Academic interests
I am interested in gene regulation, particularly post-transcriptional. Whether a specific mRNA is translated, repressed, or degraded, depends on its interactions with RNA-binding proteins and regulatory RNAs. My laboratory studies how these interactions determine mRNA fate and how posttranscriptional mechanisms control fundamental biological processes. Our main experimental models are the nematode Caenorhabditis elegans and mammalian cells, which we study using genetics, genomics, biochemistry, and cell biology.
Teaching
BIOS2910 Molecular biology (course organizer)
BIOS4030 Laboratory methods in cell biology (contributor)
BIOS4010 Methods in molecular biology and biochemistry I (contributor)
BIOS3601 Genetics and developmental biology (contributor)
Higher education and appointments
2018- Professor, Department of Biosciences, University of Oslo
2006-18 Group Leader, Friedrich Miescher Institute (Basel, CH)
2000-05 Postdoc, Fred Hutchinson Cancer Res. Center (Seattle, US)
1998-99 Postdoc, Inst. of Molecular Pathology (Vienna, AT)
1995-98 Ph.D. studies, Inst. of Molecular Pathology (Vienna, AT)
1990-95 M.Sc. studies, University of Szeged (HU)
Other appointments
2021- Section Leader, Biochemistry and Molecular Biology, Department of Biosciences, UiO
2020- Associate Investigator, Centre for Molecular Medicine Norway
2017-22 Associate Professor, Inst. of Bioorganic Chemistry (Poznań, PL)
Selected recent publications
Kumari P, Thuestad LH, Ciosk R. (2023). Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71. Nucleic Acids Research 51(19):10668-10680, 10.1093/nar/gkad729
Pekec T, Lewandowski J, Komur AA, Sobańska D, Guo Y, Świtońska-Kurkowska K, Małecki JM, Dubey AA, Pokrzywa W, Frankowski M, Figiel M, Ciosk R. (2022). Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Nature Communications 13(1): 4883, 10.1038/s41467-022-32500-z
A popular article describing this research in English or Norwegian
Nucleic Acids Research 50(14): 8226-8239, 10.1093/nar/gkac609
The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1.10: e71335, 10.7554/eLife.71335
(2021) End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologies. eLifeKumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, Pachulska-Wieczorek K, Bujnicki JM, Gut H, Großhans H, Ciosk R. (2018) Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nature Communications 9(1): 1549, 10.1038/s41467-018-03920-7