I am interested in gene regulation, particularly post-transcriptional. Whether a specific mRNA is translated, repressed, or degraded, depends on its interactions with RNA-binding proteins and regulatory RNAs. My laboratory studies how these interactions determine mRNA fate and how posttranscriptional mechanisms control fundamental biological processes. Our main experimental models are the nematode Caenorhabditis elegans and mammalian cells, which we study using genetics, genomics, biochemistry, and cell biology.
Higher education and appointments
2018- Professor, Department of Biosciences, University of Oslo
2012-2018 Senior Group Leader, Friedrich Miescher Institute (Basel, CH)
2006-2012 Junior Group Leader, Friedrich Miescher Institute (Basel, CH)
2000-2005 Postdoc, Fred Hutchinson Cancer Res. Center (Seattle, US)
1998-1999 Postdoc, Inst. of Molecular Pathology (Vienna, AT)
1995-1998 Ph.D. studies, Inst. of Molecular Pathology (Vienna, AT)
1990-1995 M.Sc. studies, University of Szeged (HU)
2021- Section Leader, Biochem. & Mol. Biol., Dept. of Biosciences, UiO
2020- Associate Investigator, Centre for Molecular Medicine Norway
2017-2022 Associate Professor, Inst. of Bioorganic Chemistry (Poznań, PL)
Selected recent publications
Pekec T, Lewandowski J, Komur AA, Sobańska D, Guo Y, Świtońska-Kurkowska K, Małecki JM, Dubey AA, Pokrzywa W, Frankowski M, Figiel M, Ciosk R. (2022). Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Nature Commun 13(1): 4883.
A popular article describing this research in Norwegian
Nucleic Acids Res 50(14): 8226-8239.The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1.
10: e71335.(2021) End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologies. eLife
Kumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, Pachulska-Wieczorek K, Bujnicki JM, Gut H, Großhans H, Ciosk R. (2018) Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nature Commun 9(1): 1549.
Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Ciosk R, Großhans H. (2017). LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms. Mol Cell 65(3): 476-89.
Habacher C, Guo Y, Venz R, Kumari P, Neagu A, Gaidatzis D, Harvald E, Færgeman N, Gut H, Ciosk R. (2016). Ribonuclease-mediated control of body fat. Dev Cell 39(3): 359-69.
Seelk S, Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, Ciosk R. (2016). Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons. eLife 5: e15477.