Tuomo Mäki-Marttunen

• Mäki-Marttunen, Tuomo & Mäki-Marttunen, Verónica (2022). Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells. PLoS Computational Biology. ISSN 1553-734X. 18(9). doi: 10.1371/journal.pcbi.1010506. Fulltekst i vitenarkiv
• Valstad, Mathias; Roelfs, Daniel; Slapø, Nora Berz; Timpe, Clara Marie Fides; Rai, Ahsan & Matziorinis, Anna Maria [Vis alle 24 forfattere av denne artikkelen] (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin. ISSN 0586-7614. 47(6), s. 1751–1760. doi: 10.1093/schbul/sbab049. Fulltekst i vitenarkiv
• Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides & Beck, Dani [Vis alle 18 forfattere av denne artikkelen] (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117302. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo; Iannella, Nicolangelo Libero; Edwards, Andrew; Einevoll, Gaute & Blackwell, Kim T. (2020). A unified computational model for cortical post-synaptic plasticity. eLIFE. ISSN 2050-084X. 9, s. 1–37. doi: 10.7554/eLife.55714. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo; Devor, Anna; Phillips, William A; Dale, Anders M.; Andreassen, Ole Andreas & Einevoll, Gaute (2019). Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology. Frontiers in Computational Neuroscience. ISSN 1662-5188. 13. doi: 10.3389/fncom.2019.00066. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan & Westlye, Lars Tjelta [Vis alle 23 forfattere av denne artikkelen] (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10. doi: 10.3389/fpsyt.2019.00534. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig & Ness, Torbjørn V [Vis alle 16 forfattere av denne artikkelen] (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. ISSN 1047-3211. 29(2), s. 875–891. doi: 10.1093/cercor/bhy291. Fulltekst i vitenarkiv
• Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J. & Bettella, Francesco [Vis alle 10 forfattere av denne artikkelen] (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 177(4), s. 454–467. doi: 10.1002/ajmg.b.32634.
• Medan, Violeta; Mäki-Marttunen, Tuomo; Sztarker, Julieta & Preuss, Thomas (2018). Differential processing in modality-specific Mauthner cell dendrites. Journal of Physiology. ISSN 0022-3751. 596(4), s. 667–689. doi: 10.1113/JP274861.
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Metzner, Christoph; Dale, Anders M. & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2018). A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. Journal of Neuroscience Methods. ISSN 0165-0270. 293, s. 264–283. doi: 10.1016/j.jneumeth.2017.10.007. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo; Lines, Glenn Terje; Edwards, Andrew G; Tveito, Aslak; Dale, Anders M. & Einevoll, Gaute [Vis alle 7 forfattere av denne artikkelen] (2017). Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Translational Psychiatry. ISSN 2158-3188. 7(5). doi: 10.1038/s41398-017-0007-4. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo (2017). An Algorithm for Motif-Based Network Design. IEEE/ACM Transactions on Computational Biology & Bioinformatics. ISSN 1545-5963. 14(5), s. 1181–1186. doi: 10.1109/TCBB.2016.2576442.
• Tveito, Aslak; Jæger, Karoline Horgmo; Lines, Glenn Terje; Paszkowski, Lukasz; Sundnes, Joakim & Edwards, Andrew [Vis alle 9 forfattere av denne artikkelen] (2017). An evaluation of the accuracy of classical models for computing the membrane potential and extracellular potential for neurons. Frontiers in Computational Neuroscience. ISSN 1662-5188. 11. doi: 10.3389/fncom.2017.00027. Fulltekst i vitenarkiv
• Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2017). Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis. Journal of Neurophysiology. ISSN 0022-3077. 118(1), s. 114–120. doi: 10.1152/jn.00976.2016. Fulltekst i vitenarkiv
• Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen & Fan, Chun Chieh [Vis alle 18 forfattere av denne artikkelen] (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry. ISSN 1359-4184. 22(6), s. 792–801. doi: 10.1038/mp.2017.33. Fulltekst i vitenarkiv
• Halnes, Geir; Mäki-Marttunen, Tuomo; Keller, Daniel; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue. PLoS Computational Biology. ISSN 1553-734X. 12(11). doi: 10.1371/journal.pcbi.1005193. Fulltekst i vitenarkiv
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Vis alle 10 forfattere av denne artikkelen] (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 1(1), s. 49–59. doi: 10.1016/j.bpsc.2015.09.002. Vis sammendrag

