Our group is interested in tumor-host biology and cellular mechanisms of cancer progression. As model systems we use the animal models; Drosophila melanogaster and human organoid-like cell culture. I will discuss recent findings uncovering tumor microenvironment support of tumor growth and invasion through autophagy.
Relevant litterature:
Microenvironmental autophagy promotes tumour growth. Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE. Nature. 2017 Jan 19
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Nature. 2016 Aug
Visit Tor Erik Rustens webpage here.
An overview summarizing recent key findings. Illustration by T. E. Rusten.