Tore Benneche

• McHale, Emily; Braovac, Susan; Steindal, Calin Constantin; Kutzke, Hartmut & Benneche, Tore (2018). Consolidation of waterlogged wood with lignin-like oligomers, In Emily Williams & Emma Hocker (ed.),  Proceedings of the 13th ICOM-CC Group on Wet Organic Archaeological Materials Conference: Florence 2016.  International Council of Museums, ICOM.  ISBN 978-92-9012-436-8.  -.  s 184 - 192
• McHale, Emily; Steindal, Calin Constantin; Kutzke, Hartmut; Benneche, Tore & Harding, Stephen Ernest (2017). In situ polymerisation of isoeugenol as a green consolidation method for waterlogged archaeological wood. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep46481 Fulltekst i vitenarkiv.
• Benneche, Tore; Chamgordani, Elahe Jafari; Herstad, Gunnar; Tannæs, Bjørg Siw Møller & Scheie, Anne Aamdal (2016). 5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors. Letters in Organic Chemistry.  ISSN 1570-1786.  13(6), s 428- 436
• Benneche, Tore & Tius, Marcus A. (2016). Synthesis of 2-oxaadamantane and 1-aryl-2-oxaadamantanes. Tetrahedron Letters.  ISSN 0040-4039.  57(29), s 3150- 3151 . doi: 10.1016/j.tetlet.2016.06.027
• Herstad, Gunnar; Molesworth, Peter Patrick; Miller, Charlotte Marie; Benneche, Tore & Tius, Marcus A. (2016). Ring-closing metathesis in an enantioselective synthesis of the macrocyclic core of crassin acetate. Tetrahedron.  ISSN 0040-4020.  72(17), s 2084- 2093 . doi: 10.1016/j.tet.2016.02.050
• Lillicrap, Adam; Macken, Ailbhe; Wennberg, Aina Charlotte; Grung, Merete; Rundberget, Jan Thomas; Fredriksen, Lene; Scheie, Anne Aamdal; Benneche, Tore & Angles d'Auriac, Marc (2016). Environmental fate and effects of novel quorum sensing inhibitors that can control biofilm formation. Chemosphere.  ISSN 0045-6535.  164, s 52- 58 . doi: 10.1016/j.chemosphere.2016.08.083
• McHale, Emily; Braovac, Susan; Steindal, Calin Constantin; Gillis, Richard B; Adams, Gary; Harding, Stephen E; Benneche, Tore & Kutzke, Hartmut (2016). Synthesis and characterisation of lignin-like oligomers as a bio-inspired consolidant for waterlogged archaeological wood. Pure and Applied Chemistry.  ISSN 0033-4545.  88(10-11), s 969- 977 . doi: 10.1515/pac-2016-0814 Fulltekst i vitenarkiv. Vis sammendrag

  The development of new materials for the consolidation of waterlogged archaeological wood from sustainable sources is an important area of research, as the most widely used consolidant today is petroleum based. Ideally a new consolidant will interact with the existing wood structure, ensuring maximum compatibility. Lignin is often the major component remaining in archaeological wood, as it is less susceptible to degradation than holocellulose. Therefore, in order to maximise the potential for interaction with the wood cells, lignin-like oligomers have been synthesized from isoeugenol using a water soluble copper salen catalyst at pH 10, giving a weight average Mw of 1.6 kDa. Analysis by NMR spectroscopy has shown that the oligomers have a lignin-like structure with β-O-4′, β-β′ and β-5′ connections. A 10 w/w% solution of the oligomers in ethyl acetate was found to thoroughly penetrate 1 cm3 samples of waterlogged archaeological wood (density of 0.146 g/mL, maximum water content of 620%) after 14 days impregnation, as determined by FTIR spectroscopy. No impregnation material could be seen by SEM, suggesting that it coats the cell walls upon drying. This indicates that dehydrogenated polymers penetrate waterlogged archaeological wood well and have the potential to be developed into consolidants.

