Dirk Bernd Kurt Linke

Image of Dirk Bernd Kurt Linke
Norwegian version of this page
Phone +47 22857654
Room 3517
Username
Visiting address Blindernveien 31 0371 Oslo
Postal address Postboks 1066 Blindern 0316 OSLO

Academic Interests

My research group focusses on the structure and function of the bacterial cell surface. 

Our work is typically comparative – we do not work on a single pathogenic “pet” organism, but instead compare related surface proteins from different species, studying their similarities and subtle differences. Our work is also interdisciplinary – we use methods from bioinformatics, structural biology and biophysics on top of classical methods from microbiology, molecular biology and biochemistry. For details, please see the group pages of the Linke lab.
 

Teaching

 

Publications

  • Rooke, Jessica; Icke, Christopher; Wells, Timothy; Rossiter, Amanda; Browning, Douglas; Morris, Faye; Leo, Jack Christopher; Schütz, Monika; Autenrieth, Ingo B.; Cunningham, Adam; Linke, Dirk & Henderson, Ian (2021). BamA and BamD Are Essential for the Secretion of Trimeric Autotransporter Adhesins. Frontiers in Microbiology.  ISSN 1664-302X.  12 . doi: 10.3389/fmicb.2021.628879 Full text in Research Archive.
  • Wimmi, S; Balinovic, A; Jeckel, H; Selinger, L; Lampaki, D; Eisemann, E; Meuskens, Ina; Linke, Dirk; Drescher, K; Endesfelder, U & Diepold, Andreas (2021). Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH. Nature Communications.  ISSN 2041-1723.  12(1) . doi: 10.1038/s41467-021-21863-4 Full text in Research Archive.
  • Campaña Perilla, Ana Lucia; Joudeh, Nadeem; Høyer, Henrik; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Probing van der Waals and magnetic forces in bacteria with magnetic nanoparticles, In  2020 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2020).  IEEE.  ISBN 978-1-7281-8506-4.  Article.  s 01NSSA03-1 - 01NSSA03-5 Full text in Research Archive. Show summary
  • Claxton, James Benedict; Joudeh, Nadeem; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Sequential magnetic mapping of bacteria loaded with Pd-Fe nanoparticles, In  2020 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2020).  IEEE.  ISBN 978-1-7281-8506-4.  Article.  s 01NIC01-1 - 01NIC01-5 Full text in Research Archive. Show summary
  • Hatlem, Daniel; Trunk, Thomas; Linke, Dirk & Leo, Jack Christopher (2020). Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins, In JH Leitao (ed.),  Microbial Virulence Factors.  MDPI.  ISBN 978-3-03936-946-1.  Kapittel 18.  s 371 - 400 Full text in Research Archive.
  • Ryoo, David; Rydmark, Marcella Orwick; Pang, Yui Tik; Lundquist, Karl P; Linke, Dirk & Gumbart, James C (2020). BamA is required for autotransporter secretion. Biochimica et Biophysica Acta - General Subjects.  ISSN 0304-4165.  1864(7), s 1- 8 . doi: 10.1016/j.bbagen.2020.129581 Full text in Research Archive.
  • Stephan, Mareike; Broeker, Nina; Saragliadis, Athanasios; Roos, Norbert; Linke, Dirk & Barbirz, Stefanie (2020). In vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles. Frontiers in Microbiology.  ISSN 1664-302X.  11 . doi: 10.3389/fmicb.2020.510638 Full text in Research Archive.
  • Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Pérez-Ortega, Jesús; Sittman, Carolin; Göttig, Stephan; Liskiewicz, Krystyna Anna; Spence, Maria Helle; Schneider, Kenneth; Leo, Jack Christopher; Arenas, Jesús & Linke, Dirk (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology.  ISSN 1462-2912.  22(7), s 2939- 2955 . doi: 10.1111/1462-2920.15051 Full text in Research Archive.
  • Chauhan, Nandini; Hatlem, Daniel; Rydmark, Marcella Orwick; Schneider, Kenneth; Flötenmeyer, Matthias; Van Rossum, Barth-J; Leo, Jack Christopher & Linke, Dirk (2019). Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA). Molecular Microbiology.  ISSN 0950-382X.  111(3), s 844- 862 . doi: 10.1111/mmi.14195 Full text in Research Archive.
  • Aoki, S.; Yoshimoto, Shogo; Ishikawa, M; Linke, Dirk; Lupas, Andrei & Hori, Katsutoshi (2019). Native display of a huge homotrimeric protein fiber on the cell surface after precise domain deletion. Journal of Bioscience and Bioengineering.  ISSN 1389-1723.  s 1- 6 . doi: 10.1016/j.jbiosc.2019.09.022
  • Finke, Sarah; Fagerlund, Annette; Smith, Veronika; Krogstad, Veronica; Zhang, Mimmi Jingxi; Saragliadis, Athanasios; Linke, Dirk; Nielsen-Leroux, Christina & Økstad, Ole Andreas (2019). Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control. The Cell Surface.  ISSN 2468-2330.  5, s 1- 12 . doi: 10.1016/j.tcsw.2019.100032 Full text in Research Archive.
  • Hatlem, Daniel; Trunk, Thomas; Linke, Dirk & Leo, Jack Christopher (2019). Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins. International Journal of Molecular Sciences.  ISSN 1422-0067.  20(9), s 1- 19 . doi: 10.3390/ijms20092129 Full text in Research Archive. Show summary
  • Meuskens, Ina; Saragliadis, Athanasios; Leo, Jack Christopher & Linke, Dirk (2019). Type V secretion systems: An overview of passenger domain functions. Frontiers in Microbiology.  ISSN 1664-302X.  10, s 1- 19 . doi: 10.3389/fmicb.2019.01163 Full text in Research Archive.
