Patrick Riss

• Perez Garcia, Raul Manuel & Riss, Patrick Johannes (2022). Mild, Organo-Catalysed Borono-Deamination as a Key to Late-Stage Pharmaceutical Precursors and 18F-Labelled Radiotracers. Frontiers in Chemistry. ISSN 2296-2646. 10. doi: 10.3389/fchem.2022.884478. Fulltekst i vitenarkiv
• Bow, John-Paul James; Adami, Valentina; Marasco, Agostino; Grønnevik, Gaute; Rivers, Dean A. & Alvaro, Guiseppe [Vis alle 7 forfattere av denne artikkelen] (2022). A direct fixation of CO<inf>2</inf> for isotopic labelling of hydantoins using iodine-phosphine charge transfer complexes. Chemical Communications. ISSN 1359-7345. 58(54), s. 7546–7549. doi: 10.1039/d2cc01754g. Fulltekst i vitenarkiv
• Lehnert, Wencke; Riss, Patrick Johannes; Hurtado de Mendoza, Ana; Lopez, Sandra; Fernandez, Gonzalo & Ilheu, Marcelo [Vis alle 8 forfattere av denne artikkelen] (2022). Whole-body biodistribution and radiation dosimetry of [¹⁸F]PR04.MZ: a new PET radiotracer for clinical management of patients with movement disorders. EJNMMI Research. ISSN 2191-219X. 12(1). doi: 10.1186/s13550-021-00873-9. Fulltekst i vitenarkiv
• Bow, John-Paul J. & Riss, Patrick Johannes (2021). Phosgene-Free Carbonyl Insertion: Hot Advances in ¹¹C-Chemistry. Chemistry-Methods. ISSN 2628-9725. 1(3), s. 139–141. doi: 10.1002/cmtd.202000029.
• Perez Garcia, Raul Manuel; Grønnevik, Gaute & Riss, Patrick (2021). A General Protocol for Cu-Mediated Fluoro-deamination: Sandmeyer Fluorination of Diverse Aromatic Substrates. Organic Letters. ISSN 1523-7060. 23(3), s. 1011–1015. doi: 10.1021/acs.orglett.0c04209. Fulltekst i vitenarkiv
• Juri, Carlos; Kramer, Vasko; Riss, Patrick; Soza-Ried, Cristian; Haeger, Arlette & Pruzzo, Rossana [Vis alle 9 forfattere av denne artikkelen] (2021). 18F]PR04.MZ PET/CT Imaging for Evaluation of Nigrostriatal Neuron Integrity in Patients With Parkinson Disease. Clinical Nuclear Medicine. ISSN 0363-9762. 46(2), s. 119–124. doi: 10.1097/RLU.0000000000003430. Fulltekst i vitenarkiv
• Gurin, Andrey; Chakrova, Yelena; Matveyeva, Ilona & Riss, Patrick Johannes (2020). Optimization of reaction parameters for the synthesis of 177Lu-DOTAELA. Revista de chimie (Bucuresti). ISSN 0034-7752. 71(8), s. 55–62. doi: 10.37358/RC.20.8.8278.
• Kramer, Vasko; Brooks, Allen; Haeger, Arlette; Kuljs, Rodrigo; Muhammad Rafique, Waqas & Koeppe, Robert [Vis alle 11 forfattere av denne artikkelen] (2020). Evaluation of [18F]N-methyl-lansoprazole as a tau PET imaging agent in first-in-human studies. . ACS Chemical Neuroscience. ISSN 1948-7193. 11(3), s. 427–435. doi: 10.1021/acschemneuro.9b00639.
• Gurin, A.N.; Riss, Patrick; Chakrova, E.T.; Matveyeva, I.V. & Kadyrbaev, E.A. (2020). Study of the Purification of ¹⁷⁷Lu-DOTAELA Complex. Pharmaceutical Chemistry Journal. ISSN 0091-150X. 54(1), s. 64–68. doi: 10.1007/s11094-020-02157-3.
