Dirk Linke

Image of Dirk Linke
Norwegian version of this page
Phone +47 22857654
Room 4126
Username
Visiting address Blindernveien 31 0371 Oslo
Postal address Postboks 1066 Blindern 0316 Oslo

Academic Interests

My research group focusses on the structure and function of the bacterial cell surface. 

Our work is typically comparative – we do not work on a single pathogenic “pet” organism, but instead compare related surface proteins from different species, studying their similarities and subtle differences. Our work is also interdisciplinary – we use methods from bioinformatics, structural biology and biophysics on top of classical methods from microbiology, molecular biology and biochemistry. For details, please see the group pages of the Linke lab.
 

Teaching

 

Tags: Microbiology, Biotechnology, Infectious Diseases, Biochemistry

Publications

  • Doudu, R; Linke, Dirk & Leo, Jack C. (2024). Fluorescent Labeling of Outer Membrane Proteins Using the SpyCatcher-SpyTag System. Methods in molecular biology. ISSN 1064-3745. 2778, p. 53–63.
  • Saragliadis, Athanasios & Linke, Dirk (2024). Bacterial Envelope Fractionation. Methods in molecular biology. ISSN 1064-3745. 2778, p. 43–52.
  • Meuskens, Ina; Leo, Jack C. & Linke, Dirk (2024). Recombinant Expression and Overproduction of Transmembrane beta-Barrel Proteins. Methods in molecular biology. ISSN 1064-3745. 2778.
  • Yoshimoto, Shogo; Ishii, Satoshi; Kawasshiri, A; Matshshita, T; Linke, Dirk & Gottig, Stephan [Show all 9 contributors for this article] (2024). Adhesion preference of the sticky bacterium Acinetobacter sp. Tol 5. Frontiers in Bioengineering and Biotechnology. ISSN 2296-4185. 12. doi: 10.3389/fbioe.2024.1342418.
  • Mertes, Verena; Saragliadis, Athanasios; Mascherin, E; Tysvær, Ellen-Beate; Roos, Norbert & Linke, Dirk [Show all 7 contributors for this article] (2024). Recombinant expression of Yersinia ruckeri outer membrane proteins in Escherichia coli extracellular vesicles. Protein Expression and Purification. ISSN 1046-5928. 215. doi: 10.1016/j.pep.2023.106409. Full text in Research Archive
  • Meuskens, Ina; Kristiansen, Per Eugen; Bardiaux, Benjamin; Koynarev, Vladimir Rosenov; Hatlem, Daniel & Prydz, Kristian [Show all 9 contributors for this article] (2023). A poly-proline II helix in YadA from Yersinia enterocolitica serotype O:9 facilitates heparin binding through electrostatic interactions. The FEBS Journal. ISSN 1742-464X. 291(4), p. 761–777. doi: 10.1111/febs.17001.
  • Campana Perilla, Ana Lucia; Saragliadis, Athanasios; Mikheenko, Pavlo & Linke, Dirk (2023). Insights into the bacterial synthesis of metal nanoparticles. Frontiers in Nanotechnology. ISSN 2673-3013. 5. doi: 10.3389/fnano.2023.1216921.
  • Hatlem, Daniel; Christensen, Mikkel; Broeker, Nina; Kristiansen, Per Eugen; Lund, Reidar & Barbirz, Stefanie [Show all 7 contributors for this article] (2023). A trimeric coiled-coil motif binds bacterial lipopolysaccharides with picomolar affinity. Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 13. doi: 10.3389/fcimb.2023.1125482. Full text in Research Archive
  • Sande, Maria G.; Ferreira, Débora; Rodrigues, Joana L.; Melo, Luís D. R.; Saragliadis, Athanasios & Linke, Dirk [Show all 9 contributors for this article] (2023). Aptasensor for the Detection of Moraxella catarrhalis Adhesin UspA2. Bioengineering. ISSN 2306-5354. 10(2), p. 1–20. doi: 10.3390/bioengineering10020178. Full text in Research Archive
  • Yoshimoto, Shogo; Aoki, Sota; Ohara, Yuki; Ishikawa, Masahito; Suzuki, Atsuo & Linke, Dirk [Show all 8 contributors for this article] (2023). Identification of the adhesive domain of AtaA from Acinetobacter sp. Tol 5 and its application in immobilizing Escherichia coli. Frontiers in Bioengineering and Biotechnology. ISSN 2296-4185. 10. doi: 10.3389/fbioe.2022.1095057. Full text in Research Archive
  • Michalik, Marcin; Djahanschiri, Bardya; Leo, Jack Christopher & Linke, Dirk (2022). An Update on “Reverse Vaccinology”: The Pathway from Genomes and Epitope Predictions to Tailored, Recombinant Vaccines. In Thomas, Sunil (Eds.), Vaccine Design. Methods and Protocols, Volume 3: Resources for Vaccine Development. Second Edition. Humana Press. ISSN 978-1-0716-1891-2. p. 45–71. doi: 10.1007/978-1-0716-1892-9. Full text in Research Archive
  • Joudeh, Nadeem; Saragliadis, Athanasios; Koster, Gerbrand; Mikheenko, Pavlo & Linke, Dirk (2022). Synthesis methods and applications of palladium nanoparticles: A review. Frontiers in Nanotechnology. ISSN 2673-3013. 4, p. 1–24. doi: 10.3389/fnano.2022.1062608. Full text in Research Archive
  • Sande, Maria; Roque, Lucia; Braga, Adelaide; Marques, Marcia; Ferreira, Debora & Saragliadis, Athanasios [Show all 11 contributors for this article] (2022). Design of new hydrolyzed collagen-modified magnetic nanoparticles to capture pathogens. Journal of Biomedical Materials Research. Part B - Applied biomaterials. ISSN 1552-4973. doi: 10.1002/jbm.b.35155.
