Dirk Linke

Bilde av Dirk Linke
English version of this page
Telefon +47 22857654
Rom 3517
Brukernavn
Besøksadresse Blindernveien 31 0371 Oslo
Postadresse Postboks 1066 Blindern 0316 Oslo

Academic Interests

My research group focusses on the structure and function of the bacterial cell surface. Currently, we work on three main topics:

  1. Bacterial Adhesion: How do bacteria stick to surfaces, or in the case of pathogens, to host cells?
  2. Membrane transport: how are adhesion molecules transported to the cell surface? And can this process be inhibited with novel antimicrobial substances?
  3. Vaccines and Biomarkers: can we exploit bacterial surface proteins as vaccine candidates or as biomarkers, e.g. for improved clinical diagnostics?

Our work is typically comparative – we do not work on a single pathogenic “pet” organism, but instead compare related surface proteins from different species, studying their similarities and subtle differences. Our work is also interdisciplinary – we use methods from bioinformatics, structural biology and biophysics on top of classical methods from microbiology, molecular biology and biochemistry.
 

Teaching

  • MBV 3060 (Basic Microbiology)
  • MBV 4910 (iGEM Competition)
  • ...


Higher education and employment history

  • since 2015 Full Professor, Department of Biosciences, UiO
  • since 2013 Associate Professor, Department of Biosciences, UiO
  • 2010 Habilitation, Department of Biology, University of Tübingen
  • 2007-2013 Project Leader, Max Planck Institute for Developmental Biology, Tübingen
  • 2003-2007 PostDoc, Max Planck Institute for Developmental Biology, Tübingen
  • 2002 PhD, Department of Chemistry, TU Berlin
  • 1991-1997, undergraduate studies in Biochemistry, FU Berlin
     

Honoraria

  • 2009 Young Academics Award from the German Society for Hygiene and Microbiology
  • 2008 and 2009 two 1-year stipends from the Bill & Melinda Gates Foundation
  • ...

Appointments

  • Advisory Board Member, Molecular Microbiology (Wiley)
  • Review Editor, Journal of Biological Chemistry
  • Review Editor, Frontiers in Microbiology

