Disputation: Kaja Frøysaa Kvåle

Doctoral candidate Kaja Frøysaa Kvåle at the Department of Informatics, Faculty of Mathematics and Natural Sciences, is defending the thesis Detection of mechanical waves in the left ventricle using high frame rate imaging  for the degree of Philosophiae Doctor.

The PhD defence and trial lecture are fully digital and streamed using Zoom. The host of the session will moderate the technicalities while the chair of the defence will moderate the disputation.

Ex auditorio questions: the chair of the defence will invite the audience to ask ex auditorio questions. This can be requested by clicking 'Participants -> Raise hand'. 

Trial lecture

"Research needs and current trends in cardiac ultrasound"


Main research findings

Echocardiography is a key imaging modality to assess cardiac anatomy and function. In the past decade, high frame rate ultrasound imaging has emerged, and has allowed for studies of rapid phenomena that occur in the heart.

The investigated phenomena are mechanical waves propagating in cardiac tissue at high velocities. Our goal was to detect properties of these waves useful for non-invasive diagnosis of cardiac diseases currently diagnosed with invasive, time consuming and expensive methods.

Regional mechanical activation of the heart was investigated for the purpose of detecting abnormal activation patterns indicating conduction disorders. A method was developed to map the mechanical activation wave occurring after electrical activation, and its feasibility demonstrated in an animal study.

Mechanical waves occurring naturally in tissue after mechanical events in the heart were investigated for the purpose of using propagation velocities to separate between healthy and pathological tissue. A method for velocity estimation was developed and its feasibility demonstrated in two studies of human populations.

Both methods have been evaluated for clinical scenarios and validated against invasive and non-invasive reference standards. They have the potential of having clinical impact in the diagnosis of several cardiac diseases related to conduction and tissue abnormalities.


Contact information to Department: Pernille Adine Nordby 

Publisert 29. sep. 2020 14:29 - Sist endret 29. juni 2021 10:29