Disputation: Katharina Vestre

PhD candidate Katharina Vestre at the Department of Biosciences will be defending the thesis "Regulation of cell migration and division by Rab GTPases" for the degree of PhD.

Profile picture of Katharina Vestre

Katharina Vestre. Photo: Emil Vestre

The trial lecture is: "Origin of ameboid migration in the immune system".

Time and place: September 26, 2022 10:15 AM, Gamle festsal(Urbygningen), Domus Academica

Main research findings

In my PhD project, I studied the functions of three different proteins of the Rab family. The Rab proteins are most known for regulating the transport between the different organelles within the cell, but increasing evidence demonstrate that they also take part in several other processes. We found a novel role for one of these Rab proteins in regulating cell migration and cancer spread. In addition, we discovered that another member of the Rab family has a specialized function in dendritic cells, which are part of the immune system. Dendritic cells find and present foreign substances to other immune cells to initiate an immune response. To do this, dendritic cells need to move efficiently to the lymph nodes, and we found that Rab7b plays an important role in regulating this process. Finally, we found that a Rab protein influences the last steps of cell division. Altogether, the work of this thesis sheds new light on the many and diverse roles of Rab proteins. Ultimately, we can use this knowledge to improve the treatment of different diseases.

Candidate contact information 



Adjudication committee

Professor J. Paul Luzio, University of Cambridge

Dr. Pablo Vargas, Institut Necker Enfants-Malades

Dr. Sandra Lopez Aviles, University of Oslo

Chair of defence

Professor Kristian Prydz, University of Oslo


Professor Cinzia Anita Maria Progida, University of Oslo

Professor emeritus Oddmund Bakke, University of Oslo

Published Sep. 12, 2022 9:53 AM - Last modified Sep. 12, 2022 11:18 AM