  • Micenková, Lenka; Bosak, Juraj; Kucera, Jiri; Hrala, Matej; Dolejsova, Tereza; Sedo, Ondrej; Linke, Dirk; Fiser, Radovan & Smajs, David (2019). Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains. Scientific Reports.  ISSN 2045-2322.  9(1), s 1- 12 . doi: 10.1038/s41598-019-47488-8 Full text in Research Archive.
  • Munoz Gonzalez, Florencia; Sycz, Gabriela; Alonso Paiva, Ivan M; Linke, Dirk; Zorreguieta, Angeles; Baldi, Pablo C & Ferrero, Mariana C (2019). The BtaF Adhesin Is Necessary for Full Virulence During Respiratory Infection by Brucella suis and Is a Novel Immunogen for Nasal Vaccination Against Brucella Infection. Frontiers in Immunology.  ISSN 1664-3224.  10, s 1- 16 . doi: 10.3389/fimmu.2019.01775 Full text in Research Archive.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen. The Cell Surface.  ISSN 2468-2330.  5, s 1- 11 . doi: 10.1016/j.tcsw.2019.100025 Full text in Research Archive.
  • Thibau, Arno; Dichter, Alexander A.; Vaca, Diana J.; Linke, Dirk; Goldman, Adrian & Kempf, Volkhard A.J. (2019). Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets. Medical Microbiology and Immmunology.  ISSN 0300-8584.  209, s 243- 263 . doi: 10.1007/s00430-019-00649-y Full text in Research Archive.
  • Tørresen, Ole K.; Star, Bastiaan; Mier, Pablo; Andrade-Navarro, Miguel A.; Bateman, Alex; Jarnot, Patryk; Gruca, Aleksandra; Grynberg, Marcin; Kajava, Andrey V.; Promponas, Vasilis J.; Anisimova, Maria; Jakobsen, Kjetill Sigurd & Linke, Dirk (2019). Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases. Nucleic Acids Research (NAR).  ISSN 0305-1048.  47(21), s 10994- 11006 . doi: 10.1093/nar/gkz841 Full text in Research Archive.
  • Weidensdorfer, Marko; Ishikawa, Masahito; Hori, Katsutoshi; Linke, Dirk; Djahanshiri, Bardya; Iruegas, Ruben; Ebersberger, Ingo; Riedel-Christ, Sara; Enders, Giulia; Leukert, Laura; Kraiczy, Peter; Rothweiler, Florian; Cinatl, Jindrich; Berger, Jürgen; Hipp, Katharina; Kempf, Volkhard A.J. & Gottig, Stephan (2019). The Acinetobacter trimeric autotransporter adhesin Ata controls key virulence traits of Acinetobacter baumannii. Virulence.  ISSN 2150-5594.  10(1), s 68- 81 . doi: 10.1080/21505594.2018.1558693 Full text in Research Archive.
  • Wróbel, Agnieszka Ewelina; Leo, Jack Christopher & Linke, Dirk (2019). Overcoming fish defences: The virulence factors of Yersinia ruckeri. Genes.  ISSN 2073-4425.  10(9), s 1- 20 . doi: 10.3390/genes10090700 Full text in Research Archive. Show summary
  • Leo, Jack Christopher & Linke, Dirk (2018). A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition. AIMS Microbiology.  ISSN 2471-1888.  4(3), s 455- 468 . doi: 10.3934/microbiol.2018.3.455 Full text in Research Archive. Show summary
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2018). pYR4 From a Norwegian Isolate of Yersinia ruckeri Is a Putative Virulence Plasmid Encoding Both a Type IV Pilus and a Type IV Secretion System. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  8, s 1- 14 . doi: 10.3389/fcimb.2018.00373 Full text in Research Archive. Show summary
  • Meuskens, Ina; Michalik, Marcin; Chauhan, Nandini; Linke, Dirk & Leo, Jack Christopher (2017). A New Strain Collection for Improved Expression of Outer Membrane Proteins. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  7 . doi: 10.3389/fcimb.2017.00464 Full text in Research Archive. Show summary
  • Michalik, Marcin; Rydmark, Marcella Orwick; Habeck, Michael; Alva, Vikram; Arnold, Thomas & Linke, Dirk (2017). An evolutionarily conserved glycine-tyrosine motif forms a folding core in outer membrane proteins. PLOS ONE.  ISSN 1932-6203.  12(8) . doi: 10.1371/journal.pone.0182016 Full text in Research Archive.
  • Mühlenkamp, Melanie C.; Hallstrom, Teresia; Autenrieth, Ingo B.; Bohn, Erwin; Linke, Dirk; Rinker, Janina; Riesbeck, Kristian; Singh, Birendra; Leo, Jack Christopher; Hammerschmidt, Sven; Zipfel, Peter F. & Schütz, Monika (2017). Vitronectin binds to a specific stretch within the head region of yersinia adhesin a and thereby modulates yersinia enterocolitica host interaction. Journal of Innate Immunity.  ISSN 1662-811X.  9(1), s 33- 51 . doi: 10.1159/000449200 Full text in Research Archive.
