Osman Gani

Førsteamanuensis
Bilde av Osman  Gani
English version of this page
Telefon +47 22857443
Brukernavn
Besøksadresse Farmasibygningen Sem Sælands vei 3 0371 OSLO
Postadresse Postboks 1068 Blindern 0316 Oslo

Faglige interesser

Beregningsbasert medisinsk kjemi og kjemisk biologi

Kjemoinformatikk

Statistisk forståelse av beregningsmetoder i legemiddelkjemi

Metodeutvikling innen beregningsmetoder

Emneord: Legemiddelkjemi, Beregningsbasert medisinsk kjemi og kjemisk biologi, beregningsmetoder i legemiddelkjemi, Kjemoinformatikk

Publikasjoner

  • Birkebaek, Niels H; Kamrath, Clemens; Grimsmann, Julia M; Aakesson, Karin; Cherubini, Valentino & Dovc, Klemen [Vis alle 26 forfattere av denne artikkelen] (2022). Impact of the COVID-19 pandemic on long-term trends in the prevalence of diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes: an international multicentre study based on data from 13 national diabetes registries. The Lancet Diabetes and Endocrinology. ISSN 2213-8587. 10(11), s. 786–794. doi: 10.1016/S2213-8587%2822%2900246-7.
  • Lanzinger, Stefanie; Zimmermann, Anthony; Ranjan, Ajenthen G.; Gani, A B S M Osman; Pons Perez, Saira & Akesson, Karin [Vis alle 21 forfattere av denne artikkelen] (2022). A collaborative comparison of international pediatric diabetes registries. Pediatric Diabetes. ISSN 1399-543X. 23(6), s. 627–640. doi: 10.1111/pedi.13362. Fulltekst i vitenarkiv
  • Rødevand, Linn ; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman & Shadrin, Alexey A. [Vis alle 18 forfattere av denne artikkelen] (2021). Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-020-01142-4. Fulltekst i vitenarkiv
  • Shadrin, Alexey A.; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Bettella, Francesco; O`Connell, Kevin & Gani, Osman [Vis alle 12 forfattere av denne artikkelen] (2020). Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR. Bioinformatics. ISSN 1367-4803. doi: 10.1093/bioinformatics/btaa568. Fulltekst i vitenarkiv
  • Alam, Kazi Asraful; Gani, Osman & Engh, Richard Alan (2020). Inhibitor binding of mutants of protein kinase A with GGGXXG and GXGXXA glycine-rich loop motifs. Journal of Molecular Recognition. ISSN 0952-3499. 2020. doi: 10.1002/jmr.2882.
  • De Santi, Concetta; Gani, Osman A. B. S. M.; Helland, Ronny & Williamson, Adele Kim (2017). Structural insight into a CE15 esterase from the marine bacterial metagenome. Scientific Reports. ISSN 2045-2322. 7:17278, s. 1–10. doi: 10.1038/s41598-017-17677-4. Fulltekst i vitenarkiv
  • Narayanan, Dilip; Gani, Osman; Gruber, Franz & Engh, Richard Alan (2017). Data driven polypharmacological drug design for lung cancer: Analyses for targeting ALK, MET, and EGFR. Journal of Cheminformatics. ISSN 1758-2946. 9(43), s. 1–19. doi: 10.1186/s13321-017-0229-8. Fulltekst i vitenarkiv
  • Gani, Osman A.B.S.M.; Thakkar, Balmukund; Narayanan, Dilip; Alam, Kazi Asraful; Kyomuhendo, Peter & Rothweiler, Ulli [Vis alle 8 forfattere av denne artikkelen] (2015). Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches. Biochimica et Biophysica Acta - Proteins and Proteomics. ISSN 1570-9639. 1854(10), s. 1605–1616. doi: 10.1016/j.bbapap.2015.05.004.
  • Gani, Osman A.B.S.M.; Narayanan, Dilip & Engh, Richard Alan (2013). Evaluating the Predictivity of Virtual Screening for Abl Kinase Inhibitors to Hinder Drug Resistance. Chemical Biology and Drug Design (CB&DD). ISSN 1747-0277. 82(5), s. 506–519. doi: 10.1111/cbdd.12170. Fulltekst i vitenarkiv
  • Åberg, espen; Lund, Bjarte Aarmo; Pflug, Alexander; Gani, Osman A.B.S.M.; Rothweiler, Ulli & Oliveira, Taiana Maia De [Vis alle 7 forfattere av denne artikkelen] (2012). Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool. Biological chemistry. ISSN 1431-6730. 393(10), s. 1121–1129. doi: 10.1515/hsz-2012-0248.
  • Gani, Osman A.B.S.M. & Engh, Richard Alan (2010). Protein kinase inhibition of clinically important staurosporine analogues. Natural product reports (Print). ISSN 0265-0568. 27(4), s. 489–498. doi: 10.1039/b923848b.
  • Odlo, Kristin; Fournier-Dit-Chabert, Jérémie; Ducki, Sylvie; Gani, Osman A.B.S.M.; Sylte, Ingebrigt & Hansen, Trond Vidar (2010). 1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18(18), s. 6874–6885. doi: 10.1016/j.bmc.2010.07.032.
  • Gani, Osman A.B.S.M. & Sylte, Ingebrigt (2009). Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor alpha. Medicinal Chemistry Research. ISSN 1054-2523. 18(1), s. 8–19. doi: 10.1007/s00044-008-9102-7.
  • Gani, Osman A.B.S.M.; Adekoya, Olayiwola; Giurato, L; Spyrakis, F; Cozzini, P & Guccione, S [Vis alle 8 forfattere av denne artikkelen] (2008). Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases. Biophysical Journal. ISSN 0006-3495. 94. doi: 10.1529/biophysj.107.111096.
  • Gani, Osman A.B.S.M. & Sylte, Ingebrigt (2008). Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma. Chemical Biology and Drug Design (CB&DD). ISSN 1747-0277. 72, s. 50–57. doi: 10.1111/j.1747-0285.2008.00677.x.
  • Odlo, K; Hentzen, J; dit Chabert, JF; Ducki, S; Gani, Osman A.B.S.M. & Sylte, Ingebrigt [Vis alle 10 forfattere av denne artikkelen] (2008). 1,5-disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 16, s. 4829–4838. doi: 10.1016/j.bmc.2008.03.049.
  • Gani, Osman A.B.S.M. & Sylte, Ingebrigt (2008). Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha. Journal of Molecular Graphics and Modelling. ISSN 1093-3263. 27, s. 217–224. doi: 10.1016/j.jmgm.2008.04.008.
  • Gani, Osman A.B.S.M. (2008). Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists? Cardiovascular Diabetology. ISSN 1475-2840. 7. doi: 10.1186/1475-2840-7-6.
  • Gani, Osman A.B.S.M. (2007). Signposts of docking and scoring in drug design. Chemical Biology and Drug Design (CB&DD). ISSN 1747-0277. 70, s. 360–365. doi: 10.1111/j.1747-0285.2007.00571.x.

