Disputation: Tonje Sønstevold
PhD candidate Tonje Sønstevold at the Department of Biosciences will be defending the thesis "Implications of poly(alkyl cyanoacrylate) nanoparticle- induced cellular stress responses with focus on autophagy" for the degree of PhD.
Tonje Sønstevold. Photo: UiO.
The disputation will be live streamed using Zoom. The host of the session will moderate the technicalities while the chair of the defence will moderate the disputation.
Ex auditorio questions: The chair of the defence will invite the audience to ask ex auditorio questions either written or oral. This can be requested by clicking "Participants" followed by clicking "Raise hand".
The meeting opens for participation just before 2.00 PM, and closes for new participants approximately 15 minutes after the defense has begun.
"Nanoparticles in precision medicine: Current knowledge and future perspectives"
Main research findings
Nanoparticles are small particles in the nanometer size range, undetectable by the human eye. Nowadays nanoparticles are investigated as carriers of therapeutic drugs to increase treatment effect and minimize side effects for the patient. However, material properties change as the size approaches the nanoscale, and we know little about how these nanoscale materials interact with biological systems. Therefore, we have compared the cellular impact of three highly similar polymer nanoparticles differing only in their chemical side chain; PBCA (butyl), PEBCA (ethylbutyl) and POCA (octyl).
In our work we showed that even these subtle variations in the chemical structure of nanoparticles led to profound differences in how the cells responded. Our findings emphasize how the specific nanoparticle composition can dictate the outcome of the nanoparticle-cell interaction having consequences for cell toxicity and mechanism of cell death. By elucidating the molecular mechanisms whereby nanoparticles induce stress, one can better exploit the mechanisms to predict possible toxicities for the patient and fine-tune the treatment effect.