• Scheie, Anne Aamdal; Chamgordani, Elahe Jafari; Naemi, Ali-Oddin; Hansen, Finn Knut & Benneche, Tore (2016). Staphylococcus epidermidis biofilm on implant material is reduced by a covalently linked thiophenone. Journal of Applied Microbiology.  ISSN 1364-5072.  121(2), s 547- 553 . doi: 10.1111/jam.13188
• Witsø, Ingun Lund; Rukke, Håkon Valen; Benneche, Tore & Scheie, Anne Aamdal (2016). Thiophenone Attenuates Enteropathogenic Escherichia coli O103:H2 Virulence by Interfering with AI-2 Signaling. PLOS ONE.  ISSN 1932-6203.  11(6) . doi: 10.1371/journal.pone.0157334 Fulltekst i vitenarkiv. Vis sammendrag

  Interference with bacterial quorum sensing communication provides an anti-virulence strategy to control pathogenic bacteria. Here, using the Enteropathogenic E. coli (EPEC) O103:H2, we showed for the first time that thiophenone TF101 reduced expression of lsrB; the gene encoding the AI-2 receptor. Combined results of transcriptional and phenotypic analyses suggested that TF101 interfere with AI-2 signalling, possibly by competing with AI-2 for binding to LsrB. This is supported by in silico docking prediction of thiophenone TF101 in the LsrB pocket. Transcriptional analyses furthermore showed that thiophenone TF101 interfered with expression of the virulence genes eae and fimH. In addition, TF101 reduced AI-2 induced E. coli adhesion to colorectal adenocarcinoma cells. TF101, on the other hand, did not affect epinephrine or norepinephrine enhanced E. coli adhesion. Overall, our results showed that thiophenone TF101 interfered with virulence expression in E. coli O103:H2, suggestedly by interfering with AI-2 mediated quorum sensing. We thus conclude that thiophenone TF101 might represent a promising future anti-virulence agent in the fight against pathogenic E. coli.

• Benneche, Tore (2015). The use of α-halo ethers in the protection of alcohols. Years 2012 – 2014. Mini-Reviews in Organic Chemistry.  ISSN 1570-193X.  12(4), s 367- 375
• Kristoffersen, Kenneth Aase & Benneche, Tore (2015). Trifluoroacetylation of electron-rich thiophenes. Journal of fluorine chemistry.  ISSN 0022-1139.  176, s 31- 34 . doi: 10.1016/j.jfluchem.2015.04.018 Fulltekst i vitenarkiv. Vis sammendrag

  Electron-rich thiophenes were trifluoroacetylated by trifluoroacetic anhydride with different nitrogen bases in dichloromethane at room temperature in good yields. Trifluoroacetylation without a base gave significantly lower yields.

• Miller, Charlotte Marie; Benneche, Tore & Tius, Marcus A. (2015). First total synthesis of the marine natural products clavulolactones II and III. Organic and biomolecular chemistry.  ISSN 1477-0520.  13(13), s 4051- 4058 . doi: 10.1039/c5ob00074b
• Yang, Qian; Scheie, Anne Aamdal; Benneche, Tore & Defoirdt, Tom (2015). Specific quorum sensing-disrupting activity (AQSI) of thiophenones and their therapeutic potential. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep18033
• Vestby, Lene Karine; Johannesen, Karianne Cecilie Strømme; Witsø, Ingun Lund; Habimana, Olivier; Scheie, Anne Aamdal; Urdahl, Anne Margrete; Benneche, Tore; Langsrud, Solveig & Nesse, Live Lingaas (2014). Synthetic brominated furanone F202 prevents biofilm formation by potentially human pathogenic Escherichia coli O103: H2 and Salmonella ser. Agona on abiotic surfaces. Journal of Applied Microbiology.  ISSN 1364-5072.  116(2), s 258- 268 . doi: 10.1111/jam.12355 Fulltekst i vitenarkiv. Vis sammendrag

