Hatice Zeynep Nenseth

• Pällmann, Nora; Livgård, Marte; Tesikova, Martina; Nenseth, Hatice Zeynep; Akkus, Erman; Sikkeland, Jørgen; Jin, Yixin; Koc, Dogukan; Kuzu, Ömer Faruk; Pradhan, Manohar; Danielsen, Håvard Emil; Kahraman, Nermin; Mokhlis, Hamada M.; Ozpolat, Bulent; Banerjee, Partha P.; Uren, Aykut; Fazli, Ladan; Rennie, Paul S.; Jin, Yang & Saatcioglu, Fahri (2019). Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene.  ISSN 0950-9232.  38, s 6301- 6318 . doi: 10.1038/s41388-019-0879-2
• Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid; Simon, Lukas; Greene, Stephanie; Zeng, Qingping; Fazli, Ladan; Rennie, Paul S.; Mills, Ian Geoffrey; Danielsen, Håvard Emil; Theis, Fabian; Patterson, John B.; Jin, Yang & Saatcioglu, Fahri (2019). IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications.  ISSN 2041-1723.  10:323, s 1- 12 . doi: 10.1038/s41467-018-08152-3
• Sikkeland, Jørgen; Lindstad, Torstein; Nenseth, Hatice Zeynep; Dezitter, Xavier Gabriel M; Qu, Su; Mohamed Muhumed, Ridhwan; Erikei, Meric; Gregor, Margaret F. & Saatcioglu, Fahri (2019). Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  93, s 75- 85 . doi: 10.1016/j.metabol.2019.01.014
• Jin, Yang; Nenseth, Hatice Zeynep & Saatcioglu, Fahri (2017). Role of PLZF as a tumor suppressor in prostate cancer. OncoTarget.  ISSN 1949-2553.  8(41), s 71317- 71324 . doi: 10.18632/oncotarget.19813
• Tesikova, Martina; Dezitter, Xavier Gabriel M; Nenseth, Hatice Zeynep; Klokk, Tove Irene; Mueller, Florian; Hager, Gordon L. & Saatcioglu, Fahri (2016). Divergent binding and transactivation by two related steroid receptors at the same response element. Journal of Biological Chemistry.  ISSN 0021-9258.  291(22), s 11899- 11910 . doi: 10.1074/jbc.M115.684480
• Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep; Zhao, Sen; Fazli, Ladan; Rennie, Paul S.; Risberg, Bjørn Åke; Wæhre, Haakon; Danielsen, Håvard Emil; Mills, Ian Geoffrey; Jin, Yang; Hotamisligil, Gökhan S & Saatcioglu, Fahri (2015). Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine.  ISSN 1757-4676.  7(6), s 788- 801 . doi: 10.15252/emmm.201404509 Fulltekst i vitenarkiv. Vis sammendrag

  The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As androgens regulate secretion and development of the normal prostate and drive prostate cancer (PCa) growth, they may affect UPR pathways. Here, we show that the canonical UPR pathways are directly and divergently regulated by androgens in PCa cells, through the androgen receptor (AR), which is critical for PCa survival. AR bound to gene regulatory sites and activated the IRE1α branch, but simultaneously inhibited PERK signaling. Inhibition of the IRE1α arm profoundly reduced PCa cell growth in vitro as well as tumor formation in preclinical models of PCa in vivo. Consistently, AR and UPR gene expression were correlated in human PCa, and spliced XBP‐1 expression was significantly upregulated in cancer compared with normal prostate. These data establish a genetic switch orchestrated by AR that divergently regulates the UPR pathways and suggest that targeting IRE1α signaling may have therapeutic utility in PCa.

• Kumpf, Robert; Thorstensen, Tage; Rahman, Mohummad Aminur; Heyman, Jefri; Nenseth, Hatice Zeynep; Lammens, Tim; Herrmann, Ullrich; Swarup, Ranjan; Veiseth, Silje Veie; Emberland, Gitiga; Bennett, Malcolm J.; De Veylder, Lieven & Aalen, Reidunn B. (2014). The ASH1-RELATED3 SET-domain protein controls cell division competence of the meristem and the quiescent center of the arabidopsis primary root. Plant Physiology.  ISSN 0032-0889.  166(2), s 632- 643 . doi: 10.1104/pp.114.244798
• Nenseth, Hatice Zeynep; Dezitter, Xavier; Tesikova, Martina; Mueller, Florian; Klokk, Tove Irene; Hager, Gordon L. & Saatcioglu, Fahri (2014). Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells. PLOS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0105204 Fulltekst i vitenarkiv.

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