Pål Falnes

Image of Pål Falnes
Norwegian version of this page
Phone +47 22854840
Room 2112
Username
Visiting address Blindernveien 31 0371 Oslo
Postal address Postboks 1066 Blindern 0316 Oslo

Academic interests

The cellular macromolecules DNA, RNA and protein are subject to numerous modifications, including methylations and hydroxylations. Such modifications often have regulatory roles, such as the epigenetic modifications of DNA and chromatin proteins. My major research interest is to identify novel human enzymes involved in the introduction and removal of such modifications, and to address the biological significance of the respective modifications. Recently, I have been studying methyltransferases and hydroxylases involved in modifying tRNA and protein, and, also, demethylases responsible for removing deleterious methyl lesions from DNA. These studies typically involve both biochemical characterization of the modification enzymes, as well as analyses of the modifications in a cellular or organismal context.

Teaching

BIOS4010 (course responsibility)
BIOS5610 (shared course responsibility)

Scientific and educational background

1983 – 88        M. Sc. (Siv.ing.) in physical chemistry from the Norwegian University of Science and Technology, Trondheim
1990 – 1995    Ph.D. (Dr. Philos.) in medical biochemistry from UiO (Faculty of Medicine). Title of Ph.D. thesis: “Mutational Analysis of Diphtheria Toxin Entry into Cells”. Supervisor: Sjur Olsnes.
1996 -2000     Postdoc and research scientist, group of Sjur Olsnes, the Norwegian Radium Hospital, Oslo, Norway.  Studies of growth factors and bacterial toxins.
2000 – 2004    Research scientist, group of Erling Seeberg, National Hospital (Rikshospitalet), Oslo, Norway. Studies of the bacterial demethylase AlkB and its human homologues.
2004 –             Professor in biochemistry at the Department of (Molecular) Biosciences (IBV).

Collaborations

I have, in recent years, published articles with collaborators from the following institutions outside UiO:

National
Oslo University Hospital
Norwegian University of Science and Technology

International
University of Southern Denmark, Odense, Denmark
National Institutes of Health, Bethesda, MD, USA
Oregon State University, Corvallis, OR, USA
Tartu University, Estonia
Lodz Technical University, Poland
Thomas Jefferson University, Philadelphia, PA, USA

Honoraria

1997    Knut Sandtrø’s memorial award from the Norwegian Biochemical Society
2002    Price for best scientific article at the National Hospital of Norway
2007    The students' price for best lecturer at IMBV

