Tore Benneche

• McHale, Emily; Braovac, Susan; Steindal, Calin Constantin; Kutzke, Hartmut & Benneche, Tore (2018). Consolidation of waterlogged wood with lignin-like oligomers. In Williams, Emily & Hocker, Emma (Ed.), Proceedings of the 13th ICOM-CC Group on Wet Organic Archaeological Materials Conference: Florence 2016. International Council of Museums Committee for Conservation (ICOM-CC). ISSN 9789290124368. p. 184–192. doi: 10.1038/srep46481. Full text in Research Archive
• McHale, Emily; Steindal, Calin Constantin; Kutzke, Hartmut; Benneche, Tore & Harding, Stephen Ernest (2017). In situ polymerisation of isoeugenol as a green consolidation method for waterlogged archaeological wood. Scientific Reports. 7. doi: 10.1038/srep46481. Full text in Research Archive Show summary

  Waterlogged archaeological wood is often in need of consolidation prior to drying to prevent shrinkage and cracking of the object. There is a need for new greener materials (than for example polyethylene glycol) and methods for consolidation to be developed. The use of wood-based components could provide good interaction between the consolidant and the remaining wood structure and would also support a shift away from fossil fuel-based materials to those with more sustainable sources. Based on this, lignin-like structures have been investigated for their ability to consolidate waterlogged archaeological wood. The in situ formation of a lignin-like material has been carried out using isoeugenol polymerised by horse radish peroxidase in aqueous solution. The formation of the oligomeric/polymeric materials within the wood following this reaction has been determined by Attenuated Total Reflectance Fourier Transform Infra Red (ATR-FTIR) spectroscopy. The oligomers remaining in solution have been characterised by ATR-FTIR and nuclear magnetic resonance (NMR) spectroscopy as well as analytical ultracentrifugation, showing that they have a weight average Mw of 0.4–0.9 kDa and a lignin-like structure rich in the β-5′ moiety. Therefore, this approach is proposed as a basis to further develop a green consolidation method for waterlogged archaeological wood.

• Witsø, Ingun Lund; Rukke, Håkon Valen; Benneche, Tore & Scheie, Anne Aamdal (2016). Thiophenone Attenuates Enteropathogenic Escherichia coli O103:H2 Virulence by Interfering with AI-2 Signaling. PLOS ONE. 11(6). doi: 10.1371/journal.pone.0157334. Full text in Research Archive Show summary

  Interference with bacterial quorum sensing communication provides an anti-virulence strategy to control pathogenic bacteria. Here, using the Enteropathogenic E. coli (EPEC) O103:H2, we showed for the first time that thiophenone TF101 reduced expression of lsrB; the gene encoding the AI-2 receptor. Combined results of transcriptional and phenotypic analyses suggested that TF101 interfere with AI-2 signalling, possibly by competing with AI-2 for binding to LsrB. This is supported by in silico docking prediction of thiophenone TF101 in the LsrB pocket. Transcriptional analyses furthermore showed that thiophenone TF101 interfered with expression of the virulence genes eae and fimH. In addition, TF101 reduced AI-2 induced E. coli adhesion to colorectal adenocarcinoma cells. TF101, on the other hand, did not affect epinephrine or norepinephrine enhanced E. coli adhesion. Overall, our results showed that thiophenone TF101 interfered with virulence expression in E. coli O103:H2, suggestedly by interfering with AI-2 mediated quorum sensing. We thus conclude that thiophenone TF101 might represent a promising future anti-virulence agent in the fight against pathogenic E. coli.

• Scheie, Anne Aamdal; Chamgordani, Elahe Jafari; Naemi, Ali-Oddin; Hansen, Finn Knut & Benneche, Tore (2016). Staphylococcus epidermidis biofilm on implant material is reduced by a covalently linked thiophenone. Journal of Applied Microbiology. ISSN 1364-5072. 121(2), p. 547–553. doi: 10.1111/jam.13188. Full text in Research Archive
• Benneche, Tore; Chamgordani, Elahe Jafari; Herstad, Gunnar; Tannæs, Bjørg Siw Møller & Scheie, Anne Aamdal (2016). 5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors. Letters in Organic Chemistry. ISSN 1570-1786. 13(6), p. 428–436. doi: 10.2174/1570178613666160620114658. Full text in Research Archive
• Lillicrap, Adam; Macken, Ailbhe; Wennberg, Aina Charlotte; Grung, Merete; Rundberget, Jan Thomas & Fredriksen, Lene [Show all 9 contributors for this article] (2016). Environmental fate and effects of novel quorum sensing inhibitors that can control biofilm formation. Chemosphere. ISSN 0045-6535. 164, p. 52–58. doi: 10.1016/j.chemosphere.2016.08.083. Full text in Research Archive
• McHale, Emily; Braovac, Susan; Steindal, Calin Constantin; Gillis, Richard B; Adams, Gary & Harding, Stephen E [Show all 8 contributors for this article] (2016). Synthesis and characterisation of lignin-like oligomers as a bio-inspired consolidant for waterlogged archaeological wood. Pure and Applied Chemistry. ISSN 0033-4545. 88(10-11), p. 969–977. doi: 10.1515/pac-2016-0814. Full text in Research Archive Show summary

