Yang Jin

Researcher

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Email yang.jin@ibv.uio.no

Phone +47-22857295

Room 3116

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Prostate enriched STAMP1 and STAMP2 belong to a family of six transmembrane proteins that share a conserved oxido-reductase domain. We have previously shown that both proteins are critical for prostate cancer cell growth and survival in vitro and in vivo, as well as being associated with prostate cancer progression. My work focuses on exploring the exact functions of STAMPs and the molecular mechanisms underlying their effects in prostate cancer cells.

Tags: Cell Signaling and Cancer

Zhang, Tingting; Zhao, Faming; Lin, Yahang; Liu, Mingsheng; Zhou, Hongqing & Cui, Fengzhen [Show all 9 contributors for this article] (2024). Integrated analysis of single-cell and bulk transcriptomics develops a robust neuroendocrine cell-intrinsic signature to predict prostate cancer progression. Theranostics. ISSN 1838-7640. 14(3), p. 1065–1080. doi: 10.7150/thno.92336.
Jin, Yang; Kozan, Darby; Anderson, Jennifer; Hensley, Monica; Shen, Meng-Chieh & Wen, Jia [Show all 10 contributors for this article] (2023). A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation. bioRxiv. ISSN 2692-8205. doi: 10.1101/2023.11.01.565134.
Sikkeland, Jørgen; Ng, Matthew; Nenseth, Hatice Zeynep; Ünal, Bilal; Qu, Su & Jin, Yang [Show all 8 contributors for this article] (2022). STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway. American Journal of Cancer Research. ISSN 2156-6976. 12(1), p. 327–336. Full text in Research Archive
Jin, Yixin; Lorvik, Kristina Berg; Jin, Yang; Beck, Carole; Sike, Adam & Persiconi, Irene [Show all 10 contributors for this article] (2022). Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer. Molecular Therapy Oncolytics. ISSN 2372-7705. 26, p. 189–206. doi: 10.1016/j.omto.2022.06.007.
Xiao, Rourou; You, Lixin; Zhang, Li; Guo, Xichen; Guo, Ensong & Zhao, Faming [Show all 29 contributors for this article] (2022). Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer. Advanced Science. ISSN 2198-3844. 9(21). doi: 10.1002/advs.202105469. Full text in Research Archive
Pällmann, Nora; Ke, Deng; Livgård, Marte; Tesikova, Martina; Jin, Yixin & Frengen, Nicolai Sebastian [Show all 18 contributors for this article] (2021). Stress-mediated reprogramming of prostate cancer one-carbon cycle drives disease progression. Cancer Research. ISSN 0008-5472. 81(15), p. 4066–4078. doi: 10.1158/0008-5472.CAN-20-3956. Full text in Research Archive
Cui, Fengzhen; Pan, Qingfei; Wang, Siyi; Zhao, Faming; Wang, Runxin & Zhang, Tingting [Show all 19 contributors for this article] (2021). Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring. Advanced Science. ISSN 2198-3844. 8, p. 1–16. doi: 10.1002/advs.202102686. Full text in Research Archive
Pihlstrøm, Nicklas; Jin, Yang; Nenseth, Hatice Zeynep; Kuzu, Omer Faruk & Saatcioglu, Fahri (2021). Stamp2 expression mediated by cytokines attenuates their growth-limiting effects in prostate cancer cells. Cancers. ISSN 2072-6694. 13(7). doi: 10.3390/cancers13071579. Full text in Research Archive
Liu, Ming-Sheng; Zhao, Hui; Xu, Chen-Xiang; Xie, Ping-Bo; Wang, Wei & Yang, Ying-Yu [Show all 9 contributors for this article] (2021). Clinical significance of EPHX2 deregulation in prostate cancer. Asian Journal of Andrology (AJA). ISSN 1008-682X. 23(1), p. 109–115. doi: 10.4103/aja.aja_34_20.
Zhang, Tingting; Li, Ningning; Sun, Chaoyang; Jin, Yang & Sheng, Xia (2020). MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? EMBO Molecular Medicine. ISSN 1757-4676. 12(5), p. 1–12. doi: 10.15252/emmm.201911845.
Jin, Yang & Saatcioglu, Fahri (2020). Targeting the unfolded protein response in hormone-regulated cancers. Trends in Cancer. ISSN 2405-8033. 6(2), p. 160–171. doi: 10.1016/j.trecan.2019.12.001.
Wang, Yu; Wang, Kai; Jin, Yang & Sheng, Xia (2019). Endoplasmic reticulum proteostasis control and gastric cancer. Cancer Letters. ISSN 0304-3835. 449, p. 263–271. doi: 10.1016/j.canlet.2019.01.034.
Pällmann, Nora; Livgård, Marte; Tesikova, Martina; Nenseth, Hatice Zeynep; Akkus, Erman & Sikkeland, Jørgen [Show all 20 contributors for this article] (2019). Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene. ISSN 0950-9232. 38, p. 6301–6318. doi: 10.1038/s41388-019-0879-2. Full text in Research Archive
Shi, Jihua; Guo, Wen-Zhi; Jin, Yang; Zhang, Hua-Peng; Pang, Chun & Li, Jie [Show all 8 contributors for this article] (2019). Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence. Cancer Medicine. ISSN 2045-7634. 8(3), p. 1269–1278. doi: 10.1002/cam4.2006. Full text in Research Archive
Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid & Simon, Lukas [Show all 16 contributors for this article] (2019). IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications. ISSN 2041-1723. 10:323, p. 1–12. doi: 10.1038/s41467-018-08152-3. Full text in Research Archive
Jalili, Mahsa; Jin, Yang; Bones, Atle M.; Olsen, Yngvar; Vadstein, Olav & Østensen, Mari-Ann [Show all 10 contributors for this article] (2019). Dietary fatty acid source has little effect on the development of the immune system in the pyloric caeca of Atlantic salmon fry. Scientific Reports. ISSN 2045-2322. 9(27), p. 1–16. doi: 10.1038/s41598-018-37266-3. Full text in Research Archive
Xu, Cheng; Wang, Yunfei; Tu, Qiu; Zhang, Zhiye; Chen, Mengrou & Mwangi, James [Show all 10 contributors for this article] (2018). Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation. Oncogene. ISSN 0950-9232. p. 1–13. doi: 10.1038/s41388-018-0556-x.
Jin, Yang; Nenseth, Hatice Zeynep & Saatcioglu, Fahri (2017). Role of PLZF as a tumor suppressor in prostate cancer. OncoTarget. ISSN 1949-2553. 8(41), p. 71317–71324. doi: 10.18632/oncotarget.19813.
Lindstad, Torstein; Qu, Su; Sikkeland, Jørgen; Jin, Yang; Kristian, Alexandr & Mælandsmo, Gunhild [Show all 8 contributors for this article] (2016). STAMP2 is required for human adipose-derived stem cell differentiation and adiposite-facilitated prostrate cancer grown in vivo. OncoTarget. ISSN 1949-2553. 8(54), p. 91817–91827. doi: 10.18632/oncotarget.11131.
Sikkeland, Jørgen; Sheng, Xia; Jin, Yang & Saatcioglu, Fahri (2016). STAMPing at the crossroads of normal physiology and disease states. Molecular and Cellular Endocrinology. ISSN 0303-7207. 425, p. 26–36. doi: 10.1016/j.mce.2016.02.013.
Cui, Xue-Yan; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip & Jin, Yang [Show all 11 contributors for this article] (2016). Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 14(2), p. 387–396. doi: 10.1111/jth.13206.
Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep & Zhao, Sen [Show all 15 contributors for this article] (2015). Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(6), p. 788–801. doi: 10.15252/emmm.201404509. Full text in Research Archive Show summary
The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As androgens regulate secretion and development of the normal prostate and drive prostate cancer (PCa) growth, they may affect UPR pathways. Here, we show that the canonical UPR pathways are directly and divergently regulated by androgens in PCa cells, through the androgen receptor (AR), which is critical for PCa survival. AR bound to gene regulatory sites and activated the IRE1α branch, but simultaneously inhibited PERK signaling. Inhibition of the IRE1α arm profoundly reduced PCa cell growth in vitro as well as tumor formation in preclinical models of PCa in vivo. Consistently, AR and UPR gene expression were correlated in human PCa, and spliced XBP‐1 expression was significantly upregulated in cancer compared with normal prostate. These data establish a genetic switch orchestrated by AR that divergently regulates the UPR pathways and suggest that targeting IRE1α signaling may have therapeutic utility in PCa.
Jin, Yang; Ling, Wang; Qu, Su; Sheng, Xia; Kristian, Alexandr & Mælandsmo, Gunhild [Show all 20 contributors for this article] (2015). STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(3), p. 315–331. doi: 10.15252/emmm.201404181. Full text in Research Archive
Sikkeland, Jørgen; Jin, Yang & Saatcioglu, Fahri (2014). Methods to assess lipid accumulation in cancer cells. Methods in Enzymology. ISSN 0076-6879. 542, p. 407–423. doi: 10.1016/B978-0-12-416618-9.00021-2.
Jin, Yang; Qu, Su; Tesikova, Martina; Ling, Wang; Kristian, Alexandr & Mælandsmo, Gunhild [Show all 19 contributors for this article] (2013). Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 110(28), p. E2572–E2581. doi: 10.1073/pnas.1304318110.
Lindstad, Torstein; Jin, Yang; Ling, Wang; Qu, Su & Saatcioglu, Fahri (2010). STAMPs at the Crossroads of Cancer and Nutrition. Nutrition and Cancer. ISSN 0163-5581. 62(7), p. 891–895. doi: 10.1080/01635581.2010.509836.
Ling, Wang; Jin, Yang; Arnoldussen, Yke Jildouw; Jonson, Ida; Qu, Su & Mælandsmo, Gunhild [Show all 11 contributors for this article] (2010). STAMP1 Is Both a Proliferative and an Antiapoptotic Factor in Prostate Cancer. Cancer Research. ISSN 0008-5472. 70(14), p. 5818–5828. doi: 10.1158/0008-5472.CAN-09-4697.

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Wei, Ji-Fu; Xu, Tian-Rui; Yu, Ming-Can; Zhou, Xing-Ding; Zhao, Zuo-Tao & Jin, Yang (2015). Protein drugs related to allergic reaction. BioMed Research International. ISSN 2314-6133. 2015. doi: 10.1155/2015/614048.

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Published Nov. 4, 2010 2:41 PM - Last modified Aug. 8, 2018 9:25 PM

Research groups

Cell signaling and cancer - Saatcioglu