  Aims Investigate the use of a synthetic brominated furanone (F202) against the establishment of biofilm by Salmonella ser. Agona and E. coli O103:H2 under temperature conditions relevant for the food and feed industry as well as under temperature conditions optimum for growth. Methods and Results Effect of F202 on biofilm formation by Salmonella ser. Agona and E. coli O103:H2 was evaluated using a microtiter plate assay and confocal microscopy. Effect of F202 on bacterial motility was investigated using swimming and swarming assays. Influence on flagellar synthesis by F202 was examined by flagellar staining. Results showed that F202 inhibited biofilm formation without being bactericidal. F202 was found to affect both swimming and swarming motility without, however, affecting the expression of flagella. Conclusions F202 showed its potential as a biofilm inhibitor of Salmonella ser. Agona and E. coli O103:H2 under temperature conditions relevant for the feed and food industry as well as temperatures optimum for growth. One potential mode of action of F202 was found to be by targeting flagellar function. Significance and Impact of the Study The present study gives valuable new knowledge to the potential use of furanones as a tool in biofilm management in the food and feed industry.

• Witsø, Ingun Lund; Benneche, Tore; Vestby, Lene Karine; Nesse, Live Lingaas; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2014). Thiophenone and Furanone in Control of Escherichia coli O103:H2 Virulence. Pathogens and Disease.  ISSN 2049-632X.  70(3), s 297- 306 . doi: 10.1111/2049-632X.12128
• Benneche, Tore; Chamgordani, Elahe Jafari & Scheie, Anne Aamdal (2013). Reation of (Z)-5-bromomethylene)thiophene-2(5H)-one with some nucleophiles in search for new biofilm inhibitors. Synthetic Communications.  ISSN 0039-7911.  43(3), s 431- 437 . doi: 10.1080/00397911.2011.602496
• Landsem, Eva; Jensen, Tomas Lunde; Kristensen, Tor Erik Holt; Hansen, Finn Knut; Benneche, Tore & Unneberg, Erik (2013). Isocyanate-Free and Dual Curing of Smokeless Composite Rocket Propellants. Propellants, explosives, pyrotechnics.  ISSN 0721-3115.  38(1), s 75- 86 . doi: 10.1002/prep.201200108
• Pande, Gde Sasmita Julyantoro; Scheie, Anne Aamdal; Benneche, Tore; Wille, Mathieu; Sorgeloos, Patrick; Bossier, Peter & Defoirdt, Tom (2013). Quorum sensing-disrupting compounds protect larvae of the giant freshwater prawn Macrobrachium rosenbergii from Vibrio harveyi infection. Aquaculture.  ISSN 0044-8486.  406-407, s 121- 124 . doi: 10.1016/j.aquaculture.2013.05.015
• Benneche, Tore; Chamgordani, Elahe Jafari & Reimer, Inga (2012). A new synthesis of five-membered heterocyclic quorum sensing inhibitors. Tetrahedron Letters.  ISSN 0040-4039.  53(51), s 6982- 6983 . doi: 10.1016/j.tetlet.2012.10.048
• Defoirdt, Tom; Benneche, Tore; Brackman, Gilles; Coenye, Tom; Sorgeloos, Patrick & Scheie, Anne Aamdal (2012). A Quorum Sensing-Disrupting Brominated Thiophenone with a Promising Therapeutic Potential to Treat Luminescent Vibriosis. PLOS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0041788
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2012). Kan bakteriers kommunikation öppna för nya infektionsbehandlingar?. Läkartidningen.  ISSN 0023-7205.  (9)
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2012). Thiophenones inhibit Staphylococcus epidermidis biofilm formation at nontoxic concentrations. FEMS Immunology and Medical Microbiology.  ISSN 0928-8244.  65(2), s 326- 334 . doi: 10.1111/j.1574-695X.2012.00964.x