  The development of new materials for the consolidation of waterlogged archaeological wood from sustainable sources is an important area of research, as the most widely used consolidant today is petroleum based. Ideally a new consolidant will interact with the existing wood structure, ensuring maximum compatibility. Lignin is often the major component remaining in archaeological wood, as it is less susceptible to degradation than holocellulose. Therefore, in order to maximise the potential for interaction with the wood cells, lignin-like oligomers have been synthesized from isoeugenol using a water soluble copper salen catalyst at pH 10, giving a weight average Mw of 1.6 kDa. Analysis by NMR spectroscopy has shown that the oligomers have a lignin-like structure with β-O-4′, β-β′ and β-5′ connections. A 10 w/w% solution of the oligomers in ethyl acetate was found to thoroughly penetrate 1 cm3 samples of waterlogged archaeological wood (density of 0.146 g/mL, maximum water content of 620%) after 14 days impregnation, as determined by FTIR spectroscopy. No impregnation material could be seen by SEM, suggesting that it coats the cell walls upon drying. This indicates that dehydrogenated polymers penetrate waterlogged archaeological wood well and have the potential to be developed into consolidants.

• Herstad, Gunnar; Molesworth, Peter Patrick; Miller, Charlotte Marie; Benneche, Tore & Tius, Marcus A. (2016). Ring-closing metathesis in an enantioselective synthesis of the macrocyclic core of crassin acetate. Tetrahedron. ISSN 0040-4020. 72(17), p. 2084–2093. doi: 10.1016/j.tet.2016.02.050. Full text in Research Archive
• Benneche, Tore & Tius, Marcus A. (2016). Synthesis of 2-oxaadamantane and 1-aryl-2-oxaadamantanes. Tetrahedron Letters. ISSN 0040-4039. 57(29), p. 3150–3151. doi: 10.1016/j.tetlet.2016.06.027. Full text in Research Archive
• Miller, Charlotte Marie; Benneche, Tore & Tius, Marcus A. (2015). First total synthesis of the marine natural products clavulolactones II and III. Organic and biomolecular chemistry. ISSN 1477-0520. 13(13), p. 4051–4058. doi: 10.1039/c5ob00074b. Full text in Research Archive
• Kristoffersen, Kenneth Aase & Benneche, Tore (2015). Trifluoroacetylation of electron-rich thiophenes. Journal of fluorine chemistry. ISSN 0022-1139. 176, p. 31–34. doi: 10.1016/j.jfluchem.2015.04.018. Full text in Research Archive Show summary

  Electron-rich thiophenes were trifluoroacetylated by trifluoroacetic anhydride with different nitrogen bases in dichloromethane at room temperature in good yields. Trifluoroacetylation without a base gave significantly lower yields.

• Benneche, Tore (2015). The use of α-halo ethers in the protection of alcohols. Years 2012 – 2014. Mini-Reviews in Organic Chemistry. ISSN 1570-193X. 12(4), p. 367–375. doi: 10.2174/1570193x12666150930222755. Full text in Research Archive
• Yang, Qian; Scheie, Anne Aamdal; Benneche, Tore & Defoirdt, Tom (2015). Specific quorum sensing-disrupting activity (AQSI) of thiophenones and their therapeutic potential. Scientific Reports. 5. doi: 10.1038/srep18033. Full text in Research Archive
• Vestby, Lene Karine; Johannesen, Karianne Cecilie Strømme; Witsø, Ingun Lund; Habimana, Olivier; Scheie, Anne Aamdal & Urdahl, Anne Margrete [Show all 9 contributors for this article] (2014). Synthetic brominated furanone F202 prevents biofilm formation by potentially human pathogenic Escherichia coli O103: H2 and Salmonella ser. Agona on abiotic surfaces. Journal of Applied Microbiology. ISSN 1364-5072. 116(2), p. 258–268. doi: 10.1111/jam.12355. Full text in Research Archive Show summary