• Wærsted, Frøydis Meen; Riss, Patrick & Skipperud, Lindis (2020). The effect of water exchange on the leaching of alum shale. Applied Geochemistry. ISSN 0883-2927. 119. doi: 10.1016/j.apgeochem.2020.104610. Fulltekst i vitenarkiv
• Ott, Julian; Spilhaug, Mona M.; Maschauer, Simone; Rafique, Waqas; Jakobsson, Jimmy Erik & Hartvig, Karoline [Vis alle 10 forfattere av denne artikkelen] (2020). Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with 18F-Labeled Derivatives in Rats. Journal of Medicinal Chemistry. ISSN 0022-2623. 63(17), s. 9484–9499. doi: 10.1021/acs.jmedchem.0c00683. Fulltekst i vitenarkiv
• Stefan, Katja; Leck, Lionel Yi Wen; Namasivayam, Vigneshwaran; Bascuñana, Pablo; Huang, Michael Li-Hsuan & Riss, Patrick [Vis alle 9 forfattere av denne artikkelen] (2020). Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development. Future Drug Discovery. ISSN 2631-3316. 4:FDD51(2), s. 1–8. doi: 10.4155/fdd-2020-0025. Fulltekst i vitenarkiv
• Bekker, Roberto Bartholomeus Wilhelmus; Fjellaksel, Richard; Hjornevik, Trine; Nuruddin, Syed; Rafique, Waqas & Hansen, Jørn H [Vis alle 9 forfattere av denne artikkelen] (2020). Discovery of a lead brain-penetrating gonadotropin-releasing hormone receptor antagonist with saturable binding in brain. ChemMedChem. ISSN 1860-7179. 15(17), s. 1624–1628. doi: 10.1002/cmdc.202000256. Fulltekst i vitenarkiv
• Kramer, Vasko; Juri, Carlos; Riss, Patrick; Pruzzo, Rossana; Soza-Ried, Cristian & Flores, Jonathan [Vis alle 10 forfattere av denne artikkelen] (2019). Pharmacokinetic evaluation of [18F]PR04.MZ for PET/CT imaging and quantification of dopamine transporters in the human brain. European Journal of Nuclear Medicine and Molecular Imaging. ISSN 1619-7070. s. 1–11. doi: 10.1007/s00259-019-04594-z.
• Alluri, Santosh Reddy; Pitman, Kathinka; Malinen, Eirik & Riss, Patrick (2019). Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 63(1), s. 6–14. doi: 10.1002/jlcr.3814. Fulltekst i vitenarkiv
• Fjellaksel, Richard; Moldes-Anaya, Angel; Vasskog, Terje; Oteiza, Ana; Martin-Armas, Maria Montserrat & Hjelstuen, Ole Kristian [Vis alle 9 forfattere av denne artikkelen] (2019). Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. s. 1–13. doi: 10.1002/jlcr.3820. Fulltekst i vitenarkiv
• Jakobsson, Jimmy Erik; Gourni, Eleni; Shivashankar, Shivashankar; Brito, Beatriz & Riss, Patrick (2019). Synthesis and Characterization in Rodent Brain of the Subtype-Selective NR2B NMDA Receptor Ligand [11C]Ro04-5595 as a Potential Radiotracer for Positron Emission Tomography. ACS Omega. ISSN 2470-1343. 4(6), s. 9925–9931. doi: 10.1021/acsomega.9b00357.
• Pitman, Kathinka; Alluri, Santosh Reddy; Kristian, Alexandr; Aarnes, Eva-Katrine; Lyng, Heidi & Riss, Patrick [Vis alle 7 forfattere av denne artikkelen] (2019). Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts. European Journal of Nuclear Medicine and Molecular Imaging. ISSN 1619-7070. 46(10), s. 2190–2198. doi: 10.1007/s00259-019-04375-8.
