Jo Christiansen Bruusgaard

Bilde av Jo Christiansen Bruusgaard
English version of this page
Telefon +47 22859062
Rom 2613
Brukernavn
Besøksadresse Blindernveien 31 0371 Oslo
Postadresse Postboks 1066 Blindern 0316 Oslo

Prosjekter

Muscle Nuclei

Injection of fluorescent oligonucleopides in muscle cells.

I work as a researcher at Kristian Gundersen's lab. My research interests revolve around the cytoarchitecture of the skeletal muscle cells, and how it changes under various conditions like training, denervation and pharmaceutical interventions. I work mainly in vivo, using confocal imaging to investigate the organisation of the various organelles with special emphasis on the dynamics of the cell's nuclei.

 

Publikasjoner

  • Hansson, Kenth-Arne; Eftestøl, Einar; Bruusgaard, Jo C.; Juvkam, Inga; Cramer, Alyssa W. & Malthe-Sørenssen, Anders [Vis alle 8 forfattere av denne artikkelen] (2020). Myonuclear content regulates cell size with similar scaling properties in mice and humans. Nature Communications. ISSN 2041-1723. 11(1). doi: 10.1038/s41467-020-20057-8. Fulltekst i vitenarkiv
  • Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Gundersen, Kristian & Bruusgaard, Jo C. (2020). Computational assessment of transport distances in living skeletal muscle fibers studied in situ. Biophysical Journal. ISSN 0006-3495. 119(11), s. 2166–2178. doi: 10.1016/j.bpj.2020.10.016.
  • Psilander, Niklas; Eftestøl, Einar; Cumming, Kristoffer Toldnes; Solgård, Inga Juvkam; Ekblom, Maria M. & Sunding, Kerstin [Vis alle 12 forfattere av denne artikkelen] (2019). Effects of training, detraining, and retraining on strength, hypertrophy, and myonuclear number in human skeletal muscle. Journal of applied physiology. ISSN 8750-7587. 126(6), s. 1636–1645. doi: 10.1152/japplphysiol.00917.2018. Fulltekst i vitenarkiv
  • Gundersen, Kristian; Bruusgaard, Jo C.; Egner, Ingrid Marie; Eftestøl, Einar & Bengtsen, Mads (2018). Muscle memory: virtues of your youth? Journal of Physiology. ISSN 0022-3751. 596(18), s. 4289–4290. doi: 10.1113/JP276354.
  • Winje, Ivan; Sheng, Xia; Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Tennøe, Simen & Saatcioglu, Fahri [Vis alle 8 forfattere av denne artikkelen] (2018). Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice. Acta Physiologica. ISSN 1748-1708. s. 1–9. doi: 10.1111/apha.13204.
  • Bakke, Marit Jørgensen; Agusti-Ridaura, Celia; Bruusgaard, Jo C.; Meenakshi Sundaram, Arvind Yegambaram & Horsberg, Tor Einar (2018). Deltamethrin resistance in the salmon louse, Lepeophtheirus salmonis (Krøyer): Maternal inheritance and reduced apoptosis . Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-26420-6. Fulltekst i vitenarkiv
  • Winje, Ivan; Bengtsen, Mads; Eftestøl, Einar; Juvkam, Inga; Bruusgaard, Jo C. & Gundersen, Kristian (2018). Specific labelling of myonuclei by an antibody against pericentriolar material 1 on skeletal muscle tissue sections. Acta Physiologica. ISSN 1748-1708. 223(4), s. 1–9. doi: 10.1111/apha.13034. Fulltekst i vitenarkiv
  • Eftestøl, Einar; Egner, Ingrid Marie; Lunde, Ida Gjervold; Ellefsen, Stian; Andersen, Tom & Sjåland, Cecilie [Vis alle 8 forfattere av denne artikkelen] (2016). Increased hypertrophic response with increased mechanical load in skeletal muscles receiving identical activity patterns. American Journal of Physiology - Cell Physiology. ISSN 0363-6143. 311(4), s. C616–C629. doi: 10.1152/ajpcell.00016.2016.