  Aims Investigate the use of a synthetic brominated furanone (F202) against the establishment of biofilm by Salmonella ser. Agona and E. coli O103:H2 under temperature conditions relevant for the food and feed industry as well as under temperature conditions optimum for growth. Methods and Results Effect of F202 on biofilm formation by Salmonella ser. Agona and E. coli O103:H2 was evaluated using a microtiter plate assay and confocal microscopy. Effect of F202 on bacterial motility was investigated using swimming and swarming assays. Influence on flagellar synthesis by F202 was examined by flagellar staining. Results showed that F202 inhibited biofilm formation without being bactericidal. F202 was found to affect both swimming and swarming motility without, however, affecting the expression of flagella. Conclusions F202 showed its potential as a biofilm inhibitor of Salmonella ser. Agona and E. coli O103:H2 under temperature conditions relevant for the feed and food industry as well as temperatures optimum for growth. One potential mode of action of F202 was found to be by targeting flagellar function. Significance and Impact of the Study The present study gives valuable new knowledge to the potential use of furanones as a tool in biofilm management in the food and feed industry.

• Witsø, Ingun Lund; Benneche, Tore; Vestby, Lene Karine; Nesse, Live Lingaas; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2014). Thiophenone and Furanone in Control of Escherichia coli O103:H2 Virulence. Pathogens and Disease. 70(3), p. 297–306. doi: 10.1111/2049-632X.12128. Full text in Research Archive
• Benneche, Tore; Chamgordani, Elahe Jafari & Scheie, Anne Aamdal (2013). Reation of (Z)-5-bromomethylene)thiophene-2(5H)-one with some nucleophiles in search for new biofilm inhibitors. Synthetic Communications. ISSN 0039-7911. 43(3), p. 431–437. doi: 10.1080/00397911.2011.602496. Full text in Research Archive
• Pande, Gde Sasmita Julyantoro; Scheie, Anne Aamdal; Benneche, Tore; Wille, Mathieu; Sorgeloos, Patrick & Bossier, Peter [Show all 7 contributors for this article] (2013). Quorum sensing-disrupting compounds protect larvae of the giant freshwater prawn Macrobrachium rosenbergii from Vibrio harveyi infection. Aquaculture. ISSN 0044-8486. 406-407, p. 121–124. doi: 10.1016/j.aquaculture.2013.05.015. Full text in Research Archive
• Landsem, Eva; Jensen, Tomas Lunde; Kristensen, Tor Erik Holt; Hansen, Finn Knut; Benneche, Tore & Unneberg, Erik (2013). Isocyanate-Free and Dual Curing of Smokeless Composite Rocket Propellants. Propellants, explosives, pyrotechnics. ISSN 0721-3115. doi: 10.1002/prep.201200108. Full text in Research Archive Show summary

  Traditional composite rocket propellants are cured by treatment of hydroxyl-terminated prepolymers with polyfunctional aliphatic isocyanates. For development of smokeless composite propellants containing nitramines and/or ammonium dinitramide (ADN), energetic binder systems using glycidyl azide polymer (GAP) are of particular interest. Polyfunctional alkynes are potential isocyanate-free curing agents for GAP through thermal azide-alkyne cycloaddition and subsequent formation of triazole crosslinkages. Propargyl succinate or closely related aliphatic derivatives have previously been reported for such isocyanate-free curing of GAP. Herein, we present the synthesis and use of a new aromatic alkyne curing agent, the crystalline solid bisphenol A bis(propargyl ether) (BABE), as isocyanate-free curing agent in smokeless propellants based on GAP, using either octogen (HMX) and/or prilled ADN as energetic filler materials. Thermal and mechanical properties, impact and friction sensitivity and ballistic characteristics were evaluated for these alkyne cured propellants. Improved mechanical properties could be obtained by combining isocyanate and alkyne curing agents (dual curing), a combination that imparted better mechanical properties in the cured propellants than either curing system did individually. The addition of a neutral polymeric bonding agent (NPBA) for improvement of binder-filler interactions was also investigated using tensile testing and dynamic mechanical analysis (DMA). It was verified that the presence of isocyanates is essential for the NPBA to improve the mechanical properties of the propellants, further strengthening the attractiveness of dual cure systems.

• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2012). Kan bakteriers kommunikation öppna för nya infektionsbehandlingar? Läkartidningen. ISSN 0023-7205. 109(17-18), p. 879–881. Full text in Research Archive
• Benneche, Tore; Chamgordani, Elahe Jafari & Reimer, Inga (2012). A new synthesis of five-membered heterocyclic quorum sensing inhibitors. Tetrahedron Letters. ISSN 0040-4039. 53(51), p. 6982–6983. doi: 10.1016/j.tetlet.2012.10.048. Full text in Research Archive
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2012). Thiophenones inhibit Staphylococcus epidermidis biofilm formation at nontoxic concentrations. FEMS Immunology and Medical Microbiology. ISSN 0928-8244. 65(2), p. 326–334. doi: 10.1111/j.1574-695X.2012.00964.x. Full text in Research Archive
• Defoirdt, Tom; Benneche, Tore; Brackman, Gilles; Coenye, Tom; Sorgeloos, Patrick & Scheie, Anne Aamdal (2012). A Quorum Sensing-Disrupting Brominated Thiophenone with a Promising Therapeutic Potential to Treat Luminescent Vibriosis. PLOS ONE. 7(7). doi: 10.1371/journal.pone.0041788. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2011). Furanones and Thiophenones in Control of Staphylococcus epidermidis Biofilm Infections? In Mendez-Vilas, Antonio (Eds.), Science and Technology against Microbial Pathogens. Research, Development and Evaluation. World Scientific. ISSN 9789814354851. p. 155–159. Full text in Research Archive
• Benneche, Tore; Herstad, Gunnar; Rosenberg, Marianne Lenes; Assev, Synnøve & Scheie, Anne Aamdal (2011). Facile synthesis of 5-(alkylidene)thiophen-2(5H)-ones. A new class of antimicrobial agents. RSC Advances. 1(2), p. 323–332. doi: 10.1039/c1ra00254f. Full text in Research Archive
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2010). A synthetic furanone potentiates the effect of disinfectants on Salmonella in biofilm. Journal of Applied Microbiology. ISSN 1364-5072. 108(3), p. 771–778. doi: 10.1111/j.1365-2672.2009.04495.x. Full text in Research Archive
• Dixon, Darryl D.; Sethumadhavan, Divakaramanon; Benneche, Tore; Banaag, April R.; Tius, Marcus A. & Thakur, Ganesh A. [Show all 9 contributors for this article] (2010). Heteroadamantyl cannabinoids. Journal of Medicinal Chemistry. ISSN 0022-2623. 53, p. 5656–5666. Full text in Research Archive
• Lönn-Stensrud, Jessica; Landin, Maria Augusta Dos S Silva; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections? Journal of Antimicrobial Chemotherapy. ISSN 0305-7453. 63(2), p. 309–316. doi: 10.1093/jac/dkn501. Full text in Research Archive
• Benneche, Tore; Hussain, Zainab; Scheie, Anne Aamdal & Lönn-Stensrud, Jessica (2008). Synthesis of 5-(bromomethylene)furan-2(5H)-ones and 3-(bromomethylene)isobenzofuran-1(3H)-ones as inhibitors of microbial quorum sensing. New Journal of Chemistry. ISSN 1144-0546. 32(9), p. 1567–1572. doi: 10.1039/b803926g. Full text in Research Archive
• Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2007). Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci. Oral Microbiology and Immunology. ISSN 0902-0055. 22, p. 340–346. Full text in Research Archive
• Benneche, Tore; Lønn-Stensrud, Anna Maria Jessica & Scheie, Anne Aamdal (2006). Synthesis of (E)- and (Z)-5-(bromomethylene)furan-2(5H)-one by bromodecarboxylation of (E)-2-(5-oxofuran-2(5H)-ylidene)acetic acid. Synthetic Communications. ISSN 0039-7911. 36. Full text in Research Archive
• Herstad, Gunnar & Benneche, Tore (2003). Decarboxylation in the synthesis of 4-alkyl-, 4-alkenyl- and 4-acylpyrimidines. Journal of Heterocyclic Chemistry. ISSN 0022-152X. 40(2), p. 219–224. Full text in Research Archive
• Johannesen, Rune & Benneche, Tore (2000). Synthesis of Trimethylgermyl Trimethylsiyl Ketone and Bis(trimethylgermyl) Ketone. Journal of the Chemical Society. Perkin transactions 1. ISSN 0300-922X. p. 2677–2679. Full text in Research Archive
• Edvardsen, Kjetil Røe; Benneche, Tore & Tius, Marcus A. (2000). Synthesis and Reactions of (E)- and (Z)-1,3-Dibromo-2-methoxypropene. Journal of Organic Chemistry. ISSN 0022-3263. 65, p. 3085–3089. Full text in Research Archive
• Bjelland, Svein; Birkeland, Nils Kåre; Benneche, Tore; Volden, Gunnar & Seeberg, Erling (1994). DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli. Journal of Biological Chemistry. ISSN 0021-9258. 269(48), p. 30489–30495. doi: 10.1016/S0021-9258(18)43840-9. Full text in Research Archive
• Falck-Pedersen, Mette Lene; Benneche, Tore & Undheim, Kjell (1993). Palladium Catalysis in Allylic Rearrangements of Propenyl 2-Pyrimidinyl Carbonates to 1-Propenyl-2(1H)-pyrimidinones. Acta Chemica Scandinavica. ISSN 0904-213X. 47, p. 63–63. Full text in Research Archive

