My main research interests are the cellular- and network-level mechanisms of heritable mental disorders. To study this question by means of computational modelling, I apply genetics data to the biophysically detailed models of single neurons or neuronal circuits, or to biochemically detailed models of subcellular compartments, such as synaptic spines. Currently, my main focus is on developing such computational models for the analysis of schizophrenia-associated phenotypes.
Tuomo Mäki-Marttunen
Researcher
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Section for Physiology and Cell Biology
Norwegian version of this page
Username
Visiting address
Blindernveien 31
0371 Oslo
Postal address
Postboks 1066 Blindern
0316 Oslo
Publications
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Mäki-Marttunen, Tuomo & Mäki-Marttunen, Verónica (2022). Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells. PLoS Computational Biology. ISSN 1553-734X. 18(9). doi: 10.1371/journal.pcbi.1010506. Full text in Research Archive
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Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan & Matziorinis, Anna Maria [Show all 24 contributors for this article] (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin. ISSN 0586-7614. 47(6), p. 1751–1760. doi: 10.1093/schbul/sbab049. Full text in Research Archive
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Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides & Beck, Dani [Show all 18 contributors for this article] (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117302. Full text in Research Archive
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Mäki-Marttunen, Tuomo; Iannella, Nicolangelo Libero; Edwards, Andrew; Einevoll, Gaute & Blackwell, Kim T. (2020). A unified computational model for cortical post-synaptic plasticity. eLIFE. ISSN 2050-084X. 9, p. 1–37. doi: 10.7554/eLife.55714. Full text in Research Archive
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Mäki-Marttunen, Tuomo; Devor, Anna; Phillips, William A; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. Frontiers in Computational Neuroscience. ISSN 1662-5188. 13. doi: 10.3389/fncom.2019.00066. Full text in Research Archive
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Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan & Westlye, Lars Tjelta [Show all 23 contributors for this article] (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10. doi: 10.3389/fpsyt.2019.00534. Full text in Research Archive
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Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig & Ness, Torbjørn V [Show all 16 contributors for this article] (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. ISSN 1047-3211. 29(2), p. 875–891. doi: 10.1093/cercor/bhy291. Full text in Research Archive
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Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J. & Bettella, Francesco [Show all 10 contributors for this article] (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 177(4), p. 454–467. doi: 10.1002/ajmg.b.32634.
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Medan, Violeta; Mäki-Marttunen, Tuomo; Sztarker, Julieta & Preuss, Thomas (2018). Differential processing in modality-specific Mauthner cell dendrites. Journal of Physiology. ISSN 0022-3751. 596(4), p. 667–689. doi: 10.1113/JP274861.
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Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Metzner, Christoph; Dale, Anders M. & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2018). A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. Journal of Neuroscience Methods. ISSN 0165-0270. 293, p. 264–283. doi: 10.1016/j.jneumeth.2017.10.007. Full text in Research Archive
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Mäki-Marttunen, Tuomo; Lines, Glenn Terje; Edwards, Andrew G; Tveito, Aslak; Dale, Anders M. & Einevoll, Gaute [Show all 7 contributors for this article] (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational Psychiatry. ISSN 2158-3188. 7(5). doi: 10.1038/s41398-017-0007-4. Full text in Research Archive
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Mäki-Marttunen, Tuomo (2017). An Algorithm for Motif-Based Network Design. IEEE/ACM Transactions on Computational Biology & Bioinformatics. ISSN 1545-5963. 14(5), p. 1181–1186. doi: 10.1109/TCBB.2016.2576442.