  • Egner, Ingrid Marie; Bruusgaard, Jo C. & Gundersen, Kristian (2016). Satellite cell depletion prevents fiber hypertrophy in skeletal muscle. Development. ISSN 0950-1991. 143(16), s. 2898–2906. doi: 10.1242/dev.134411.
  • Omairi, Saleh; Matsakas, Antonios; Degens, Hans; Kretz, Oliver; Hansson, Kenth-Arne & Solbrå, Andreas Våvang [Vis alle 20 forfattere av denne artikkelen] (2016). Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. eLIFE. ISSN 2050-084X. 5(AUGUST). doi: 10.7554/eLife.16940.
  • Løvås, Tom-Ole; Bruusgaard, Jo C.; Øynebråten, Inger; Gundersen, Kristian & Bogen, Bjarne (2014). DNA vaccines: MHC II-targeted vaccine protein produced by transfected muscle fibres induces a local inflammatory cell infiltrate in mice. PLOS ONE. ISSN 1932-6203. 9(10). doi: 10.1371/journal.pone.0108069. Fulltekst i vitenarkiv
  • Eftestøl, Einar; Alver, Tine Norman; Gundersen, Kristian & Bruusgaard, Jo C. (2014). Overexpression of SMPX in adult skeletal muscle does not change skeletal muscle fiber type or size. PLOS ONE. ISSN 1932-6203. 9(6). doi: 10.1371/journal.pone.0099232. Fulltekst i vitenarkiv
  • Egner, Ingrid Marie; Bruusgaard, Jo C.; Eftestøl, Einar & Gundersen, Kristian (2013). A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids. Journal of Physiology. ISSN 0022-3751. 591(24), s. 6221–6230. doi: 10.1113/jphysiol.2013.264457.
  • Bruusgaard, Jo C.; Egner, Ingrid Marie; Klungervik, Tove; Dupre-Aucouturier, S; Desplanches, D & Gundersen, Kristian (2012). No change in myonuclear number during muscle unloading and reloading. Journal of applied physiology. ISSN 8750-7587. 113(2), s. 290–296. doi: 10.1152/japplphysiol.00436.2012.
  • Lunde, Ida Gjervold; Anton, Siobhan Lisa; Bruusgaard, Jo C.; Rana, Zaheer Ahmad; Ellefsen, Stian & Gundersen, Kristian (2011). Hypoxia inducible factor 1α links fast-patterned muscle activity and fast muscle phenotype in rats. Journal of Physiology. ISSN 0022-3751. 589(6), s. 1443–1454. doi: 10.1113/jphysiol.2010.202762.
  • Bruusgaard, Jo C.; Johansen, Ida Beitnes; Egner, Ingrid Marie; Rana, Zaheer Ahmad & Gundersen, Kristian (2010). Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 107(34), s. 15111–15116. doi: 10.1073/pnas.0913935107.
  • Gundersen, Kristian & Bruusgaard, Jo C. (2008). Nuclear domains during muscle atrophy: nuclei lost or paradigm lost? Journal of Physiology. ISSN 0022-3751. 586. doi: 10.1113/jphysiol.2008.154369.
  • Bruusgaard, Jo C. & Gundersen, Kristian (2008). In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy. Journal of Clinical Investigation. ISSN 0021-9738. 118. doi: 10.1172/JCI34022.
  • Bruusgaard, Jo C.; Liestøl, Knut & Gundersen, Kristian (2006). Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice. Journal of applied physiology. ISSN 8750-7587. 100, s. 2024–2030.
  • Bedet, Ceclie; Bruusgaard, Jo C.; Vergo, Stephanie; Groth-Pedersen, Line; Eimer, Stephan & Triller, Antoine [Vis alle 7 forfattere av denne artikkelen] (2006). Regulation of gephyrin assembly and glycine receptor synaptic stability. Journal of Biological Chemistry. ISSN 0021-9258. 281(40), s. 30046–30056.
  • Bruusgaard, Jo C.; Brack, AS; Hughes, SM & Gundersen, Kristian (2005). Muscle hypertrophy induced by the Ski protein: cyto-architecture and ultrastructure. Acta Physiologica Scandinavica. ISSN 0001-6772. 185(2), s. 141–149.
  • Bruusgaard, Jo C.; Liestøl, Knut; Ekmark, Merete; Kollstad, K & Gundersen, Kristian (2003). Number and spatial distribution of nuclei in the muscle fibres of normal mice studied in vivo. Journal of Physiology. ISSN 0022-3751. 551(2), s. 467–478.