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher; Gulla, Snorre & Linke, Dirk (2017). The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a “Y. ruckeri invasin-like molecule”, (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen.. Journal of Structural Biology.  ISSN 1047-8477.  201(2), s 171- 183 . doi: 10.1016/j.jsb.2017.08.008
  • Fan, Enguo; Chauhan, Nandini; Udatha, D.B.R.K. Gupta; Leo, Jack Christopher & Linke, Dirk (2016). Type V secretion systems in bacteria, In Indira T. Kudva; Nancy A. Cornick; Paul J. Plummer; Qijing Zhang; Tracy L. Nicholson; John P. Bannantine & Bryan H. Bellaire (ed.),  Virulence Mechanisms of Bacterial Pathogens.  ASM International.  ISBN 9781555819279.  Chapter 11.  s 305 - 335
  • Curkić, I; Schütz, Monika; Oberhettinger, Philipp; Diard, P; Claassen, M; Linke, Dirk & Hardt, W (2016). Epitope-Tagged Autotransporters as Single-Cell Reporters for Gene Expression by a Salmonella Typhimurium wbaP Mutant. PLOS ONE.  ISSN 1932-6203.  11(5) . doi: 10.1371/journal.pone.0154828 Full text in Research Archive.
  • Koiwai, Kotaro; Hartmann, Marcus; Linke, Dirk; Lupas, Andrei & Hori, Katsutoshi (2016). Structural basis for toughness and flexibility in the C-terminal passenger domain of an acinetobacter trimeric autotransporter adhesin. Journal of Biological Chemistry.  ISSN 0021-9258.  291(8), s 3705- 3724 . doi: 10.1074/jbc.M115.701698 Full text in Research Archive.
  • Leo, Jack Christopher; Oberhettinger, Philipp; Yoshimoto, Shogo; Udatha, D.B.R.K. Gupta; Morth, Jens Preben; Schutz, Monika; Hori, Katsutoshi & Linke, Dirk (2016). Secretion of the Intimin passenger domain is driven by protein folding. Journal of Biological Chemistry.  ISSN 0021-9258.  291(38), s 20096- 20112 . doi: 10.1074/jbc.M116.731497 Full text in Research Archive.
  • Michalik, Marcin; Djahanshiri, Bardya; Leo, Jack Christopher & Linke, Dirk (2016). Reverse Vaccinology: The Pathway from Genomes and Epitope Predictions to Tailored Recombinant Vaccines, In Sunil Thomas (ed.),  Vaccine Design Methods and Protocols: Volume 1: Vaccines for Human Diseases.  Springer.  ISBN 978-1-4939-3385-3.  Chapter 4.  s 87 - 106
  • Pozzi, Roberta; Coles, Murray; Linke, Dirk; Kulik, Andreas; Nega, Mulugeta; Wohlleben, Wolfgang & Stegmann, Evi (2016). Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain MicrobisporaATCC PTA-5024. Environmental Microbiology.  ISSN 1462-2912.  18(1), s 118- 132 . doi: 10.1111/1462-2920.12892
  • Rydmark, Marcella Orwick; Arnold, Thomas & Linke, Dirk (2016). The use of detergents to purify membrane proteins. Current Protocols in Protein Science.  ISSN 1934-3655.  2016, s 4.8.1- 4.8.35 . doi: 10.1002/0471140864.ps0408s84
  • Shahid, Shakeel A; Nagaraj, Madhu; Chauhan, Nandini; Franks, Trent W; Bardiaux, Benjamin; Habeck, Michael; Rydmark, Marcella Orwick; Linke, Dirk & Van Rossum, Barth-J (2015). Solid-state NMR study of the YadA membrane-anchor domain in the bacterial outer membrane. Angewandte Chemie International Edition.  ISSN 1433-7851.  54(43), s 12602- 12606 . doi: 10.1002/anie.201505506
  • Shahid, Shakeel; Nagaraj, Madhu; Chauhan, Nandini; Franks, Trent; Bardiaux, Benjamin; Habeck, Michael; Rydmark, Marcella Orwick; Linke, Dirk & van Rossum, Barth (2015). Festkörper-NMR-Studien an der Membrananker-Domaene von YadA in der bakteriellen Außenmembran. Angewandte Chemie.  ISSN 0044-8249.  127, s 12792- 12797 . doi: 10.1002/ange.201505506
  • Kretschmer, D; Rautenberg, M; Linke, Dirk & Peschel, A (2015). Peptide length and folding state govern the capacity of staphylococcal beta-type phenol-soluble modulins to activate human formyl-peptide receptors 1 or 2. Journal of Leukocyte Biology.  ISSN 0741-5400.  97(4), s 689- 697 . doi: 10.1189/jlb.2A0514-275R
  • Leo, Jack Christopher; Oberhettinger, Philipp; Chaubey, Manish; Schütz, Monika; Kuhner, Daniel; Bertsche, Ute; Schwarz, Heinz; Gotz, Friedrich; Autenrieth, Ingo B. & Linke, Dirk (2015). The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan. Molecular Microbiology.  ISSN 0950-382X.  95(1), s 80- 100 . doi: 10.1111/mmi.12840 Full text in Research Archive.
