Yang Jin

Forsker - Seksjon for biokjemi og molekylærbiologi

English version of this page

E-post yang.jin@ibv.uio.no

Brukernavn

Besøksadresse 0316 OSLO Blindernveien 31

Postadresse Postboks 1066 Blindern 0316 Oslo

Last ned visittkort

Project

Prostate enriched STAMP1 and STAMP2 belong to a family of six transmembrane proteins that share a conserved oxido-reductase domain. We have previously shown that both proteins are critical for prostate cancer cell growth and survival in vitro and in vivo, as well as being associated with prostate cancer progression. My work focuses on exploring the exact functions of STAMPs and the molecular mechanisms underlying their effects in prostate cancer cells.

Zhang, Tingting; Zhao, Faming; Lin, Yahang; Liu, Mingsheng; Zhou, Hongqing & Cui, Fengzhen [Vis alle 9 forfattere av denne artikkelen] (2024). Integrated analysis of single-cell and bulk transcriptomics develops a robust neuroendocrine cell-intrinsic signature to predict prostate cancer progression. Theranostics. ISSN 1838-7640. 14(3), s. 1065–1080. doi: 10.7150/thno.92336.
Jin, Yang; Kozan, Darby; Anderson, Jennifer; Hensley, Monica; Shen, Meng-Chieh & Wen, Jia [Vis alle 10 forfattere av denne artikkelen] (2023). A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation. bioRxiv. ISSN 2692-8205. doi: 10.1101/2023.11.01.565134.
Sikkeland, Jørgen; Ng, Matthew; Nenseth, Hatice Zeynep; Ünal, Bilal; Qu, Su & Jin, Yang [Vis alle 8 forfattere av denne artikkelen] (2022). STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway. American Journal of Cancer Research. ISSN 2156-6976. 12(1), s. 327–336. Fulltekst i vitenarkiv
Jin, Yixin; Lorvik, Kristina Berg; Jin, Yang; Beck, Carole; Sike, Adam & Persiconi, Irene [Vis alle 10 forfattere av denne artikkelen] (2022). Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer. Molecular Therapy Oncolytics. ISSN 2372-7705. 26, s. 189–206. doi: 10.1016/j.omto.2022.06.007.
Xiao, Rourou; You, Lixin; Zhang, Li; Guo, Xichen; Guo, Ensong & Zhao, Faming [Vis alle 29 forfattere av denne artikkelen] (2022). Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer. Advanced Science. ISSN 2198-3844. 9(21). doi: 10.1002/advs.202105469. Fulltekst i vitenarkiv
Pällmann, Nora; Ke, Deng; Livgård, Marte; Tesikova, Martina; Jin, Yixin & Frengen, Nicolai Sebastian [Vis alle 18 forfattere av denne artikkelen] (2021). Stress-mediated reprogramming of prostate cancer one-carbon cycle drives disease progression. Cancer Research. ISSN 0008-5472. 81(15), s. 4066–4078. doi: 10.1158/0008-5472.CAN-20-3956. Fulltekst i vitenarkiv
Cui, Fengzhen; Pan, Qingfei; Wang, Siyi; Zhao, Faming; Wang, Runxin & Zhang, Tingting [Vis alle 19 forfattere av denne artikkelen] (2021). Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring. Advanced Science. ISSN 2198-3844. 8, s. 1–16. doi: 10.1002/advs.202102686. Fulltekst i vitenarkiv
Pihlstrøm, Nicklas; Jin, Yang; Nenseth, Hatice Zeynep; Kuzu, Omer Faruk & Saatcioglu, Fahri (2021). Stamp2 expression mediated by cytokines attenuates their growth-limiting effects in prostate cancer cells. Cancers. ISSN 2072-6694. 13(7). doi: 10.3390/cancers13071579. Fulltekst i vitenarkiv
Liu, Ming-Sheng; Zhao, Hui; Xu, Chen-Xiang; Xie, Ping-Bo; Wang, Wei & Yang, Ying-Yu [Vis alle 9 forfattere av denne artikkelen] (2021). Clinical significance of EPHX2 deregulation in prostate cancer. Asian Journal of Andrology (AJA). ISSN 1008-682X. 23(1), s. 109–115. doi: 10.4103/aja.aja_34_20.
Zhang, Tingting; Li, Ningning; Sun, Chaoyang; Jin, Yang & Sheng, Xia (2020). MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? EMBO Molecular Medicine. ISSN 1757-4676. 12(5), s. 1–12. doi: 10.15252/emmm.201911845.
Jin, Yang & Saatcioglu, Fahri (2020). Targeting the unfolded protein response in hormone-regulated cancers. Trends in Cancer. ISSN 2405-8033. 6(2), s. 160–171. doi: 10.1016/j.trecan.2019.12.001.
Wang, Yu; Wang, Kai; Jin, Yang & Sheng, Xia (2019). Endoplasmic reticulum proteostasis control and gastric cancer. Cancer Letters. ISSN 0304-3835. 449, s. 263–271. doi: 10.1016/j.canlet.2019.01.034.
Pällmann, Nora; Livgård, Marte; Tesikova, Martina; Nenseth, Hatice Zeynep; Akkus, Erman & Sikkeland, Jørgen [Vis alle 20 forfattere av denne artikkelen] (2019). Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene. ISSN 0950-9232. 38, s. 6301–6318. doi: 10.1038/s41388-019-0879-2. Fulltekst i vitenarkiv
Shi, Jihua; Guo, Wen-Zhi; Jin, Yang; Zhang, Hua-Peng; Pang, Chun & Li, Jie [Vis alle 8 forfattere av denne artikkelen] (2019). Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence. Cancer Medicine. ISSN 2045-7634. 8(3), s. 1269–1278. doi: 10.1002/cam4.2006. Fulltekst i vitenarkiv
Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid & Simon, Lukas [Vis alle 16 forfattere av denne artikkelen] (2019). IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications. ISSN 2041-1723. 10:323, s. 1–12. doi: 10.1038/s41467-018-08152-3. Fulltekst i vitenarkiv
Jalili, Mahsa; Jin, Yang; Bones, Atle M.; Olsen, Yngvar; Vadstein, Olav & Østensen, Mari-Ann [Vis alle 10 forfattere av denne artikkelen] (2019). Dietary fatty acid source has little effect on the development of the immune system in the pyloric caeca of Atlantic salmon fry. Scientific Reports. ISSN 2045-2322. 9(27), s. 1–16. doi: 10.1038/s41598-018-37266-3. Fulltekst i vitenarkiv
Xu, Cheng; Wang, Yunfei; Tu, Qiu; Zhang, Zhiye; Chen, Mengrou & Mwangi, James [Vis alle 10 forfattere av denne artikkelen] (2018). Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation. Oncogene. ISSN 0950-9232. s. 1–13. doi: 10.1038/s41388-018-0556-x.
Jin, Yang; Nenseth, Hatice Zeynep & Saatcioglu, Fahri (2017). Role of PLZF as a tumor suppressor in prostate cancer. OncoTarget. ISSN 1949-2553. 8(41), s. 71317–71324. doi: 10.18632/oncotarget.19813.
Lindstad, Torstein; Qu, Su; Sikkeland, Jørgen; Jin, Yang; Kristian, Alexandr & Mælandsmo, Gunhild [Vis alle 8 forfattere av denne artikkelen] (2016). STAMP2 is required for human adipose-derived stem cell differentiation and adiposite-facilitated prostrate cancer grown in vivo. OncoTarget. ISSN 1949-2553. 8(54), s. 91817–91827. doi: 10.18632/oncotarget.11131.
Sikkeland, Jørgen; Sheng, Xia; Jin, Yang & Saatcioglu, Fahri (2016). STAMPing at the crossroads of normal physiology and disease states. Molecular and Cellular Endocrinology. ISSN 0303-7207. 425, s. 26–36. doi: 10.1016/j.mce.2016.02.013.
Cui, Xue-Yan; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip & Jin, Yang [Vis alle 11 forfattere av denne artikkelen] (2016). Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 14(2), s. 387–396. doi: 10.1111/jth.13206.
Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep & Zhao, Sen [Vis alle 15 forfattere av denne artikkelen] (2015). Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(6), s. 788–801. doi: 10.15252/emmm.201404509. Fulltekst i vitenarkiv Vis sammendrag
The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As androgens regulate secretion and development of the normal prostate and drive prostate cancer (PCa) growth, they may affect UPR pathways. Here, we show that the canonical UPR pathways are directly and divergently regulated by androgens in PCa cells, through the androgen receptor (AR), which is critical for PCa survival. AR bound to gene regulatory sites and activated the IRE1α branch, but simultaneously inhibited PERK signaling. Inhibition of the IRE1α arm profoundly reduced PCa cell growth in vitro as well as tumor formation in preclinical models of PCa in vivo. Consistently, AR and UPR gene expression were correlated in human PCa, and spliced XBP‐1 expression was significantly upregulated in cancer compared with normal prostate. These data establish a genetic switch orchestrated by AR that divergently regulates the UPR pathways and suggest that targeting IRE1α signaling may have therapeutic utility in PCa.
Jin, Yang; Ling, Wang; Qu, Su; Sheng, Xia; Kristian, Alexandr & Mælandsmo, Gunhild [Vis alle 20 forfattere av denne artikkelen] (2015). STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(3), s. 315–331. doi: 10.15252/emmm.201404181. Fulltekst i vitenarkiv
Sikkeland, Jørgen; Jin, Yang & Saatcioglu, Fahri (2014). Methods to assess lipid accumulation in cancer cells. Methods in Enzymology. ISSN 0076-6879. 542, s. 407–423. doi: 10.1016/B978-0-12-416618-9.00021-2.
Jin, Yang; Qu, Su; Tesikova, Martina; Ling, Wang; Kristian, Alexandr & Mælandsmo, Gunhild [Vis alle 19 forfattere av denne artikkelen] (2013). Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 110(28), s. E2572–E2581. doi: 10.1073/pnas.1304318110.
Lindstad, Torstein; Jin, Yang; Ling, Wang; Qu, Su & Saatcioglu, Fahri (2010). STAMPs at the Crossroads of Cancer and Nutrition. Nutrition and Cancer. ISSN 0163-5581. 62(7), s. 891–895. doi: 10.1080/01635581.2010.509836.
Ling, Wang; Jin, Yang; Arnoldussen, Yke Jildouw; Jonson, Ida; Qu, Su & Mælandsmo, Gunhild [Vis alle 11 forfattere av denne artikkelen] (2010). STAMP1 Is Both a Proliferative and an Antiapoptotic Factor in Prostate Cancer. Cancer Research. ISSN 0008-5472. 70(14), s. 5818–5828. doi: 10.1158/0008-5472.CAN-09-4697.

Se alle arbeider i Cristin

Wei, Ji-Fu; Xu, Tian-Rui; Yu, Ming-Can; Zhou, Xing-Ding; Zhao, Zuo-Tao & Jin, Yang (2015). Protein drugs related to allergic reaction. BioMed Research International. ISSN 2314-6133. 2015. doi: 10.1155/2015/614048.

Se alle arbeider i Cristin

Publisert 4. nov. 2010 14:41 - Sist endret 7. juni 2016 15:33

Forskergrupper

Saatcioglu group