• Benneche, Tore; Herstad, Gunnar; Rosenberg, Marianne Lenes; Assev, Synnøve & Scheie, Anne Aamdal (2011). Facile synthesis of 5-(alkylidene)thiophen-2(5H)-ones. A new class of antimicrobial agents. RSC Advances.  ISSN 2046-2069.  1(2), s 323- 332 . doi: 10.1039/c1ra00254f
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2011). Furanones and Thiophenones in Control of Staphylococcus epidermidis Biofilm Infections?, In Antonio Mendez-Vilas (ed.),  Science and Technology against Microbial Pathogens. Research, Development and Evaluation.  World Scientific.  ISBN 978-981-4354-85-1.  Antimicrobial Surfaces. Biofilms. Quorum Sensing. Consumer Products.  s 155 - 159
• Dixon, Darryl D.; Sethumadhavan, Divakaramanon; Benneche, Tore; Banaag, April R.; Tius, Marcus A.; Thakur, Ganesh A.; Bowman, Anna; Wood, JodiAnne T. & Makriyannis, Alexandros (2010). Heteroadamantyl cannabinoids. Journal of Medicinal Chemistry.  ISSN 0022-2623.  53, s 5656- 5666
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2010). A synthetic furanone potentiates the effect of disinfectants on Salmonella in biofilm. Journal of Applied Microbiology.  ISSN 1364-5072.  108(3), s 771- 778 . doi: 10.1111/j.1365-2672.2009.04495.x
• Lönn-Stensrud, Jessica; Landin, Maria Augusta Dos S Silva; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?. Journal of Antimicrobial Chemotherapy.  ISSN 0305-7453.  63(2), s 309- 316 . doi: 10.1093/jac/dkn501
• Benneche, Tore; Hussain, Zainab; Scheie, Anne Aamdal & Lönn-Stensrud, Jessica (2008). Synthesis of 5-(bromomethylene)furan-2(5H)-ones and 3-(bromomethylene)isobenzofuran-1(3H)-ones as inhibitors of microbial quorum sensing. New Journal of Chemistry.  ISSN 1144-0546.  32(9), s 1567- 1572 . doi: 10.1039/b803926g
• Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2007). Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci. Oral Microbiology and Immunology.  ISSN 0902-0055.  22, s 340- 346
• Benneche, Tore; Lønn-Stensrud, Anna Maria Jessica & Scheie, Anne Aamdal (2006). Synthesis of (E)- and (Z)-5-(bromomethylene)furan-2(5H)-one by bromodecarboxylation of (E)-2-(5-oxofuran-2(5H)-ylidene)acetic acid. Synthetic Communications.  ISSN 0039-7911.  36
• Herstad, Gunnar & Benneche, Tore (2003). Decarboxylation in the synthesis of 4-alkyl-, 4-alkenyl- and 4-acylpyrimidines. Journal of Heterocyclic Chemistry.  ISSN 0022-152X.  40(2), s 219- 224
• Edvardsen, Kjetil Røe; Benneche, Tore & Tius, Marcus A. (2000). Synthesis and Reactions of (E)- and (Z)-1,3-Dibromo-2-methoxypropene. Journal of Organic Chemistry.  ISSN 0022-3263.  65, s 3085- 3089
• Johannesen, Rune & Benneche, Tore (2000). Synthesis of Trimethylgermyl Trimethylsiyl Ketone and Bis(trimethylgermyl) Ketone. Journal of the Chemical Society. Perkin transactions 1.  ISSN 0300-922X.  s 2677- 2679
• Falck-Pedersen, Mette Lene; Benneche, Tore & Undheim, Kjell (1993). Palladium Catalysis in Allylic Rearrangements of Propenyl 2-Pyrimidinyl Carbonates to 1-Propenyl-2(1H)-pyrimidinones. Acta Chemica Scandinavica.  ISSN 0904-213X.  47, s 63
• Falck-Pedersen, Mette Lene; Benneche, Tore & Undheim, Kjell (1993). Palladium-Catalyzed Rearrangements of 2-Cyclopentenyloxypyrimidines in the Preparation of Pyrimidine Carbonucleosides. Acta Chemica Scandinavica.  ISSN 0904-213X.  47, s 72

Se alle arbeider i Cristin

• Benneche, Tore (ed.) (2007). Compounds with two carbon-heteroatom bonds. Georg Thieme Verlag.  ISBN 9781588904614.  76 s.
• Karen, Pavel & Benneche, Tore (2004). KJM1010 Kjemiske strukturer og prinsipper - Laboratoriekurs. Universitetet i Oslo, Reprosentralen.  81 s.

