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Naveen Parmar

Image of Naveen Parmar
Room 2609
Username
Visiting address Blindernveien 31 0371 Oslo
Postal address Postboks 1066 Blindern 0316 Oslo

Background

Before joining IBV, I was a postdoctoral fellow at the Centre of Molecular Inflammation Research (CEMIR), NTNU, and at the Department of Pathology, University of Oslo. During my time in Norway, I employed innovative approaches in infection biology, tissue engineering, and both human and mouse organoid technologies. This work has led to publications in high-impact peer-reviewed journals, including PLOS Pathogens and Science Immunology.

My research focuses on the gut as a key site of infection by diverse pathogens, each triggering distinct immune responses necessary for control and clearance. I am particularly interested in how the intestinal epithelium regulates these immune responses, and conversely, how immune signaling shapes epithelial function. By investigating this bidirectional communication, my goal is to uncover critical mechanisms that govern host-pathogen interactions and maintain gut homeostasis.

To address these questions, I apply a broad range of techniques including bulk RNA sequencing, single-cell RNA sequencing, ATAC-seq, intestinal organoid cultures, flow cytometry, and advanced microscopy.

In addition to research, I am passionate about teaching and mentoring. I actively supervise master’s students and welcome those interested in gut biology and the development of organoid-based models.

 

Publications

  • Sanchez, Alberto Diez; Lindholm, Håvard Takle; Vornewald, Pia Magdalena; Ostrop, Jenny; Yao, Rouan & Single, Andrew Bruce [Show all 11 contributors for this article] (2024). LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model. Nature Communications. 15:3412(1), p. 1–20. doi: 10.1038/s41467-024-47815-2. Full text in Research Archive
  • Vornewald, Pia Magdalena; Forman, Ruth; Yao, Rouan; Parmar, Naveen; Lindholm, Håvard Takle & Lee, Lilith Sian Kaspersen [Show all 9 contributors for this article] (2023). Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection. Frontiers in Immunology. 14:1243528, p. 1–16. doi: 10.3389/fimmu.2023.1243528. Full text in Research Archive
  • Das, Saykat; Stamnæs, Jorunn; Kemppainen, Esko; Hervonen, Kaisa; Lundin, Knut & Parmar, Naveen [Show all 12 contributors for this article] (2023). Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis. Advanced Science. 10:2300401(25), p. 1–10. doi: 10.1002/advs.202300401. Full text in Research Archive
  • Lindholm, Håvard Takle; Parmar, Naveen; Drurey, Claire; Poveda, Marta Campillo; Vornewald, Pia & Ostrop, Jenny [Show all 9 contributors for this article] (2022). BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia. Science immunology. 7(71). doi: 10.1126/sciimmunol.abl6543. Full text in Research Archive
  • Roberts, Luke B.; Schnoeller, Corinna; Berkachy, Rita; Darby, Matthew; Pillaye, Jamie & Oudhoff, Menno [Show all 17 contributors for this article] (2021). Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths. Science immunology. 6(57), p. 1–14. doi: 10.1126/sciimmunol.abd0359. Full text in Research Archive
  • Ostrop, Jenny; Zwiggelaar, Rosalie Theda Margien; Pedersen, Marianne Terndrup; Gerbe, François; Bösl, Korbinian & Lindholm, Håvard Takle [Show all 14 contributors for this article] (2021). A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation. Frontiers in Cell and Developmental Biology. 8:618552, p. 1–20. doi: 10.3389/fcell.2020.618552. Full text in Research Archive
  • Parmar, Naveen; Burrows, Kyle; Vornewald, Pia; Lindholm, Håvard Takle; Zwiggelaar, Rosalie Theda Margien & Sanchez, Alberto Diez [Show all 12 contributors for this article] (2021). Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection. PLoS Pathogens. ISSN 1553-7366. 17(3). doi: 10.1371/JOURNAL.PPAT.1009476. Full text in Research Archive
  • Parmar, Naveen; Chandrakar, Pragya & Kar, Susanta (2020). Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-g)/M(IL-10) Polarization. Journal of Immunology. ISSN 0022-1767. 204(10), p. 2762–2778. doi: 10.4049/jimmunol.1900251. Full text in Research Archive
  • Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki & Sanchez, Alberto Diez [Show all 20 contributors for this article] (2020). LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium. Science Advances. 6(37). doi: 10.1126/sciadv.abc0367. Full text in Research Archive

View all works in NVA

  • Parmar, Naveen (2019). Decoding the role of the H3K4 demethylase LSD1 in mediating host defense against intestinal pathogens. Full text in Research Archive

View all works in NVA

Published June 16, 2025 10:24 AM - Last modified June 17, 2025 10:52 AM