Tone Fredsvik Gregers

Senior Lecturer - Laboratory School in Biology
Image of Tone Fredsvik Gregers
Norwegian version of this page
Phone +47-22856183
Mobile phone 99697154
Room 3104
Username
Visiting address Blindernveien 31 None 0371 OSLO
Postal address Postboks 1066 Blindern 0316 OSLO

Academic Interests

Immunology, cell biology, molecular biology. More specifically intracellular transport and regulation of immunomolecules.

Teaching

  • MBV1010 - Cell biology and genetics
  • MBV4260 - Advanced immunology
  • MBV4320 - Advanced Physiology and Cell Biology

Higher education and employment history

My education is from University of Oslo, with a master in cell biology (1997) and a PhD (dr. scient.) degree in cellular immunology. I worked for three years as a post. doc. at Institute of Cancer Research, the Radium Hospital in the lab of Professor Kirsten Sandvig, and then for 2 years as a scientific assistant in the lab of Professor Oddmund Bakke at Department of Molecular Biosciences, University of Oslo. June 2008 I started a new post. doc. period, financed by the Norwegian Research Council, as a group leader. I am still attached to Oddmund Bakkes group, where I tutor PhD and master students.

Appointments

  • Member of the board of the Norwegian Immunological Society 2007-2008
  • Secretary of the Norwegian Immunological Society 2008-2009

Collaborations

Since our group is a member of Centre for Immune Regulation (CIR) I have various internal collaborations, e.g. with Jan Terje Andersen in the group of Inger Sandlie, looking at intracellular trafficking of the neonatal Fc receptor. Outside CIR i collaborate with Vibeke Gjerstad in the group of Anne Spurkland, mapping the subcellular localization of signal molecules involved in T-cell signalling and migration. I also collaborate with the group of Johanna Olweus  at Institute of Cancer Research, the Radium Hospital, working on immune therapy and antigen presentation. Recently I started a collaboration with Unni Grimholt and Kjetill Jakobsen, CEES (Centre for Ecological and Evolutionary Synthesis), where mapping of the immune system of fish (cod and salmon) is a central topic.