Se alle arbeider i Cristin

• Vestby, Lene Karine; Berg, Kristin; Porwollik, Steffen; McClelland, Michael; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2019). To form a biofilm or not- that is the question for Salmonella under exposure to furanone.
• McHale, Emily; Benneche, Tore & Kutzke, Hartmut (2018). The Development of Lignin-Like Oligomers for the Consolidation of Waterlogged Archaeological Wood. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 2036.
• McHale, Emily; Harding, Stephen & Benneche, Tore (2017). Branching out: Using the Chemistry of trees to preserve archaeological wood.
• McHale, Emily; Braovac, Susan; Steindal, Calin Constantin; Kutzke, Hartmut & Benneche, Tore (2016). Consolidation of waterlogged archaeological wood with lignin-like oligomers.
• McHale, Emily; Steindal, Calin Constantin; Benneche, Tore; Kutzke, Hartmut & Harding, Stephen E. (2016). IN SITU PREPARATION OF LIGNIN-LIKE OLIGOMERS FOR THE CONSOLIDATAION OF WATERLOGGED ARCHAEOLOGICAL WOOD.
• McHale, Emily; Steindal, Calin Constantin; Braovac, Susan; Gillis, Richard; Adams, Gary; Benneche, Tore & Kutzke, Hartmut (2016). Synthesis and characterisation of lignin-like oligomers as a bio-inspired consolidant for waterlogged archaeological wood.
• Chamgordani, Elahe Jafari; Benneche, Tore & Hansen, Finn Knut (2015). Synthesis of 5-Membered Heterocycles as Quorum Sensing Inhibitors.
• Kristoffersen, Kenneth Aase & Benneche, Tore (2015). Syntese av tiofenoner som bakteriell cellefommunikasjons inhibitorer. Vis sammendrag

  Bacteria communicate using small signaling molecules as part of a system of communication called quorum sensing (QS) to control gene expression for synchronized bacterial behaviors. A task performed by bacteria that is often controlled by this means is biofilm production, making bacteria more resistant to external factors. Naturally occurring furanones that were isolated from a red macroalgae have been shown to have the ability to interrupt this communication. As a result thiophenones have been synthesized and investigated as a novel class of quorum sensing inhibitors (QSIs). Molecules of this class have greater biofilm reduction abilities than furanone equivalents for some bacteria. This discovery resulted in many more thiophenones with a variety of functional groups being synthesized using both classical and new methods. These compounds have been used in biological assays to determine their quorum sensing inhibition (QSI) potential, and have shown promising results. In this study tiobovolide has been synthesized and confirmed to exhibit some QSI properties. In addition to this trifluoromethyllated thiophenones have been synthesized and tested for QSI ability. It was found that most exhibited QSI properties, but that compounds with methyl groups in the 3- and 4-position showed no biological activity. This finding may support a 1,6-Michael-type reaction mechanism that has been suggested to be responsible for bioactivity.