  • Leo, Jack Christopher; Oberhettinger, Philipp; Schütz, Monika & Linke, Dirk (2015). The inverse autotransporter family: Intimin, invasin and related proteins.. International Journal of Medical Microbiology.  ISSN 1438-4221.  305(2), s 276- 282 . doi: 10.1016/j.ijmm.2014.12.011
  • Muhlenkamp, Melanie; Oberhettinger, Philipp; Leo, Jack Christopher; Linke, Dirk & Schütz, Monika (2015). Yersinia adhesin A (YadA) - Beauty & beast.. International Journal of Medical Microbiology.  ISSN 1438-4221.  305(2), s 252- 258 . doi: 10.1016/j.ijmm.2014.12.008
  • Oberhettinger, Philipp; Leo, Jack Christopher; Linke, Dirk; Autenrieth, Ingo B. & Schütz, Monika (2015). The Inverse Autotransporter Intimin Exports Its Passenger Domain via a Hairpin Intermediate. Journal of Biological Chemistry.  ISSN 0021-9258.  290(3), s 1837- 1849 . doi: 10.1074/jbc.M114.604769
  • Thoma, L.; Dobrovinski, H.; Finger, C.; Guezguez, J.; Linke, Dirk; Sepulveda, E. & Muth, G. (2015). A multiprotein DNA translocation complex directs intramycelial plasmid spreading during streptomyces conjugation. mBio.  ISSN 2161-2129.  6(3), s 1- 10 . doi: 10.1128/mBio.02559-14
  • Weidensdorfer, M; Chae, J.; Makobe, C.; Stahl, J; Averhoff, B; Müller, V.; Schürmann, C; Brandes, R; Wilharm, G.; Ballhorn, Wibke; Christ, S; Linke, Dirk; Fischer, D; Gottig, Stephan & Kempf, Volkhard A.J. (2015). Analysis of Endothelial Adherence of Bartonella henselae and Acinetobacter baumannii Using a Dynamic Human Ex Vivo Infection Model.. Infection and Immunity.  ISSN 0019-9567.  84(3), s 711- 722 . doi: 10.1128/IAI.01502-15
  • Grin, Iwan; Hartmann, Marcus; Sauer, Guido; Hernandez Alvarez, Birte; Schütz, Monika; Wagner, Samuel; Madlung, Johannes; Macek, Boris; Felipe-Lopez, Alfonso; Hensel, Michael; Lupas, Andrei & Linke, Dirk (2014). A trimeric lipoprotein assists in trimeric autotransporter biogenesis in Enterobacteria. Journal of Biological Chemistry.  ISSN 0021-9258.  289(11), s 7388- 7398 . doi: 10.1074/jbc.M113.513275
  • Gundersen, Cathrine Brecke; Andersen, Tom; Lindahl, Sofia; Linke, Dirk & Vogt, Rolf David (2014). Bacterial response from exposure to selected aliphatic nitramines. Energy Procedia.  ISSN 1876-6102.  63, s 791- 800 . doi: 10.1016/j.egypro.2014.11.089 Full text in Research Archive.
  • Schmidgen, Thomas; Kaiser, Patrick O.; Ballhorn, Wibke; Franz, Bettina; Gottig, Stephan; Linke, Dirk & Kempf, Volkhard A.J. (2014). Heterologous expression of Bartonella adhesin a in Escherichia coli by exchange of trimeric autotransporter adhesin domains results in enhanced adhesion properties and a pathogenic phenotype. Journal of Bacteriology.  ISSN 0021-9193.  196(12), s 2155- 2165 . doi: 10.1128/JB.01461-13
  • Shen, Xiantao; Svensson Bonde, Johan; Kamra, Tripta; Bülow, Leif; Leo, Jack Christopher; Linke, Dirk & Ye, Lei (2014). Bacterial imprinting at pickering emulsion interfaces. Angewandte Chemie International Edition.  ISSN 1433-7851.  53(40), s 10687- 10690 . doi: 10.1002/anie.201406049
  • Ulrich, Thomas; Oberhettinger, Philipp; Schütz, Monika; Holzer, Katharina; Ramms, Anne; Linke, Dirk; Autenrieth, Ingo B. & Rapaport, Doron (2014). Evolutionary conservation in biogenesis of β-barrel proteins allows mitochondria to assemble a functional bacterial trimeric autotransporter protein. Journal of Biological Chemistry.  ISSN 0021-9258.  289(43), s 29457- 29470 . doi: 10.1074/jbc.M114.565655

View all works in Cristin

  • Linke, Dirk (ed.) (2011). Bacterial Adhesion: Chemistry, Biology, and Physics. Springer.  ISBN 978-94-007-0939-3.  380 s.

View all works in Cristin

  • Hermansen, Simen; Linke, Dirk & Orwick-Rydmark, Marcella (2021). Investigating the effects of loop modifications on the folding of outer membrane protein X.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the fibronectin binding properties of B. henselae adhesin A.
  • Campaña Perilla, Ana Lucia; Joudeh, Nadeem; Høyer, Henrik; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Probing van der Waals and magnetic forces in bacteria with magnetic nanoparticles. Show summary
  • Claxton, James; Joudeh, Nadeem; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Sequential magnetic mapping of bacteria loaded with Pd-Fe nanoparticles. Show summary
  • Linke, Dirk (2020). Biofilm-forming adhesins of the fish pathogen Yersinia ruckeri.
  • Linke, Dirk (2020, 04. desember). Dette munnbindet skal drepe koronaviruset. [Internett].  TV2 website. Show summary
  • Linke, Dirk (2020). LPS-Binding Peptides: New Tools for Endotoxin Detection and Removal?.
  • Linke, Dirk (2020, 01. desember). Norsk kobber inn i kampen mot koronaviruset: verdens første selvrensende munnbind. [Internett].  Nordox website.
  • Linke, Dirk (2020). Palladium nanoparticles made by bacteria.
  • Ryoo, David; Orwick-Rydmark, Marcella; Pang, Y; Lundqvist, Daniel; Linke, Dirk & Gumbart, JC (2020). Quantitative Comparisons of Competing Models of Autotransporter Passenger-Domain Secretion.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2020). Analysing the fibronectin binding properties of Bartonella henselae adhesin A.
  • Trunk, Thomas; Leo, Jack Christopher & Linke, Dirk (2020). Characterization and comparative analyses of type Vd-secreted phospholipases expressed in pathogenic bacteria.