Publications

  • Solbakken, Monica Hongrø; Tørresen, Ole Kristian; Nederbragt, Alexander Johan; Seppola, Marit; Gregers, Tone Fredsvik; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2016). Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep25211 Full text in Research Archive. Show summary
  • Sand, Kine Marita Knudsen; Landsverk, Ole J. B.; Berg-Larsen, Axel; Bakke, Oddmund & Gregers, Tone Fredsvik (2014). The human-specific invariant chain isoform Iip35 modulates Iip33 trafficking and function. Immunology and Cell Biology.  ISSN 0818-9641.  92(9), s 791- 798 . doi: 10.1038/icb.2014.54
  • Waelchli, Sebastien; Kumari, Shraddha; Fallang, Lars-Egil; Sand, Kine Marita Knudsen; Yang, Weiwen; Landsverk, Ole J. B.; Bakke, Oddmund; Olweus, Johanna & Gregers, Tone Fredsvik (2014). Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation. European Journal of Immunology.  ISSN 0014-2980.  44(3), s 774- 784 . doi: 10.1002/eji.201343671
  • Berg-Larsen, Axel; Landsverk, Ole J. B.; Progida, Cinzia; Gregers, Tone Fredsvik & Bakke, Oddmund (2013). Differential Regulation of Rab GTPase Expression in Monocyte-Derived Dendritic Cells upon Lipopolysaccharide Activation: A Correlation to Maturation-Dependent Functional Properties. PLoS ONE.  ISSN 1932-6203.  8(9) . doi: 10.1371/journal.pone.0073538
  • Gregers, Tone Fredsvik; Skånland, Sigrid Strand; Waelchli, Sebastien; Bakke, Oddmund & Sandvig, Kirsten (2013). BiP Negatively Affects Ricin Transport. Toxins.  ISSN 2072-6651.  5(5), s 969- 982 . doi: 10.3390/toxins5050969
  • Malmstrøm, Martin; Jentoft, Sissel; Gregers, Tone Fredsvik & Jakobsen, Kjetill Sigurd (2013). Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy. PLoS ONE.  ISSN 1932-6203.  8(9) . doi: 10.1371/journal.pone.0074004 Full text in Research Archive.
  • Skjeldal, Frode Miltzow; Strunze, Sten; Bergeland, Trygve; Walseng, Even; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). The fusion of early endosomes induces molecular-motor-driven tubule formation and fission. Journal of Cell Science.  ISSN 0021-9533.  125(8), s 1910- 1919 . doi: 10.1242/jcs.092569
  • Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian & Jakobsen, Kjetill Sigurd (2011). The genome sequence of Atlantic cod reveals a unique immune system. Nature.  ISSN 0028-0836.  477(7363), s 207- 210 . doi: 10.1038/nature10342 Full text in Research Archive.
  • Landsverk, Ole J. B.; Barois, Nicolas; Gregers, Tone Fredsvik & Bakke, Oddmund (2011). Invariant chain increases the half-life of MHC II by delaying endosomal maturation. Immunology and Cell Biology.  ISSN 0818-9641.  89(5), s 619- 629 . doi: 10.1038/icb.2010.143
  • Landsverk, OJB; Bakke, Oddmund & Gregers, TF (2009). MHC II and the Endocytic Pathway: Regulation by Invariant Chain. Scandinavian Journal of Immunology.  ISSN 0300-9475.  70(3), s 184- 193 . doi: 10.1111/j.1365-3083.2009.02301.x
  • Walchli, S; Skånland, Sigrid Strand; Gregers, Tone Fredsvik; Lauvrak, Silje Anett Ugland; Torgersen, Maria Lyngaas; Ying, M; Kuroda, S; Maturana, A & Sandvig, Kirsten (2008). The mitogen-activated protein kinase p38 links Shiga toxin-dependent signaling and trafficking. Molecular Biology of the Cell.  ISSN 1059-1524.  19(1), s 95- 104 . doi: 10.1091/mbc.E07-06-0565
  • Michaelsen, Terje Einar; Thommesen, John E.; Ihle, Øistein; Gregers, Tone F.; Sandin, Randi Helene; Brekke, Ole Henrik & Sandlie, Inger (2006). A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells. European Journal of Immunology.  ISSN 0014-2980.  36(1), s 129- 138 . doi: 10.1002/eji.200535178 Show summary
  • Slominska-Wojewodzka, M; Gregers, Tone Fredsvik; Waelchli, Sebastien & Sandvig, Kirsten (2006). EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol. Molecular Biology of the Cell.  ISSN 1059-1524.  17, s 1664- 1675
  • Gregers, Tone Fredsvik (2015). Slik fungerer vaksinene i barnevaksinasjonsprogrammet. Aftenposten Viten.
  • Gregers, Tone Fredsvik & Sørbye, Sveinung Wergeland (2014, 13. januar). Derfor blir menn sykere av influensa. [Internett].  ABC nyheter. Show summary
  • Berg-Larsen, Axel; Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). Rab GTPases are differentially regulated during DC maturation. Molecular Immunology.  ISSN 0161-5890.  51(1), s 8- 8 . doi: 10.1016/j.molimm.2012.02.016
  • Kucera, Ana; Bakke, Oddmund & Gregers, Tone Fredsvik (2012). Direct targeting of invariant chain to the MHC II loading compartment. Molecular Immunology.  ISSN 0161-5890.  51(1), s 20- 21 . doi: 10.1016/j.molimm.2012.02.054
  • Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte derived dendritic cells and how invariant chain increases the half-life of MHC II by delaying endosomal maturation. Molecular Immunology.  ISSN 0161-5890.  51(1), s 7- 7 . doi: 10.1016/j.molimm.2012.02.012
  • Sand, Kine Marita Knudsen; Landsverk, Ole J. B.; Bakke, Oddmund & Gregers, Tone Fredsvik (2012). Intracellular trafficking of the human invariant chain isoforms, Iip33 and Iip35. Molecular Immunology.  ISSN 0161-5890.  51(1), s 30- 30 . doi: 10.1016/j.molimm.2012.02.081
  • Wälchli, Sebastien; Landsverk, Ole J. B.; Fallang, Lars-Egil; Olweus, Johanna; Bakke, Oddmund & Gregers, Tone Fredsvik (2012). Invariant chain as a tool to load antigenic peptides on MHC class I. Molecular Immunology.  ISSN 0161-5890.  51(1), s 16- 16 . doi: 10.1016/j.molimm.2012.02.039
  • Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Solbakken, Monica Hongrø; Paulsen, Jonas; Lagesen, Karin; Tooming-Klunderud, Ave; Tina, Kirubakaran G.; Espelund, Mari; Skage, Morten; Berg, Paul Ragnar; Omholt, Stig W; Stenseth, Nils Christian & Jakobsen, Kjetill Sigurd (2011). The genome of Atlantic cod reveals a unique immune system.
  • Berg-Larsen, Axel; Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2011). Rab GTPases are Differentially Regulated Duringe DC Maturation. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 361- 361
  • Kucera, Ana; Bakke, Oddmund & Gregers, Tone Fredsvik (2011). Direct Targeting of Invariant Chain to the MHC II Loading Compartment. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 362- 362
  • Kucera, Ana; Bakke, Oddmund & Gregers, Tone Fredsvik (2011). The Role of Inhibitory NKR-P1 Receptors in the Gut. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 362- 363
  • Sand, Kine Marita Knudsen; Bakke, Oddmund & Gregers, Tone Fredsvik (2011). The Role of li p35 in MHC Class II Antigen Presentation. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 358- 358
Published Nov. 4, 2010 2:38 PM - Last modified June 6, 2014 11:13 AM