View all works in NVA

• Benneche, Tore (2007). Compounds with two carbon-heteroatom bonds. Georg Thieme Verlag. ISBN 9781588904614. 76 p. Full text in Research Archive
• Karen, Pavel & Benneche, Tore (2004). KJM1010 Kjemiske strukturer og prinsipper - Laboratoriekurs. Universitetet i Oslo. 81 p. Full text in Research Archive

View all works in NVA

• Vestby, Lene Karine; Berg, Kristin; Porwollik, Steffen; McClelland, Michael; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2019). To form a biofilm or not- that is the question for Salmonella under exposure to furanone. Full text in Research Archive
• McHale, Emily; Harding, Stephen & Benneche, Tore (2017). Branching out: Using the Chemistry of trees to preserve archaeological wood. Full text in Research Archive
• McHale, Emily; Steindal, Calin Constantin; Braovac, Susan; Gillis, Richard; Adams, Gary & Benneche, Tore [Show all 7 contributors for this article] (2016). Synthesis and characterisation of lignin-like oligomers as a bio-inspired consolidant for waterlogged archaeological wood. Full text in Research Archive
• McHale, Emily; Steindal, Calin Constantin; Benneche, Tore; Kutzke, Hartmut & Harding, Stephen E. (2016). IN SITU PREPARATION OF LIGNIN-LIKE OLIGOMERS FOR THE CONSOLIDATAION OF WATERLOGGED ARCHAEOLOGICAL WOOD. Full text in Research Archive
• McHale, Emily; Braovac, Susan; Steindal, Calin Constantin; Kutzke, Hartmut & Benneche, Tore (2016). Consolidation of waterlogged archaeological wood with lignin-like oligomers. Full text in Research Archive
• Vestby, Lene Karine; Berg, Kristin; Porwollik, Steffen; McClelland, Michael; Cheng, Pui & Scheie, Anne Aamdal [Show all 8 contributors for this article] (2015). Gene expression by Salmonella in the presence of a synthetic brominated furanone which inhibits biofilm formation. Full text in Research Archive
• McHale, Emily; Kutzke, Hartmut & Benneche, Tore (2015). Preservation of archaeological wood: a challenge for bio-inspired materials. Full text in Research Archive
• Kutzke, Hartmut; McHale, Emily; McQueen, Caitlin; Christensen, Mikkel & Benneche, Tore (2015). Curing wood with wood: wood components as consolidation materials for the conservation of archaeological wood. Full text in Research Archive
• Yang, qian; Scheie, Anne Aamdal; Benneche, Tore & Defoirdt, Tom (2015). NOVEL QUORUM SENSING-DISRUPTING THIOPHENONES AND THEIR THERAPEUTIC POTENTIAL. Full text in Research Archive
• Kutzke, Hartmut; McHale, Emily; McQueen, Caitlin; Christensen, Mikkel & Benneche, Tore (2015). Learning from nature - on the way to new bio-inspired materials for the conservation of archaeological wood. Full text in Research Archive
• Kutzke, Hartmut; Christensen, Mikkel; McHale, Emily; McQueen, Caitlin & Benneche, Tore (2015). Bio-inspired materials: a new generation of materials for preservation of art and archaeological objects? Full text in Research Archive
• Vestby, Lene Karine; Nesse, Live Lingaas; Delacroix, Stephanie; Osland, Ane Mohr; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2015). The potential of thiophenones as biofilm inhibitors in the petroleum industry. Full text in Research Archive
• McHale, Emily; Benneche, Tore; Kutzke, Hartmut; Christensen, Mikkel & Braovac, Susan (2014). Preservation of archaeological wood: a challenge for biomimetic materials. Full text in Research Archive
• Vestby, Lene Karine; Berg, K; Scheie, Anne Aamdal; Uhlig, Silvio; Benneche, Tore & Witsø, Ingun Lund [Show all 7 contributors for this article] (2014). Biofilm- naturlig bekjempelse. Full text in Research Archive
• Witsø, Ingun Lund; Rukke, Håkon Valen; Assev, Synnøve; Benneche, Tore; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2014). Structure-activity relationships in thiophenone. Full text in Research Archive
• Miller, Charlotte Marie & Benneche, Tore (2013). Total synthesis of the marine prostanoid clavulolactone II. Full text in Research Archive
• Molesworth, Peter Patrick; Herstad, Gunnar & Benneche, Tore (2013). Towards the enantioselective total synthesis of crassin acetate. Full text in Research Archive
• Molesworth, Peter Patrick; Herstad, Gunnar & Benneche, Tore (2013). Towards the enantioselective total synthesis of crassin acetate. Full text in Research Archive
• Molesworth, Peter Patrick; Herstad, Gunnar & Benneche, Tore (2013). Towards the enantioselective total synthesis of crassin acetate. Full text in Research Archive
• Landin, Maria Augusta Dos S Silva; Lonn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2013). Effekter av ikke toksiske furanoner på biofilm dannelse. Full text in Research Archive Show summary