  BACKGROUND: Recent genome-wide association studies have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cells and identified possible common alterations in behavior across SCZ-related genes. METHODS: We applied a biophysically detailed multicompartmental model to study the excitability of a layer V pyramidal cell. We reviewed the literature on functional genomics for variants of genes associated with SCZ and used changes in neuron model parameters to represent the effects of these variants. RESULTS: We present and apply a framework for examining the effects of subtle single nucleotide polymorphisms in ion channel and calcium transporter-encoding genes on neuron excitability. Our analysis indicates that most of the considered SCZ-related genetic variants affect the spiking behavior and intracellular calcium dynamics resulting from summation of inputs across the dendritic tree. CONCLUSIONS: Our results suggest that alteration in the ability of a single neuron to integrate the inputs and scale its excitability may constitute a fundamental mechanistic contributor to mental disease, alongside the previously proposed deficits in synaptic communication and network behavior. Keywords: Biophysical modeling, Functional genomics, Genome-wide association studies, Layer V pyramidal cell, Neuron excitability, Schizophrenia

• Aćimović, Jugoslava; Mäki-Marttunen, Tuomo Mikael & Linne, Marja-Leena (2015). The effects of neuron morphology on graph theoretic measures of network connectivity: The analysis of a two-level statistical model. Frontiers in Neuroanatomy. ISSN 1662-5129. 9:76(June). doi: 10.3389/fnana.2015.00076.

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• Banono, Nancy Saana; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; van der Ent, Wietske; Kukula-Koch, Wirginia & Fyhn, Marianne [Vis alle 10 forfattere av denne artikkelen] (2023). Novel zebrafish model for studying neurodevelopment in Timothy syndrome.
• Banono, Nancy Saana; van der Ent, Wietske; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; Kukula-Koch, Wirginia & Einevoll, Gaute [Vis alle 9 forfattere av denne artikkelen] (2021). Functional characterisation of cacna1c mutations in zebrafish larvae.
• Mäki-Marttunen, Tuomo; Edwards, Andrew G; Einevoll, Gaute & Blackwell, Kim T (2020). Biochemically detailed single compartmental model for neocortical postsynaptic long term plasticity.
• Mäki-Marttunen, Tuomo; Einevoll, Gaute; Devor, Anna; Phillips, Wiliam; Dale, Anders M. & Andreassen, Ole Andreas (2019). A computational model of the spontaneous activity of gonadotropin-releasing cells in the teleos fish medaka.
• Iannella, Nicolangelo Libero & Mäki-Marttunen, Tuomo (2019). Modelling intracellular cascades and neural plasticity.
• Mäki-Marttunen, Tuomo; Blackwell, Kim T & Edwards, Andrew G (2018). Unified biochemical model for long-term synaptic plasticity in the cortex – what are the essential pathways?
• Mäki-Marttunen, Tuomo; Edwards, Andrew G & Blackwell, Kim T (2018). Construction of a biochemically detailed single-compartment model for post-synaptic long-term potentiation: application to cortical plasticity.
• Mäki-Marttunen, Tuomo (2018). Lecture series on modelling of neuronal electrophysiology.
• Halnes, Geir; Solbrå, Andreas Våvang; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Malthe-Sørensen, Anders [Vis alle 7 forfattere av denne artikkelen] (2017). Modelling electrical and chemical dynamics in brain tissue.
• Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Andreassen, Ole Andreas & Einevoll, Gaute T. (2017). Extracellular diffusion can introduce errors in current source density estimates.
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Metzner, Christoph; Devor, Anna & Djurovic, Srdjan [Vis alle 9 forfattere av denne artikkelen] (2017). Layer V pyramidal cells as mediators of delta oscillations: Insights from biophysically detailed modeling and connections with schizophrenia genetics.
• Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Moberget, Torgeir; Elvsåshagen, Torbjørn & Metzner, Christoph [Vis alle 11 forfattere av denne artikkelen] (2017). Delta oscillations in schizophrenia: Insights from biophysically detailed modeling of networks of layer V pyramidal cells.
• Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2016). Effects of ionic diffusion on power spectra of local field potentials (LFP).
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Vis alle 10 forfattere av denne artikkelen] (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked gens on single-neuron excitability.
• Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas Henning; Keller, Daniel; Andreassen, Ole Andreas & Einevoll, Gaute (2015). Can ionic diffusion have an effect on extracellular potentials?
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Vis alle 10 forfattere av denne artikkelen] (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability.
• Mäki-Marttunen, Tuomo; Einevoll, Gaute & Andreassen, Ole Andreas (2015). Neural modeling for schizophrenia research. META : Magazine. 02.

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