Tags: Life sciences

Publications

  • Davydova, Erna; Shimazu, Tadahiro; Schuhmacher, Maren Kirstin; Jakobsson, Magnus E.; Willemen, Hanneke L.D.M. & Liu, Tongri [Show all 28 contributors for this article] (2021). The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature Communications. ISSN 2041-1723. 12:891, p. 1–14. doi: 10.1038/s41467-020-20670-7. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; O'Donohue, Marie-Francoise; Kim, Yeji; Jakobsson, Magnus; Gessa, Luca & Pinto, Rita [Show all 14 contributors for this article] (2021). Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function. Nucleic Acids Research (NAR). ISSN 0305-1048. doi: 10.1093/nar/gkab088. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; Willemen, Hanneke L.D.M.; Pinto, Rita; Ho, Angela Yeuan Yen; Moen, Anders & Eijkelkamp, Niels [Show all 7 contributors for this article] (2019). Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration . Journal of Biological Chemistry. ISSN 0021-9258. 294(31), p. 11654–11664. doi: 10.1074/jbc.RA119.009045.
  • Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P & O'Donohue, Marie-Francoise [Show all 16 contributors for this article] (2019). The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR). ISSN 0305-1048. 48(2), p. 830–846. doi: 10.1093/nar/gkz1147. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; Willemen, Hanneke L.D.M.; Pinto, Rita; Ho, Angela Yeuan Yen; Moen, Anders & Kjønstad, Ingrid Fadum [Show all 10 contributors for this article] (2018). Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase. Journal of Biological Chemistry. ISSN 0021-9258. 294(4), p. 1128–1141. doi: 10.1074/jbc.RA118.005473.
  • Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw & Falnes, Pål Øystein (2018). Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation. RNA Biology. ISSN 1547-6286. 15(3), p. 314–319. doi: 10.1080/15476286.2018.1440875.
  • Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Halabelian, Levon; Nilges, Benedikt S.; Pinto, Rita & Kudithipudi, Srikanth [Show all 14 contributors for this article] (2018). The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nature Communications. ISSN 2041-1723. 9:3411, p. 1–15. doi: 10.1038/s41467-018-05646-y. Full text in Research Archive
  • Willemen, Hanneke L.D.M.; Kavelaars, Annemieke; Prado, Judith; Maas, MIrjam; Versteeg, Sabine & Nellissen, Lara J.J. [Show all 16 contributors for this article] (2018). Identification of FAM173B as a protein methyltransferase promoting chronic pain. PLoS Biology. ISSN 1544-9173. 16(2). doi: 10.1371/journal.pbio.2003452.
  • Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild & Falnes, Pål (2017). Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. Journal of Biological Chemistry. ISSN 0021-9258. 292(43), p. 17950–17962. doi: 10.1074/jbc.M117.808451. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; Aileni, Vinay Kumar; Ho, Angela Yeuan Yen; Schwarz, Juliane; Moen, Anders & Sørensen, Vigdis [Show all 10 contributors for this article] (2017). The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Research (NAR). ISSN 0305-1048. 45(8), p. 4370–4389. doi: 10.1093/nar/gkx002.
  • Aileni, Vinay Kumar; Davydova, Erna; Moen, Anders & Falnes, Pål (2017). A System for Enzymatic Lysine Methylation in a Desired Sequence Context. ACS Omega. ISSN 2470-1343. 2(2), p. 462–469. doi: 10.1021/acsomega.6b00486. Full text in Research Archive
  • Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Nilges, Benedikt S.; Moen, Anders; Leidel, Sebastian A. & Falnes, Pål (2017). Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Research (NAR). ISSN 0305-1048. 45, p. 8239–8254. doi: 10.1093/nar/gkx432. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; Dahl, Helge-Andre; Moen, Anders; Davydova, Erna & Falnes, Pål (2016). The METTL20 homologue from agrobacterium tumefaciens is a dual specificity protein-lysine methyltransferase that targets ribosomal protein L7/L12 and the β subunit of electron transfer flavoprotein (ETFβ). Journal of Biological Chemistry. ISSN 0021-9258. 291(18), p. 9581–9595. doi: 10.1074/jbc.M115.709261.
  • Falnes, Pål; Jakobsson, Magnus; Davydova, Erna; Ho, Angela Yeuan Yen & Malecki, Jedrzej Mieczyslaw (2016). Protein lysine methylation by seven-β-strand methyltransferases. Biochemical Journal. ISSN 0264-6021. 473(14), p. 1995–2009. doi: 10.1042/BCJ20160117.
  • Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål & Klungland, Arne (2015). Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice. PLOS ONE. ISSN 1932-6203. 10(11). doi: 10.1371/journal.pone.0141472. Full text in Research Archive
  • Jakobsson, Magnus; Moen, Anders; Davidson, Ben & Falnes, Pål (2015). Hsp70 (HSPA1) lysine methylation status as a potential prognostic factor in metastatic high-grade serous carcinoma. PLOS ONE. ISSN 1932-6203. 10:e0140168(10). doi: 10.1371/journal.pone.0140168. Full text in Research Archive
  • Zdzalik, Daria; Domanska, Anna; Prorok, Paulina; Kosicki, Konrad; Van den Born, Erwin & Falnes, Pål [Show all 9 contributors for this article] (2015). Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair. ISSN 1568-7864. 30, p. 1–10. doi: 10.1016/j.dnarep.2015.02.021.
  • Jakobsson, Magnus; Davydova, Erna; Malecki, Jedrzej Mieczyslaw; Moen, Anders & Falnes, Pål (2015). Saccharomyces cerevisiae eukaryotic elongation factor 1A (eEF1A) is methylated at Lys-390 by a METTL21-like methyltransferase. PLOS ONE. ISSN 1932-6203. 10(6). doi: 10.1371/journal.pone.0131426. Full text in Research Archive
  • Malecki, Jedrzej Mieczyslaw; Ho, Angela Yeuan Yen; Moen, Anders; Dahl, Helge-Andre & Falnes, Pål (2015). Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. Journal of Biological Chemistry. ISSN 0021-9258. 290(1), p. 423–434. doi: 10.1074/jbc.M114.614115.
  • Davydova, Erna; Ho, Angela Yeuan Yen; Malecki, Jedrzej Mieczyslaw; Moen, Anders; Enserink, Jorrit & Jakobsson, Magnus [Show all 8 contributors for this article] (2014). Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). Journal of Biological Chemistry. ISSN 0021-9258. 289(44), p. 30499–30510. doi: 10.1074/jbc.M114.601658.
  • Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja & Maciejewska, Agnieszka M. [Show all 11 contributors for this article] (2014). Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE. ISSN 1932-6203. 9(6). doi: 10.1371/journal.pone.0098729. Full text in Research Archive
  • Jakobsson, Magnus; Moen, Anders; Bousset, Luc; Jacobsen, Wolfgang Mathias; Kernstock, Jens Stefan & Melki, Ronald [Show all 7 contributors for this article] (2013). Identification and characterization of a novel human methyltransferase modulating hsp70 Protein function through lysine methylation. Journal of Biological Chemistry. ISSN 0021-9258. 288(39), p. 27752–27763. doi: 10.1074/jbc.M113.483248.
  • Lin, Fu-Jung; Shen, Li; Jang, Chuan-Wei; Falnes, Pål & Zhang, Yi (2013). Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression. PLoS Genetics. ISSN 1553-7390. 9(5). doi: 10.1371/journal.pgen.1003516.