  Staphylococcus epidermidis (S. epidermis) er ofte påvist i biofilm som foråsaker infeksjoner forbundet med medisinske inplantater. Noen furanoner minsker biofilm dannelse tilsynelatende uten å forårsake irritasjon eller genotoksiske effekter, og uten å påvirke S. epidermidis vekst. Furanoner hindrer kommunikasjon mellom bakterier og har stor potensial for å hemme biofilm dannelse. Mål: Å studere biofilmhemmende og genotoksisk effekt av ulike furanoner Materialer og metoder: 11 furanoner ble undersøkt vha bioluminisens og biofilm assayer. MIC (minste inhiberende konsentrasjon) for disse furanonene ble bestemt for å undersøke om dannelse av biofilm eller bakterievekst ble påvirket. Effekter av furanoner på bakterie kommunikasjon ble også undersøkt ved bioluminisensmålinger. Preliminære genotoksiske effekter hos CD-1 muselever og nyrer ble undersøkt vha mikromatriser og membran matriser. Resultater: Fire furanoner ble valgt ut for videre biofilm analyser etter bioluminisens test. Hver furanon ble testet med konsentrasjoner som ikke påvirket bakterie proliferasjon, men biofilm dannelse ble signifikant redusert ved bruk av disse furanoner. For de to mest effektive furanoner (F202 og F202) som også ble testet in vivo, ble det ikke påvist akutt toksisitet eller genotoksisitet.

