Niveditha Umesh Katyayini

• Caulier, Benjamin William; Joaquina, Sandy; Gelebart, Pascal Francois; Dowling, Tara Helen Steinsland; Kaveh, Fatemeh & Thomas, Moritz [Show all 20 contributors for this article] (2024). CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia. Cell Reports Medicine. 5(6). doi: 10.1016/j.xcrm.2024.101572. Full text in Research Archive Show summary

  Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid cells in the bone marrow and the peripheral blood. Nearly half of the AML patients relapse after standard induction therapy, and new forms of therapy are urgently needed. Chimeric antigen receptor (CAR) T therapy has so far not been successful in AML due to lack of efficacy and safety. Indeed, the most attractive antigen targets are stem cell markers such as CD33 or CD123. We demonstrate that CD37, a mature B cell marker, is expressed in AML samples, and its presence correlates with the European LeukemiaNet (ELN) 2017 risk stratification. We repurpose the anti-lymphoma CD37CAR for the treatment of AML and show that CD37CAR T cells specifically kill AML cells, secrete proinflammatory cytokines, and control cancer progression in vivo. Importantly, CD37CAR T cells display no toxicity toward hematopoietic stem cells. Thus, CD37 is a promising and safe CAR T cell AML target.

• Katyayini, Niveditha Umesh; Rinne, Paivi L.H.; Tarkowská, Danuše; Strnad, Miroslav & Schoot, Christiaan van der (2020). Dual Role of Gibberellin in Perennial Shoot Branching: Inhibition and Activation. Frontiers in Plant Science. 11, p. 1–18. doi: 10.3389/fpls.2020.00736. Full text in Research Archive
• Katyayini, Niveditha Umesh; Rinne, Paivi L.H. & Schoot, Christiaan van der (2019). Strigolactone-Based Node-to-Bud Signaling May Restrain Shoot Branching in Hybrid Aspen. Plant and Cell Physiology. ISSN 0032-0781. 60(12), p. 2797–2811. doi: 10.1093/pcp/pcz170. Full text in Research Archive Show summary

  The biosynthesis and roles of strigolactones (SLs) have been investigated in herbaceous plants, but so far, their role in trees has received little attention. In this study, we analyzed the presence, spatial/temporal expression and role of SL pathway genes in Populus tremula × Populus tremuloides. In this proleptic species, axillary buds (AXBs) become para-dormant at the bud maturation point, providing an unambiguous starting point to study AXB activation. We identified previously undescribed Populus homologs of DWARF27 (D27), LATERAL BRANCHING OXIDOREDUCTASE (LBO) and DWARF53-like (D53-like) and analyzed the relative expression of all SL pathway genes in root tips and shoot tissues. We found that, although AXBs expressed MORE AXILLARY GROWTH1 (MAX1) and LBO, they did not express MAX3 and MAX4, whereas nodal bark expressed high levels of all SL biosynthesis genes. By contrast, expression of the SL perception and signaling genes MAX2, D14 and D53 was high in AXBs relative to nodal bark and roots. This suggests that AXBs are reliant on the associated nodes for the import of SLs and SL precursors. Activation of AXBs was initiated by decapitation and single-node isolation. This rapidly downregulated SL pathway genes downstream of MAX4, although later these genes were upregulated coincidently with primordia formation. GR24-feeding counteracted all activation-related changes in SL gene expression but did not prevent AXB outgrowth showing that SL is ineffective once AXBs are activated. The results indicate that nodes rather than roots supply SLs and its precursors to AXBs, and that SLs may restrain embryonic shoot elongation during AXB formation and para-dormancy in intact plants.

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• Katyayini, Niveditha Umesh; Rinne, Paivi L.H. & Schoot, Christiaan van der (2017). Branching out: The molecular regulation of stem-bud communication in Populus (Hybrid aspen). Full text in Research Archive

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