  • Kernstock, Jens Stefan; Davydova, Erna; Jakobsson, Magnus; Moen, Anders; Pettersen, Solveig & Mælandsmo, Gunhild [Show all 8 contributors for this article] (2012). Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nature Communications. ISSN 2041-1723. 3. doi: 10.1038/ncomms2041.
  • Korvald, Hanne; Falnes, Pål; Lærdahl, Jon Kristen; Bjørås, Magnar & Alseth, Ingrun (2012). The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity. DNA Repair. ISSN 1568-7864. 11(5), p. 453–462. doi: 10.1016/j.dnarep.2012.01.014.
  • Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés & Falnes, Pål (2012). Human ALKBH4 Interacts with Proteins Associated with Transcription. PLOS ONE. ISSN 1932-6203. 7(11). doi: 10.1371/journal.pone.0049045. Full text in Research Archive
  • Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne & Grini, Paul Eivind [Show all 7 contributors for this article] (2012). The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR). ISSN 0305-1048. 40(14), p. 6620–6631. doi: 10.1093/nar/gks327. Full text in Research Archive
  • Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar & Grini, Paul Eivind [Show all 8 contributors for this article] (2011). Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research (NAR). ISSN 0305-1048. 39(17), p. 7688–7701. doi: 10.1093/nar/gkr406. Full text in Research Archive
  • Bjørnstad, Linn; Zoppellaro, Giorgio; Tomter, Ane Berg; Falnes, Pål & Andersson, K. Kristoffer (2011). Spectroscopic and Magnetic Studies of wild-type and mutant forms of the FeII and 2-oxoglutarate dependent decarboxylase ALKBH4. Biochemical Journal. ISSN 0264-6021. 434(3), p. 391–398. doi: 10.1042/BJ20101667.
  • Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor & Leszczynska, G [Show all 11 contributors for this article] (2011). ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications. ISSN 2041-1723. 2. doi: 10.1038/ncomms1173. Full text in Research Archive
  • Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T & Krokan, Hans Einar [Show all 9 contributors for this article] (2010). Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology. ISSN 0270-7306. 30(7), p. 1814–1827. doi: 10.1128/MCB.01602-09.
  • Falnes, Pål; Van den Born, Erwin & Meza, Trine Johansen (2009). Demethylation of DNA and RNA by AlkB proteins. In Grosjean, Henri (Eds.), DNA and RNA modification enzymes. Landes Bioscience. ISSN 978-1-58706-329-9. p. 170–180.
  • Van den Born, Erwin; Bekkelund, Anders; Moen, Marivi; Omelchenko, M.V.; Klungland, Arne & Falnes, Pål (2009). Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria. Nucleic Acids Research (NAR). ISSN 0305-1048. 37(21). doi: 10.1093/nar/gkp774.
  • Ringvoll, Jeanette; Moen, Marivi N.; Nordstrand, Line M.; Meira, Lisiane B.; Pang, Bo & Bekkelund, Anders [Show all 11 contributors for this article] (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research. ISSN 0008-5472. 68(11), p. 4142–4149.
  • Van den Born, Erwin; Omelchenko, M.V.; Bekkelund, Anders; Leihne, VIbeke; Koonin, E. V. & Dolja, V.V. [Show all 7 contributors for this article] (2008). Viral AlkB proteins repair RNA damage by oxidative demethylation. Nucleic Acids Research (NAR). ISSN 0305-1048. 36(17), p. 5451–5461. doi: 10.1093/nar/gkn519.
  • Wærsted, Jeanette Ringvoll; Nabong, Marivi; Nordstrand, Line Mari; Meira, LB; Pang, B & Bekkelund, Anders [Show all 11 contributors for this article] (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research. ISSN 0008-5472. 68(11), p. 4142–4149. doi: 10.1158/0008-5472.CAN-08-0796.