• Kutzke, Hartmut; Christensen, Mikkel; McHale, Emily; McQueen, Caitlin & Benneche, Tore (2015). Bio-inspired materials: a new generation of materials for preservation of art and archaeological objects?.
• Kutzke, Hartmut; McHale, Emily; McQueen, Caitlin; Christensen, Mikkel & Benneche, Tore (2015). Curing wood with wood: wood components as consolidation materials for the conservation of archaeological wood.
• Kutzke, Hartmut; McHale, Emily; McQueen, Caitlin; Christensen, Mikkel & Benneche, Tore (2015). Learning from nature - on the way to new bio-inspired materials for the conservation of archaeological wood.
• McHale, Emily; Kutzke, Hartmut & Benneche, Tore (2015). Preservation of archaeological wood: a challenge for bio-inspired materials.
• Vestby, Lene Karine; Berg, Kristin; Porwollik, Steffen; McClelland, Michael; Cheng, Pui; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2015). Gene expression by Salmonella in the presence of a synthetic brominated furanone which inhibits biofilm formation.
• Vestby, Lene Karine; Nesse, Live Lingaas; Delacroix, Stephanie; Osland, Ane Mohr; Scheie, Anne Aamdal; Benneche, Tore & Angles d'Auriac, Marc (2015). The potential of thiophenones as biofilm inhibitors in the petroleum industry.
• Yang, qian; Scheie, Anne Aamdal; Benneche, Tore & Defoirdt, Tom (2015). NOVEL QUORUM SENSING-DISRUPTING THIOPHENONES AND THEIR THERAPEUTIC POTENTIAL.
• McHale, Emily; Benneche, Tore; Kutzke, Hartmut; Christensen, Mikkel & Braovac, Susan (2014). Preservation of archaeological wood: a challenge for biomimetic materials.
• Vestby, Lene Karine; Berg, K; Scheie, Anne Aamdal; Uhlig, Silvio; Benneche, Tore; Witsø, Ingun Lund & Nesse, Live Lingaas (2014). Biofilm- naturlig bekjempelse.
• Witsø, Ingun Lund; Rukke, Håkon Valen; Assev, Synnøve; Benneche, Tore; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2014). Structure-activity relationships in thiophenone.
• Landin, Maria Augusta Dos S Silva; Lonn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2013). Effekter av ikke toksiske furanoner på biofilm dannelse. Vis sammendrag

  Staphylococcus epidermidis (S. epidermis) er ofte påvist i biofilm som foråsaker infeksjoner forbundet med medisinske inplantater. Noen furanoner minsker biofilm dannelse tilsynelatende uten å forårsake irritasjon eller genotoksiske effekter, og uten å påvirke S. epidermidis vekst. Furanoner hindrer kommunikasjon mellom bakterier og har stor potensial for å hemme biofilm dannelse. Mål: Å studere biofilmhemmende og genotoksisk effekt av ulike furanoner Materialer og metoder: 11 furanoner ble undersøkt vha bioluminisens og biofilm assayer. MIC (minste inhiberende konsentrasjon) for disse furanonene ble bestemt for å undersøke om dannelse av biofilm eller bakterievekst ble påvirket. Effekter av furanoner på bakterie kommunikasjon ble også undersøkt ved bioluminisensmålinger. Preliminære genotoksiske effekter hos CD-1 muselever og nyrer ble undersøkt vha mikromatriser og membran matriser. Resultater: Fire furanoner ble valgt ut for videre biofilm analyser etter bioluminisens test. Hver furanon ble testet med konsentrasjoner som ikke påvirket bakterie proliferasjon, men biofilm dannelse ble signifikant redusert ved bruk av disse furanoner. For de to mest effektive furanoner (F202 og F202) som også ble testet in vivo, ble det ikke påvist akutt toksisitet eller genotoksisitet.