  • Leva-Bueno, Juan; Meuskens, Ina; Linke, Dirk; Millner, Paul & Peyman, Sally A. (2022). A novel, proof-of-concept electrochemical impedimetric biosensor based on extracellular matrix protein-adhesin interaction. Sensors & Diagnostics. ISSN 2635-0998. 1(5), p. 1003–1013. doi: 10.1039/d2sd00075j. Full text in Research Archive
  • Thibau, Arno; Vaca, Diana J.; Bagowski, Marlene; Hipp, Katharina; Bender, Daniela & Ballhorn, Wibke [Show all 8 contributors for this article] (2022). Adhesion of Bartonella henselae to Fibronectin Is Mediated via Repetitive Motifs Present in the Stalk of Bartonella Adhesin A. Microbiology spectrum. ISSN 2165-0497. 10(5). doi: 10.1128/spectrum.02117-22. Full text in Research Archive
  • Sande, Maria; Ferreira, Debora; Rodrigues, Joana; Melo, Luis; Linke, Dirk & Silva, Carla [Show all 9 contributors for this article] (2022). Electrochemical Aptasensor for the Detection of the Key Virulence Factor YadA of Yersinia enterocolitica. Biosensors. ISSN 2079-6374. 12(8). doi: 10.3390/bios12080614. Full text in Research Archive
  • Hermansen, Simen; Ryoo, David; Rydmark, Marcella Christine Orwick; Saragliadis, Athanasios; Gumbart, James C & Linke, Dirk (2022). The Role of Extracellular Loops in the Folding of Outer Membrane Protein X (OmpX) of Escherichia coli. Frontiers in Molecular Biosciences. ISSN 2296-889X. 9. doi: 10.3389/fmolb.2022.918480. Full text in Research Archive
  • Vaca, Diana; Thibau, Arno; Leisegang, Matthias; Malmström, Johan; Linke, Dirk & Eble, Johannes A. [Show all 10 contributors for this article] (2022). Interaction of Bartonella henselae with Fibronectin Represents the Molecular Basis for Adhesion to Host Cells. Microbiology spectrum. ISSN 2165-0497. 10(3). doi: 10.1128/spectrum.00598-22. Full text in Research Archive
  • Joudeh, Nadeem & Linke, Dirk (2022). Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. Journal of Nanobiotechnology. ISSN 1477-3155. 20(1). doi: 10.1186/s12951-022-01477-8. Full text in Research Archive
  • Thibau, Arno; Hipp, Katharina; Vaca, Diana; Chowdhury, Sounak; Malmström, Johan & Saragliadis, Athanasios [Show all 9 contributors for this article] (2022). Long-read sequencing reveals genetic adaptation of Bartonella adhesin A among different Bartonella henselae isolates. Frontiers in Microbiology. ISSN 1664-302X. 13. doi: 10.3389/fmicb.2022.838267. Full text in Research Archive
  • Hermansen, Simen; Linke, Dirk & Leo, Jack Christopher (2022). Transmembrane β-barrel proteins of bacteria: From structure to function. In Donev, Rossen (Eds.), Membrane Proteins. Academic Press. ISSN 978-0-323-98895-7. p. 113–161. doi: 10.1016/bs.apcsb.2021.07.002.
  • Meuskens, Ina; Leva-Bueno, Juan; Millner, Paul; Schütz, Monika; Peyman, Sally & Linke, Dirk (2022). The Trimeric Autotransporter Adhesin YadA of Yersinia enterocolitica Serotype O:9 Binds Glycan Moieties. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.738818. Full text in Research Archive
  • Beal, J.; Saragliadis, Athanasios & Linke, Dirk (2021). Comparative analysis of three studies measuring fluorescence from engineered bacterial genetic constructs. PLOS ONE. ISSN 1932-6203. 16(6). doi: 10.1371/journal.pone.0252263. Full text in Research Archive
  • Mekasha, Sophanit & Linke, Dirk (2021). Secretion Systems in Gram-Negative Bacterial Fish Pathogens. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.782673. Full text in Research Archive
  • Chowdhury, Sounak; Khakzad, Hamed; Bergdahl, Gizem Ertürk; Lood, Rolf; Ekström, Simon & Linke, Dirk [Show all 9 contributors for this article] (2021). Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes. mSystems. ISSN 2379-5077. 6(5). doi: 10.1128/mSystems.00271-21. Full text in Research Archive
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2021). Magnetic decoration of Escherichia coli loaded with Palladium nanoparticles , 2021 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2021). IEEE (Institute of Electrical and Electronics Engineers). ISSN 978-1-6654-3907-7. p. NCI01-1–NCI01-5. doi: 10.1109/NAP51885.2021.9568523. Full text in Research Archive
  • Zhang, Zijian; Ryoo, David; Balusek, Curtis; Acharya, Atanu; Rydmark, Marcella Orwick & Linke, Dirk [Show all 7 contributors for this article] (2021). Inward-facing glycine residues create sharp turns in β-barrel membrane proteins. Biochimica et Biophysica Acta - Biomembranes. ISSN 0005-2736. 1863(10). doi: 10.1016/j.bbamem.2021.183662.