  • Falnes, Pål; Klungland, Arne & Alseth, Ingrun (2007). Repair of methyl lesions in DNA and RNA by oxidative demethylation. Neuroscience. ISSN 0306-4522. 145. doi: 10.1016/j.neuroscience.2006.11.018.
  • Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB & Talstad, Vivi [Show all 15 contributors for this article] (2006). Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal. ISSN 0261-4189. 25, p. 2189–2198.
  • Falnes, Pål (2005). RNA repair - the latest addition to the toolbox for macromolecular maintenance. RNA Biology. ISSN 1547-6286. 2(1), p. 14–16.
  • Aamodt, Randi; Falnes, Pål; Johansen, RF; Seeberg, Erling Christen & Bjørås, Magnar (2004). The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N-6-ethenoadenine as preferred substrates. Journal of Biological Chemistry. ISSN 0021-9258. 279, p. 13601–13606.
  • Falnes, Pål (2004). Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Research (NAR). ISSN 0305-1048. 32(21), p. 6260–6267.
  • Ougland, Rune; Zhang, Chun-mei; Liiv, Aivar; Johansen, Rune F.; Seeberg, Erling Christen & Hou, Ya-ming [Show all 8 contributors for this article] (2004). AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Molecular Cell. ISSN 1097-2765. 16(1), p. 107–116.
  • Falnes, Pål; Bjoras, M; Bjørås, Magnar; Aas, PA; Sundheim, Ottar & Seeberg, E (2004). Substrate specificities of bacterial and human AlkB proteins. Nucleic Acids Research (NAR). ISSN 0305-1048. 30(11), p. 3456–3461.
  • Falnes, Pål & Rognes, Torbjørn (2003). DNA repair by bacterial AlkB proteins. Research in Microbiology. ISSN 0923-2508. 154, p. 0923–2508.
  • Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank & Akbari, Mansour [Show all 11 contributors for this article] (2003). Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. ISSN 0028-0836. 421, p. 859–863.
  • Falnes, Pål; Johansen, R. F. & Seeberg, Erling Christen (2002). AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature. ISSN 0028-0836. 419, p. 178–182.
  • Falnes, P.Ø.; Ariansen, Sarah Louise & Sandvig, Kirsten (2000). Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphteria toxin. Journal of Biological Chemistry. ISSN 0021-9258. 275, p. 4363–4368.
  • Falnes, P.Ø.; Ariansen, Sarah Louise; Sandvig, Kirsten & Olsnes, Sjur (2000). Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphteria toxin. Journal of Biological Chemistry. ISSN 0021-9258. 275, p. 4363–4368.
  • Falnes, P.Ø. & Sandvig, Kirsten (2000). Penetration of protein toxins into cells. Current Opinion in Cell Biology. ISSN 0955-0674. 12, p. 407–413.
  • Rapak, A.; Falnes, P.Ø. & Olsnes, Sjur (1997). Retrogade transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 94, p. 3783–3788.
  • Lanzrein, Markus; Falnes, P.Ø.; Sand, Olav & Olsnes, Sjur (1997). Structure-function relationship of the ion channel formed by diphtheria toxin in Vero cell membrane. Journal of Membrane Biology. ISSN 0022-2631. 156, p. 141–148.
  • Olsnes, Sjur; Klingenberg, Olav; Muños, R.; Rapak, A.; Falnes, P.Ø. & Wiedlocha, Antoni (1997). Toxins as transporting tools. In Aktories, K. (Eds.), Bacterial toxins. Chapman & Hall, Weinheim.. p. 273–294.
  • Falnes, Pål & Olsnes, Sjur (1996). Farnesylation of a CaaX-motif as a measure of translocation of an externally added protein to the cytosol. Zentrbl. Bact. suppl.. 28, p. 343–344.
  • Olsnes, Sjur; Klingenberg, Olav; Falnes, Pål; Valdizan, Elsa; Lanzrein, Markus & Wiedlocha, Antoni (1996). Translocation of diphtheria toxin across cellular membranes. Zentrbl. Bact. suppl.. 28, p. 154–160.

