helgead

• Dahl, Helge-Andre; Johansen, Anette; Nilsson, Göran Erik & Lefevre, Sjannie (2021). The Metabolomic Response of Crucian Carp (Carassius carassius) to Anoxia and Reoxygenation Differs between Tissues and Hints at Uncharacterized Survival Strategies. Metabolites. ISSN 2218-1989. 11(7), p. 1–26. doi: 10.3390/metabo11070435. Full text in Research Archive
• Malecki, Jedrzej Mieczyslaw; Dahl, Helge-Andre; Moen, Anders; Davydova, Erna & Falnes, Pål (2016). The METTL20 homologue from agrobacterium tumefaciens is a dual specificity protein-lysine methyltransferase that targets ribosomal protein L7/L12 and the β subunit of electron transfer flavoprotein (ETFβ). Journal of Biological Chemistry. ISSN 0021-9258. 291(18), p. 9581–9595. doi: 10.1074/jbc.M115.709261.
• Malecki, Jedrzej Mieczyslaw; Ho, Angela Yeuan Yen; Moen, Anders; Dahl, Helge-Andre & Falnes, Pål (2015). Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. Journal of Biological Chemistry. ISSN 0021-9258. 290(1), p. 423–434. doi: 10.1074/jbc.M114.614115.

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• Gerber, Lucie; Helle-Valle, Tellef; Resseguier, Julien Alain Andre; Torp, May-Kristin; Dahl, Helge Andre & Nilsson, Göran Erik [Show all 8 contributors for this article] (2022). Prolyl Hydroxylase Domains in the Anoxia Tolerant Crucian Carp (c. carassius): Insights into the Regulation of the HIF Response to Anoxia-Reoxygenation.
• Gerber, Lucie; Helle-Valle, Tellef; Resseguier, Julien Alain Andre; Torp, May-Kristin; Dahl, Helge Andre & Nilsson, Göran Erik [Show all 8 contributors for this article] (2022). Prolyl Hydroxylase Domains in the Anoxia Tolerant Crucian Carp (c. carassius): Insights into the Regulation of the HIF Response to Anoxia-Reoxygenation.
• Lefevre, Sjannie & Dahl, Helge Andre (2022). Insights from ‘omics’ about crucian carp anoxia tolerance. Show summary

  The crucian carp (Carassius carassius) is extremely tolerant to the absence of oxygen. Its metabolically most active organs, such as the brain, can maintain function over extended periods of anoxia. Our research seeks to understand the cellular and molecular mechanisms involved in regulating the response of the crucian carp to anoxia. We take a discovery-driven approach, using metabolomics, transcriptomics and translatomics, to identify key mechanisms and signalling pathways behind the extreme anoxia tolerance. In this talk, I will present results on sequencing and quantification of mRNA and ribosome-protected (i.e. translated) mRNA fragments in brain tissue from crucian carp exposed to normoxia, anoxia and re-oxygenation, as well as metabolites from multiple tissues.

• Lefevre, Sjannie; Lau, Gigi Yik Chee; Dahl, Helge-Andre & Nilsson, Göran Erik (2019). Re-oxygenation resilience - the other aspect of the crucian carp’s anoxia tolerance.
• Lefevre, Sjannie; Lau, Gigi Yik Chee; Dahl, Helge-Andre & Nilsson, Göran Erik (2019). Crucian carp: mitochondria, anoxia and reoxygenation.
• Dahl, Helge-Andre & Lefevre, Sjannie (2018). Protection against reperfusion injury: can insight be gained from crucian carp?

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