  • Hatlem, Daniel; Chauhan, Nandini; Orwick-Rydmark, Marcella; Schneider, Kenneth; Flötenmeyer, Matthias; Van Rossum, Barth-J; Leo, Jack Christopher & Linke, Dirk (2019). Insights into the autotransport of a trimeric autotransporter.
  • Orwick-Rydmark, Marcella; Lindemann, Florian; Chauhan, Nandini; Yarava, J; Oschkinat, Hartmut; Van Rossum, Barth-J & Linke, Dirk (2019). In situ structural and dynamic analysis of a membrane protein.
  • Chauhan, Nandini; Hatlem, Daniel; Orwick-Rydmark, Marcella; Schneider, Kenneth; Linke, Dirk & Leo, Jack Christopher (2019). Using the SpyCatcher-SpyTag technology for topology mapping of outer membrane proteins in Gram-negative bacteria.
  • Chowdhury, Sounak; Happonen, Lotta Johanna; Linke, Dirk & Malmström, Johan (2019). QUANTITATIVE AFFINITY-PURIFICATION AND SURFACE-ADSORPTION MASS SPECTROMETRY TO MAP STREPTOCOCCUS PYOGENES AND HUMAN PROTEIN INTERACTION.
  • Joudeh, Nadeem & Linke, Dirk (2019). Bio-engineered Palladium Nanoparticles.
  • Joudeh, Nadeem & Linke, Dirk (2019). Bio-engineered Pd Nanoparticles.
  • Joudeh, Nadeem; Røyne, Anja; Mikheenko, Pavlo & Linke, Dirk (2019). Bio-Engineered Palladium Nanoparticles (BEDPAN).
  • Kandanur, Sai Priya Sarma; Linke, Dirk & Leo, Jack Christopher (2019). Hairpin Formation and Passenger Secretion in the Inverse Autotransporter Intimin.
  • Leukert, L; Weidensdorfer, M; Djahanshiri, Bardya; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2019). The Acinetobacter Trimeric Autotransporter Adhesin Ata Controls Key Virulence Traits of Acinetobacter baumannii.
  • Leva, Juan; Meuskens, Ina; Gibson, Timothy M.; Linke, Dirk & Millner, Paul (2019). Biosensors for pathogen detection.
  • Linke, Dirk (2019). Autotransporter Adhesins in the fish pathogen Yersinia ruckeri.
  • Linke, Dirk (2019). Insights into the autotransport process of a trimeric autotransporter, YadA.
  • Linke, Dirk (2019). The Gram-Negative Bacterial Cell Surface: How to Study Its Protein Components and How to Remove Endotoxin.
  • Linke, Dirk (2019). Type V secretion: membrane transport and anchoring of bacterial adhesins.
  • Linke, Dirk & Joudeh, Nadeem (2019, 15. desember). Centre for Digital Life helps researchers right out of the gate (Senter for digitalt liv hjelper forskere ut av innovasjonsstartgropa). [Internett].  Center For Digital Life - Website.
  • Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
  • Meuskens, Ina; Higson, Seamus & Linke, Dirk (2019). Innovative training networks: a new way of collaboration-propped PhD training. Medical Microbiology and Immmunology.  ISSN 0300-8584.  209, s 215- 216 . doi: 10.1007/s00430-019-00647-0
  • Meuskens, Ina; Leva, Juan; Millner, Paul & Linke, Dirk (2019). Differential Adhesion of Trimeric Autotransporter Adhesins to Extracellular Matrix Proteins.
  • Meuskens, Ina & Linke, Dirk (2019). Binding of Yersinia Ahesin A to ECM molecules: a biosensor approach.
  • Mikheenko, Pavlo; Mikheenko, Iryna; Joudeh, Nadeem; Claxton, J. B.; Røyne, Anja & Linke, Dirk (2019). Imaging magnetism of biologically produced palladium nanoparticles.
  • Orwick-Rydmark, Marcella; Chauhan, Nandini; Van Rossum, Barth-J & Linke, Dirk (2019). Towards the structure of the YadA anchor domain in the native membrane.
  • Orwick-Rydmark, Marcella & Linke, Dirk (2019, 05. juni). A novel antibiotic idea: Preventing bacterial stickiness. [Internett].  international.
  • Orwick-Rydmark, Marcella; Van Rossum, Barth-J; Oschkinat, Hartmut & Linke, Dirk (2019). Towards the in situ structure of the Yersinia Adhesin A membrane anchor domain.
  • Røsjø, Bjarne; Orwick-Rydmark, Marcella; Linke, Dirk; Leo, Jack Christopher & Hatlem, Daniel (2019, 13. mai). Ny antibiotika-idé: Vil hindre bakteriene i å feste seg. [Internett].  TITAN.NO.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen.
  • Saragliadis, Athanasios & Linke, Dirk (2019). Screening for small-molecule inhibitors of YadA adhesion to collagen.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk; Ballhorn, Wibke & Kempf, Volkhard A.J. (2019). Analysing the Fibronectin Binding Domain of the Bartonella henselae Adhesin A.
  • Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2019). Analysing the fibronectin binding domain of the Bartonella henselae adhesin A.
  • Tietgen, M; Weidensdorfer, M; Djahanshiri, Bardya; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2019). Virulence of Acinetobacter baumannii depends on the Acinetobacter trimeric autotransporter adhesin Ata.
  • Tietgen, M; Weidensdorfer, M; Leukert, L; Djahanshiri, Bardya; Iruegas, R; Ebersberger, Ingo; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2019). Virulence of Acinetobacter baumannii depends on the Acinetobacter trimeric autotransporter adhesin (Ata).
