Bacterial adhesion mechanisms
The lack of knowledge about bacterial adhesion mechanisms hinders the development of novel antibacterial surfaces. Consequences are failing implants, inefficient electrodes, and biofouling of off-shore materials. The current, slow approach to this problem is trial-and-error testing of potentially beneficial surface modifications. We are pursuing a bottom-up approach, starting with molecular biology studies of bacterial adhesion factors, and of their interaction with surfaces.
My project involves the development of bacteria-surface adhesion assays, to obtain new knowledge on adhesin function. Secondly, I will translate the results into novel surface modifications to test the theories, leading to more effective antibacterial surfaces, and the improvement of the adhesion assays. These aims will be achieved in close collaboration with the Department of Biomaterials (BIOMAT) at the University of Oslo Institute for Clinical Dentistry.
PhD in Chemistry at the University of Bath
Purpose: Development of electrode materials for photo-microbial fuel cells.
Essential discovery: Inherently conductive Ti2AlC ceramic enabled the fabrication of reticulated electrode shapes with defined porosity and good surface roughness for improved cell adhesion, thereby maximising the area for electricity generating cells.
Office telephone: +47 228 54793
Office at IBV in room: 3523
Laboratory at IBV in room: 3522
Google Scholar Profile: https://scholar.google.com/citations?user=aTUvAFoAAAAJ&hl=de
“Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA)” in Molecular Microbioly, 2019. 111: 844-862. (Chauhan, N., Hatlem, D., Orwick‐Rydmark, M., Schneider, K., Floetenmeyer, M., van Rossum, B., Leo, J. C. and Linke, D.)
“An investigation of anode and cathode materials in photomicrobial fuel cells” in Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and Engineering Sciences, 2016. 374: p.2061. (Kenneth Schneider, Rebecca J Thorne, Petra J Cameron)
“Iron reduction by the cyanobacterium Synechocystis sp. PCC 6803” in Bioelectrochemistry, 2015. 105: p. 103-109. (Rebecca Thorne, Kenneth Schneider, Huaining Hu and Petra J. Cameron)
“A small-scale air-cathode microbial fuel cell for on-line monitoring of water quality” in Biosensors and Bioelectronics, 2014. 62(0): p. 182-188. (Mirella Di Lorenzo, Alexander R. Thomson, Kenneth Schneider, Petra J. Cameron, Ioannis Ieropoulos).
“Trapping of redox-mediators at the surface of Chlorella vulgaris leads to error in measurements of cell reducing power” in Physical Chemistry Chemical Physics, 2014. 16(12): p. 5810-5816. (Rebecca J. Thorne, Huaining Hu, Kenneth Schneider and Petra J. Cameron).
“Surface morphology and surface energy of anode materials influence power outputs in a multi-channel mediatorless bio-photovoltaic (BPV) system” in Physical Chemistry Chemical Physics, 2012. 14(35): p. 12221-12229. (Paolo Bombelli, Marie Zarrouati, Rebecca J. Thorne, Kenneth Schneider, Stephen J. L. Rowden, Akin Ali, Kamran Yunus, Petra J. Cameron, Adrian C. Fisher, D. Ian Wilson, Christopher J. Howe and Alistair J. McCormick).
“Porous ceramic anode materials for photo-microbial fuel cells” in Journal of Materials Chemistry, 2011. 21(44): p. 18055-18060. (Rebecca Thorne, Huaining Hu, Kenneth Schneider, Paolo Bombelli, Adrian Fisher, Laurence M. Peter, Andrew Dent and Petra J. Cameron).
Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Pérez-Ortega, Jesús; Sittman, Carolin; Göttig, Stephan & Liskiewicz, Krystyna Anna [Show all 11 contributors for this article] (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology. ISSN 1462-2912. 22(7), p. 2939–2955. doi: 10.1111/1462-2920.15051. Full text in Research Archive
Chauhan, Nandini; Hatlem, Daniel; Rydmark, Marcella Orwick; Schneider, Kenneth; Flötenmeyer, Matthias & Van Rossum, Barth-J [Show all 8 contributors for this article] (2019). Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA). Molecular Microbiology. ISSN 0950-382X. 111(3), p. 844–862. doi: 10.1111/mmi.14195. Full text in Research Archive
Schneider, Kenneth; Thorne, Rebecca Jayne & Cameron, Petra J. (2016). An investigation of anode and cathode materials in photomicrobial fuel cells. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. ISSN 1364-503X. 374(2061). doi: 10.1098/rsta.2015.0080.
Hatlem, Daniel; Chauhan, Nandini; Orwick-Rydmark, Marcella; Schneider, Kenneth; Flötenmeyer, Matthias & Van Rossum, Barth-J [Show all 8 contributors for this article] (2019). Insights into the autotransport of a trimeric autotransporter.
Chauhan, Nandini; Hatlem, Daniel; Orwick-Rydmark, Marcella; Schneider, Kenneth; Linke, Dirk & Leo, Jack Christopher (2019). Using the SpyCatcher-SpyTag technology for topology mapping of outer membrane proteins in Gram-negative bacteria.
Hatlem, Daniel; Chauhan, Nandini; Rydmark, Marcella Orwick; Schneider, Kenneth; Floetenmeyer, Matthias & Leo, Jack Christopher [Show all 7 contributors for this article] (2018). Insights into the autotransporter process of a trimeric autotransporter, Yersinia Adhesin A (YadA).
Schneider, Kenneth; Haugen, Håvard Jostein & Linke, Dirk (2017). Assay Development: Adhesin Interaction with Implant Materials.
Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
Leo, Jack Christopher; Schneider, Kenneth & Linke, Dirk (2015). Autotransporters as mediators of bacterial adhesion.