Dirk Linke

Bilde av Dirk Linke
English version of this page
Telefon +47 22857654
Rom 3517
Brukernavn
Besøksadresse Blindernveien 31 0371 Oslo
Postadresse Postboks 1066 Blindern 0316 Oslo

Academic Interests

My research group focusses on the structure and function of the bacterial cell surface. Currently, we work on three main topics:

  1. Bacterial Adhesion: How do bacteria stick to surfaces, or in the case of pathogens, to host cells?
  2. Membrane transport: how are adhesion molecules transported to the cell surface? And can this process be inhibited with novel antimicrobial substances?
  3. Vaccines and Biomarkers: can we exploit bacterial surface proteins as vaccine candidates or as biomarkers, e.g. for improved clinical diagnostics?

Our work is typically comparative – we do not work on a single pathogenic “pet” organism, but instead compare related surface proteins from different species, studying their similarities and subtle differences. Our work is also interdisciplinary – we use methods from bioinformatics, structural biology and biophysics on top of classical methods from microbiology, molecular biology and biochemistry.
 

Teaching

  • MBV 3060 (Basic Microbiology)
  • MBV 4910 (iGEM Competition)
  • ...


Higher education and employment history

  • since 2015 Full Professor, Department of Biosciences, UiO
  • since 2013 Associate Professor, Department of Biosciences, UiO
  • 2010 Habilitation, Department of Biology, University of Tübingen
  • 2007-2013 Project Leader, Max Planck Institute for Developmental Biology, Tübingen
  • 2003-2007 PostDoc, Max Planck Institute for Developmental Biology, Tübingen
  • 2002 PhD, Department of Chemistry, TU Berlin
  • 1991-1997, undergraduate studies in Biochemistry, FU Berlin
     

Honoraria

  • 2009 Young Academics Award from the German Society for Hygiene and Microbiology
  • 2008 and 2009 two 1-year stipends from the Bill & Melinda Gates Foundation
  • ...

Appointments

  • Advisory Board Member, Molecular Microbiology (Wiley)
  • Review Editor, Journal of Biological Chemistry
  • Review Editor, Frontiers in Microbiology

