Vladimir's PhD research investigated how antimicrobial peptides, which are promising candidates for new antibiotics, interact with and permeabilise bacterial cell membranes. He primarily used model membranes, small-angle X-ray and neutron scattering, and scattering-data modelling. Through this work, he showed that these peptides can both reorganise the lateral composition of membranes and permeabilise them without forming classical pores. These previously unknown mechanisms provide new insights into the modes of action of antimicrobial peptides.
Vladimir's postdoctoral project is part of the PERMEATE Convergence Environment, which aims to use antimicrobial and other surface-active peptides to transport drugs across the membranes of human cells for therapeutic purposes.
Vladimir on his postdoctoral research:
– My work will focus on developing and applying molecular-dynamics simulations to study peptide–membrane interactions in larger and more realistic membrane systems. The goal is both to elucidate how these peptides can facilitate drug transport into cells and to identify promising candidate peptides.
- Employment: 01 August 2026 for 4 years at Hylleraas Centre, node UiO.
- Office in the Life Science Building, 3rd floor field 5 (E3-F5-17)
Welcome to the team, Vladimir!