• Fjellaksel, Richard; Oteiza, Ana; Martin-Armas, Montserrat; Riss, Patrick; Hjelstuen, Ole Kristian & Kuttner, Samuel [Vis alle 8 forfattere av denne artikkelen] (2018). First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor. BMC Research Notes. ISSN 1756-0500. 11(1), s. 1–6. doi: 10.1186/s13104-018-3924-2. Fulltekst i vitenarkiv
• Rafique, Waqas; Kramer, Vasko; Pardo, Tania; Smits, René; Spilhaug, Mona M. & Hoepping, Alexander [Vis alle 11 forfattere av denne artikkelen] (2018). Image-guided development of heterocyclic sulfoxides as ligands for tau neurofibrillary tangles: From first-in-man to second-generation ligands. ACS Omega. ISSN 2470-1343. 3(7), s. 7567–7579. doi: 10.1021/acsomega.8b00975.
• Jakobsson, Jimmy Erik; Grønnevik, Gaute; Rafique, Waqas; Hartvig, Karoline & Riss, Patrick (2018). Formamide as an Unconventional Amine Protecting Group for PET Radiochemistry. European Journal of Organic Chemistry. ISSN 1434-193X. 2018(27), s. 3701–3704. doi: 10.1002/ejoc.201800554.
• Munthe, Else; Riss, Patrick; Saga, T.; Haraldsen, Ira Hebold; Grad, Iwona & Bogsrud, Trond [Vis alle 7 forfattere av denne artikkelen] (2018). FDG-based quantitative comparison of glucose metabolism in vitro, exemplified by a head-to-head comparison between a triple-negative breast cancer cell line and a non-malignant foetal cell line. Clinical Physiology and Functional Imaging. ISSN 1475-0961. 38(1), s. 34–37. doi: 10.1111/cpf.12378.
• Jakobsson, Jimmy Erik & Riss, Patrick (2018). Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex. RSC Advances. ISSN 2046-2069. 8(38), s. 21288–21291. doi: 10.1039/c8ra03757d.
• Alluri, Santosh Reddy & Riss, Patrick (2018). Poly(ADP-ribose) polymerase in neurodegeneration: Radiosynthesis and radioligand binding in ARC-SWE tg mice. ACS Chemical Neuroscience. ISSN 1948-7193. 9(6), s. 1259–1263. doi: 10.1021/acschemneuro.8b00053.
• Alluri, Santosh Reddy & Riss, Patrick (2018). Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography. Organic and biomolecular chemistry. ISSN 1477-0520. 16(13), s. 2219–2224. doi: 10.1039/c8ob00184g.
• Fjellaksel, Richard; Sundset, Rune; Riss, Patrick & Hansen, Jørn H (2018). Copper-mediated late-stage iodination and 123I-labelling of triazole-benzimidazole bioactives. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. ISSN 0936-5214. 29(11), s. 1491–1495. doi: 10.1055/s-0036-1591985.
• Fjellaksel, Richard; Dugalic, Damir; Demissie, Taye Beyene; Riss, Patrick; Hjelstuen, Ole Kristian & Sundset, Rune [Vis alle 7 forfattere av denne artikkelen] (2018). An acylation-Finkelstein approach to radioiodination of bioactives: The role of amide group anchimeric assistance. Journal of Physical Organic Chemistry. ISSN 0894-3230. 31(7), s. 1–12. doi: 10.1002/poc.3835. Fulltekst i vitenarkiv
• Jakobsson, Jimmy Erik; Grønnevik, Gaute & Riss, Patrick (2017). Organocatalyst-assisted Ar-18F bond formation: A universal procedure for direct aromatic radiofluorination. Chemical Communications. ISSN 1359-7345. 53(96), s. 12906–12909. doi: 10.1039/c7cc07211b.
• Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri & Klaveness, Jo (2017). Recent development of non-peptide GnRH antagonists. Molecules. ISSN 1431-5157. 22:2188(12), s. 1–25. doi: 10.3390/molecules22122188. Fulltekst i vitenarkiv
• Rafique, Waqas; Shivashankar, Shivashankar; Milde, Mona & Riss, Patrick (2017). Reaching out for sensitive evaluation of the Mu opioid receptor in vivo: positron emission tomography imaging of the Agonist [11C]AH7921. ACS Chemical Neuroscience. ISSN 1948-7193. 8(9), s. 1847–1852. doi: 10.1021/acschemneuro.7b00075.
