Erna Davydova

• Falnes, Pål; Malecki, Jedrzej Mieczyslaw; Herrera Gonzalez-Molina, Maria del Carmen; Bengtsen, Mads & Davydova, Erna (2023). Human seven-β-strand (METTL) methyltransferases - conquering the universe of protein lysine methylation. Journal of Biological Chemistry. ISSN 0021-9258. 299(6), p. 1–15. doi: 10.1016/j.jbc.2023.104661. Full text in Research Archive
• Malecki, Jedrzej Mieczyslaw; Davydova, Erna & Falnes, Pål (2022). Protein methylation in mitochondria. Journal of Biological Chemistry. ISSN 0021-9258. 298(4). doi: 10.1016/j.jbc.2022.101791. Full text in Research Archive
• Dalum, Alf Seljenes; Kraus, Aurora; Khan, Shanawaz; Davydova, Erna; Rigaudeau, Dimitri & Bjørgen, Håvard [Show all 13 contributors for this article] (2021). High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue. Frontiers in Immunology. ISSN 1664-3224. doi: 10.3389/fimmu.2021.769901.
• Dalum, Alf Seljenes; Kraus, Aurora; Khan, Shanawaz; Davydova, Erna; Rigaudeau, Dimitri & Bjørgen, Håvard [Show all 13 contributors for this article] (2021). High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.769901. Full text in Research Archive Show summary

  The zebrafish is extensively used as an animal model for human and fish diseases. However, our understanding of the structural organization of its immune system remains incomplete, especially the mucosa-associated lymphoid tissues (MALTs). Teleost MALTs are commonly perceived as diffuse and scattered populations of immune cells throughout the mucosa. Yet, structured MALTs have been recently discovered in Atlantic salmon (Salmo salar L.), including the interbranchial lymphoid tissue (ILT) in the gills. The existence of the ILT was only recently identified in zebrafish and other fish species, highlighting the need for in-depth characterizations of the gill-associated lymphoid tissue (GIALT) in teleosts. Here, using 3-D high-resolution microscopy, we analyze the GIALT of adult zebrafish with an immuno-histology approach that reveals the organization of lymphoid tissues via the labeling of T/NK cells with an antibody directed to a highly conserved epitope on the kinase ZAP70. We show that the GIALT in zebrafish is distributed over at least five distinct sub-regions, an organization found in all pairs of gill arches. The GIALT is diffuse in the pharyngeal part of the gill arch, the interbranchial septum and the filaments/ lamellae, and structured in two sub-regions: the ILT, and a newly discovered lymphoid structure located along each side of the gill arch, which we named the Amphibranchial Lymphoid Tissue (ALT). Based on RAG2 expression, neither the ILT nor the ALT constitute additional thymi. The ALT shares several features with the ILT such as presence of abundant lymphoid cells and myeloid cells embedded in a network of reticulated epithelial cells. Further, the ILT and the ALT are also a site for T/NK cell proliferation. Both ILT and ALT show structural changes after infection with Spring Viraemia of Carp Virus (SVCV). Together, these data suggest that ALT and ILT play an active role in immune responses. Comparative studies show that whereas the ILT seems absent in most neoteleosts (“Percomorphs”), the ALT is widely present in cyprinids, salmonids and neoteleosts, suggesting that it constitutes a conserved tissue involved in the protection of teleosts via the gills.