  • Joudeh, Nadeem; Saragliadis, Athanasios; Schulz, Christian; Voigt, Andre; Almaas, Eivind & Linke, Dirk (2021). Transcriptomic Response Analysis of Escherichia coli to Palladium Stress. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.741836. Full text in Research Archive
  • van Belkum, Alex; Almeida, Carina; Bardiaux, Benjamin; Barrass, Sarah V.; Butcher, Sarah J. & Çaykara, Tuğçe [Show all 34 contributors for this article] (2021). Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens. Diagnostics (Basel). ISSN 2075-4418. 11(7), p. 1–22. doi: 10.3390/diagnostics11071259. Full text in Research Archive
  • Wimmi, Stephan; Balinovic, Alexander; Jeckel, Hannah; Selinger, Lisa; Lampaki, Dimitrios & Eisemann, Emma [Show all 11 contributors for this article] (2021). Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH. Nature Communications. ISSN 2041-1723. 12(1), p. 1–14. doi: 10.1038/s41467-021-21863-4. Full text in Research Archive
  • Rooke, Jessica; Icke, Christopher; Wells, Timothy; Rossiter, Amanda; Browning, Douglas & Morris, Faye [Show all 12 contributors for this article] (2021). BamA and BamD Are Essential for the Secretion of Trimeric Autotransporter Adhesins. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.628879. Full text in Research Archive
  • Beal, J; Saragliadis, Athanasios & Linke, Dirk (2020). Robust estimation of bacterial cell count from optical density. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-01127-5. Full text in Research Archive
  • Claxton, James Benedict; Joudeh, Nadeem; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Sequential magnetic mapping of bacteria loaded with Pd-Fe nanoparticles , 2020 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2020). IEEE (Institute of Electrical and Electronics Engineers). ISSN 978-1-7281-8506-4. p. 01NIC01-1–01NIC01-5. doi: 10.1109/NAP51477.2020.9309619. Full text in Research Archive
  • Campaña Perilla, Ana Lucia; Joudeh, Nadeem; Høyer, Henrik; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Probing van der Waals and magnetic forces in bacteria with magnetic nanoparticles, 2020 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2020). IEEE (Institute of Electrical and Electronics Engineers). ISSN 978-1-7281-8506-4. p. 01NSSA03-1–01NSSA03-5. doi: 10.1109/NAP51477.2020.9309722. Full text in Research Archive
  • Stephan, Mareike; Broeker, Nina; Saragliadis, Athanasios; Roos, Norbert; Linke, Dirk & Barbirz, Stefanie (2020). In vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles. Frontiers in Microbiology. ISSN 1664-302X. 11. doi: 10.3389/fmicb.2020.510638. Full text in Research Archive
  • Hatlem, Daniel; Trunk, Thomas; Linke, Dirk & Leo, Jack Christopher (2020). Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins. In Leitao, JH (Eds.), Microbial Virulence Factors. MDPI. ISSN 978-3-03936-946-1. p. 371–400. doi: 10.3390/ijms20092129. Full text in Research Archive
  • Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Pérez-Ortega, Jesús; Sittman, Carolin; Göttig, Stephan & Liskiewicz, Krystyna Anna [Show all 11 contributors for this article] (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology. ISSN 1462-2912. 22(7), p. 2939–2955. doi: 10.1111/1462-2920.15051. Full text in Research Archive
  • Ryoo, David; Rydmark, Marcella Orwick; Pang, Yui Tik; Lundquist, Karl P; Linke, Dirk & Gumbart, James C (2020). BamA is required for autotransporter secretion. Biochimica et Biophysica Acta - General Subjects. ISSN 0304-4165. 1864(7), p. 1–8. doi: 10.1016/j.bbagen.2020.129581. Full text in Research Archive
  • Thibau, Arno; Dichter, Alexander A.; Vaca, Diana J.; Linke, Dirk; Goldman, Adrian & Kempf, Volkhard A.J. (2019). Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets. Medical Microbiology and Immmunology. ISSN 0300-8584. 209, p. 243–263. doi: 10.1007/s00430-019-00649-y. Full text in Research Archive
  • Aoki, S.; Yoshimoto, Shogo; Ishikawa, M; Linke, Dirk; Lupas, Andrei & Hori, Katsutoshi (2019). Native display of a huge homotrimeric protein fiber on the cell surface after precise domain deletion. Journal of Bioscience and Bioengineering. ISSN 1389-1723. p. 1–6. doi: 10.1016/j.jbiosc.2019.09.022.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen. The Cell Surface. ISSN 2468-2330. 5, p. 1–11. doi: 10.1016/j.tcsw.2019.100025. Full text in Research Archive
  • Finke, Sarah; Fagerlund, Annette; Smith, Veronika; Krogstad, Veronica; Zhang, Mimmi Jingxi & Saragliadis, Athanasios [Show all 9 contributors for this article] (2019). Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control. The Cell Surface. ISSN 2468-2330. 5, p. 1–12. doi: 10.1016/j.tcsw.2019.100032. Full text in Research Archive
  • Tørresen, Ole K.; Star, Bastiaan; Mier, Pablo; Andrade-Navarro, Miguel A.; Bateman, Alex & Jarnot, Patryk [Show all 13 contributors for this article] (2019). Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases. Nucleic Acids Research (NAR). ISSN 0305-1048. 47(21), p. 10994–11006. doi: 10.1093/nar/gkz841. Full text in Research Archive