• Fjellaksel, Richard; Boomgaren, Marc; Sundset, Rune; Haraldsen, Ira Hebold; Hansen, Jørn H & Riss, Patrick (2017). Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor. MedChemComm. ISSN 2040-2503. 8(10), s. 1965–1969. doi: 10.1039/c7md00320j. Fulltekst i vitenarkiv
• Maschauer, Simone; Haller, Adelina; Riss, Patrick; Kuwert, Torsten; Prante, Olaf & Cumming, Paul (2015). Specific binding of [18F]fluoroethyl-harmol to monoamine oxidase A in rat brain cryostat sections, and compartmental analysis of binding in living brain. Journal of Neurochemistry. ISSN 0022-3042. 135(5), s. 908–917. doi: 10.1111/jnc.13370.
• Sommer, Theis; Bjerregaard-Andersen, Kaare; Simensen, Stine Marie; Jensen, Jan K.; Jochimsen, Bjarne & Riss, Patrick [Vis alle 8 forfattere av denne artikkelen] (2015). Enzymatic detection and quantification assay of isatin, a putative stress biomarker in blood. ACS Chemical Neuroscience. ISSN 1948-7193. 6(8), s. 1353–1360. doi: 10.1021/cn500346x.
• Cumming, Paul; Maschauer, Simone; Riss, Patrick; Grill, Eva; Pischetsrieder, Monika & Kuwert, Torsten [Vis alle 7 forfattere av denne artikkelen] (2015). Perturbed Development of Striatal Dopamine Transporters in Fatty Versus Lean Zucker Rats: a Follow-up Small Animal PET Study. Molecular Imaging and Biology. ISSN 1536-1632. 17(4), s. 521–528. doi: 10.1007/s11307-014-0811-7.
• Lien, Vegard Torp & Riss, Patrick (2014). Radiosynthesis of [18F]trifluoroalkyl groups: Scope and limitations. BioMed Research International. ISSN 2314-6133. 2014:380124. doi: 10.1155/2014/380124.
• Cumming, Paul; Maschauer, Simone; Riss, Patrick; Tschammer, Nuska; Fehler, Stefanie K. & Heinrich, Markus R. [Vis alle 8 forfattere av denne artikkelen] (2014). Radiosynthesis and validation of 18 F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 34(7), s. 1148–1156. doi: 10.1038/jcbfm.2014.63.
• Rühl, Thomas; Rafique, Waqas; Lien, Vegard Torp & Riss, Patrick (2014). Cu(I)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes†. Chemical Communications. ISSN 1359-7345. 50(45), s. 6056–6059. doi: 10.1039/c4cc01641f.
• Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm & Engebråten, Olav [Vis alle 8 forfattere av denne artikkelen] (2014). Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts. Acta Oncologica. ISSN 0284-186X. 53(8), s. 1086–1092. doi: 10.3109/0284186X.2014.934398.
• Riss, Patrick; Hoehnemann, Sabine; Piel, Markus & Roesch, F. (2013). Two-step radiosynthesis of [18F]FE--CIT and [18F]PR04.MZ. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 56(7), s. 356–359. doi: 10.1002/jlcr.3032.
• Riss, Patrick; Brichard, Laurent; Ferrari, Valentina; Williamson, David J.; Fryer, Tim D. & Hong, Young T. [Vis alle 8 forfattere av denne artikkelen] (2013). Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of tau-pathology. MedChemComm. ISSN 2040-2503. 4(5), s. 852–855. doi: 10.1039/c3md00017f.
• Riss, Patrick; Hong, Young T.; Marton, Janos; Caprioli, Daniele; Williamson, Derek & Ferrari, Valentina [Vis alle 12 forfattere av denne artikkelen] (2013). Synthesis and Evaluation of F-18-FE-PEO in Rodents: An F-18-Labeled Full Agonist for Opioid Receptor Imaging. Journal of Nuclear Medicine. ISSN 0161-5505. 54(2), s. 299–305. doi: 10.2967/jnumed.112.108688.