  • Wrobel, Agnieszka & Linke, Dirk (2019). Structural and functional studies of the Yersinia ruckeri inverse autotransporters.
  • Balusek, Curtis; Linke, Dirk & Gumbart, JC (2018). The effect of beta-barrel geometry on ion conduction through Escherichia coli OmpX.
  • Hatlem, Daniel; Chauhan, Nandini; Rydmark, Marcella Orwick; Schneider, Kenneth; Floetenmeyer, Matthias; Leo, Jack Christopher & Linke, Dirk (2018). Insights into the autotransporter process of a trimeric autotransporter, Yersinia Adhesin A (YadA).
  • Hatlem, Daniel & Linke, Dirk (2018). Insights into the autotransporter process of a trimeric autotransporter, Yersinia Adhesin A (YadA).
  • Joudeh, Nadeem; Leo, Jack Christopher; Torgeman, Eric & Linke, Dirk (2018). Mechanism of Palladium and Gold uptake and reduction in E. coli.
  • Joudeh, Nadeem & Linke, Dirk (2018, 20. oktober). BEDPAN - Nanoparticles from Bacteria. [Internett].  Digital Life Website.
  • Khalil, Hawzeen; Øgaard, Jonas; Linke, Dirk & Leo, Jack Christopher (2018). Co-aggregation properties of trimeric autotransporter adhesins.
  • Leo, Jack Christopher; Oberhettinger, Philipp; Schuetz, Monika & Linke, Dirk (2018). Type Ve secretion: the mechanism of inverse autotransport.
  • Leo, Jack Christopher; Schütz, Monika & Linke, Dirk (2018). Type Ve Secretion in Enterobacteria.
  • Linke, Dirk (2018). Structural Biology of Membrane Proteins: Expression Tricks, and to Solubilize or Not to Solubilize.
  • Linke, Dirk (2018). Trimeric Autotransporter Adhesins and routes to their inhibition.
  • Linke, Dirk (2018, 25. mars). Vi må gjøre noe nå, før millioner av pasienter dør. [Internett].  Forsking.NO.
  • Linke, Dirk & Meuskens, Ina (2018). Adhesion of Yersinia Adhesin A to Collagen.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2018). The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a “Y. ruckeri invasin-like molecule”, (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen.
  • Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
  • Økstad, Ole Andreas Løchen & Linke, Dirk (2018). Hvor farlig er antibiotikaresistens?. Ingeniørenes Stemme.  Vinter 2018, s 37- 37
  • Orwick-Rydmark, Marcella; Chauhan, Nandini; Shahid, Shakeel & Linke, Dirk (2017). Solid-state NMR studies on Yersinia YadA: from autotransport to drug screening.
  • Chauhan, Nandini & Linke, Dirk (2017). Molecular characterization of the autotransport process of Yersinia adhesin A (YadA).
  • Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
  • Joudeh, Nadeem; Leo, Jack Christopher; Torgeman, Eric; Mikheenko, Pavlo & Linke, Dirk (2017). Mechanism of Palladium and Gold uptake and transport in E. coli.
  • Joudeh, Nadeem & Linke, Dirk (2017). Mechanism of palladium and gold uptake and transport in E. coli.
  • Leo, Jack Christopher & Linke, Dirk (2017). Inverse autotransport: the mechanism of type Ve secretion​..
  • Leo, Jack Christopher; Oberhettinger, Philipp; Schütz, Monika & Linke, Dirk (2017). Inverse autotransport: the mechanism of type Ve secretion.
  • Linke, Dirk (2017). Do we have to purify membrane proteins? Solid-state NMR in the native membrane.
  • Linke, Dirk (2017). Trimeric Autotransporter Evolution.
  • Linke, Dirk (2017). Trimeric Autotrasnporter Adhesins: Stucture, Function, and Evolution.
  • Linke, Dirk (2017). Trimeric autotransporter adhesins (TAAs) and routes to their inhibition.
  • Linke, Dirk (2017). Type Ve secretion in Gram-negative Bacteria.
  • Liskiewicz, Krystyna; Wrobel, Agnieszka; Leo, Jack Christopher & Linke, Dirk (2017). Identification of potential adhesin receptors from Yersinia ruckeri.
  • Michalik, Marcin; Orwick-Rydmark, Marcella; Arnold, Thomas; Habeck, Michael & Linke, Dirk (2017). An evolutionarily conserved motif forms a folding core in Outer membrane proteins.
  • Saragliadis, Athanasios & Linke, Dirk (2017). STRUCTURE-FUNCTION RELATIONSHIP IN BACTERIAL ADHESINS.
  • Schneider, Kenneth; Haugen, Håvard Jostein & Linke, Dirk (2017). Assay Development: Adhesin Interaction with Implant Materials.
  • Torgeman, Eric; Linke, Dirk & Leo, Jack Christopher (2017). Biosynthesis of gold and palladium nanoparticles via bacteria.
  • Weidensdorfer, M; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2017). Establishing of a dynamic human ex vivo infection model for analyzing endothelial adherence of Acinetobacter baumannii.
  • Wrobel, Agnieszka; Leo, Jack Christopher; Ottoni, Claudio; Gulla, Snorre & Linke, Dirk (2017). Comparative structure-function analysis of adhesins from different Yersinia ruckeri strains.
  • Wrobel, Agnieszka & Linke, Dirk (2017). The repeat structure of two paralogous invasin genes from Yersinia ruckeri sheds light on the evolution of adhesive capacities of a Fish pathogen.
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2017). IDENTIFICATION AND CHARACTERIZATION OF INVERSE AUTOTRANSPORTERS FROM A FISH PATHOGEN, YERSINIA RUCKERI.
