Arild C.; Marlene, Just; Just, Marlene; Rolf K, Berge; Berge, Rolf Kristian; Drevon, Christian André & Gaster, Michael (2009). Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation. Diabetes.  ISSN 0012-1797.  58(3), s 527- 535 . doi: 10.2337/db08-1043
  • Kjær, Marte Avranden; Vegusdal, Anne; Gjøen, Tor; Rustan, Arild; Todorevic, M & Ruyter, B (2008). Effect of rapeseed oil and dietary n-3 fatty acids on triacylglycerol synthesis and secretion in Atlantic salmon hepatocytes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1781 . doi: 10.1016/j.bbalip.2007.12.004
  • Kjær, Marte Avranden; Vegusdal, Anne; Gjøen, Tor; Rustan, Arild; Todorcevic, Marijana & Ruyter, Bente (2008). Effect of rapeseed oil and dietary n-3 fatty acids on triacylglycerol synthesis and secretion in Atlantic salmon hepatocytes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1781(3), s 112- 122 . doi: 10.1016/j.bbalip.2007.12.004 Show summary
  • Kase, Eili Tranheim; Thoresen, G. Hege; Westerlund, S; Højlund, K; Rustan, Arild & Gaster, M (2007). Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals. Diabetologia.  ISSN 0012-186X.  50, s 2171- 2180 . doi: 10.1007/s00125-007-0760-7
  • Meyer, BJ; Hammervold, T; Rustan, Arild & Howe, PRC (2007). Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. Lipids.  ISSN 0024-4201.  42 . doi: 10.1007/s11745-006-3014-4
  • Wensaas, Andreas Johansen; Rustan, Arild; Lovstedt, K; Kull, B; Wikstrom, S; Drevon, Christian A & Hallen, S (2007). Cell-based multiwell assays for the detection of substrate accumulation and oxidation. Journal of Lipid Research.  ISSN 0022-2275.  48, s 961- 967 . doi: 10.1194/jlr.D600047-JLR200
  • Aas, Vigdis; Rokling-Andersen, Merethe; Kase, Eili Tranheim; Thoresen, G. Hege; Thoresen, G. Hege & Rustan, Arild Chr. (2006). Eicosapentaenoic acid (20 : 5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells. Journal of Lipid Research.  ISSN 0022-2275.  47
  • Florholmen, Geir; Thoresen, G. Hege; Thoresen, G. Hege; Rustan, Arild Chr.; Jensen, Jørgen; Christensen, Geir & Aas, Vigdis (2006). Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure. Diabetologia.  ISSN 0012-186X.  49, s 724- 731 . doi: 10.1007/s00125-006-0150-6 Show summary
  • Iversen, Per O.; Sørensen, Dag R.; Tronstad, Karl Johan; Gudbrandsen, Oddrun; Rustan, Arild C.; Berge, Rolf Kristian & Drevon, Christian A (2006). A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia. Clinical Cancer Research.  ISSN 1078-0432.  12(11), s 3525- 3531 . doi: 10.1158/1078-0432.CCR-05-2802
  • Kase, Eili Tranheim; Andersen, Bård; Nebb, Hilde Irene; Rustan, Arild & Thoresen, G. Hege (2006). 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1761, s 1515- 1522
  • Aas, Vigdis; Rokling-Andersen, Merethe; Wensaas, Andreas J.; Thoresen, G. Hege; Kase, Eili Tranheim & Rustan, Arild Chr. (2005). Lipid metabolism in human skeletal muscle cells: effects of palmitic acid and chronic hyperglycaemia. Acta Physiologica Scandinavica.  ISSN 0001-6772.  183, s 31- 41

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  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Bakke, Siril S.; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2015). Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2.
  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Rustan, Arild; Thoresen, G. Hege; Kase, Eili Tranheim & Rongved, Pål (2015). Analogs of 22-S-hydroxycholesterol as potential Liver X Receptor-modulators: Synthesis and biological evaluation.
  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2014). Increased lipid oxidation and decreased lipid storage in myotubes lacking perilipin2.