Publikasjoner

Se alle arbeider i Cristin

  • Linke, Dirk (2024). Trimeric Autotransporter Adhesins: structure, function, evolution.
  • Linke, Dirk & Falk, Jonathan (2024). Beroliger folk etter «zombie-virus»-funn. [Internett]. VG.NO.
  • Linke, Dirk (2023). Trimeric Autotransporters: non-globular, repetitive virulence factors with peculiar genomic recombination mechanisms.
  • Linke, Dirk (2023). A trimeric coiled-coil motif binds bacterial lipopolysaccharides with picomolar affinity.
  • Petrikonyte, Patricija; Mekasha, Sophanit & Linke, Dirk (2023). Tenacibaculum maritimum virulence factors.
  • Mekasha, Sophanit; Tøndervik, Anne & Linke, Dirk (2023). Exploring virulence factors of Tenacibaculum maritimum.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Bacterial synthesis of Palladium nanoparticles.
  • Yoshimoto, Shogo; Aoki, S.; Ohara, Y; Ishikawa, Masahito; Suzuki, A & Lupas, Andrei [Vis alle 8 forfattere av denne artikkelen] (2023). Identification of the adhesive domain of AtaA from Acinetobacter sp. Tol 5 and its application in immobilizing Escherichia coli.
  • Saragliadis, Athanasios & Linke, Dirk (2023). Development of assays for novel antimicrobials: screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Petrikonyte, Patricija; Mekasha, Sophanit & Linke, Dirk (2023). T. maritimum virulence factors.
  • Reese, Jan-Ole; Haugen, Håvard Jostein; Saragliadis, Athanasios & Linke, Dirk (2023). Development of multi-species biofilm models for evaluating medical approaches in dentistry .
  • Lislerud, Anna; Nakatani, Hajime; Spence, Maria Helle; Saragliadis, Athanasios; Hori, Katsutoshi & Linke, Dirk (2023). Adhesins of Yersinia ruckeri.
  • Mekasha, Sophanit; Haslene-Hox, Hanne; Sperstad, Sigrid Bakken; Tøndervik, Anne & Linke, Dirk (2023). Exploring virulence factors of Tenacibaculum maritimum.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Bacterial synthesis of Palladium nanoparticles.
  • Mertes, Verena; Saragliadis, Athanasios; Mascherin, E; Antenucci, Fabio; Bojesen, Anders Miki & Colquhoun, Duncan John [Vis alle 8 forfattere av denne artikkelen] (2023). Characterization of bacterial extracellular vesicles A versatile tool for potential vaccine application in aquaculture.
  • Linke, Dirk (2023). Structure, Function and Evolution of Autotransporter Adhesins.
  • Linke, Dirk (2023). Tandem repeat adhesins and dead repeat genes in bacteria.
  • Yoshimoto, Shogo; Aoki, S.; Ohara, Y; Ishikawa, Masahito; Suzuki, A & Linke, Dirk [Vis alle 7 forfattere av denne artikkelen] (2023). Downsizing of AtaA from Acinetobacter p. Tol5 and its application in immobilizing E.coli.
  • Sanz Gaitero, Marta; Cunha, Eva S.; Linke, Dirk & Luecke, Hartmut (2023). Using Escherichia coli as a model to test Helicobacter pylori urease inhibitors.
  • Linke, Dirk (2023). Trimeric Autotransporter Adhesins: Structure, Function, and Evolution.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Biosynthesis and characterization of Palladium-based nanoparticles produced by Escherichia coli.
  • Lislerud, Anna; Nakatani, Hajime; Spence, Maria Helle; Saragliadis, Athanasios; Hori, Katsutoshi & Linke, Dirk (2023). Adhesins of Yersinia ruckeri - Characterization of adhesion factors from the microbial fish pathogen Yersinia ruckeri and their association with host receptors. .
  • Petrikonyte, Patricija; Mekasha, Sophanit & Linke, Dirk (2023). Tenacibaculum maritimum virulence factors.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2023). Development of multi-species biofilm models for evaluating medical approaches in dentistry.
  • Meuskens, Ina; Kristiansen, Per Eugen; Bardiaux, Benjamin; Koynarev, Vladimir Rosenov; Hatlem, Daniel & Prydz, Kristian [Vis alle 9 forfattere av denne artikkelen] (2023). Strain variations in a bacterial adhesin lead to different binding partners in the pathogen Yersinia enterocolitica .
  • Mekasha, Sophanit & Linke, Dirk (2023). Virulence factors of the bacterial fish pathogen Tenacibaculum maritimum.
  • Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Colquhoun, Duncan John; Linke, Dirk & Winther-Larsen, Hanne Cecilie (2023). Characterization of extracellular membrane vesicles secreted from the Gram-negative bacterial fish pathogen Yersinia ruckeri .
  • Saragliadis, Athanasios & Linke, Dirk (2023). Assay development for novel antimicrobials: screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Lislerud, Anna; Nakatani, Hajime; Hori, Katsutoshi; Spence, Maria Helle; Saragliadis, Athanasios & Linke, Dirk (2023). Characterization of adhesion factors from the microbial fish pathogen Yersinia ruckeri and their association with host receptors.
  • Fan, Enguo & Linke, Dirk (2023). Methods and assays to study protein transport in vivo.
  • Ledo, Jesus & Linke, Dirk (2023). Biofouling on metal surfaces.
  • Hori, Katsutoshi & Linke, Dirk (2023). Application of a bacterial adhesin to bioprocesses.
  • Nakatani, Hajime; Linke, Dirk & Hori, Katsutoshi (2023). Study on the fish epidermal bacterial flora for fish disease control.
  • Leo, Jack C.; Linke, Dirk & Morth, P (2023). Role of the extracellular 'juncture' domain in the secretion and function of inverse autotransporters.
  • Yoshimoto, Shogo; Linke, Dirk & Hori, Katsutoshi (2023). Single-cell analysis of adhesive bacteria using atomic force microscopy.