Se alle arbeider i Cristin

  • Eftestøl, Einar & Bruusgaard, Jo C. (2021). Long-lasting cellular imprinting. Performance hacking towards the Olympics? Physiology News. 1222, s. 34–36.
  • Eftestøl, Einar; Psilander, Niklas; Cumming, Kristoffer Toldnes; Juvkam, Inga; Ekblom, Maria M. & Sunding, Kerstin [Vis alle 12 forfattere av denne artikkelen] (2019). Muscle memory: Are myonuclei ever lost? Journal of applied physiology. ISSN 8750-7587. 128(2), s. 456–457. doi: 10.1152/japplphysiol.00761.2019.
  • Benestad, Haakon Breien; Sand, Kristin Larsen & Bruusgaard, Jo C. (2018). Less than recommended training of aerobic fitness and muscle strength: What to expect? Acta Physiologica. ISSN 1748-1708. 224(4). doi: 10.1111/apha.13104.
  • Bruusgaard, Jo C.; Kalhovde, John Magne; Paulsen, Gøran; Sefland, Iren; Støve, Kjersti & Raastad, Truls (2018). Tetranectin labels myofibrillar disruptions after eccentric exercise in humans. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. doi: 10.1007/s10974-016-9457-1.
  • Hansson, Kenth-Arne; Gundersen, Kristian & Bruusgaard, Jo C. (2018). In vivo confocal imaging and 3D rendering of the neuromuscular end plate and its synaptic myonuclei. Acta Physiologica. ISSN 1748-1708.
  • Jensenius, Alexander Refsum; Bjerkestrand, Kari Anne Vadstensvik; Donnarumma, Marco; Brean, Are & Bruusgaard, Jo C. (2017). Panel: Biophysical Music.
  • Egner, Ingrid Marie; Bruusgaard, Jo C. & Gundersen, Kristian (2017). An apparent lack of effect of satellite cell depletion on hypertrophy could be due to methodological limitations. Response to `Methodological issues limit interpretation of negative effects of satellite cell depletion on adult muscle hypertrophy? Development. ISSN 0950-1991. 144(8), s. 1365–1367. doi: 10.1242/dev.148163.
  • Eftestøl, Einar; Egner, Ingrid Marie; Ellefsen, Stian; Andersen, Tom; Gundersen, Kristian & Bruusgaard, Jo C. (2016). The importance of mechanosensation in skeletal muscle hypertrophy.
  • Bruusgaard, Jo C.; Kalhovde, John Magne; Raastad, Truls; Paulsen, Gøran; Støve, Kjersti & Sefland, Iren (2016). Tetranectin labels myofibrillar disruptions after eccentric exercise in humans.
  • Bruusgaard, Jo C. & Gundersen, Kristian (2014). Musklene dine kan huske. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.
  • Egner, Ingrid Marie; Bruusgaard, Jo C.; Eftestøl, Einar & Gundersen, Kristian (2012). Effects of anabolic steroid on nuclear number and muscle mass.
  • Eftestøl, Einar; Bruusgaard, Jo C. & Gundersen, Kristian (2012). The contraction duration is not important for hypertrophy in strength trained rats.
  • Gundersen, Kristian; Eftestøl, Einar; Egner, Ingrid Marie & Bruusgaard, Jo C. (2011). The effect of testosterone propionate on overloaded skeletal muscle.
  • Anton, Siobhan Lisa; Bruusgaard, Jo C. & Gundersen, Kristian (2011). In vivo knockdown of myogenin leads to a faster muscle phenotype. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 32, s. 345–346. doi: 10.1007/s10974-011-9265-6.