• Malecki, Jedrzej Mieczyslaw; O'Donohue, Marie-Francoise; Kim, Yeji; Jakobsson, Magnus; Gessa, Luca & Pinto, Rita [Show all 14 contributors for this article] (2021). Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function. Nucleic Acids Research (NAR). ISSN 0305-1048. 49(6), p. 3185–3203. doi: 10.1093/nar/gkab088. Full text in Research Archive
• Davydova, Erna; Shimazu, Tadahiro; Schuhmacher, Maren Kirstin; Jakobsson, Magnus E.; Willemen, Hanneke L.D.M. & Liu, Tongri [Show all 28 contributors for this article] (2021). The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature Communications. ISSN 2041-1723. 12, p. 1–14. doi: 10.1038/s41467-020-20670-7. Full text in Research Archive
• Kabashi, Saranda; Vindenes, Vigdis; Bryun, Eugeniy Alekseevich; Koshkina, Evgenia A.; Nadezhdin, Alexey V. & Tetenova, Elena J. [Show all 16 contributors for this article] (2019). Harmful alcohol use among acutely ill hospitalized medical patients in Oslo and Moscow: A cross-sectional study. Drug and Alcohol Dependence. ISSN 0376-8716. 204:107588, p. 1–9. doi: 10.1016/j.drugalcdep.2019.107588. Full text in Research Archive
• Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Halabelian, Levon; Nilges, Benedikt S.; Pinto, Rita & Kudithipudi, Srikanth [Show all 14 contributors for this article] (2018). The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nature Communications. ISSN 2041-1723. 9:3411, p. 1–15. doi: 10.1038/s41467-018-05646-y. Full text in Research Archive
• Aileni, Vinay Kumar; Davydova, Erna; Moen, Anders & Falnes, Pål (2017). A System for Enzymatic Lysine Methylation in a Desired Sequence Context. ACS Omega. ISSN 2470-1343. 2(2), p. 462–469. doi: 10.1021/acsomega.6b00486. Full text in Research Archive
• Malecki, Jedrzej Mieczyslaw; Dahl, Helge-Andre; Moen, Anders; Davydova, Erna & Falnes, Pål (2016). The METTL20 homologue from agrobacterium tumefaciens is a dual specificity protein-lysine methyltransferase that targets ribosomal protein L7/L12 and the β subunit of electron transfer flavoprotein (ETFβ). Journal of Biological Chemistry. ISSN 0021-9258. 291(18), p. 9581–9595. doi: 10.1074/jbc.M115.709261.
• Falnes, Pål; Jakobsson, Magnus; Davydova, Erna; Ho, Angela Yeuan Yen & Malecki, Jedrzej Mieczyslaw (2016). Protein lysine methylation by seven-β-strand methyltransferases. Biochemical Journal. ISSN 0264-6021. 473(14), p. 1995–2009. doi: 10.1042/BCJ20160117.
• Jakobsson, Magnus; Davydova, Erna; Malecki, Jedrzej Mieczyslaw; Moen, Anders & Falnes, Pål (2015). Saccharomyces cerevisiae eukaryotic elongation factor 1A (eEF1A) is methylated at Lys-390 by a METTL21-like methyltransferase. PLOS ONE. ISSN 1932-6203. 10(6). doi: 10.1371/journal.pone.0131426. Full text in Research Archive
• Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja & Maciejewska, Agnieszka M. [Show all 11 contributors for this article] (2014). Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE. ISSN 1932-6203. 9(6). doi: 10.1371/journal.pone.0098729. Full text in Research Archive
• Davydova, Erna; Ho, Angela Yeuan Yen; Malecki, Jedrzej Mieczyslaw; Moen, Anders; Enserink, Jorrit & Jakobsson, Magnus [Show all 8 contributors for this article] (2014). Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). Journal of Biological Chemistry. ISSN 0021-9258. 289(44), p. 30499–30510. doi: 10.1074/jbc.M114.601658.
• Kernstock, Jens Stefan; Davydova, Erna; Jakobsson, Magnus; Moen, Anders; Pettersen, Solveig & Mælandsmo, Gunhild [Show all 8 contributors for this article] (2012). Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nature Communications. ISSN 2041-1723. 3. doi: 10.1038/ncomms2041.

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• Aileni, Vinay Kumar; Davydova, Erna; Kernstock, Jens Stefan; Moen, Anders & Falnes, Pål (2016). VCP-KMT (METTL21D)-mediated lysine methylation of histone H3 peptide sequences grafted onto a VCP-derived scaffold.

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