  • Munoz Gonzalez, Florencia; Sycz, Gabriela; Alonso Paiva, Ivan M; Linke, Dirk; Zorreguieta, Angeles & Baldi, Pablo C [Show all 7 contributors for this article] (2019). The BtaF Adhesin Is Necessary for Full Virulence During Respiratory Infection by Brucella suis and Is a Novel Immunogen for Nasal Vaccination Against Brucella Infection. Frontiers in Immunology. ISSN 1664-3224. 10, p. 1–16. doi: 10.3389/fimmu.2019.01775. Full text in Research Archive
  • Wróbel, Agnieszka Ewelina; Leo, Jack Christopher & Linke, Dirk (2019). Overcoming fish defences: The virulence factors of Yersinia ruckeri. Genes. ISSN 2073-4425. 10(9), p. 1–20. doi: 10.3390/genes10090700. Full text in Research Archive
  • Weidensdorfer, Marko; Ishikawa, Masahito; Hori, Katsutoshi; Linke, Dirk; Djahanshiri, Bardya & Iruegas, Ruben [Show all 17 contributors for this article] (2019). The Acinetobacter trimeric autotransporter adhesin Ata controls key virulence traits of Acinetobacter baumannii. Virulence. ISSN 2150-5594. 10(1), p. 68–81. doi: 10.1080/21505594.2018.1558693. Full text in Research Archive
  • Micenková, Lenka; Bosak, Juraj; Kucera, Jiri; Hrala, Matej; Dolejsova, Tereza & Sedo, Ondrej [Show all 9 contributors for this article] (2019). Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains. Scientific Reports. ISSN 2045-2322. 9(1), p. 1–12. doi: 10.1038/s41598-019-47488-8. Full text in Research Archive
  • Meuskens, Ina; Saragliadis, Athanasios; Leo, Jack Christopher & Linke, Dirk (2019). Type V secretion systems: An overview of passenger domain functions. Frontiers in Microbiology. ISSN 1664-302X. 10, p. 1–19. doi: 10.3389/fmicb.2019.01163. Full text in Research Archive
  • Hatlem, Daniel; Trunk, Thomas; Linke, Dirk & Leo, Jack Christopher (2019). Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins. International Journal of Molecular Sciences. ISSN 1661-6596. 20(9), p. 1–19. doi: 10.3390/ijms20092129. Full text in Research Archive
  • Chauhan, Nandini; Hatlem, Daniel; Rydmark, Marcella Orwick; Schneider, Kenneth; Flötenmeyer, Matthias & Van Rossum, Barth-J [Show all 8 contributors for this article] (2019). Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA). Molecular Microbiology. ISSN 0950-382X. 111(3), p. 844–862. doi: 10.1111/mmi.14195. Full text in Research Archive
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2018). pYR4 From a Norwegian Isolate of Yersinia ruckeri Is a Putative Virulence Plasmid Encoding Both a Type IV Pilus and a Type IV Secretion System. Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 8, p. 1–14. doi: 10.3389/fcimb.2018.00373. Full text in Research Archive
  • Leo, Jack Christopher & Linke, Dirk (2018). A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition. AIMS Microbiology. ISSN 2471-1888. 4(3), p. 455–468. doi: 10.3934/microbiol.2018.3.455. Full text in Research Archive

View all works in Cristin

  • Linke, Dirk (2024). Trimeric Autotransporter Adhesins: structure, function, evolution.
  • Linke, Dirk & Falk, Jonathan (2024). Beroliger folk etter «zombie-virus»-funn. [Internet]. VG.NO.
  • Linke, Dirk (2023). Trimeric Autotransporters: non-globular, repetitive virulence factors with peculiar genomic recombination mechanisms.
  • Linke, Dirk (2023). A trimeric coiled-coil motif binds bacterial lipopolysaccharides with picomolar affinity.
  • Petrikonyte, Patricija; Mekasha, Sophanit & Linke, Dirk (2023). Tenacibaculum maritimum virulence factors.
  • Mekasha, Sophanit; Tøndervik, Anne & Linke, Dirk (2023). Exploring virulence factors of Tenacibaculum maritimum.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Bacterial synthesis of Palladium nanoparticles.
  • Yoshimoto, Shogo; Aoki, S.; Ohara, Y; Ishikawa, Masahito; Suzuki, A & Lupas, Andrei [Show all 8 contributors for this article] (2023). Identification of the adhesive domain of AtaA from Acinetobacter sp. Tol 5 and its application in immobilizing Escherichia coli.
  • Saragliadis, Athanasios & Linke, Dirk (2023). Development of assays for novel antimicrobials: screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Petrikonyte, Patricija; Mekasha, Sophanit & Linke, Dirk (2023). T. maritimum virulence factors.
  • Reese, Jan-Ole; Haugen, Håvard Jostein; Saragliadis, Athanasios & Linke, Dirk (2023). Development of multi-species biofilm models for evaluating medical approaches in dentistry .
  • Lislerud, Anna; Nakatani, Hajime; Spence, Maria Helle; Saragliadis, Athanasios; Hori, Katsutoshi & Linke, Dirk (2023). Adhesins of Yersinia ruckeri.
  • Mekasha, Sophanit; Haslene-Hox, Hanne; Sperstad, Sigrid Bakken; Tøndervik, Anne & Linke, Dirk (2023). Exploring virulence factors of Tenacibaculum maritimum.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Bacterial synthesis of Palladium nanoparticles.