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2017). IDENTIFICATION AND CHARACTERIZATION OF INVERSE AUTOTRANSPORTERS FROM A FISH PATHOGEN, YERSINIA RUCKERI..
  • Rydmark, Marcella Orwick; Chauhan, Nandini & Linke, Dirk (2016). Structure and Dynamics of The Yersinia Adhesin A Membrane-Anchor Domain by NMR.
  • Hatlem, Daniel; Kempf, Volkhard A.J.; Krengel, Ute & Linke, Dirk (2016). Bacterial adhesion: Characterization of trimeric autotransporter binding.
  • Leo, Jack Christopher & Linke, Dirk (2016). Inverse autotransport: surface export of Intimin and other type Ve secretion systems.
  • Leo, Jack Christopher & Linke, Dirk (2016). Secretion of the Intimin Passenger Domain Is Driven by Protein Folding..
  • Leo, Jack Christopher & Linke, Dirk (2016). Type Ve secretion - inverse autotransport​.
  • Leo, Jack Christopher; Oberhettinger, Philipp; Schütz, Monika; Hori, Katsutoshi; Yoshimoto, Shogo & Linke, Dirk (2016). The secretion of the Intimin passenger is driven by protein folding.
  • Leo, Jack Christopher; Yoshimoto, Shogo; Oberhettinger, Philipp; Schütz, Monika; Hori, Katsutoshi & Linke, Dirk (2016). The secretion of the Intimin passenger domain is driven by protein folding..
  • Linke, Dirk (2016, 10. februar). NRK Forbrukerinspektørene. [TV].  NRK. Show summary
  • Linke, Dirk (2016). Solid-State NMR Studies of Yersinia Adhesin A: From Autotransport Mechansim to Drug Screening.
  • Linke, Dirk (2016). Structre, Function and Evolution of Trimeric Autotransporter Adhesins.
  • Linke, Dirk (2016). Structure and dynamics of the Translocation Domain of an Autotransporter by Nuclear Magnetic Resonance and Molecular Dynamics Simulations.
  • Linke, Dirk (2016). Structure, Function and Evolution of Trimeric Autotransporter Adhesins.
  • Michalik, Marcin & Linke, Dirk (2016). Identification and evaluation of peptides for active and passive immunization against Pseudomonas aeruginosa.
  • Michalik, Marcin & Linke, Dirk (2016). Identification and evaluation of peptides for immunization against Pseudomonas aeruginosa.
  • Orwick-Rydmark, Marcella; Arnold, Thomas & Linke, Dirk (2016). The Use of Detergents to Purify Membrane Proteins, In JE Coligan; BM Dunn; DW Speicher & PT Wignfield (ed.),  Current Protocols in Protein Science.  John Wiley & Sons.  ISBN 978-0-471-11184-9.  Unit 4.8.  s 4.8.1. - 4.8.35
  • Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
  • Wrobel, Agnieszka & Linke, Dirk (2016). Zebrafish as a model system for studying Yersinia ruckeri infections.
  • Wrobel, Agnieszka & Linke, Dirk (2016). Zebrafish embryos as a model system for studying Yersinia ruckeri infection.
  • Chauhan, Nandini & Linke, Dirk (2015). Correction to the paper: "Purification of the YadA membrane anchor for secondary structure analysis and crystallization". International Journal of Biological Macromolecules.  ISSN 0141-8130.  81, s 599 . doi: 10.1016/j.ijbiomac.2015.08.052
  • Chauhan, Nandini & Linke, Dirk (2015). Insights into the autotransport mechanism of the trimeric autotransporter YadA.
  • Chauhan, Nandini; Shahid, Shakeel & Linke, Dirk (2015). Insights into the autotransport mechanism of trimeric autotransporter YadA.
  • Shahid, Shakeel; Chauhan, Nandini; Habeck, Michael; van Rossum, Barth & Linke, Dirk (2015). Trieric Autotransporter Adhesins (TAAs): Structural studies of the translocation process and and perspectives for its inhibition.
  • Hatlem, Daniel; Saragliadis, Athanasios; Leo, Jack Christopher; Shahid, Shakeel; van Rossum, Barth & Linke, Dirk (2015). TAAs: fibrous adhesins on the bacterial cell surface.
  • Leo, Jack Christopher & Linke, Dirk (2015, 01. oktober). A Talk with Dr. Dirk Linke and Dr. Jack Leo. [Tidsskrift].  Micrographia Today Vol 2 Issue 3 pp 43-46.
  • Leo, Jack Christopher; Oberhettinger, Philipp; Chaubey, Manish; Schütz, Monika; Coles, Murray & Linke, Dirk (2015). The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan.
  • Leo, Jack Christopher; Oberhettinger, Philipp; Chaubey, Manish; Schütz, Monika; Kuhner, Daniel; Bertsche, Ute; Schwarz, Heinz; Gotz, Friedrich; Autenrieth, Ingo B.; Coles, Murray & Linke, Dirk (2015). The Intimin periplasmic domain mediates binding to peptidoglycan.
  • Leo, Jack Christopher; Oberhettinger, Philipp & Linke, Dirk (2015). Assessing the Outer Membrane Insertion and Folding of Multimeric Transmembrane β-Barrel Proteins, In Susan Buchanan & Nicholas Noinaj (ed.),  The BAM Complex: Methods and Protocols.  Springer.  ISBN 978-1-4939-2870-5.  Chapter 12.  s 157 - 168
  • Leo, Jack Christopher; Schneider, Kenneth & Linke, Dirk (2015). Autotransporters as mediators of bacterial adhesion.