• Witsø, Ingun Lund; Rukke, Håkon Valen; Benneche, Tore & Scheie, Anne Aamdal (2013). Thiophenone interferes with AI-2 stimulated quorum sensing in Escherichia coli. Full text in Research Archive
• Miller, Charlotte Marie; Benneche, Tore & Gundersen, Lise-Lotte (2013). Total synthesis of the prostanoids Clavulolactone II, Clavulolactone III and Carijenone. Full text in Research Archive
• Vestby, Lene Karine; Johannesen, Karianne Cecilie Strømme; Witsø, Ingun Lund; Habimana, Olivier; Scheie, Anne Aamdal & Benneche, Tore [Show all 8 contributors for this article] (2012). Biofilm formation by Salmonella and E. coli and their response to a synthetic furanone F202. Full text in Research Archive
• Witsö, I.L.; Benneche, Tore; Nesse, Live L.; Vestby, Lene Karine; Lönn-Stensrud, Jessica & Scheie, Anne Aamdal (2012). Thiophenone TF101 in control of E. coli biofilm? Full text in Research Archive
• Liao, S; Wang, Y; Bitoun, J.P.; Yao, X; Scheie, Anne Aamdal & Benneche, Tore [Show all 9 contributors for this article] (2012). Identification of small molecules against biofilm formation by Streptococcus mutans. Full text in Research Archive
• Landsem, Eva; Jensen, Tomas Lunde; Kristensen, Tor Erik; Unneberg, Erik; Benneche, Tore & Hansen, Finn Knut (2012). Improving the properties of minimum smoke composite rocket propellants. Full text in Research Archive
• Landsem, Eva; Tungen, Jørn Eivind; Kristensen, Tor Erik; Unneberg, Erik; Benneche, Tore & Hansen, Finn Knut (2011). Isocyanate-Free Curing of Glycidyl Azide Polymer (GAP). Full text in Research Archive
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Assev, Synnøve; Benneche, Tore & Scheie, Anne Aamdal (2011). New synthetic thiophenones inhibit biofilm formation by S. epidermidis. Full text in Research Archive
• Benneche, Tore & Benneche, Andreas (2010). Cannabinoider - noe mer enn rusmiddel? Kjemi. ISSN 0023-1983. p. 5–9. Full text in Research Archive
• Vestby, Lene Karine; Møretrø, Trond; Ballance, Simon; Benneche, Tore; Scheie, Anne Aamdal & Lönn-Stensrud, Jessica [Show all 8 contributors for this article] (2010). Persistence and eradication of Salmonella from the feed environment. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore & Scheie, Anne Aamdal (2010). Furanones and thiophenones in control of S. epidermidis biofilm infections? Full text in Research Archive
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm. Full text in Research Archive
• Scheie, Anne Aamdal & Benneche, Tore (2009). Norsk oppfinnelse kan hindre infeksjon i proteser. [Journal]. Aftenposten (morgenutg. : trykt utg.). Full text in Research Archive
• Vestby, Lene K.; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm. Full text in Research Archive
• Scheie, Anne Aamdal; Benneche, Tore & Vogt, Yngve (2009). Slutt på bakterieangrep i kunstige hofter. Full text in Research Archive
• Solheim, Heidi; Ahmed, Nibras Ayad Abdul-Majeed; Scheie, Anne Aamdal; Urdahl, Anne Margrete; Benneche, Tore & Møretrø, Trond [Show all 7 contributors for this article] (2009). Effect of two synthetic brominated furanones on Escherichia coli O103 in biofilm. Proceedings from Pathogenic E. coli. Full text in Research Archive
• Nesse, Live; Langsrud, Solveig; Møretrø, Trond; Scheie, Anne Aamdal; Benneche, Tore & Vestby, Lene K. (2009). Vil hindre bakteriesamtaler. Forskning.no. ISSN 1891-635X. Full text in Research Archive
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm. Full text in Research Archive
• Vestby, Lene Karine; Lönn-Stensrud, Jessica; Møretrø, Trond; Langsrud, Solveig; Scheie, Anne Aamdal & Benneche, Tore [Show all 7 contributors for this article] (2009). The effect of a synthetic furanone and disinfectants on Salmonella in biofilm. Full text in Research Archive
• Vestby, Lene Karine; Nesse, Live Lingaas; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond & Langsrud, Solveig [Show all 8 contributors for this article] (2008). AI-2 production by different wild-type Salmonella strains and the effect of biofilm formation by introducing AHL, GMP and a synthetic bromated furanones. Full text in Research Archive
• Nesse, Live; Vestby, Lene K.; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond & Langsrud, Solveig [Show all 8 contributors for this article] (2008). The effect of a synthetic bromated furanone on the production of biofilm by different Salmonella wild type strains. Full text in Research Archive
• Benneche, Tore (2007). Kan vi bekjempe bakterielle infeksjoner med bromerte furanoner. Kjemi. ISSN 0023-1983. p. 8–11. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Biofilm formation in Staphylococcus epidermidis is inhibited by synthetic bromated furanones. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Furanones Inhibit AI-2 Mediated Communication in Bacteria at Non-Irritant Concentrations. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakterier snakker, vi lider. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakteriesnakk gir tanntrøbbel. Forskning.no. ISSN 1891-635X. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Biofilm formation in Staphylococcus epidermidis is Inhibited by Synthetic Brominated Furanones. Full text in Research Archive Show summary