  • Mertes, Verena; Saragliadis, Athanasios; Mascherin, E; Antenucci, Fabio; Bojesen, Anders Miki & Colquhoun, Duncan John [Show all 8 contributors for this article] (2023). Characterization of bacterial extracellular vesicles A versatile tool for potential vaccine application in aquaculture.
  • Linke, Dirk (2023). Structure, Function and Evolution of Autotransporter Adhesins.
  • Linke, Dirk (2023). Tandem repeat adhesins and dead repeat genes in bacteria.
  • Yoshimoto, Shogo; Aoki, S.; Ohara, Y; Ishikawa, Masahito; Suzuki, A & Linke, Dirk [Show all 7 contributors for this article] (2023). Downsizing of AtaA from Acinetobacter p. Tol5 and its application in immobilizing E.coli.
  • Sanz Gaitero, Marta; Cunha, Eva S.; Linke, Dirk & Luecke, Hartmut (2023). Using Escherichia coli as a model to test Helicobacter pylori urease inhibitors.
  • Linke, Dirk (2023). Trimeric Autotransporter Adhesins: Structure, Function, and Evolution.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Biosynthesis and characterization of Palladium-based nanoparticles produced by Escherichia coli.
  • Lislerud, Anna; Nakatani, Hajime; Spence, Maria Helle; Saragliadis, Athanasios; Hori, Katsutoshi & Linke, Dirk (2023). Adhesins of Yersinia ruckeri - Characterization of adhesion factors from the microbial fish pathogen Yersinia ruckeri and their association with host receptors. .
  • Petrikonyte, Patricija; Mekasha, Sophanit & Linke, Dirk (2023). Tenacibaculum maritimum virulence factors.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2023). Development of multi-species biofilm models for evaluating medical approaches in dentistry.
  • Meuskens, Ina; Kristiansen, Per Eugen; Bardiaux, Benjamin; Koynarev, Vladimir Rosenov; Hatlem, Daniel & Prydz, Kristian [Show all 9 contributors for this article] (2023). Strain variations in a bacterial adhesin lead to different binding partners in the pathogen Yersinia enterocolitica .
  • Mekasha, Sophanit & Linke, Dirk (2023). Virulence factors of the bacterial fish pathogen Tenacibaculum maritimum.
  • Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Colquhoun, Duncan John; Linke, Dirk & Winther-Larsen, Hanne Cecilie (2023). Characterization of extracellular membrane vesicles secreted from the Gram-negative bacterial fish pathogen Yersinia ruckeri .
  • Saragliadis, Athanasios & Linke, Dirk (2023). Assay development for novel antimicrobials: screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Lislerud, Anna; Nakatani, Hajime; Hori, Katsutoshi; Spence, Maria Helle; Saragliadis, Athanasios & Linke, Dirk (2023). Characterization of adhesion factors from the microbial fish pathogen Yersinia ruckeri and their association with host receptors.
  • Fan, Enguo & Linke, Dirk (2023). Methods and assays to study protein transport in vivo.
  • Ledo, Jesus & Linke, Dirk (2023). Biofouling on metal surfaces.
  • Hori, Katsutoshi & Linke, Dirk (2023). Application of a bacterial adhesin to bioprocesses.
  • Nakatani, Hajime; Linke, Dirk & Hori, Katsutoshi (2023). Study on the fish epidermal bacterial flora for fish disease control.
  • Leo, Jack C.; Linke, Dirk & Morth, P (2023). Role of the extracellular 'juncture' domain in the secretion and function of inverse autotransporters.
  • Yoshimoto, Shogo; Linke, Dirk & Hori, Katsutoshi (2023). Single-cell analysis of adhesive bacteria using atomic force microscopy.
  • Campana, A.; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Biosynthesis and characterization of Palladium-based nanoparticles produced by Escherichia coli.
  • Mekasha, Sophanit; Petrikonytė, Patricija & Linke, Dirk (2023). Virulence factors of the bacterial fish pathogen Tenacibaculum maritimum.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2023). Development of multi-species biofilm models for testing biotechnological approaches in dentistry.
  • Sanz-Gaitero, Marta; Cunha, Eva S.; Linke, Dirk & Lücke, Hartmut (2023). Using Escherichia coli as a model to test Helicobacter pylori urease inhibitors.
  • Linke, Dirk (2023). Trimeric Autotransporters: Function, Structure, Evolution.
  • Linke, Dirk (2023). Type-5-secreted adhesins in human and animal disease.
  • Linke, Dirk (2023). BEDPAN: Palladium nanoparticles from bacteria.
  • Linke, Dirk (2022). Structure, Function, and Evolution of trimeric autotransporter adhesins.
  • Linke, Dirk (2022). Bacterial adhesion and how to inhibit it.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2022). Development of multi-species biofilm models for testing biotechnological approaches in dentistry.
  • Mekasha, Sophanit & Linke, Dirk (2022). Toxins and secretion systems in Gram-negative bacterial fish pathogens.
  • Saragliadis, Athanasios & Linke, Dirk (2022). Structure-function relationship in bacterial adhesins.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Røyne, Anja & Linke, Dirk [Show all 7 contributors for this article] (2022). Biosynthesis and characterization of Palladium-Based Nanoparticles using Escherichia coli.
  • Mekasha, Sophanit & Linke, Dirk (2022). Toxins and secretion systems in Gram-negative bacterial fish pathogens. The case of T. maritimum.