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Tveito, Aslak; Jæger, Karoline Horgmo; Lines, Glenn Terje; Paszkowski, Lukasz; Sundnes, Joakim & Edwards, Andrew [Show all 9 contributors for this article] (2017). An evaluation of the accuracy of classical models for computing the membrane potential and extracellular potential for neurons. Frontiers in Computational Neuroscience. ISSN 1662-5188. 11. doi: 10.3389/fncom.2017.00027. Full text in Research Archive
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Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis. Journal of Neurophysiology. ISSN 0022-3077. 118(1), p. 114–120. doi: 10.1152/jn.00976.2016. Full text in Research Archive
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Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen & Fan, Chun Chieh [Show all 18 contributors for this article] (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry. ISSN 1359-4184. 22(6), p. 792–801. doi: 10.1038/mp.2017.33. Full text in Research Archive
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Halnes, Geir; Mäki-Marttunen, Tuomo; Keller, Daniel; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue. PLoS Computational Biology. ISSN 1553-734X. 12(11). doi: 10.1371/journal.pcbi.1005193. Full text in Research Archive
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Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Show all 10 contributors for this article] (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 1(1), p. 49–59. doi: 10.1016/j.bpsc.2015.09.002. Show summary
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Aćimović, Jugoslava; Mäki-Marttunen, Tuomo Mikael & Linne, Marja-Leena (2015). The effects of neuron morphology on graph theoretic measures of network connectivity: The analysis of a two-level statistical model. Frontiers in Neuroanatomy. ISSN 1662-5129. 9:76(June). doi: 10.3389/fnana.2015.00076.
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Banono, Nancy Saana; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; van der Ent, Wietske; Kukula-Koch, Wirginia & Fyhn, Marianne [Show all 10 contributors for this article] (2023). Novel zebrafish model for studying neurodevelopment in Timothy syndrome.
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Banono, Nancy Saana; van der Ent, Wietske; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; Kukula-Koch, Wirginia & Einevoll, Gaute [Show all 9 contributors for this article] (2021). Functional characterisation of cacna1c mutations in zebrafish larvae.
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Mäki-Marttunen, Tuomo; Edwards, Andrew G; Einevoll, Gaute & Blackwell, Kim T (2020). Biochemically detailed single compartmental model for neocortical postsynaptic long term plasticity.
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Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
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Iannella, Nicolangelo Libero & Mäki-Marttunen, Tuomo (2019). Modelling intracellular cascades and neural plasticity.
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Mäki-Marttunen, Tuomo; Blackwell, Kim T & Edwards, Andrew G (2018). Unified biochemical model for long-term synaptic plasticity in the cortex – what are the essential pathways?
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Mäki-Marttunen, Tuomo; Edwards, Andrew G & Blackwell, Kim T (2018). Construction of a biochemically detailed single-compartment model for post-synaptic long-term potentiation: application to cortical plasticity.
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Mäki-Marttunen, Tuomo (2018). Lecture series on modelling of neuronal electrophysiology.
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Halnes, Geir; Solbrå, Andreas Våvang; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Malthe-Sørensen, Anders [Show all 7 contributors for this article] (2017). Modelling electrical and chemical dynamics in brain tissue.
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Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute T. (2017). Extracellular diffusion can introduce errors in current source density estimates.
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Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Metzner, Christoph; Devor, Anna & Djurovic, Srdjan [Show all 9 contributors for this article] (2017). Layer V pyramidal cells as mediators of delta oscillations: Insights from biophysically detailed modeling and connections with schizophrenia genetics.
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Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Moberget, Torgeir; Elvsåshagen, Torbjørn & Metzner, Christoph [Show all 11 contributors for this article] (2017). Delta oscillations in schizophrenia: Insights from biophysically detailed modeling of networks of layer V pyramidal cells.
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Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effects of ionic diffusion on power spectra of local field potentials (LFP).
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Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Show all 10 contributors for this article] (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked gens on single-neuron excitability.
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Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas Henning; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2015). Can ionic diffusion have an effect on extracellular potentials?
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Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Show all 10 contributors for this article] (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability.
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Mäki-Marttunen, Tuomo; Einevoll, Gaute & Andreassen, Ole Andreas (2015). Neural modeling for schizophrenia research. META : Magazine. 02.
Published
Oct. 2, 2020 11:28 AM
- Last modified
Dec. 1, 2020 10:41 AM