Tuomo Mäki-Marttunen

Image of Tuomo Mäki-Marttunen
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Visiting address Blindernveien 31 0371 Oslo
Postal address Postboks 1066 Blindern 0316 Oslo

My main research interests are the cellular- and network-level mechanisms of heritable mental disorders. To study this question by means of computational modelling, I apply genetics data to the biophysically detailed models of single neurons or neuronal circuits, or to biochemically detailed models of subcellular compartments, such as synaptic spines. Currently, my main focus is on developing such computational models for the analysis of schizophrenia-associated phenotypes.

Publications

  • Mäki-Marttunen, Tuomo; Iannella, Nicolangelo Libero; Edwards, Andrew; Einevoll, Gaute & Blackwell, Kim T. (2020). A unified computational model for cortical post-synaptic plasticity. eLIFE.  ISSN 2050-084X.  9, s 1- 37 . doi: 10.7554/eLife.55714 Full text in Research Archive.
  • Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides; Beck, Dani; Richard, Geneviève; Sæther, Linn Sofie; Haatveit, Beathe Christin; Skaug, Knut-André; Nordvik, Jan Egil; Hatlestad-Hall, Christoffer; Einevoll, Gaute; Mäki-Marttunen, Tuomo; Westlye, Lars Tjelta; Jönsson, Erik Gunnar; Andreassen, Ole Andreas & Elvsåshagen, Torbjørn (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage.  ISSN 1053-8119. . doi: 10.1016/j.neuroimage.2020.117302 Full text in Research Archive.
  • Mäki-Marttunen, Tuomo; Devor, Anna; Phillips, William A; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. Frontiers in Computational Neuroscience.  ISSN 1662-5188.  13 . doi: 10.3389/fncom.2019.00066 Full text in Research Archive.
  • Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan; Westlye, Lars Tjelta; Linne, Marja-Leena; Rietschel, Marcella; Schubert, Dirk; Borgwardt, Stefan; Efrim-Budisteanu, Magdalena; Bettella, Francesco; Halnes, Geir; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Edwards, Andrew G.; Metzner, Christoph; Fyhn, Marianne; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.. Frontiers in Psychiatry.  ISSN 1664-0640.  10 . doi: 10.3389/fpsyt.2019.00534 Full text in Research Archive.
  • Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex.  ISSN 1047-3211.  29(2), s 875- 891 . doi: 10.1093/cercor/bhy291 Full text in Research Archive.
  • Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Wang, Yunpeng (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  ISSN 1552-4841.  177(4), s 454- 467 . doi: 10.1002/ajmg.b.32634
  • Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Metzner, Christoph; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2018). A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. Journal of Neuroscience Methods.  ISSN 0165-0270.  293, s 264- 283 . doi: 10.1016/j.jneumeth.2017.10.007 Full text in Research Archive.
  • Medan, Violeta; Mäki-Marttunen, Tuomo; Sztarker, Julieta & Preuss, Thomas (2018). Differential processing in modality-specific Mauthner cell dendrites. Journal of Physiology.  ISSN 0022-3751.  596(4), s 667- 689 . doi: 10.1113/JP274861
  • Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen; Fan, Chun Chieh; Schork, Andrew J.; Holland, Dominic; Thompson, Wesley Kurt; Witoelar, Aree; Chen, Chi-Hua; Desikan, Rahul S.; McEvoy, Linda K.; Djurovic, Srdjan; Greengard, Paul; Svenningsson, Per; Einevoll, Gaute & Dale, Anders (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry.  ISSN 1359-4184.  22(6), s 792- 801 . doi: 10.1038/mp.2017.33 Full text in Research Archive.
  • Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis. Journal of Neurophysiology.  ISSN 0022-3077.  118(1), s 114- 120 . doi: 10.1152/jn.00976.2016 Full text in Research Archive.
  • Mäki-Marttunen, Tuomo (2017). An Algorithm for Motif-Based Network Design. IEEE/ACM Transactions on Computational Biology & Bioinformatics.  ISSN 1545-5963.  14(5), s 1181- 1186 . doi: 10.1109/TCBB.2016.2576442
  • Mäki-Marttunen, Tuomo; Lines, Glenn Terje; Edwards, Andrew G; Tveito, Aslak; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational Psychiatry.  ISSN 2158-3188.  7(5) . doi: 10.1038/s41398-017-0007-4 Full text in Research Archive.
  • Tveito, Aslak; Jæger, Karoline Horgmo; Lines, Glenn Terje; Paszkowski, Lukasz; Sundnes, Joakim; Edwards, Andrew; Mäki-Marttunen, Tuomo; Halnes, Geir & Einevoll, Gaute (2017). An evaluation of the accuracy of classical models for computing the membrane potential and extracellular potential for neurons. Frontiers in Computational Neuroscience.  ISSN 1662-5188.  11 . doi: 10.3389/fncom.2017.00027 Full text in Research Archive.
  • Halnes, Geir; Mäki-Marttunen, Tuomo; Keller, Daniel; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue. PLoS Computational Biology.  ISSN 1553-734X.  12(11) . doi: 10.1371/journal.pcbi.1005193 Full text in Research Archive.
  • Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  1(1), s 49- 59 . doi: 10.1016/j.bpsc.2015.09.002 Show summary
  • Aćimović, Jugoslava; Mäki-Marttunen, Tuomo Mikael & Linne, Marja-Leena (2015). The effects of neuron morphology on graph theoretic measures of network connectivity: The analysis of a two-level statistical model. Frontiers in Neuroanatomy.  ISSN 1662-5129.  9:76(June) . doi: 10.3389/fnana.2015.00076

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  • Mäki-Marttunen, Tuomo; Edwards, Andrew G; Einevoll, Gaute & Blackwell, Kim T (2020). Biochemically detailed single compartmental model for neocortical postsynaptic long term plasticity.
  • Iannella, Nicolangelo Libero & Mäki-Marttunen, Tuomo (2019). Modelling intracellular cascades and neural plasticity.
  • Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
  • Mäki-Marttunen, Tuomo (2018). Lecture series on modelling of neuronal electrophysiology.
  • Mäki-Marttunen, Tuomo; Blackwell, Kim T & Edwards, Andrew G (2018). Unified biochemical model for long-term synaptic plasticity in the cortex – what are the essential pathways?.
  • Mäki-Marttunen, Tuomo; Edwards, Andrew G & Blackwell, Kim T (2018). Construction of a biochemically detailed single-compartment model for post-synaptic long-term potentiation: application to cortical plasticity..
  • Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute T. (2017). Extracellular diffusion can introduce errors in current source density estimates..
  • Halnes, Geir; Solbrå, Andreas Våvang; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas; Malthe-Sørensen, Anders & Einevoll, Gaute T. (2017). Modelling electrical and chemical dynamics in brain tissue.
  • Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Layer V pyramidal cells as mediators of delta oscillations: Insights from biophysically detailed modeling and connections with schizophrenia genetics..
  • Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Delta oscillations in schizophrenia: Insights from biophysically detailed modeling of networks of layer V pyramidal cells..
  • Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effects of ionic diffusion on power spectra of local field potentials (LFP).
  • Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas Henning; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2015). Can ionic diffusion have an effect on extracellular potentials?.
  • Mäki-Marttunen, Tuomo; Einevoll, Gaute & Andreassen, Ole Andreas (2015). Neural modeling for schizophrenia research. META : Magazine.  02
  • Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability.
  • Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked gens on single-neuron excitability.

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Published Oct. 2, 2020 11:28 AM - Last modified Dec. 1, 2020 10:41 AM