View all works in Cristin

  • Falnes, Pål Øystein (2020). Novel human methyltransferases - roles in mitochondrial respiration, protein synthesis and beyond.
  • Falnes, Pål Øystein (2019). Regulation of protein synthesis through methylation of human eukaryotic elongation factor 1 alpha (eEF1A) .
  • Falnes, Pål Øystein (2019). Identification and characterisation of novel human methyltransferases.
  • Falnes, Pål Øystein (2019). Modulation of human mitochondrial metabolism by novel lysine-specific methyltransferases .
  • Falnes, Pål Øystein (2019). "Nobelprisen i kjemi 2018" (om dirigert evolusjon).
  • Falnes, Pål Øystein (2018). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins .
  • Falnes, Pål Øystein (2018). Regulation of human eukaryotic elongation factor 1 alpha (eEF1A) by lysine methylation .
  • Falnes, Pål (2017). Identification and characterisation of lysine-specific methyltransferases in humans.
  • Jakobsson, Magnus; Moen, Anders & Falnes, Pål (2016). Correspondence: On the enzymology and significance of HSPA1 lysine methylation. Nature Communications. ISSN 2041-1723. 7. doi: 10.1038/ncomms11464.
  • Aileni, Vinay Kumar; Davydova, Erna; Kernstock, Jens Stefan; Moen, Anders & Falnes, Pål (2016). VCP-KMT (METTL21D)-mediated lysine methylation of histone H3 peptide sequences grafted onto a VCP-derived scaffold.
  • Falnes, Pål (2016). Metylering av DNA og proteiner - både skadelig og nødvendig.
  • Jakobsson, Magnus; Moen, Anders; Davidson, Ben & Falnes, Pål (2016). METTL21A-catalysed lysine methylation of Hsp70 proteins.
  • Falnes, Pål (2016). Lysine methylation of non-histone proteins - new enzymes, new functions.
  • Falnes, Pål (2015). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins.
  • Falnes, Pål (2015). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins .
  • Falnes, Pål & Ho, Angela Yeuan Yen (2015). Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA. In Schofield, Christopher J. & Hausinger, Robert (Ed.), 2-Oxoglutarate-Dependent Oxygenases. Royal Society of Chemistry. ISSN 978-1-84973-950-4. p. 275–288. doi: 10.1039/9781782621959-00275.
  • Falnes, Pål (2015). Metylering av DNA og proteiner– skadelig og nødvendig .
  • Falnes, Pål (2015). Merkelapper på DNA og proteiner – både skadelig og nødvendig.
  • Falnes, Pål (2014). Functional characterization of a novel family of protein lysine methyltransferases.
  • Falnes, Pål (2014). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins.
  • Falnes, Pål (2013). Role of the bifunctional ALKBH8 enzyme in the formation of modified wobble uridines in tRNA.
  • Falnes, Pål (2012). Merkelapper på DNA og proteiner –både skadelig og nødvendig.
  • Falnes, Pål (2012). Merkelapper på DNA og proteiner – både skadelig og nødvendig.
  • Bjørnstad, Linn; Zoppellaro, Giorgio; Tomter, Ane Berg; Falnes, Pål & Andersson, K. Kristoffer (2011). Spectroscopic and Magnetic Studies of wild-type and mutant forms of the FeII and 2-oxoglutarate dependent decarboxylase ALKBH4.
  • Meza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar & Arne, Klungland [Show all 8 contributors for this article] (2010). The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage.
  • Falnes, Pål (2009). AlkB-like dioxygenases - roles in nucleic acid repair and modification.
  • Falnes, Pål; Van den Born, Erwin; Leihne, VIbeke; Meza, Trine Johansen; Songe-Møller, Lene & Klungland, Arne (2009). AlkB-like dioxygenases-roles in nucleic acid repair and modification.
  • Falnes, Pål (2009). Oxidative demethylation of RNA by AlkB proteins.
  • Falnes, Pål (2008). "DNA and RNA repair by AlkB-mediated oxidative demethylation".
  • Falnes, Pål (2008). RNA repair by oxidative demethylation.
  • Falnes, Pål (2007). Oxidative demethylation of DNA, RNA, and proteins by AlkB-like enzymes.
  • Falnes, Pål (2007). DNA and RNA repair by human and bacterial AlkB proteins.
  • Falnes, Pål (2006). A novel mechanism for demethylation of DNA, RNA, and proteins.
  • Falnes, Pål (2006). Repair of methyl lesions in DNA and RNA by oxidative demetylation.
  • Falnes, Pål; Ougland, Rune; Bekkelund, Anders & Ulleland, Marius Andreas (2006). DNA and RNA repair by human and bacterial ALkB proteins.
  • Falnes, Pål (2005). AlkB proteins – in general and in Arabidopsis.
  • Ougland, Rune; Zhang, Chun-mei; Liiv, Aivar; Johansen, Rune F.; Seeberg, Erling & Hou, Ya-ming [Show all 8 contributors for this article] (2005). Functional recovery of chemically methylated mRNA and tRNA by AlkB-mediated repair.
  • Falnes, Pål (2004). Recovery of RNA function upon AlkB mediated repair of alkyl lesions.
  • Falnes, Pål (2004). Repair of alkylation damage in DNA and RNA.
  • Ougland, Rune; Zhang, Chun-mei; Liiv, Aivar; Johansen, Rune F.; Seeberg, Erling Christen & Remme, Jaanus [Show all 8 contributors for this article] (2004). AlkB mediated repair of methyl lesions in mRNA and tRNA is accompanied by functional recovery.
  • Falnes, Pål (2003). Repair of DNA and RNA by AlkB mediated oxidative demethylation.
  • Falnes, Pål (2003). Repair of alkylated DNA by oxidative demethylation.
  • Falnes, Pål (2003). Repair of both DNA and RNA by AlkB mediated oxidative demethylation.
  • Falnes, Pål; Johansen, Rune F. & Seeberg, Erling Christen (2003). A third mechanism for DNA damage reversal catalysed by AlkB protein in E. coli.
  • Eriksen, Stig; Falnes, Pål; Sandvik, K.; Olsnes, Sjur & Sand, Olav (1993). Diphteria toxin induces a cation-selective conductance increase and membrane depolarization in Vero cells. Acta Physiologica Scandinavica. ISSN 0001-6772. 140.

View all works in Cristin

Published Nov. 4, 2010 2:38 PM - Last modified Nov. 10, 2020 10:14 PM