Anteneh Assefa Desalegn

• Rodríguez-Carrillo, Andrea; Remy, Sylvie; Koppen, Gudrun; Wauters, Natasha; Mustieles, Vicente & Desalegn, Anteneh Assefa [Vis alle 20 forfattere av denne artikkelen] (2024). Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies. Science of the Total Environment. ISSN 0048-9697. 929. doi: 10.1016/j.scitotenv.2024.172426.
• Orangzeb, Saima; Desalegn, Anteneh Assefa; Trinh, Nhung; Zhao, Jing; Nordeng, Hedvig Marie Egeland & Lupattelli, Angela (2024). COVID-19 vaccine uptake among children and adolescents in Norway: A comprehensive registry-based cohort study of over 800,000 individuals. Vaccine. ISSN 0264-410X. doi: 10.1016/j.vaccine.2024.04.039.
• Desalegn, Anteneh Assefa; van der Ent, Wietske; Lenters, Virissa Claire; Torcelino-Iszatt, Nina Louise; Stigum, Hein & Lyche, Jan Ludvig [Vis alle 10 forfattere av denne artikkelen] (2023). Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies. Environment International. ISSN 0160-4120. 181. doi: 10.1016/j.envint.2023.108271. Fulltekst i vitenarkiv
• Rodríguez-Carrillo, Andrea; Remy, Sylvie; Koppen, Gudrun; Wauters, Natasha; Freire, Carmen & Olivas-Martínez, Alicia [Vis alle 24 forfattere av denne artikkelen] (2023). PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies. Environmental Pollution (1987). ISSN 0269-7491. 335. doi: 10.1016/j.envpol.2023.122214.
• Cox, Bianca; Wauters, Natasha; Rodríguez-Carrillo, Andrea; Portengen, Lützen; Gerofke, Antje & Kolossa-Gehring, Marike [Vis alle 21 forfattere av denne artikkelen] (2023). PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies. Toxics. ISSN 2305-6304. 11(8). doi: 10.3390/toxics11080711.
• Schillemans, Tessa; Iszatt, Nina; Remy, Sylvie; Schoeters, Greet; Fernández, Mariana F. & D'Cruz, Shereen Cynthia [Vis alle 28 forfattere av denne artikkelen] (2022). Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies. Environmental Pollution (1987). ISSN 0269-7491. 316(1). doi: 10.1016/j.envpol.2022.120566. Fulltekst i vitenarkiv
• Desalegn, Anteneh Assefa; Collet, Bérénice; Iszatt, Nina; Stigum, Hein; Jensen, Tina K. & Jonker, Lydia [Vis alle 9 forfattere av denne artikkelen] (2022). Aryl hydrocarbon receptor activity in human breast milk and cryptorchidism: A case-control study within the prospective Norwegian HUMIS cohort. Environmental Research. ISSN 0013-9351. 214, s. 1–11. doi: 10.1016/j.envres.2022.113861. Vis sammendrag

  Background The etiology of cryptorchidism remains poorly understood. Endocrine disrupting chemicals can impact estrogen signaling by interacting with aryl hydrocarbon receptor (AhR) activity. Objective To evaluate whether AhR activity in breast milk samples is associated with cryptorchidism. Method We conducted a case-control study based on 199 mother-child pairs (n = 91 cases/108 controls) selected from the Norwegian Human Milk Study (2002–2009). We defined cases for cryptorchidism based on maternal reports at 1-, 6-, 12-, and 24- months after birth. Chemically- and biologically stable AhR activity (pg 2,3,7,8-TCDD equivalent (TEQ)/g lipid) was determined by DR- CALUX® assay in the mothers’ milk collected at a median of 33 (10th–90th percentile: 18–57) days after delivery. We used multivariate logistic regression to compare AhR activity levels between cases and controls, and linear regression separately, to establish the relationship with the presence of 27 potential EDCs measured in breast milk and AhR activity. Results The average estimated daily intake (EDI) of dioxin and (dioxin-like (dl)-compounds via breast milk is 33.7 ± 17.9 pg TEQ/kg bodyweight per day among Norwegian children. There were no significant differences in AhR activation in breast milk samples between cases with cryptorchidism and controls. Among the 27 chemicals measured in breast milk, AhR activity was (borderline) significantly associated with all dl-PCBs, three non-dioxin-like (ndl)-PCBs (PCB-74, PCB-180, PCB-194) and two organochlorine pesticides (OCPs; HCB, β-HCH). No associations between AhR activity and brominated flame retardants (PBDEs) or poly- and perfluoroalkyl substances (PFASs). Conclusion No association between AhR activity and cryptorchidism was found among Norwegian boys. The average EDI of dioxin and dl-compounds in exclusively breastfed Norwegian infants remains above the safety threshold and, therefore requires further reduction measures. Consistent with a possible role in the observed AhR activity, all dl-PCBs were associated with AhR activity whereas the association was null for either PBDEs or PFASs.

