Catherine Anne Heyward

• Yang, Yang; Pullisaar, Helen; Landin, Maria Augusta Dos S Silva; Heyward, Catherine Anne; Schröder, Maria & Geng, Tianxiang [Vis alle 8 forfattere av denne artikkelen] (2021). FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts. Archives of Oral Biology. ISSN 0003-9969. doi: 10.1016/j.archoralbio.2021.105061. Fulltekst i vitenarkiv
• Rahmati, Maryam; Silva, Eduardo A.; Reseland, Janne Elin; Heyward, Catherine Anne & Haugen, Håvard Jostein (2020). Biological responses to physicochemical properties of biomaterial surface. Chemical Society Reviews. ISSN 0306-0012. 49(15), s. 5178–5224. doi: 10.1039/d0cs00103a. Fulltekst i vitenarkiv
• Ganan, Monica; Lorentzen, Silje Benedicte; Agger, Jane Wittrup; Heyward, Catherine Anne; Bakke, Oddmund & Knutsen, Svein Halvor [Vis alle 10 forfattere av denne artikkelen] (2019). Antifungal activity of well-defined chitooligosaccharide preparations against medically relevant yeasts. PLOS ONE. ISSN 1932-6203. 14(1). doi: 10.1371/journal.pone.0210208. Fulltekst i vitenarkiv Vis sammendrag

  Due to their antifungal activity, chitosan and its derivatives have potential to be used for treating yeast infections in humans. However, to be considered for use in human medicine, it is necessary to control and know the chemical composition of the compound, which is not always the case for polymeric chitosans. Here, we analyze the antifungal activity of a soluble and well-defined chito-oligosaccharide (CHOS) with an average polymerization degree (DPn) of 32 and fraction of acetylation (FA) of 0.15 (C32) on 52 medically relevant yeast strains. Minimal inhibitory concentrations (MIC) varied widely among yeast species, strains and isolates (from > 5000 to < 9.77 μg mL-1) and inhibition patterns showed a time- and dose-dependencies. The antifungal activity was predominantly fungicidal and was inversely proportional to the pH, being maximal at pH 4.5, the lowest tested pH. Furthermore, antifungal effects of CHOS fractions with varying average molecular weight indicated that those fractions with an intermediate degree of polymerization, i.e. DP 31 and 54, had the strongest inhibitory effects. Confocal imaging showed that C32 adsorbs to the cell surface, with subsequent cell disruption and accumulation of C32 in the cytoplasm. Thus, C32 has potential to be used as a therapy for fungal infections.

• Stakkestad, Øystein; Heyward, Catherine Anne; Lyngstadaas, Ståle Petter; Medin, Tirill; Vondrasek, Jiri & Lian, Aina-Mari [Vis alle 8 forfattere av denne artikkelen] (2018). An ameloblastin C-terminus variant is present in human adipose tissue. Heliyon. ISSN 2405-8440. 4(12). doi: 10.1016/j.heliyon.2018.e01075. Fulltekst i vitenarkiv
• Chahal, Aman Singh; Schweikle, Manuel; Heyward, Catherine Anne & Tiainen, Hanna (2018). Attachment and spatial organisation of human mesenchymal stem cells on poly(ethylene glycol) hydrogels. Journal of The Mechanical Behavior of Biomedical Materials. ISSN 1751-6161. 84, s. 46–53. doi: 10.1016/j.jmbbm.2018.04.025. Fulltekst i vitenarkiv

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