Rafal Ciosk

Image of Rafal Ciosk
Norwegian version of this page
Phone +47 22859070
Room 2102B
Username
Visiting address Kristine Bonnevies hus Blindernvn. 31 Oslo
Postal address Postboks 1066 Blindern 0316 Oslo

Academic interests

I am interested in gene regulation, particularly post-transcriptional. Whether a specific mRNA is translated, repressed, or degraded, depends on its interactions with RNA-binding proteins and regulatory RNAs. My laboratory studies how these interactions determine mRNA fate and how posttranscriptional mechanisms control fundamental biological processes. Our main experimental models are the nematode Caenorhabditis elegans and mammalian cells, which we study using genetics, genomics, biochemistry, and cell biology.

Teaching

BIOS2910   Molecular biology (organizer)
MBV4030    Methods in cell biology (contributor)
MBV4010    Methods in molecular biology and biochemistry I (contributor)
BIOS3601   Genetics and developmental biology (contributor)

Higher education and appointments

2018-now   Professor, Department of Biosciences, University of Oslo
2020-now   Associate Investigator, Centre for Molecular Medicine Norway (Oslo)
2017-now   Associate Professor, Inst. of Bioorganic Chemistry (Poznan, Poland)
2012-2018  Senior group leader, Friedrich Miescher Institute (Basel, Switzerland)
2006-2012  Junior group leader, Friedrich Miescher Institute (Basel, Switzerland)
2000-2005  Postdoc, Fred Hutchinson Cancer Res. Center (Seattle, USA)
1998-1999  Postdoc, Inst. of Molecular Pathology (Vienna, Austria)
1995-1998  Ph.D. studies, Inst. of Molecular Pathology (Vienna, Austria)
1990-1995  M.Sc. studies, University of Szeged (Hungary)

Selected recent publications

Venz R, Pekec T, Katic I, Ciosk R, Ewald CY. (2021) End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologies. eLife 10: e71335.

Kumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, Pachulska-Wieczorek K, Bujnicki JM, Gut H, Großhans H, and Ciosk R.  (2018) Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nature Commun 9(1): 1549.

Fassnacht C, Tocchini C, Kumari P, Gaidatzis D, Stadler MB, and Ciosk R (2018). The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans. PLoS Genet 14(3): e1007252.

Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Ciosk R, and Großhans H (2017). LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms.  Mol Cell 65, 476-89.

Habacher C, Guo Y, Venz R, Kumari P, Neagu A, Gaidatzis D, Harvald E, Færgeman N, Gut H, and Ciosk R (2016). Ribonuclease-mediated control of body fat.  Dev Cell 39, 359-69.

Seelk S, Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, and Ciosk R (2016). Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprogramming of germ cells into neurons.  eLife 5: e15477.

Link to all publications

Published May 3, 2018 12:52 PM - Last modified Feb. 22, 2022 11:55 AM

Research groups