dCod 1.0: decoding the systems toxicology of Atlantic cod (Gadus morhua)
About the project
The goal of the dCod-project is to combine the competencies in environmental toxicology, biology, bioinformatics and mathematics across the traditional department boundaries, to create a deeper understanding of cods' adaptations and reactions to stressors in the environment.
Building on the thoroughly studies and mapping of the cod genome at UiO and the long research traditions on cod at the Department of Biology at UiB, the dCod project will expand our knowledge with methods based on genomics; where the use of the cod genome under different environmental conditions will be investigated.
UiO, IBV is leading Work Package 5 (WP5) - Phenotypic anchoring, with studies focusing on pathological and physiological responses in cod.
The projects aims to generate large amounts of experimental data to be the basis of mathematical models that can describe these responses based on different scenarios.
Overall, the goal is to create a tool for environmental monitoring and risk assessment that can be used in assessing the impacts of for example the oil industry, sewage discharge into harbours and industrial discharge into Norwegian fjords. Climate change and ocean acidification, in addition to cocktail effects of several stressors, will also be studied.
UiO, IBV is leading the WP5 of the project, with the following objectives:
•to determine relationships between exposure to toxicants, toxicogenomic expression profiles and neurodevelopment, behavior, pathology and physiology,
•to identify the most important events in the mode of action of selected toxicants,
•to identify key phenotypic processes that link back to defined toxicogenomic expression profiles.
RCN (Research Council of Norway) through DNL (Digital Life Norway).
The dCod-project is carried out by a consortium led by UiB’s Department of Biology, in collaboration with the Department of Mathematics and the Department of Informatics at UiB and national partners from NTNU, UiO, the Norwegian University of Life Sciences (NMBU), the Institute of Marine Research (IMR), the National Institute of Nutrition and Seafood Research (NIFES) and the International Research Institute of Stavanger (IRIS). Additionally, further insights will be obtained through collaborations with international partners that include University of Gothenburg (Sweden) and CSIC (Barcelona, Spain) as well as Woods Hole Oceanographic Institution (Massachusetts), Florida State University, and Ayasdi Inc (Stanford, California) (all in the United States).