  • Linke, Dirk (2015). Bacterial Type V secretion systems: autotransport and adhesion to surfaces.
  • Linke, Dirk (2015). Bacterial membrane separation, fractionation and solubilization as essential steps in membrane protein purification.
  • Linke, Dirk (2015). TAAs: rigid, fibrous adhesins on the bacterial cell surface.
  • Linke, Dirk (2015). Trimeric Autotransporter Adhesins: Structure, Function, and Evolution.
  • Linke, Dirk & Mathiesen, Bård Enger (2015, 12. mars). TV2 Matkontrollen participation. [TV].  TV2 Matkontrollen.
  • Linke, Dirk; Udatha, Dasaradhi B R K G & Leo, Jack Christopher (2015). Comparative Infection Biology at the Department of Biosciences, UiO.
  • Michalik, Marcin & Linke, Dirk (2015). Identification and evaluation of peptides for active and passive immunization against Pseudomonas aeruginosa.
  • Michalik, Marcin & Linke, Dirk (2015). Identification and evaluation of peptides for immunization against Pseudomonas aeruginosa.
  • Paramasivam, Nagarajan & Linke, Dirk (2015). Strategies for the Analysis of Bam Recognition Motifs in Outer Membrane Proteins, In Susan Buchanan & Nicholas Noinaj (ed.),  The BAM Complex: Methods and Protocols.  Springer.  ISBN 978-1-4939-2870-5.  Chapter 21.  s 271 - 279
  • Roell, Marc-Sven; Noordzij, Hanna Theodora; Skar Mjønes, Caroline; Boye, Ole; Levchenko, Vladimir; Kimara, Chiharu; Ramberg, Sigmund; Lycke, Max; Mathiesen, Bård Enger; de Muinck, Eric; Grini, Paul Eivind & Linke, Dirk (2015). Methane Incorporated.
  • Roell, Marc-Sven; Noordzij, Hanna Theodora; Skar Mjønes, Caroline; Boye, Ole; Levchenko, Vladimir; Kimara, Chiharu; Ramberg, Sigmund; Lycke, Max; Mathiesen, Bård Enger; De Muinck, Eric; Grini, Paul Eivind & Linke, Dirk (2015). Methane Incorporated - iGEM Lecture.
  • Udatha, Dasaradhi B R K G & Linke, Dirk (2015). In silico strategies for the identification and classification of bacterial autotransporter proteins.
  • Winther, Anja Ruud; Leo, Jack Christopher & Linke, Dirk (2015). Fluorescent biomarkers for membrane separation.
  • Wrobel, Agnieszka & Linke, Dirk (2015). Comparative structure-function analysis of adhesin proteins from different Yersinia species.
  • Wrobel, Agnieszka & Linke, Dirk (2015). Optimization of a highly efficient electroporation system for construction of a green fluorescent protein-tagged Yersinia ruckeri.
  • Wrobel, Agnieszka & Linke, Dirk (2015). Zebrafish embryos as a model for studying Yersinia ruckeri infection.
  • Linke, Dirk (2014). Autotransport of Gram-negative bacterial adhesins to the cell surface. NBS-nytt.  ISSN 0801-3535.
  • Linke, Dirk (2014). Autotransport of Gram-negative bacterial adhesins to the cell surface.
  • Linke, Dirk (2014). Autotransporters of Gram negative bacteria: Structure, assembly and function.
  • Chauhan, Nandini & Linke, Dirk (2014). Insights into the autotransport mechanism of Yersinia YadA.
  • Chauhan, Nandini & Linke, Dirk (2014). Insights into the autotransport mechanism of Yersinia enterocolitica YadA.
  • Gundersen, Cathrine Brecke; Andersen, Tom; Lindahl, Sofia; Linke, Dirk & Vogt, Rolf David (2014). Bacterial response from exposure to selected aliphatic nitramines.
  • Leo, Jack Christopher & Linke, Dirk (2014). Formation mechanism of metallic bio-nanoparticles.
  • Leo, Jack Christopher & Linke, Dirk (2014). The periplasmic domain of Intimin mediates dimerisation and binding to peptidoglycan.
  • Leo, Jack Christopher & Linke, Dirk (2014). Type Ve secretion: a novel autotransport mechanism.
  • Linke, Dirk (2014). Structure, Function, and Evolution of Autotransporters in Gram-negative bacteria.
  • Linke, Dirk (2014). Trimeric Autotransporter Adhesins (TAAs) and strategies for their inhibition.
  • Linke, Dirk & Leo, Jack Christopher (2014). Type Ve secretion systems.
  • Makobe, C.; Frank, D.; Christ, S.; Enders, G.; Wilharm, G.; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2014). Evaluation of A. baumannii Trimeric Autotransporter Adhesin as an Adhesion and Virulence factor. BioSpektrum.  ISSN 0947-0867.  DGHM Tagungsband 2014(Special Issue), s 300- 301
  • Makobe, C.; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2014). Evaluation of Acinetobacter baumannii Trimeric Autotransporter Adhesin as an Adhesion and Virulence factor.
  • Michalik, Marcin & Linke, Dirk (2014). Evaluation of peptides for active and passive immunization against Pseudomonas aeruginosa.
  • Michalik, Marcin & Linke, Dirk (2014). Identification and evaluation of peptides for active and passive immunization against P. aeruginosa.
  • Michalik, Marcin & Linke, Dirk (2014). Identification and evaluation of peptides for active and passive immunization against Pseudomonas aeruginosa.

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Published Oct. 16, 2013 9:37 AM - Last modified Feb. 10, 2021 1:05 PM