• Miller, Charlotte Marie & Benneche, Tore (2013). Total synthesis of the marine prostanoid clavulolactone II.
• Miller, Charlotte Marie; Benneche, Tore & Gundersen, Lise-Lotte (2013). Total synthesis of the prostanoids Clavulolactone II, Clavulolactone III and Carijenone.
• Molesworth, Peter Patrick; Herstad, Gunnar & Benneche, Tore (2013). Towards the enantioselective total synthesis of crassin acetate.
• Molesworth, Peter Patrick; Herstad, Gunnar & Benneche, Tore (2013). Towards the enantioselective total synthesis of crassin acetate.
• Molesworth, Peter Patrick; Herstad, Gunnar & Benneche, Tore (2013). Towards the enantioselective total synthesis of crassin acetate.
• Witsø, Ingun Lund; Rukke, Håkon Valen; Benneche, Tore & Scheie, Anne Aamdal (2013). Thiophenone interferes with AI-2 stimulated quorum sensing in Escherichia coli.
• Landsem, Eva; Hansen, Finn Knut; Unneberg, Erik & Benneche, Tore (2012). Development of Smokeless Composite Rocket Propellants.
• Landsem, Eva; Jensen, Tomas Lunde; Kristensen, Tor Erik; Unneberg, Erik; Benneche, Tore & Hansen, Finn Knut (2012). Improving the properties of minimum smoke composite rocket propellants.
• Liao, S; Wang, Y; Bitoun, J.P.; Yao, X; Scheie, Anne Aamdal; Benneche, Tore; Sintim, H.O.; Xu, X & Wen, Z.T. (2012). Identification of small molecules against biofilm formation by Streptococcus mutans.
• Vestby, Lene Karine; Johannesen, Karianne Cecilie Strømme; Witsø, Ingun Lund; Habimana, Olivier; Scheie, Anne Aamdal; Benneche, Tore; Urdahl, Anne Margrete & Nesse, Live Lingaas (2012). Biofilm formation by Salmonella and E. coli and their response to a synthetic furanone F202.
• Witsö, I.L.; Benneche, Tore; Nesse, Live L.; Vestby, Lene Karine; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2012). Thiophenone TF101 in control of E. coli biofilm?.
• Landsem, Eva; Tungen, Jørn Eivind; Kristensen, Tor Erik; Unneberg, Erik; Benneche, Tore & Hansen, Finn Knut (2011). Isocyanate-Free Curing of Glycidyl Azide Polymer (GAP).
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Assev, Synnøve; Benneche, Tore & Scheie, Anne Aamdal (2011). New synthetic thiophenones inhibit biofilm formation by S. epidermidis.
• Benneche, Tore & Benneche, Andreas (2010). Cannabinoider - noe mer enn rusmiddel?. Kjemi.  ISSN 0023-1983.  (7/8), s 5- 9
• Herstad, Gunnar; Benneche, Tore & Tius, Marcus A. (2010). Synthetic studies towards an enantioselective synthesis of crassin acetate.
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2010). Furanones and thiophenones in control of S. epidermidis biofilm infections?.
• Vestby, Lene Karine; Møretrø, Trond; Ballance, Simon; Benneche, Tore; Scheie, Anne Aamdal; Lönn-Stensrud, Jessica; Heir, Even & Nesse, Live Lingaas (2010). Persistence and eradication of Salmonella from the feed environment.
• Nesse, Live; Langsrud, Solveig; Møretrø, Trond; Scheie, Anne Aamdal; Benneche, Tore & Vestby, Lene K. (2009). Vil hindre bakteriesamtaler. Forskning.no.  ISSN 1891-635X.
• Scheie, Anne Aamdal & Benneche, Tore (2009). Norsk oppfinnelse kan hindre infeksjon i proteser. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Scheie, Anne Aamdal; Benneche, Tore & Vogt, Yngve (2009, 02. desember). Slutt på bakterieangrep i kunstige hofter.
• Solheim, Heidi; Abdul-Majeed Ahmed, Nibras Ayad; Scheie, Anne Aamdal; Urdahl, Anne Margrete; Benneche, Tore; Møretrø, Trond & Nesse, Live Lingaas (2009). Effect of two synthetic brominated furanones on Escherichia coli O103 in biofilm. Proceedings from Pathogenic E. coli.
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal; Benneche, Tore & Nesse, Live Lingaas (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm.
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• Nesse, Live; Vestby, Lene K.; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond; Langsrud, Solveig; Benneche, Tore & Scheie, Anne Aamdal (2008). The effect of a synthetic bromated furanone on the production of biofilm by different Salmonella wild type strains.
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• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakterier snakker, vi lider. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
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  The coagulase-negative staphylococci (CNS) are commensals of human skin and mucous membranes. Staphylococcus epidermidis is the most frequently isolated CNS species, and also one of the major nosocomial pathogens associated with infections on medical implants. The cause of infections is primarily related to biofilm formation on the implant. S. epidermidis infections represent a major burden to the public health system, and are often responsible for prolonged hospitalisation and occasional deaths. Microorganisms in nature prefer a biofilm life style. Biofilm infections are often difficult to treat due to increased resistance both to antibiotics and to the immune system. The algae Delisea pulchra produces bromated furanones that prevent bacterial biofilm formation on its surface. Similar furanones may interfere with both autoinducer-2 and autoinducer-1 signalling in Gram-positive and Gram-negative microorganisms without affecting bacterial growth.

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