• Collet, Bérénice; Desalegn, Anteneh Assefa; Swart, Kees; Naderman, Matthijs; Iszatt, Nina & Stigum, Hein [Vis alle 10 forfattere av denne artikkelen] (2022). Anti-androgenic compounds in breast milk and cryptorchidism among Norwegian boys in the HUMIS birth cohort. Science of the Total Environment. ISSN 0048-9697. 803. doi: 10.1016/j.scitotenv.2021.149746. Fulltekst i vitenarkiv Vis sammendrag

  The prevalence of cryptorchidism has increased over the past decades, yet its origins remain poorly understood. Testis descent is dependent on androgens and likely affected by endocrine disrupting compounds (EDCs), targeting the androgen receptor (AR). We investigated the association between anti-androgenic activity, not derived from natural hormones, in maternal breast milk and impaired testis descent among boys. We performed a case-control study based on 199 breast milk samples from 94 mothers of cryptorchid boys and 105 random non-cryptorchid boys participating in the Norwegian HUMIS (Human Milk Study) cohort. For each participant, apolar, and polar fractions were extracted, and combined to reconstitute a mixture. Anti-androgenic activity was measured in all three fractions using the human cell-based in vitro anti-AR CALUX® assay and expressed in μg of flutamide equivalent, a well-known antiandrogen. Results from fraction analyses were compared among boys with cryptorchidism and controls using multiple logistic regression, controlling for appropriate confounders identified using a directed acyclic graph. Children's daily exposure to anti-androgenic EDCs through breastfeeding was estimated to 78 μg flutamide eq./kg of body weigh/day. The activity was higher in the polar fraction (1.48 ± 1.37 μg flutamide eq./g of milk) mainly representing non-persistent chemicals, in contrast to other fractions. However, the activity in the polar extracts was decreased when in mixtures with the apolar fraction, indicating synergistic interactions. No significant difference in the activity was observed according to cryptorchid status for polar, apolar or mixed breast milk fractions. The study showed anti-androgenic activity in nearly all human milk samples, and at levels higher than the advisory threshold. However, no significant association was observed between cryptorchidism and antiandrogenic activity measured in either polar, apolar, or mixture fractions derived from breast milk.

• Desalegn, Anteneh Assefa; Iszatt, Nina; Stigum, Hein; Jensen, Tina Kold & Eggesbø, Merete Åse (2021). A case-cohort study of perinatal exposure to potential endocrine disrupters and the risk of cryptorchidism in the Norwegian HUMIS study. Environment International. ISSN 0160-4120. 157, s. 1–9. doi: 10.1016/j.envint.2021.106815. Fulltekst i vitenarkiv
• Desalegn, Anteneh Assefa; Bopp, Stephanie; Asturiol, David; Lamon, Lara; Paini, Alicia & Worth, Andrew (2019). Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures – A review. Computational Toxicology. ISSN 2468-1113. 10, s. 158–168. doi: 10.1016/j.comtox.2018.09.001.
• Paini, Alicia; Leonard, J.A.; Joossens, E.; Dorne, J.L.; Desalegn, Anteneh Assefa & Gosling, J.P. [Vis alle 19 forfattere av denne artikkelen] (2019). Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making. Computational Toxicology. ISSN 2468-1113. 9, s. 61–72. doi: 10.1016/j.comtox.2018.11.002.
• Carlander, Ulrika; Desalegn, Anteneh ; Moto, Tshepo Paulsen; Yokel, Robert A & Johanson, Gunnar (2018). Physiologically Based Pharmacokinetic Modeling of Nanoceria Systemic Distribution in Rats Suggests Dose- and Route-Dependent Biokinetics. International Journal of Nanomedicine. ISSN 1176-9114. 13, s. 2631–2646. doi: 10.2147/IJN.S157210.
• Desalegn, Anteneh Assefa; Bopp, Stephanie K.; Asturiol, David; Lamon, Lara; Worth, Andrew & Paini, Alicia (2018). Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures - A review. Computational Toxicology. ISSN 2468-1113. doi: 10.1016/j.comtox.2018.09.001. Fulltekst i vitenarkiv
• Desalegn, Anteneh Assefa & Berhan, Asres (2014). Cheating on examinations and its predictors among undergraduate students at Hawassa University College of Medicine and Health Science, Hawassa, Ethiopia. BMC Medical Education. ISSN 1472-6920. doi: 10.1186/1472-6920-14-89.
• Desalegn, Anteneh Assefa & Berhan, Asres (2014). Absenteeism among medical and health science undergraduate students at Hawassa University, Ethiopia. . BMC Medical Education. ISSN 1472-6920. doi: 10.1186/1472-6920-14-81.
• Desalegn, Anteneh Assefa (2013). Assessment of drug use pattern using WHO prescribing indicators at Hawassa University teaching and referral hospital, south Ethiopia: a cross-sectional study. BMC Health Services Research. ISSN 1472-6963. doi: 10.1186/1472-6963-13-170.

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