  • Mertes, Verena; Saragliadis, Athanasios; Attenucci, Fabio; Wrobel, Agnieszka; Ciani, Elia & Linke, Dirk [Show all 8 contributors for this article] (2022). Characterization of bacterial extracellular vesicles from a fish pathogen, their role in virulence and possible function as vaccine in aquaculture.
  • Linke, Dirk (2022). Bacterial adhesion by fish pathogens.
  • Linke, Dirk (2022). Bacterial adhesion - structure and evolution of autotransporters.
  • Linke, Dirk (2022). Bacterial Adhesins - Structure and Function.
  • Linke, Dirk (2022). Trimeric Autotransporter Adhesins: Structure, Function, and Evolution.
  • Linke, Dirk (2022). How to apply for a PhD position... and how not to!
  • Hatlem, Daniel; Linke, Dirk Bernd Kurt & Andersen, Elisabeth K. (2022). Forskerprosjekt på antibiotika og blodforgiftning. [Internet]. Website Oslo Cancer Cluster.
  • Wimmi, Stephan; Balinovic, Alexander; Jeckel, Hannah; Selinger, Lisa; Lampaki, Dimitrios & Eisemann, Emma [Show all 11 contributors for this article] (2021). Author Correction: Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH (Nature Communications, (2021), 12, 1, (1625), 10.1038/s41467-021-21863-4). Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-23080-5.
  • Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Linke, Dirk; Colquhoun, Duncan J & Winther-Larsen, Hanne Cecilie (2021). Characterization of membrane vesicles from fish pathogens, their role in virulence and possible function as a vaccine in aquaculture.
  • Linke, Dirk (2021). Developing inhibitors that block adhesin-collagen interactions.
  • Fan, Enguo & Linke, Dirk (2021). the exchange program MISC - Options for internships at PMUC (with descriptions of current projects).
  • Hori, Katsutoshi & Linke, Dirk (2021). the exchange program MISC - Options for internships at Nagoya University (with descriptions of current projects by students).
  • Linke, Dirk; Økstad, Ole Andreas; Haugen, Håvard Jostein & Winther-Larsen, Hanne Cecilie (2021). The exchange program MISC - Options for internships at the University of Oslo (with descriptions of current projects).
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2021). Magnetic decoration of Escherichia coli loaded with Palladium nanoparticles .
  • Chowdhury, Sounak; Linke, Dirk; Happonen, Lotta Johanna & Malmström, Johan (2021). Streptococcus pyogenes forms M protein specific host-environment dependent protein complexes.
  • Thibau, Arno; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the fibronectin binding properties and genomic variation of Bartonella henselae adhesin.
  • Leva-Bueno, Juan; Meuskens, Ina; Linke, Dirk; Millner, Paul & Peyman, Sally (2021). Impedimetric biosensor based on extracellular matrix protein-adhesin interaction.
  • Meuskens, Ina; Leva-Bueno, Juan; Millner, Paul; Schütz, Monika; Peyman, Sally & Linke, Dirk (2021). The Trimeric Autotransporter Adhesin YadA of Yersinia binds to glycan moieties.
  • Vaca, Diana; Thibau, Arno; Linke, Dirk; Happonen, Lotta Johanna; Malmström, Johan & Kempf, Volkhard A.J. (2021). Interaction between Bartonella adhesin A and fibronectin in bacterial adherence to human endothelial cells.
  • Linke, Dirk (2021). Using LPS-Binding Peptides To Detect Endotoxins.
  • Chowdhury, Sounak; Linke, Dirk; Happonen, Lotta Johanna & Malmström, Johan (2021). Streptococcus Pyogenes Forms M Protein Specific Host-microenvironment Dependent Protein Complexes.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the Fibronectin Binding Properties of Bartonella henselae Adhesin A.
  • Leva, Juan; Meuskens, Ina; Linke, Dirk; Peyman, Sally & Millner, Paul (2021). Novel Electrochemical Biosensor for Pathogen Detection Based on Extracellular Matrix (ECM) Protein - Adhesin Interaction.
  • Meuskens, Ina & Linke, Dirk (2021). The Trimeric Autotransporter Adhesin YadA of Yersinia Binds to Glycan Moieties.
  • Vaca, Diana; Happonen, Lotta Johanna; Goldman, Adrian & Linke, Dirk (2021). Bacterial and Viral Adhesion; Two Sides of the Same Coin?
  • Butcher, Sarah Jane & Linke, Dirk (2021). Viral and Bacterial Adhesion - examples from current ViBrANT research.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the fibronectin binding properties of B. henselae adhesin A .
  • Meuskens, Ina; Michalik, Marcin; Chauhan, Nandini; Linke, Dirk & Leo, Jack Christopher (2020). Corrigendum: A New Strain Collection for Improved Expression of Outer Membrane Proteins (Frontiers in Cellular and Infection Microbiology, (2017), 7, (464), 10.3389/fcimb.2017.00464). Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 10. doi: 10.3389/fcimb.2020.00220.
  • Linke, Dirk (2020). LPS-Binding Peptides: New Tools for Endotoxin Detection and Removal?
  • Linke, Dirk (2020). Dette munnbindet skal drepe koronaviruset. [Internet]. TV2 website.
  • Campaña Perilla, Ana Lucia; Joudeh, Nadeem; Høyer, Henrik; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Probing van der Waals and magnetic forces in bacteria with magnetic nanoparticles.
  • Claxton, James; Joudeh, Nadeem; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Sequential magnetic mapping of bacteria loaded with Pd-Fe nanoparticles .