  • Campana, A.; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Linke, Dirk & Mikheenko, Pavlo (2023). Biosynthesis and characterization of Palladium-based nanoparticles produced by Escherichia coli.
  • Mekasha, Sophanit; Petrikonytė, Patricija & Linke, Dirk (2023). Virulence factors of the bacterial fish pathogen Tenacibaculum maritimum.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2023). Development of multi-species biofilm models for testing biotechnological approaches in dentistry.
  • Sanz-Gaitero, Marta; Cunha, Eva S.; Linke, Dirk & Lücke, Hartmut (2023). Using Escherichia coli as a model to test Helicobacter pylori urease inhibitors.
  • Linke, Dirk (2023). Trimeric Autotransporters: Function, Structure, Evolution.
  • Linke, Dirk (2023). Type-5-secreted adhesins in human and animal disease.
  • Linke, Dirk (2023). BEDPAN: Palladium nanoparticles from bacteria.
  • Linke, Dirk (2022). Structure, Function, and Evolution of trimeric autotransporter adhesins.
  • Linke, Dirk (2022). Bacterial adhesion and how to inhibit it.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2022). Development of multi-species biofilm models for testing biotechnological approaches in dentistry.
  • Mekasha, Sophanit & Linke, Dirk (2022). Toxins and secretion systems in Gram-negative bacterial fish pathogens.
  • Saragliadis, Athanasios & Linke, Dirk (2022). Structure-function relationship in bacterial adhesins.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Røyne, Anja & Linke, Dirk [Vis alle 7 forfattere av denne artikkelen] (2022). Biosynthesis and characterization of Palladium-Based Nanoparticles using Escherichia coli.
  • Mekasha, Sophanit & Linke, Dirk (2022). Toxins and secretion systems in Gram-negative bacterial fish pathogens. The case of T. maritimum.
  • Mertes, Verena; Saragliadis, Athanasios; Attenucci, Fabio; Wrobel, Agnieszka; Ciani, Elia & Linke, Dirk [Vis alle 8 forfattere av denne artikkelen] (2022). Characterization of bacterial extracellular vesicles from a fish pathogen, their role in virulence and possible function as vaccine in aquaculture.
  • Linke, Dirk (2022). Bacterial adhesion by fish pathogens.
  • Linke, Dirk (2022). Bacterial adhesion - structure and evolution of autotransporters.
  • Linke, Dirk (2022). Bacterial Adhesins - Structure and Function.
  • Linke, Dirk (2022). Trimeric Autotransporter Adhesins: Structure, Function, and Evolution.
  • Linke, Dirk (2022). How to apply for a PhD position... and how not to!
  • Hatlem, Daniel; Linke, Dirk Bernd Kurt & Andersen, Elisabeth K. (2022). Forskerprosjekt på antibiotika og blodforgiftning. [Internett]. Website Oslo Cancer Cluster.
  • Wimmi, Stephan; Balinovic, Alexander; Jeckel, Hannah; Selinger, Lisa; Lampaki, Dimitrios & Eisemann, Emma [Vis alle 11 forfattere av denne artikkelen] (2021). Author Correction: Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH (Nature Communications, (2021), 12, 1, (1625), 10.1038/s41467-021-21863-4). Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-23080-5.
  • Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Linke, Dirk; Colquhoun, Duncan J & Winther-Larsen, Hanne Cecilie (2021). Characterization of membrane vesicles from fish pathogens, their role in virulence and possible function as a vaccine in aquaculture.
  • Linke, Dirk (2021). Developing inhibitors that block adhesin-collagen interactions.
  • Fan, Enguo & Linke, Dirk (2021). the exchange program MISC - Options for internships at PMUC (with descriptions of current projects).
  • Hori, Katsutoshi & Linke, Dirk (2021). the exchange program MISC - Options for internships at Nagoya University (with descriptions of current projects by students).
  • Linke, Dirk; Økstad, Ole Andreas; Haugen, Håvard Jostein & Winther-Larsen, Hanne Cecilie (2021). The exchange program MISC - Options for internships at the University of Oslo (with descriptions of current projects).
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2021). Magnetic decoration of Escherichia coli loaded with Palladium nanoparticles .
  • Linke, Dirk; Mikheenko, Pavlo; Campana Perilla, Ana Lucia & Røyne, Anja (2024). Palladium-based nanoparticles produced by Escherichia coli. Universitetet i Oslo.
  • Meuskens, Ina; Linke, Dirk & Bardiaux, Benjamin (2022). Insights into the Binding Mechanism and Function of Bacterial Adhesins - Interactions between YadA and Host Extracellular Matrix Components. Universitetet i Oslo.
  • Hatlem, Daniel; Linke, Dirk & Krengel, Ute (2022). Probing the role of lipopolysaccharides in Gram-negative protein secretion and biogenesis. Universitetet i Oslo.
  • Bergvoll, Helga; Linke, Dirk & Saragliadis, Athanasios (2022). Secreted toxin components in the fish pathogen Tenacibaculum maritimum. Universitetet i Oslo.
  • Hovland, Hege; Linke, Dirk & Saragliadis, Athanasios (2022). Palladium nanoparticles in copper transport mutants of Escherichia coli. Universitetet i Oslo.
  • Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2022). Escherichia coli-mediated palladium nanoparticle synthesis. Universitetet i Oslo.
  • Spence, Maria Helle; Linke, Dirk & Saragliadis, Athanasios (2021). Yersinia adhesins: Investigating the role of autotransporter adhesins in fish infection by Yersinia ruckeri. Universitetet i Oslo.

Se alle arbeider i Cristin

Publisert 16. okt. 2013 09:29 - Sist endret 29. jan. 2015 11:53