  • Kong, Xiang Yi; Nesset, Cecilie Kåsi; Schjalm, Camilla; Løberg, Else Marit; Rustan, Arild; Thoresen, G. Hege; Kase, Eili Tranheim & Eskild, Winnie (2014). NCU-G1GT/GT MICE: A LONG-LIVED MODEL FOR LIVER FIBROSIS.
  • Covington, Jeffrey D.; Galgani, Jose E.; Rustan, Arild; Zhang, Zhengyu; Moro, Cedric; Smith, Steven R.; Ravussin, Eric & Bajpeyi, S (2013). Muscle perilipin 3 is reduced using in vitro and in vivo exercise models and negatively associated with exercise lipid oxidation. The FASEB Journal.  ISSN 0892-6638.  27
  • Kase, Eili Tranheim; Lund, Jenny; Feng, Yuan Zeng; Langleite, Torgrim Mikal; Aas, Vigdis; Jensen, Jan S.; Birkeland, Kåre I.; Gulseth, Hanne Løvdal; Drevon, Christian A; Rustan, Arild & Thoresen, G. Hege (2013). Effect of exercise on fatty acid and glucose metabolism in cultured human myotubes. Diabetologia.  ISSN 0012-186X.  56, s S250- S250
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Solberg, Rigmor (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Aas, Vigdis; Bakke, Siril Skaret; Nikolic, Natasa; Hjelmesæth, Jøran; Thoresen, G. Hege & Rustan, Arild (2012). Altered energy metabolism in skeletal muscle cells derived from morbidly obese subjects.
  • Bakke, Siril Skaret; Feng, Yuan Zeng; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2012). Lower lipolysis to counteract the development of type 2 diabetes mellitus - evidence from myotubes established from extremely obese subjects.
  • Bakke, Siril Skaret; Nikolic, Natasa; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2012). ALTERED ENERGY METABOLISM IN SKELETAL MUSCLE CELLS DERIVED FROM MORBIDLY OBESE INDIVIDUALS. Show summary
  • Bakke, Siril Skaret; Nikolic, Natasa; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege & Aas, Vigdis (2012). Altered energy metabolism in skeletal muscle cells derived from morbidly obese donors.
  • Bakke, Siril Skaret; Nikolic, Natasa; Moro, Cedric; Lauvhaug, Line; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2011). DIFFERENT HANDLING OF PALMITIC ACID AND OLEIC ACID IN HUMAN SKELETAL MUSCLE CELLS.
  • Bakke, Siril Skaret; Nikolic, Natasa; Moro, Cedric; Lauvhaug, Line; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2011). Different handling of palmitic acid and oleic acid in human skeletal muscle cells.
  • Halle, Ingeborg F.; Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2011). Electrical pulse stimulation of cultured human skeletal muscle cells as a model of exercise in vitro.
  • Lauvhaug, Line; Bakke, Siril Skaret; Thoresen, G. Hege & Rustan, Arild (2011). Different handling of oleic, palmitic, linoleic and eicosapentaenoic acids in cultured human skeletal muscle cells.
  • Aas, Vigdis; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2010). Chronic hyperglycemia impairs mitochondrial function in human myotubes.
  • Aas, Vigdis; Hessvik, Nina; Thoresen, Hege & Rustan, Arild Chr. (2010). Chronic hyperglycaemia impairs mitochondrial function in human myotubes.
  • Bakke, Siril Skaret; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2010). HANDLING OF PALMITIC ACID AND OLEIC ACID IN HUMAN SKELETAL MUSCLE CELLS. Show summary
  • Bakke, Siril Skaret; Hessvik, Nina Pettersen; Thoresen, G. Hege & Rustan, Arild (2010). The impact of the n-3 fatty acid eicosapentaenoic acid (EPA) on metabolic switching in human skeletal muscle cells. Show summary
  • Dembinska-Kiec, A.; Knapp, A.; Kiec-Wilk, B.; Sliwa, A.; Czech, U.; Korczynska, M. & Rustan, Arild (2010). Metabolism of endothelial and adipose stromal vascular (SVF) fraction in the presence of fatty acids. European Journal of Clinical Investigation.  ISSN 0014-2972.  40, s 78- 79
  • Hessvik, Nina Pettersen; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Kase, Eili Tranheim (2010). Effects of 22-S-hydroxycholesterol (a liver X receptor modulator) on Lipid Metabolism. Show summary
  • Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2010). Chronic electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise.
  • Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2010). Chronic electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise.
  • Nikolic, Natasa; Bakke, Siril Skaret; Thoresen, G. Hege; Rustan, Arild & Aas, Vigdis (2010). Energimetabolismen i humane skjelettmuskelceller - Utvikling av in vitro treningsmodell.
  • Rustan, Arild (2010). The impact of eicosapentaenoic acid (EPA) on regulation of fatty acid metabolism, metabolic flexibility and gene expression in human skeletal muscle cells. Show summary
  • Rustan, Arild Chr.; Wettergreen, Marianne; Hessvik, Nina; Thoresen, G. Hege & Aas, Vigdis (2010). Chronic hyperglycaemia impairs metabolic switching of human myotubes.
  • Bakke, Siril Skaret; Hessvik, Nina Pettersen; Fjørkenstad, Anne; Koster, Gerbrand; Rustan, Arild & Thoresen, G. Hege (2009). Eicosapentaenoic acid improves metabolic switching of human myotubes. Show summary
  • Aas, Vigdis; Wettergreen, Marianne; Hessvik, Nina P.; Thoresen, G. Hege & Rustan, Arild Chr. (2009). Chronic hyperglycemia reduces myotube mitochondrial function without changing mitochondrial gene expression or mitochondrial content.
  • Corpeleijn, E; Hessvik, Nina Pettersen; Blaak, EE; Thoresen, G. Hege; Gaster, M & Rustan, Arild (2008). Utilization of intramyocellular lipids for oxidation in human skeletal muscle cells from lean and type 2 diabetic subjects. Diabetologia.  ISSN 0012-186X.  51, s S303- S303
  • Aas, Vigdis; Wensaas, Andreas J.; Thoresen, G. Hege; Hallèn, Stefan & Rustan, Arild Chr. (2007). Chronic hyperglycemia impairs flexibility related to fatty acid metabolism in human myotubes.
  • Rustan, Arild (2007). Legemidler ved behandling av fedme.
  • Florholmen, Geir; Thoresen, G. Hege; Rustan, Arild Chr.; Jensen, Jørgen; Christensen, Geir & Aas, Vigdis (2006). Leukaemia Inhibitory Factor Stimulates Glucose Transport in Isolated Cardiomyocytes and Induces Insulin Resistance after Chronic Exposure.
  • Florholmen, Geir; Thoresen, G. Hege; Rustan, Arild; Jensen, Jørgen; Christensen, Geir Arve & Aas, Vigdis (2006). Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure.
  • Kase, Eili Tranheim; Wensaas, Andreas J.; Aas, Vigdis; Andersen, B; Højlund, Kurt; Levin, K; Beck-Nielsen, Henning; Nebb, Hilde I.; Gaster, Michael; Rustan, Arild Chr. & Thoresen, G. Hege (2006). A role for LXR in lipid and glucose metabolism in human skeletal muscle.
  • Rustan, Arild (2006). Metabolism and biological effects of n-3 fatty acids.
  • Aas, Vigdis; Wensaas, Andreas J.; Thoresen, G. Hege & Rustan, Arild Chr. (2006). Chronic hyperglycaemia impairs flexibility related to fatty acid metabolism in human myotubes.
  • Rustan, Arild (2006). CELL BASED MULTI-WELL ASSAYS FOR DETECTION OF SUBSTRATE ACCUMULATION AND OXIDATION.
  • Rustan, Arild (2006). FATTY ACID-MEDIATED ACCUMULATION OF TRIACYLGLYCEROL IN MYOTUBES FROM TYPE 2 DIABETICS IS REDUCED BY A PAN-PPAR AGONIST TETRADECYL-THIOACETIC ACID (TTA).
  • Rustan, Arild (2006). Insulinresistens i humane skje-lettmuskelceller i kultur: Gunstige metabolske effekter av omega-3 fettsyrer. Toksikologen.  ISSN 1504-5773.  2

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Published Nov. 3, 2010 3:43 PM - Last modified Apr. 22, 2018 10:20 PM

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