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• Gurin, A.N.; Riss, Patrick Johannes; Chakrova, E.T.; Matveyeva, I.V. & Kadyrbaev, E.A. (2020). Correction to: Study of the Purification of ¹⁷⁷Lu-DOTAELA Complex (Pharmaceutical Chemistry Journal, (2020), 54, 1, (64-68), 10.1007/s11094-020-02157-3). Pharmaceutical Chemistry Journal. ISSN 0091-150X. 54(7). doi: 10.1007/s11094-020-02270-3.
• Gee, Antony D.; Andersson, Jan; Bhalla, Rajiv; Choe, Yearn Seong; Dick, David W. & Herth, Matthias M. [Vis alle 28 forfattere av denne artikkelen] (2020). Training the next generation of radiopharmaceutical scientists. Nuclear Medicine and Biology. ISSN 0969-8051. 88-89, s. 10–13. doi: 10.1016/j.nucmedbio.2020.06.004.
• Fjellaksel, Richard; Oteiza, Ana; Martin, armas maria montserrat; Hansen, Jørn H; Moldes-Anaya, Angel & Vasskog, Terje [Vis alle 9 forfattere av denne artikkelen] (2018). Development and evaluation of gonadotropin releasing hormone SPECT radioligands.
• Fjellaksel, Richard; Hansen, Jørn H; Moldes-Anaya, Angel; Martin, armas maria montserrat; Oteiza, Ana & Riss, Patrick [Vis alle 7 forfattere av denne artikkelen] (2017). Development and evaluation of gonadotropin releasing hormone (GnRH) SPECT radioligands.
• Prante, Olaf; Haubner, Roland; Riss, Patrick & Neumaier, Bernd (2014). Recent trends in pharmaceutical radiochemistry for molecular PET imaging. BioMed Research International. ISSN 2314-6133. 2014. doi: 10.1155/2014/890540.
• Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm & Engebråten, Olav [Vis alle 8 forfattere av denne artikkelen] (2014). Pharmacokinetic modeling of dynamic 18F‐Choline PET reflects choline metabolism in breast carcinoma xenografts.
• Hartvig, Karoline; Riss, Patrick; Hjelstuen, Olaug & Brevik, Ellen Mengshoel (2020). Synthesis and evaluation of radiopharmaceuticals for targeted radionuclide therapy. Universitetet i Oslo. Vis sammendrag

  Nowadays, radionuclides play an important role in oncology, especially in the developing field of targeted radionuclide therapy (TRT). In this master thesis, the focus is to evaluate different radiolabeled targeting molecules for human epidermal growth factor receptor 2 (HER2) positive breast cancer and metastatic castration-resistant prostate cancer (mCRPC). The chosen targeting molecules are Herceptin® (trastuzumab) and PSMA-617, which will specifically target HER2- and PSMA-receptors, respectively. The HER2- and PSMA-receptors are excellent targets for use in targeted radionuclide therapy and should be explored further to achieve better and more efficient treatments than current treatments and for obtaining more personalized treatment regimens for patients. The β-emitter lutetium-177 (177Lu) has been thoroughly investigated with both trastuzumab and PSMA-617, but the use of the α-emitter actinium-225 (225Ac) is less studied with these targeting molecules. Although the 225Ac-PSMA-617 has been tested in patients, there is still a need for more knowledge about actinium-225, and a deeper understanding of the use of 225Ac in PSMA-617 and trastuzumab with regard to radiolabeling conditions, stability and their effects on cancer cells. This work has resulted in a successful synthesis of 225Ac-DOTA-trastuzumab, 225Ac-PSMA-617, [177Lu]Lu-DOTA-trastuzumab and [177Lu]Lu-PSMA-617 with high radiochemical yields (> 90 %). A new radiolabeling routine was obtained for 225Ac-PSMA-617 giving a yield of 98 % with good reproducibility. Furthermore, the stability of each radiolabeled conjugate has been thoroughly investigated and showed that all radiolabeled conjugates had a shelf-life of five days in the temperature range of 5-37 °C, except for 225Ac-DOTA-trastuzumab which only showed high stability over two days. Moreover, radiolysis effects were not observed for 225Ac-PSMA-617 samples with specific activities up to 216 kBq/µg, showing high stabilities