  • Linke, Dirk (2020). Palladium nanoparticles made by bacteria.
  • Linke, Dirk (2020). Biofilm-forming adhesins of the fish pathogen Yersinia ruckeri.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2020). Analysing the fibronectin binding properties of Bartonella henselae adhesin A.
  • Ryoo, David; Orwick-Rydmark, Marcella; Pang, Y; Lundqvist, Daniel; Linke, Dirk & Gumbart, JC (2020). Quantitative Comparisons of Competing Models of Autotransporter Passenger-Domain Secretion.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2019). Analysing the fibronectin binding domain of the Bartonella henselae adhesin A.
  • Orwick-Rydmark, Marcella & Linke, Dirk (2019). A novel antibiotic idea: Preventing bacterial stickiness. [Internet]. international.
  • Meuskens, Ina; Higson, Seamus & Linke, Dirk (2019). Innovative training networks: a new way of collaboration-propped PhD training. Medical Microbiology and Immmunology. ISSN 0300-8584. 209, p. 215–216. doi: 10.1007/s00430-019-00647-0.
  • Linke, Dirk (2019). The Gram-Negative Bacterial Cell Surface: How to Study Its Protein Components and How to Remove Endotoxin.
  • Mikheenko, Pavlo; Mikheenko, Iryna; Joudeh, Nadeem; Claxton, J. B.; Røyne, Anja & Linke, Dirk (2019). Imaging magnetism of biologically produced palladium nanoparticles .
  • Linke, Dirk & Joudeh, Nadeem (2019). Centre for Digital Life helps researchers right out of the gate (Senter for digitalt liv hjelper forskere ut av innovasjonsstartgropa). [Internet]. Center For Digital Life - Website.
  • Tietgen, M; Weidensdorfer, M; Leukert, L; Djahanshiri, Bardya; Iruegas, R & Ebersberger, Ingo [Show all 9 contributors for this article] (2019). Virulence of Acinetobacter baumannii depends on the Acinetobacter trimeric autotransporter adhesin (Ata).
  • Orwick-Rydmark, Marcella; Lindemann, Florian; Chauhan, Nandini; Yarava, J; Oschkinat, Hartmut & Van Rossum, Barth-J [Show all 7 contributors for this article] (2019). In situ structural and dynamic analysis of a membrane protein.
  • Linke, Dirk (2019). Type V secretion: membrane transport and anchoring of bacterial adhesins.
  • Joudeh, Nadeem & Linke, Dirk (2019). Bio-engineered Palladium Nanoparticles.
  • Joudeh, Nadeem & Linke, Dirk (2019). Bio-engineered Pd Nanoparticles.
  • Joudeh, Nadeem; Røyne, Anja; Mikheenko, Pavlo & Linke, Dirk (2019). Bio-Engineered Palladium Nanoparticles (BEDPAN).
  • Chowdhury, Sounak; Happonen, Lotta Johanna; Linke, Dirk & Malmström, Johan (2019). QUANTITATIVE AFFINITY-PURIFICATION AND SURFACE-ADSORPTION MASS SPECTROMETRY TO MAP STREPTOCOCCUS PYOGENES AND HUMAN PROTEIN INTERACTION.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk; Ballhorn, Wibke & Kempf, Volkhard A.J. (2019). Analysing the Fibronectin Binding Domain of the Bartonella henselae Adhesin A.
  • Meuskens, Ina; Leva, Juan; Millner, Paul & Linke, Dirk (2019). Differential Adhesion of Trimeric Autotransporter Adhesins to Extracellular Matrix Proteins.
  • Leva, Juan; Meuskens, Ina; Gibson, Timothy M.; Linke, Dirk & Millner, Paul (2019). Biosensors for pathogen detection.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen.
  • Linke, Dirk (2019). Autotransporter Adhesins in the fish pathogen Yersinia ruckeri.
  • Røsjø, Bjarne; Orwick-Rydmark, Marcella; Linke, Dirk; Leo, Jack Christopher & Hatlem, Daniel (2019). Ny antibiotika-idé: Vil hindre bakteriene i å feste seg. [Internet]. TITAN.NO.
  • Linke, Dirk (2019). Insights into the autotransport process of a trimeric autotransporter, YadA.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Orwick-Rydmark, Marcella; Van Rossum, Barth-J; Oschkinat, Hartmut & Linke, Dirk (2019). Towards the in situ structure of the Yersinia Adhesin A membrane anchor domain.
  • Meuskens, Ina & Linke, Dirk (2019). Binding of Yersinia Ahesin A to ECM molecules: a biosensor approach.
  • Hatlem, Daniel; Chauhan, Nandini; Orwick-Rydmark, Marcella; Schneider, Kenneth; Flötenmeyer, Matthias & Van Rossum, Barth-J [Show all 8 contributors for this article] (2019). Insights into the autotransport of a trimeric autotransporter.
  • Orwick-Rydmark, Marcella; Chauhan, Nandini; Van Rossum, Barth-J & Linke, Dirk (2019). Towards the structure of the YadA anchor domain in the native membrane.
  • Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
  • Kandanur, Sai Priya Sarma; Linke, Dirk & Leo, Jack Christopher (2019). Hairpin Formation and Passenger Secretion in the Inverse Autotransporter Intimin.
  • Chauhan, Nandini; Hatlem, Daniel; Orwick-Rydmark, Marcella; Schneider, Kenneth; Linke, Dirk & Leo, Jack Christopher (2019). Using the SpyCatcher-SpyTag technology for topology mapping of outer membrane proteins in Gram-negative bacteria.