Se alle arbeider i Cristin

  • Thakkar, Balmukund; Gani, Osman & Engh, Richard Alan (2016). Practical Applications of Informatics Tools to Identify Drug Targets for Novel Compounds from Bio- and Chemoprospecting.
  • Boomgaren, Marc; Gani, Osman; Engh, Richard Alan & Hansen, Jørn H (2016). Bioactive Heterocycle Libraries for Anticancer Drug Discovery - Development of Covalent Binding TK Inhibitors.
  • Boomgaren, Marc; Gani, Osman A.B.S.M.; Engh, Richard Alan & Hansen, Jørn H (2015). Bioactive Heterocycle Libraries for Anticancer Drug Discovery.
  • Gani, Osman A.B.S.M. & Sylte, Ingebrigt (2006). Molecular recognition of fatty acids by PPAR-alpha.
  • Adekoya, Olayiwola Adedotun; Dahl, Svein G.; Gabrielsen, Mari; Gani, Osman A.B.S.M.; Khan, Mahmud Tareq Hassan & Kristiansen, kurt [Vis alle 10 forfattere av denne artikkelen] (2006). The molecular modelling group.
  • Gani, Osman A.B.S.M. & Sylte, Ingebrigt (2006). Molecular recognition of fatty acids by PPAR-alpha.
  • Gani, Osman A.B.S.M. & Sylte, Ingebrigt (2006). The effect of E-Z isomerization of docosahexaeonic acid (DHA) double bonds on binding to nuclear receptors.

Se alle arbeider i Cristin

Publisert 2. sep. 2022 12:01 - Sist endret 16. sep. 2022 18:12