over two weeks with approximately 90 % radiochemical purity. For 225Ac-DOTA-trastuzumab, only the samples with the lowest specific activities (< 1357 kBq/mg) were unaffected by radiolysis. The cell binding assays resulted in high cell-binding values of 94 % and 93 % for 225Ac-DOTA-trastuzumab and [177Lu]Lu-DOTA-trastuzumab on SKBR-3 cells. Furthermore, cell-binding values of 84 % and 85 % were obtained for 225Ac-PSMA-617 and [177Lu]Lu-PSMA-617 on LNCaP cells. Cell viability assays were performed and showed that 225Ac-PSMA-617 (in the range 2.5-600 Bq) is a more efficient therapeutic agent than [177Lu]Lu-PSMA-617 (in the range 50-400 kBq). The cell viability assays also confirmed that 225Ac-DOTA-trastuzumab has the potential of being a more efficient agent for the treatment of HER2-positive breast cancer than non-radioactive Herceptin®. The results of this thesis provide a significant contribution to the field of targeted alpha therapy (TAT) through studying the radiolabeling with 225Ac, the stability of 225Ac-labeled conjugates, their binding affinities and their ability to deplete cancer cells of ATP.

• Alluri, Santosh Reddy; Riss, Patrick & Henriksen, Gjermund (2018). Target oriented synthesis methods for imaging of proteins linked to cell-damage. University of Oslo. 2018(2049).
• Rafique, Waqas; Riss, Patrick & Omtvedt, Jon Petter (2018). Synthesis of Fluorine-18 Labelled Radiotraces and Their Pre-Clinical and Clinical Characterization. Kjemisk institutt, Universitetet i Oslo. ISSN 1501-7710. 2018(2013). Vis sammendrag

  Positron emission tomography (PET) is one of the most sensitive in vivo imaging techniques available to clinicians and researchers. It helps in understanding the biological interactions and mechanism of various diseases through use of radiolabelled compounds called radiotracers. Herein is described the development of facile radiolabelling approaches for straightforward access to 18F-labelled trifluoromethyl radiotracers. Direct nucleophilic radiofluorination of difluorovinyl precursors was achieved for 18F-trifluoromethylation of aliphatic compounds, and applied to the radiosynthesis of [18F]lansoprazole and N-methyl[18F]lansoprazole. The compounds were used to analyze the blood-brain barrier penetration in healthy persons and for the detection of tau-neurofibrillary tangles in Alzheimer’s patients. For 18F-trifluoromethylation of aromatic compounds, in situ synthesis of Cu[18F]CF3 was achieved and used in 18F-trifluoromethylation of iodo-arenes using a single vial one-step method. The procedure was applied for radiosynthesis of a derivative of AH7921, which is a sub-type selective mu-opioid receptor agonist. The developed procedures are applicable to available radiosynthesis hardware, and provide access to desired compounds within 40 minutes in high radiochemical yields. In addition, a series of new compounds were synthesized with aim to discover the new radioligands based on modifications to the lead compounds i.e. lansoprazole and AH7921. Several interesting candidates with good combination of affinity and selectivity were identified from each series, and radiolabelled with fluorine-18. The newly developed 18F-labelled compounds have good potential to provide the in vivo characterization of tau-neurofibrillary tangles and quantification of the opioid receptors using the PET imaging.

• Spilhaug, Mona M.; Riss, Patrick & Schoultz, Bent Wilhelm (2017). Determination of partitioning coefficients and protein binding using high performance liquid chromatography: Towards in vitro pharmacology in radiotracer development. Universitetet i Oslo.
• Grønnevik, Gaute; Riss, Patrick & Jakobsson, Jimmy Erik (2017). Radiofluorination of amines via hypervalent iodonium (III) ylides, reduction and activating group approach. Universitetet i Oslo.

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