Publikasjoner

Se alle arbeider i Cristin

  • Linke, Dirk (2022). Structure, Function, and Evolution of trimeric autotransporter adhesins.
  • Linke, Dirk (2022). Bacterial adhesion and how to inhibit it.
  • Reese, Jan-Ole; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2022). Development of multi-species biofilm models for testing biotechnological approaches in dentistry.
  • Mekasha, Sophanit & Linke, Dirk (2022). Toxins and secretion systems in Gram-negative bacterial fish pathogens.
  • Saragliadis, Athanasios & Linke, Dirk (2022). Structure-function relationship in bacterial adhesins.
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Merroun, Mohamed; Gomez-Bolivar, Jamie; Røyne, Anja & Linke, Dirk [Vis alle 7 forfattere av denne artikkelen] (2022). Biosynthesis and characterization of Palladium-Based Nanoparticles using Escherichia coli.
  • Mekasha, Sophanit & Linke, Dirk (2022). Toxins and secretion systems in Gram-negative bacterial fish pathogens. The case of T. maritimum.
  • Mertes, Verena; Saragliadis, Athanasios; Attenucci, Fabio; Wrobel, Agnieszka; Ciani, Elia & Linke, Dirk [Vis alle 8 forfattere av denne artikkelen] (2022). Characterization of bacterial extracellular vesicles from a fish pathogen, their role in virulence and possible function as vaccine in aquaculture.
  • Linke, Dirk (2022). Bacterial adhesion by fish pathogens.
  • Linke, Dirk (2022). Bacterial adhesion - structure and evolution of autotransporters.
  • Linke, Dirk (2022). Bacterial Adhesins - Structure and Function.
  • Linke, Dirk (2022). Trimeric Autotransporter Adhesins: Structure, Function, and Evolution.
  • Linke, Dirk (2022). How to apply for a PhD position... and how not to!
  • Hatlem, Daniel; Linke, Dirk Bernd Kurt & Andersen, Elisabeth K. (2022). Forskerprosjekt på antibiotika og blodforgiftning. [Internett]. Website Oslo Cancer Cluster.
  • Wimmi, Stephan; Balinovic, Alexander; Jeckel, Hannah; Selinger, Lisa; Lampaki, Dimitrios & Eisemann, Emma [Vis alle 11 forfattere av denne artikkelen] (2021). Author Correction: Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH (Nature Communications, (2021), 12, 1, (1625), 10.1038/s41467-021-21863-4). Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-23080-5.
  • Mertes, Verena; Saragliadis, Athanasios; Ciani, Elia; Linke, Dirk; Colquhoun, Duncan J & Winther-Larsen, Hanne Cecilie (2021). Characterization of membrane vesicles from fish pathogens, their role in virulence and possible function as a vaccine in aquaculture.
  • Linke, Dirk (2021). Developing inhibitors that block adhesin-collagen interactions.
  • Fan, Enguo & Linke, Dirk (2021). the exchange program MISC - Options for internships at PMUC (with descriptions of current projects).
  • Hori, Katsutoshi & Linke, Dirk (2021). the exchange program MISC - Options for internships at Nagoya University (with descriptions of current projects by students).
  • Linke, Dirk; Økstad, Ole Andreas; Haugen, Håvard Jostein & Winther-Larsen, Hanne Cecilie (2021). The exchange program MISC - Options for internships at the University of Oslo (with descriptions of current projects).
  • Campana Perilla, Ana Lucia; Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2021). Magnetic decoration of Escherichia coli loaded with Palladium nanoparticles .
  • Chowdhury, Sounak; Linke, Dirk; Happonen, Lotta Johanna & Malmström, Johan (2021). Streptococcus pyogenes forms M protein specific host-environment dependent protein complexes.
  • Thibau, Arno; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the fibronectin binding properties and genomic variation of Bartonella henselae adhesin.
  • Leva-Bueno, Juan; Meuskens, Ina; Linke, Dirk; Millner, Paul & Peyman, Sally (2021). Impedimetric biosensor based on extracellular matrix protein-adhesin interaction.
  • Meuskens, Ina; Leva-Bueno, Juan; Millner, Paul; Schütz, Monika; Peyman, Sally & Linke, Dirk (2021). The Trimeric Autotransporter Adhesin YadA of Yersinia binds to glycan moieties.
  • Vaca, Diana; Thibau, Arno; Linke, Dirk; Happonen, Lotta Johanna; Malmström, Johan & Kempf, Volkhard A.J. (2021). Interaction between Bartonella adhesin A and fibronectin in bacterial adherence to human endothelial cells.
  • Linke, Dirk (2021). Using LPS-Binding Peptides To Detect Endotoxins.
  • Chowdhury, Sounak; Linke, Dirk; Happonen, Lotta Johanna & Malmström, Johan (2021). Streptococcus Pyogenes Forms M Protein Specific Host-microenvironment Dependent Protein Complexes.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the Fibronectin Binding Properties of Bartonella henselae Adhesin A.
  • Leva, Juan; Meuskens, Ina; Linke, Dirk; Peyman, Sally & Millner, Paul (2021). Novel Electrochemical Biosensor for Pathogen Detection Based on Extracellular Matrix (ECM) Protein - Adhesin Interaction.
  • Meuskens, Ina & Linke, Dirk (2021). The Trimeric Autotransporter Adhesin YadA of Yersinia Binds to Glycan Moieties.
  • Vaca, Diana; Happonen, Lotta Johanna; Goldman, Adrian & Linke, Dirk (2021). Bacterial and Viral Adhesion; Two Sides of the Same Coin?
