Tone Fredsvik Gregers

Senior Lecturer - Laboratory School in Biology

Norwegian version of this page

Email t.f.gregers@ibv.uio.no

Phone +47-22856183

Mobile phone 99697154

Room 3104

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Visiting address Blindernveien 31 None 0371 OSLO

Postal address Postboks 1066 Blindern 0316 OSLO

Other affiliations Faculty of Mathematics and Natural Sciences (Student) Department of Teacher Education and School Research (Student)

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Academic Interests

Immunology, cell biology, molecular biology. More specifically intracellular transport and regulation of immunomolecules.

Teaching

MBV1010 - Cell biology and genetics
MBV4260 - Advanced immunology
MBV4320 - Advanced Physiology and Cell Biology

Higher education and employment history

My education is from University of Oslo, with a master in cell biology (1997) and a PhD (dr. scient.) degree in cellular immunology. I worked for three years as a post. doc. at Institute of Cancer Research, the Radium Hospital in the lab of Professor Kirsten Sandvig, and then for 2 years as a scientific assistant in the lab of Professor Oddmund Bakke at Department of Molecular Biosciences, University of Oslo. June 2008 I started a new post. doc. period, financed by the Norwegian Research Council, as a group leader. I am still attached to Oddmund Bakkes group, where I tutor PhD and master students.

Appointments

Member of the board of the Norwegian Immunological Society 2007-2008
Secretary of the Norwegian Immunological Society 2008-2009

Collaborations

Since our group is a member of Centre for Immune Regulation (CIR) I have various internal collaborations, e.g. with Jan Terje Andersen in the group of Inger Sandlie, looking at intracellular trafficking of the neonatal Fc receptor. Outside CIR i collaborate with Vibeke Gjerstad in the group of Anne Spurkland, mapping the subcellular localization of signal molecules involved in T-cell signalling and migration. I also collaborate with the group of Johanna Olweus at Institute of Cancer Research, the Radium Hospital, working on immune therapy and antigen presentation. Recently I started a collaboration with Unni Grimholt and Kjetill Jakobsen, CEES (Centre for Ecological and Evolutionary Synthesis), where mapping of the immune system of fish (cod and salmon) is a central topic.

Niazy, Naima; Temme, Sebastian; Bocuk, Derya; Giesen, Carmen; Konig, Angelika; Temme, Nadine; Ziegfeld, Angelique; Gregers, Tone Fredsvik; Bakke, Oddmund; Lang, Thorsten; Eis-Hübinger, Anna M. & Koch, Norbert (2017). Misdirection of endosomal trafficking mediated by herpes simplex virus-encoded glycoprotein B. The FASEB Journal. ISSN 0892-6638. 31(4), s 1650- 1667 . doi: 10.1096/fj.201600521R
Solbakken, Monica Hongrø; Tørresen, Ole Kristian; Nederbragt, Alexander Johan; Seppola, Marit; Gregers, Tone Fredsvik; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2016). Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions. Scientific Reports. ISSN 2045-2322. 6 . doi: 10.1038/srep25211 Full text in Research Archive. Show summary
Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern recognition receptor (PRR) family of Toll-like receptors (TLR). In a comparative genomic setting, using an improved version of the genome, we characterize PRRs in Atlantic cod with emphasis on TLRs demonstrating the loss of TLR1/6, TLR2 and TLR5 and expansion of TLR7, TLR8, TLR9, TLR22 and TLR25. We find that Atlantic cod TLR expansions are strongly influenced by diversifying selection likely to increase the detectable ligand repertoire through neo- and subfunctionalization. Using RNAseq we find that Atlantic cod TLRs display likely tissue or developmental stage-specific expression patterns. In a broader perspective, a comprehensive vertebrate TLR phylogeny reveals that the Atlantic cod TLR repertoire is extreme with regards to losses and expansions compared to other teleosts. In addition we identify a substantial shift in TLR repertoires following the evolutionary transition from an aquatic vertebrate (fish) to a terrestrial (tetrapod) life style. Collectively, our findings provide new insight into the function and evolution of TLRs in Atlantic cod as well as the evolutionary history of vertebrate innate immunity.
Sand, Kine Marita Knudsen; Landsverk, Ole J. B.; Berg-Larsen, Axel; Bakke, Oddmund & Gregers, Tone Fredsvik (2014). The human-specific invariant chain isoform Iip35 modulates Iip33 trafficking and function. Immunology and Cell Biology. ISSN 0818-9641. 92(9), s 791- 798 . doi: 10.1038/icb.2014.54
Waelchli, Sebastien; Kumari, Shraddha; Fallang, Lars-Egil; Sand, Kine Marita Knudsen; Yang, Weiwen; Landsverk, Ole J. B.; Bakke, Oddmund; Olweus, Johanna & Gregers, Tone Fredsvik (2014). Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation. European Journal of Immunology. ISSN 0014-2980. 44(3), s 774- 784 . doi: 10.1002/eji.201343671
Berg-Larsen, Axel; Landsverk, Ole J. B.; Progida, Cinzia; Gregers, Tone Fredsvik & Bakke, Oddmund (2013). Differential Regulation of Rab GTPase Expression in Monocyte-Derived Dendritic Cells upon Lipopolysaccharide Activation: A Correlation to Maturation-Dependent Functional Properties. PLoS ONE. ISSN 1932-6203. 8(9) . doi: 10.1371/journal.pone.0073538
Gregers, Tone Fredsvik; Skånland, Sigrid Strand; Waelchli, Sebastien; Bakke, Oddmund & Sandvig, Kirsten (2013). BiP Negatively Affects Ricin Transport. Toxins. ISSN 2072-6651. 5(5), s 969- 982 . doi: 10.3390/toxins5050969
Malmstrøm, Martin; Jentoft, Sissel; Gregers, Tone Fredsvik & Jakobsen, Kjetill Sigurd (2013). Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy. PLoS ONE. ISSN 1932-6203. 8(9) . doi: 10.1371/journal.pone.0074004 Full text in Research Archive.

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Gregers, Tone Fredsvik (2015). Slik fungerer vaksinene i barnevaksinasjonsprogrammet. Aftenposten Viten.
Gregers, Tone Fredsvik & Sørbye, Sveinung Wergeland (2014, 13. januar). Derfor blir menn sykere av influensa. [Internett]. ABC nyheter. Show summary
Ved Stanford University School of Medicine har man sett nærmere på menn og kvinners reaksjoner på influensavaksinen, og studien viser at menn faktisk har det verre enn kvinner når de får influensa. Kvinner og menn med lavt testosteronnivå har et immunforsvar som beskytter bedre mot influensavirus enn de som er skikkelige testosteronbunter. Overlege ved avdeling for klinisk patologi ved Universitetssykeshuset i Nord-Norge, Sveinung Sørbye, stiller seg mer kritisk til studien. – Selv om kvinner har høyere immunrespons av influensavaksine når det gjelder antistoffer, betyr ikke det automatisk at man er mer utsatt for harde runder med influensa i den perioden av livet da man har høyest testosteronnivå, sier han.
Berg-Larsen, Axel; Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). Rab GTPases are differentially regulated during DC maturation. Molecular Immunology. ISSN 0161-5890. 51(1), s 8- 8 . doi: 10.1016/j.molimm.2012.02.016

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Published Nov. 4, 2010 2:38 PM - Last modified June 6, 2014 11:13 AM