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• Rolfsen, Jacob Strand; Cherukupalli, Srinivasulu; Sundby, Eirik & Hoff, Bård Helge (2026). Triazole-Functionalized 7-Azaindoles: A synthetic Study Using Sonogashira Cross-Coupling and Copper-Catalyzed Azide-Alkyne Cycloaddition. Fulltekst i vitenarkiv Vis sammendrag

  The majority of recently approved small-molecule drugs contain at least one nitrogen heterocycle.1 Among these, the 7-azaindole scaffold is recognized as a kinase-privileged fragment and is featured in several commercial inhibitors, including the colony-stimulating factor 1 receptor inhibitor Pexidartinib.2 Likewise, 1,2,3-triazoles have emerged as significant motifs in drug discovery due to their ease of synthesis and broad pharmacological activity.3,4 Combining structural features of Pexidartinib and 1,2,3-triazoles, herein we outline our latest work on triazole functionalized 7-azaindoles.

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