  • Anton, Siobhan Lisa; Bruusgaard, Jo C. & Gundersen, Kristian (2011). In Vivo Knockdown of Myogenin Leads to a Faster Muscle Phenotype.
  • Anton, Siobhan Lisa; Lunde, Ida Gjervold; Bruusgaard, Jo C. & Gundersen, Kristian (2010). HIF-1a regulates the oxidative capacity of adult rat skeletal muscle.
  • Anton, Siobhan Lisa; Lunde, Ida Gjervold; Bruusgaard, Jo C. & Gundersen, Kristian (2010). HIF-1a regulates the oxidative capacity of adult rat skeletal muscle. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 32, s. 136–136. doi: 10.1007/s10974-011-9257-6.
  • Bruusgaard, Jo C.; Johansen, Ida Beitnes; Egner, Ingrid Marie & Gundersen, Kristian (2009). Are myonuclei forever? Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 30(1).
  • Hansen, Einar Eftestøl Holm; Bruusgaard, Jo C. & Gundersen, Kristian (2009). What is the role of SMPX in skeletal muscle? Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 129(1).
  • Lunde, Ida Gjervold; Bruusgaard, Jo C. & Gundersen, Kristian (2009). HIF-1a regulates fast MyHC expression in skeletal muscle of normally active adult rats. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 129(1).
  • Brandtzæg, Per; Bruusgaard, Jo C. & Gundersen, Kristian (2009). Djevelens advokat i Snåsa. Morgenbladet. ISSN 0805-3847.
  • Brandtzæg, Per; Bruusgaard, Jo C. & Gundersen, Kristian (2009). Lemfeldig observasjon. Morgenbladet. ISSN 0805-3847.
  • Bruusgaard, Jo C. (2009). Brainbow – hjerneforskning med manetproteiner. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 129(1).
  • Brandtzæg, Per; Bruusgaard, Jo C. & Gundersen, Kristian (2008). Tvilsom bevisvurdering. Morgenbladet. ISSN 0805-3847.
  • Bruusgaard, Jo C. & Gundersen, Kristian (2007). No loss of myonuclei after inactivity-induced skeletal muscle atrophy. Acta Physiologica Scandinavica. ISSN 0001-6772.
  • Bruusgaard, Jo C. & Gundersen, Kristian (2006). Muscle atrophy is not accompanied by loss of myonuclei. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 27(5-7).
  • Bruusgaard, Jo C.; Brack, Andrew; Hughes, Simon & Gundersen, Kristian (2004). Ultrastrucural changes in young mice expressing the MSVski proto-oncogene. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 25.
  • Bruusgaard, Jo C.; Liestøl, Knut; Ekmark, Merete; Kollstad, Kjetil & Gundersen, Kristian (2003). Number and spatial distribution of nuclei in muscle fibers of normal mice studied in vivo. Journal of Muscle Research and Cell Motility. ISSN 0142-4319. 24.
  • Utvik, Jo Kristian; Ashtari, Ohmid; Bruusgaard, Jo C.; Bezakova, Gabriela; Mathiesen, Iacob & Lømo, Terje [Vis alle 8 forfattere av denne artikkelen] (1997). Injection and expression of foreign DNA in single skeletal muscle fibers in vivo.
  • Bruusgaard, Jo C. & Gundersen, Kristian (2005). Number and spatial distribution of myonuclei studied in vivo. Unipub forlag.
  • Bruusgaard, Jo C. (1999). Hemming av acetylcholinreseptorsyntese i enkelt-musklefibre in vivo. Universitetet i Oslo.

Se alle arbeider i Cristin

Publisert 4. nov. 2010 14:36 - Sist endret 10. mai 2022 13:01