Linda Hofstad Haugen

• Guadagno, Noemi Antonella; Margiotta, Azzurra; Bjørnestad, Synne Arstad; Haugen, Linda Hofstad; Kjos, Ingrid; Xiaochun, Xu; Hu, Xian; Bakke, Oddmund; Margadant, Felix Martin & Progida, Cinzia (2020). Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum. Journal of Cell Biology.  ISSN 0021-9525.  219(7), s 1- 23 . doi: 10.1083/JCB.201809020 Full text in Research Archive. Show summary

  The members of the Rab family of small GTPases are molecular switches that regulate distinct steps in different membrane traffic pathways. In addition to this canonical function, Rabs can play a role in other processes, such as cell adhesion and motility. Here, we reveal the role of the small GTPase Rab18 as a positive regulator of directional migration in chemotaxis, and the underlying mechanism. We show that knockdown of Rab18 reduces the size of focal adhesions (FAs) and influences their dynamics. Furthermore, we found that Rab18, by directly interacting with the endoplasmic reticulum (ER)-resident protein kinectin-1, controls the anterograde kinesin-1–dependent transport of the ER required for the maturation of nascent FAs and protrusion orientation toward a chemoattractant. Altogether, our data support a model in which Rab18 regulates kinectin-1 transport toward the cell surface to form ER–FA contacts, thus promoting FA growth and cell migration during chemotaxis

• Mousavi, Seyed Ali; Skjeldal, Frode Miltzow; Fønhus, Marita Sporstøl; Haugen, Linda Hofstad; Eskild, Winnie; Berg, Trond & Bakke, Oddmund (2019). Receptor-mediated endocytosis of VEGF-A in rat liver sinusoidal endothelial cells. BioMed Research International.  ISSN 2314-6133.  2019, s 1- 12 . doi: 10.1155/2019/5496197 Full text in Research Archive.
• Distefano, Marita Borg; Haugen, Linda Hofstad; Wang, Yan; Perdreau-Dahl, Harmonie; Kjos, Ingrid; Jia, Da; Morth, Jens Preben; Neefjes, Jacques; Bakke, Oddmund & Progida, Cinzia (2018). TBC1D5 controls the GTPase cycle of Rab7b. Journal of Cell Science.  ISSN 0021-9533.  131(17), s 1- 13 . doi: 10.1242/jcs.216630 Full text in Research Archive.
• Dukic, Aleksandra; Haugen, Linda Hofstad; Pidoux, Guillaume; Leithe, Edward; Bakke, Oddmund & Tasken, Kjetil (2017). A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cellular Signalling.  ISSN 0898-6568.  32, s 1- 11 . doi: 10.1016/j.cellsig.2017.01.008 Full text in Research Archive.
• Haugen, Linda Hofstad; Skjeldal, Frode Miltzow; Bergeland, Trygve & Bakke, Oddmund (2017). Endosomal binding kinetics of Eps15 and Hrs specifically regulate the degradation of RTKs. Scientific Reports.  ISSN 2045-2322.  7:17962, s 1- 13 . doi: 10.1038/s41598-017-17320-2 Full text in Research Archive.
• Bergeland, Trygve; Haugen, Linda; Landsverk, Ole J.B.; Stenmark, Harald & Bakke, Oddmund (2008). Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1. EMBO Reports.  ISSN 1469-221X.  9(2), s 171- 178 . doi: 10.1038/sj.embor.7401152

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