  • Tietgen, M; Weidensdorfer, M; Djahanshiri, Bardya; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2019). Virulence of Acinetobacter baumannii depends on the Acinetobacter trimeric autotransporter adhesin Ata.
  • Leukert, L; Weidensdorfer, M; Djahanshiri, Bardya; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2019). The Acinetobacter Trimeric Autotransporter Adhesin Ata Controls Key Virulence Traits of Acinetobacter baumannii .
  • Linke, Dirk (2018). Vi må gjøre noe nå, før millioner av pasienter dør. [Internet]. Forsking.NO.
  • Hatlem, Daniel; Chauhan, Nandini; Rydmark, Marcella Orwick; Schneider, Kenneth; Floetenmeyer, Matthias & Leo, Jack Christopher [Show all 7 contributors for this article] (2018). Insights into the autotransporter process of a trimeric autotransporter, Yersinia Adhesin A (YadA).
  • Leo, Jack Christopher; Oberhettinger, Philipp; Schuetz, Monika & Linke, Dirk (2018). Type Ve secretion: the mechanism of inverse autotransport.
  • Joudeh, Nadeem & Linke, Dirk (2018). BEDPAN - Nanoparticles from Bacteria. [Internet]. Digital Life Website.
  • Hatlem, Daniel & Linke, Dirk (2018). Insights into the autotransporter process of a trimeric autotransporter, Yersinia Adhesin A (YadA).
  • Linke, Dirk (2018). Structural Biology of Membrane Proteins: Expression Tricks, and to Solubilize or Not to Solubilize.
  • Økstad, Ole Andreas Løchen & Linke, Dirk (2018). Hvor farlig er antibiotikaresistens? Ingeniørenes Stemme. Vinter 2018, p. 37–37.
  • Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
  • Linke, Dirk & Meuskens, Ina (2018). Adhesion of Yersinia Adhesin A to Collagen.
  • Linke, Dirk (2018). Trimeric Autotransporter Adhesins and routes to their inhibition.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
  • Joudeh, Nadeem; Leo, Jack Christopher; Torgeman, Eric & Linke, Dirk (2018). Mechanism of Palladium and Gold uptake and reduction in E. coli.
  • Balusek, Curtis; Linke, Dirk & Gumbart, JC (2018). The effect of beta-barrel geometry on ion conduction through Escherichia coli OmpX.
  • Leo, Jack Christopher; Schütz, Monika & Linke, Dirk (2018). Type Ve Secretion in Enterobacteria.
  • Khalil, Hawzeen; Øgaard, Jonas; Linke, Dirk & Leo, Jack Christopher (2018). Co-aggregation properties of trimeric autotransporter adhesins.
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2018). The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a “Y. ruckeri invasin-like molecule”, (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen.
  • Weidensdorfer, M; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2017). Establishing of a dynamic human ex vivo infection model for analyzing endothelial adherence of Acinetobacter baumannii.
  • Liskiewicz, Krystyna; Wrobel, Agnieszka; Leo, Jack Christopher & Linke, Dirk (2017). Identification of potential adhesin receptors from Yersinia ruckeri.
  • Linke, Dirk (2017). Do we have to purify membrane proteins? Solid-state NMR in the native membrane.
  • Meuskens, Ina; Linke, Dirk & Bardiaux, Benjamin (2022). Insights into the Binding Mechanism and Function of Bacterial Adhesins - Interactions between YadA and Host Extracellular Matrix Components. Universitetet i Oslo.
  • Hatlem, Daniel; Linke, Dirk & Krengel, Ute (2022). Probing the role of lipopolysaccharides in Gram-negative protein secretion and biogenesis. Universitetet i Oslo.
  • Bergvoll, Helga; Linke, Dirk & Saragliadis, Athanasios (2022). Secreted toxin components in the fish pathogen Tenacibaculum maritimum. Universitetet i Oslo.
  • Hovland, Hege; Linke, Dirk & Saragliadis, Athanasios (2022). Palladium nanoparticles in copper transport mutants of Escherichia coli. Universitetet i Oslo.
  • Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2022). Escherichia coli-mediated palladium nanoparticle synthesis. Universitetet i Oslo.
  • Spence, Maria Helle; Linke, Dirk & Saragliadis, Athanasios (2021). Yersinia adhesins: Investigating the role of autotransporter adhesins in fish infection by Yersinia ruckeri. Universitetet i Oslo.
  • Hermansen, Simen; Linke, Dirk & Orwick-Rydmark, Marcella (2021). Investigating the effects of loop modifications on the folding of outer membrane protein X. Universitetet i Oslo.
  • Trunk, Thomas; Leo, Jack Christopher & Linke, Dirk (2020). Characterization and comparative analyses of type Vd-secreted phospholipases expressed in pathogenic bacteria. Universitetet i Oslo.
  • Wrobel, Agnieszka & Linke, Dirk (2019). Structural and functional studies of the Yersinia ruckeri inverse autotransporters. Universitetet i Oslo.
  • Chauhan, Nandini & Linke, Dirk (2017). Molecular characterization of the autotransport process of Yersinia adhesin A (YadA). Universitetet i Oslo.
  • Torgeman, Eric; Linke, Dirk & Leo, Jack Christopher (2017). Biosynthesis of gold and palladium nanoparticles via bacteria. Universitetet i Oslo.

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Published Oct. 16, 2013 9:37 AM - Last modified June 17, 2022 3:11 AM