  The coagulase-negative staphylococci (CNS) are commensals of human skin and mucous membranes. Staphylococcus epidermidis is the most frequently isolated CNS species, and also one of the major nosocomial pathogens associated with infections on medical implants. The cause of infections is primarily related to biofilm formation on the implant. S. epidermidis infections represent a major burden to the public health system, and are often responsible for prolonged hospitalisation and occasional deaths. Microorganisms in nature prefer a biofilm life style. Biofilm infections are often difficult to treat due to increased resistance both to antibiotics and to the immune system. The algae Delisea pulchra produces bromated furanones that prevent bacterial biofilm formation on its surface. Similar furanones may interfere with both autoinducer-2 and autoinducer-1 signalling in Gram-positive and Gram-negative microorganisms without affecting bacterial growth.

• Benneche, Tore (2007). Kan vi bekjempe bakterier med 5-brommetylen-2(5H)-furanoner? Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2006). AI-2 Mediated Communication in Streptococcus anginosus, Streptococcus intermedius and Streptococcus mutans is Inhibited by Bromated Furanone. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2006). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone. Full text in Research Archive
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2006). AI-2 Mediated Communication in Oral Streptococci is Inhibited by Bromated Furanone. Full text in Research Archive
• Benneche, Tore; Tilset, Mats & Uggerud, Einar (2002). Den tredje industrielle epoke:Grønn kjemi. Apollon : Forskningsmagasin for Universitetet i Oslo. ISSN 0803-6926. 2. Full text in Research Archive
• Gundersen, Lise-Lotte; Benneche, Tore & Undheim, Kjell (1993). Pd(0)-Catalyzed Allylic Alkylation in the Synthesis of Carbocyclic Nucleosides. Full text in Research Archive
• McHale, Emily; Benneche, Tore & Kutzke, Hartmut (2018). The Development of Lignin-Like Oligomers for the Consolidation of Waterlogged Archaeological Wood. University of Oslo. Full text in Research Archive
• Chamgordani, Elahe Jafari; Benneche, Tore & Hansen, Finn Knut (2015). Synthesis of 5-Membered Heterocycles as Quorum Sensing Inhibitors. Universitetet i Oslo. Full text in Research Archive
• Kristoffersen, Kenneth Aase & Benneche, Tore (2015). Synthesis of thiophenones as quorum sensing inhibitors. Universitetet i Oslo. Full text in Research Archive Show summary

  Bacteria communicate using small signaling molecules as part of a system of communication called quorum sensing (QS) to control gene expression for synchronized bacterial behaviors. A task performed by bacteria that is often controlled by this means is biofilm production, making bacteria more resistant to external factors. Naturally occurring furanones that were isolated from a red macroalgae have been shown to have the ability to interrupt this communication. As a result thiophenones have been synthesized and investigated as a novel class of quorum sensing inhibitors (QSIs). Molecules of this class have greater biofilm reduction abilities than furanone equivalents for some bacteria. This discovery resulted in many more thiophenones with a variety of functional groups being synthesized using both classical and new methods. These compounds have been used in biological assays to determine their quorum sensing inhibition (QSI) potential, and have shown promising results. In this study tiobovolide has been synthesized and confirmed to exhibit some QSI properties. In addition to this trifluoromethyllated thiophenones have been synthesized and tested for QSI ability. It was found that most exhibited QSI properties, but that compounds with methyl groups in the 3- and 4-position showed no biological activity. This finding may support a 1,6-Michael-type reaction mechanism that has been suggested to be responsible for bioactivity.

• Landsem, Eva; Hansen, Finn Knut; Unneberg, Erik & Benneche, Tore (2012). Development of Smokeless Composite Rocket Propellants. Universitetet i Oslo. Full text in Research Archive
• Herstad, Gunnar; Benneche, Tore & Tius, Marcus A. (2010). Synthetic studies towards an enantioselective synthesis of crassin acetate. Universitetet i Oslo. Full text in Research Archive
• Benneche, Tore (2006). KJM1011 Organisk Kjemi I Laboratoriekurs. Akademisk Forlag. Full text in Research Archive
• Karen, Pavel & Benneche, Tore (2005). KJM1010 Kjemiske strukturer og prinsipper, Laboratoriekurs, vårsemester 2005. Universitetet i Oslo. Full text in Research Archive
• Benneche, Tore (2005). KJM 1020 Laboratoriekurs. Akademisk Forlag. Full text in Research Archive

View all works in NVA