  • Butcher, Sarah Jane & Linke, Dirk (2021). Viral and Bacterial Adhesion - examples from current ViBrANT research.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the fibronectin binding properties of B. henselae adhesin A .
  • Meuskens, Ina; Michalik, Marcin; Chauhan, Nandini; Linke, Dirk & Leo, Jack Christopher (2020). Corrigendum: A New Strain Collection for Improved Expression of Outer Membrane Proteins (Frontiers in Cellular and Infection Microbiology, (2017), 7, (464), 10.3389/fcimb.2017.00464). Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 10. doi: 10.3389/fcimb.2020.00220.
  • Linke, Dirk (2020). LPS-Binding Peptides: New Tools for Endotoxin Detection and Removal?
  • Linke, Dirk (2020). Dette munnbindet skal drepe koronaviruset. [Internett]. TV2 website.
  • Campaña Perilla, Ana Lucia; Joudeh, Nadeem; Høyer, Henrik; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Probing van der Waals and magnetic forces in bacteria with magnetic nanoparticles.
  • Claxton, James; Joudeh, Nadeem; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Sequential magnetic mapping of bacteria loaded with Pd-Fe nanoparticles .
  • Linke, Dirk (2020). Palladium nanoparticles made by bacteria.
  • Linke, Dirk (2020). Biofilm-forming adhesins of the fish pathogen Yersinia ruckeri.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2020). Analysing the fibronectin binding properties of Bartonella henselae adhesin A.
  • Ryoo, David; Orwick-Rydmark, Marcella; Pang, Y; Lundqvist, Daniel; Linke, Dirk & Gumbart, JC (2020). Quantitative Comparisons of Competing Models of Autotransporter Passenger-Domain Secretion.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2019). Analysing the fibronectin binding domain of the Bartonella henselae adhesin A.
  • Orwick-Rydmark, Marcella & Linke, Dirk (2019). A novel antibiotic idea: Preventing bacterial stickiness. [Internett]. international.
  • Meuskens, Ina; Higson, Seamus & Linke, Dirk (2019). Innovative training networks: a new way of collaboration-propped PhD training. Medical Microbiology and Immmunology. ISSN 0300-8584. 209, s. 215–216. doi: 10.1007/s00430-019-00647-0.
  • Linke, Dirk (2019). The Gram-Negative Bacterial Cell Surface: How to Study Its Protein Components and How to Remove Endotoxin.
  • Mikheenko, Pavlo; Mikheenko, Iryna; Joudeh, Nadeem; Claxton, J. B.; Røyne, Anja & Linke, Dirk (2019). Imaging magnetism of biologically produced palladium nanoparticles .
  • Linke, Dirk & Joudeh, Nadeem (2019). Centre for Digital Life helps researchers right out of the gate (Senter for digitalt liv hjelper forskere ut av innovasjonsstartgropa). [Internett]. Center For Digital Life - Website.
  • Tietgen, M; Weidensdorfer, M; Leukert, L; Djahanshiri, Bardya; Iruegas, R & Ebersberger, Ingo [Vis alle 9 forfattere av denne artikkelen] (2019). Virulence of Acinetobacter baumannii depends on the Acinetobacter trimeric autotransporter adhesin (Ata).
  • Orwick-Rydmark, Marcella; Lindemann, Florian; Chauhan, Nandini; Yarava, J; Oschkinat, Hartmut & Van Rossum, Barth-J [Vis alle 7 forfattere av denne artikkelen] (2019). In situ structural and dynamic analysis of a membrane protein.
  • Linke, Dirk (2019). Type V secretion: membrane transport and anchoring of bacterial adhesins.
  • Joudeh, Nadeem & Linke, Dirk (2019). Bio-engineered Palladium Nanoparticles.
  • Joudeh, Nadeem & Linke, Dirk (2019). Bio-engineered Pd Nanoparticles.
  • Joudeh, Nadeem; Røyne, Anja; Mikheenko, Pavlo & Linke, Dirk (2019). Bio-Engineered Palladium Nanoparticles (BEDPAN).
  • Meuskens, Ina; Linke, Dirk & Bardiaux, Benjamin (2022). Insights into the Binding Mechanism and Function of Bacterial Adhesins - Interactions between YadA and Host Extracellular Matrix Components. Universitetet i Oslo.
  • Hatlem, Daniel; Linke, Dirk & Krengel, Ute (2022). Probing the role of lipopolysaccharides in Gram-negative protein secretion and biogenesis. Universitetet i Oslo.
  • Bergvoll, Helga; Linke, Dirk & Saragliadis, Athanasios (2022). Secreted toxin components in the fish pathogen Tenacibaculum maritimum. Universitetet i Oslo.
  • Hovland, Hege; Linke, Dirk & Saragliadis, Athanasios (2022). Palladium nanoparticles in copper transport mutants of Escherichia coli. Universitetet i Oslo.
  • Joudeh, Nadeem; Linke, Dirk & Mikheenko, Pavlo (2022). Escherichia coli-mediated palladium nanoparticle synthesis. Universitetet i Oslo.
  • Spence, Maria Helle; Linke, Dirk & Saragliadis, Athanasios (2021). Yersinia adhesins: Investigating the role of autotransporter adhesins in fish infection by Yersinia ruckeri. Universitetet i Oslo.
  • Hermansen, Simen; Linke, Dirk & Orwick-Rydmark, Marcella (2021). Investigating the effects of loop modifications on the folding of outer membrane protein X. Universitetet i Oslo.
  • Trunk, Thomas; Leo, Jack Christopher & Linke, Dirk (2020). Characterization and comparative analyses of type Vd-secreted phospholipases expressed in pathogenic bacteria. Universitetet i Oslo.
  • Wrobel, Agnieszka & Linke, Dirk (2019). Structural and functional studies of the Yersinia ruckeri inverse autotransporters. Universitetet i Oslo.

Se alle arbeider i Cristin

Publisert 16. okt. 2013 09:29 - Sist endret 29. jan. 2015 11:53