Kristian Lensjø

https://www.nature.com/articles/s41593-020-0651-5

https://www.nature.com/articles/s41467-020-20241-w

https://www.science.org/doi/10.1126/sciadv.abd5684

http://www.pnas.org/content/115/3/607

http://www.jneurosci.org/content/37/5/1269

• Grødem, Sverre; Nymoen, Ingeborg; Vatne, Guro Helén; Rogge, Frederik Sebastian; Björnsdottir, Valgerdur & Lensjø, Kristian [Vis alle 7 forfattere av denne artikkelen] (2023). An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice. Nature Communications. ISSN 2041-1723. 14(1), s. 608–1. doi: 10.1038/s41467-023-36324-3. Fulltekst i vitenarkiv
• Lepperød, Mikkel Elle; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Buccino, Alessio Paolo; Yu, Jai & Fyhn, Marianne [Vis alle 7 forfattere av denne artikkelen] (2021). Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells. Science Advances. ISSN 2375-2548. 7(19). doi: 10.1126/sciadv.abd5684. Fulltekst i vitenarkiv
• Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Sutterud, Hallvard & Blackstad, Jan Sigurd [Vis alle 8 forfattere av denne artikkelen] (2021). Perineuronal nets stabilize the grid cell network. Nature Communications. ISSN 2041-1723. 12. doi: 10.1038/s41467-020-20241-w. Fulltekst i vitenarkiv
• Sugden, Arthur; Zaremba, Jeffrey; Sugden, Lauren A; Maguire, Kelly; Lutas, Andrew & Ramesh, Rohan [Vis alle 10 forfattere av denne artikkelen] (2020). Cortical reactivations of recent sensory experiences predict bidirectional network changes during learning. Nature Neuroscience. ISSN 1097-6256. 23, s. 981–991. doi: 10.1038/s41593-020-0651-5.
• Christensen, Ane Charlotte; Lepperød, Mikkel; Lensjø, Kristian Kinden; Dragly, Svenn-Arne; Blackstad, Jan Sigurd Beddari & Fyhn, Marianne [Vis alle 7 forfattere av denne artikkelen] (2019). Perineuronal nets stabilize the grid cell network. bioRxiv. ISSN 2692-8205. doi: 10.1101/796342.
• Rowlands, Daire; Lensjø, Kristian Kinden; Dinh, Tovy; Yang, Sujeon; Andrews, Melissa & Hafting, Torkel [Vis alle 9 forfattere av denne artikkelen] (2018). Aggrecan directs extracellular matrix mediated neuronal plasticity. Journal of Neuroscience. ISSN 0270-6474. 38(47), s. 10102–10113. doi: 10.1523/JNEUROSCI.1122-18.2018. Vis sammendrag

  In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan utilizing a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin expressing inhibitory interneurons towards a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.

• Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Malthe-sørenssen, Anders; Hafting, Torkel & Fyhn, Marianne (2018). Removal of perineuronal nets disrupts recall of a remote fear memory. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(3), s. 607–612. doi: 10.1073/pnas.1713530115. Fulltekst i vitenarkiv
• Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Tennøe, Simen; Fyhn, Marianne & Hafting, Torkel (2017). Differential Expression and Cell-Type Specificity of Perineuronal Nets in Hippocampus, Medial Entorhinal Cortex and Visual Cortex Examined in the Rat and Mouse. eNeuro. ISSN 2373-2822. 4(3), s. 1–18. doi: 10.1523/ENEURO.0379-16.2017. Fulltekst i vitenarkiv
• Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2017). Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma Activity. Journal of Neuroscience. ISSN 0270-6474. 37(5), s. 1269–1283. doi: 10.1523/JNEUROSCI.2504-16.2016.

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• Schlegel, Ulrike; Hjallar, Viktor A.; Lensjø, Kristian; Uggerud, Ida Margrethe; Bjaalie, Jan G. & Hvoslef-Eide, Martha [Vis alle 8 forfattere av denne artikkelen] (2022). Mapping of parahippocampal and visual neural networks in mice: Preliminary evidence for feedback projections from perirhinal cortex to visual areas. Vis sammendrag

  Feedback projections from higher-order processing areas to lower-order areas within the visual system havebeen observed in several species. While much is known about the function of feedforward connections in thevisual processing pathway, feedback connections are not as well studied. They are thought to cause behaviorssuch as (selective) attention or expectations, but the exact mechanism and underlying neural connectivity isstill unknown. The perirhinal cortex (PRH) forms the intersection between perceptual and mnemonic areas ofthe visual processing pathway. Evidence from rats, monkeys and humans suggests that it is involved in bothobject memory and perceptual tasks, which is reflected in its connectivity. PRH forms numerous feedforwardand feedback projections with other areas of the visual processing pathway. However, little is known about thefunction and organization of feedback projections from PRH, and other parahippocampal regions, to visualareas in mice. Given the widespread availability of genetic and molecular tools, novel opportunities toinvestigate the function of these feedback projections would be enabled by mapping them in mice. Here wepresent preliminary data from anterograde and retrograde tract tracing experiments showing feedbackprojections from PRH, and other parahippocampal regions, to visual areas. We have found first evidence forfeedback projections from PRH to lower-order visual areas that were assumed to be exclusive to higher-developed animals such as monkeys or humans. Further, we have identified feedback projections from otherparahippocampal regions with specific subregional distribution.

• Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2019). Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
• Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2019). Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
• Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Stöber, Tristan Manfred & Einevoll, Gaute [Vis alle 8 forfattere av denne artikkelen] (2018). Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
• Grødem, Sverre; Sandvik, Guro Katrine; Hazen, Jennifer; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2018). A CRISPR-Cas9 platform for genetic perturbations of brain extracellular matrix regulators in vivo .
• Lensjø, Kristian Kinden; Rowlands, Daire; Dinh, Tovy; Thompson, Elise Holter; Andrews, Melissa & Hafting, Torkel [Vis alle 9 forfattere av denne artikkelen] (2018). Conditional knock-out of the Acan gene removes perineuronal nets in adult mice and induces life-long brian plasticity.
• Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2018). Stable orientation tuning in the freely moving rat: Movement-robust orientation selective neurons in the deep layers of the primary visual cortex.
• Aasebø, Ida Elisabeth Jørgensen; Røe, Malin Benum; Mobarhan, Milad; Lensjø, Kristian Kinden; Stöber, Tristan Manfred & Einevoll, Gaute [Vis alle 8 forfattere av denne artikkelen] (2018). Orientation selectivity in the freely moving rat: Movement-robust orientation-selectivity (MROS) of units in the deep layers of the rat visual cortex .
• Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2018). Movement-resistant orientation selectivity of cells in the deep layers of the rat visual cortex.
• Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Fyhn, Marianne & Hafting, Torkel (2017). The role of extracellular matrix molecules for spatial representations in medial entorhinal cortex.
• Aasebø, Ida E. J.; Mobarhan, Milad; Røe, Malin Benum; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2017). Movement-resistant orientation-selective units in the deep layers of the visual cortex.
• Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Malthe-Sørenssen, Anders & Fyhn, Marianne (2017). The perineuronal nets in the lateral secondary visual cortex are essential for remote visual fear memory.
• Dinh, Tovy; Lensjø, Kristian Kinden; Lanton, Rune Alexander; Dick, Gunnar; Fyhn, Marianne & Hafting, Torkel (2017). Increased ocular dominance plasticity in adult visual cortex after genetic knock out of aggrecan, an essential component of perineuronal nets.
• Blackstad, Jan Sigurd; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Involvement of perineuronal nets in spatial information transfer between the entorhinal cortex and hippocampus.
• Blackstad, Jan Sigurd; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Involvement of perineuronal nets in spatial information transfer between the entorhinal cortex and hippocampus.
• Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Fyhn, Marianne & Malthe-Sørenssen, Anders (2016). The perineuronal nets in the lateral secondary visual cortex are essential for remote visual memory.
• Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, Mina Martine; Lensjø, Kristian Kinden; Einevoll, Gaute & Solstad, Trygve [Vis alle 8 forfattere av denne artikkelen] (2016). On the role of input-specific perturbations of medial septal projections to the grid cell network.
• Røe, Malin Benum; Aasebø, Ida E. J.; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Orientation selective cells in layer six of the primary visual cortex are resistant to the animal's movement.
• Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel & Fyhn, Marianne (2016). The perineuronal nets in the lateral secondary visual cortex and their impact on remote visual fear memory.
• Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2016). Removal of perineuronal nets affects information processing and plasticity in the primary visual cortex.
• Lepperød, Mikkel Elle; Wigestrand, Mattis B; Lensjø, Kristian Kinden; Frey, M.M.; Dragly, Svenn-Arne & Einevoll, Gaute [Vis alle 9 forfattere av denne artikkelen] (2016). Grid cell network resilient to input-specific medial septum perturbations.
• Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, M.M.; Lensjø, Kristian Kinden; Einevoll, Gaute & Solstad, Trygve [Vis alle 8 forfattere av denne artikkelen] (2016). Role of input-specific perturbations of medial septal projections to the grid cell network.
• Lepperød, Mikkel Elle; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2015). Building an entorhinal cortex network.
• Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2015). Removal of perineuronal nets in the visual cortex leads to a reduced inhibition and mimics critical period plasticity .
• Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Fyhn, Marianne & Hafting, Torkel (2015). The role of extracellular matrix molecules for spatial representations and plasticity in entorhinal cortex.
• Hafting, Torkel; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Dick, Gunnar & Fyhn, Marianne (2014). Perineuronal nets, plasticity and information-processing in visual cortex, medial entorhinal cortex and hippocampus.
• Aasebø, Ida E. J.; Norheim, Eivind Skjønsberg; Lensjø, Kristian Kinden; Fyhn, Marianne & Fyhn, Torkel Hafting (2013). The effect of anesthesia on activity and modulation of visually responsive neurons in cortical and subcortical areas.
• Lensjø, Kristian Kinden; Dick, Gunnar; Fyhn, Torkel Hafting & Fyhn, Marianne (2013). Cortical processing in awake, behaving rats after removal of perineuronal nets.

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